Role of immunomarkers in the clinicopathological analysis of unicystic ameloblastoma.

Abstract:

PURPOSE:The clinical behavior of unicystic ameloblastoma varies according to its subtype. The assessment of its proliferative capacity, neovascularization, and invasiveness using relevant immunomarkers may aid in appropriate surgical therapeutic protocol. METHODS:18 cases of clinically and histologically confirmed unicystic ameloblastoma, categorized as luminal, intraluminal, or mural subtypes, were analyzed retrospectively. Immunomarkers such as Ki-67, CD34, MMP-2, and MMP-9 were studied to evaluate their behavior. RESULTS:Labeling index of Ki-67 was 4.25% in the intraluminal subtype, compared with 2.14% in the luminal and 4.04% in the mural variant (P = 0.3). CD34 immunostaining was significantly higher in the mural variant (43 per high power field) than the other two subtypes (P = 0.04). MMP-2 and MMP-9 were strongly expressed in mural, moderately in intraluminal, and weakly to absent in luminal variant. CONCLUSIONS:High proliferative index, angiogenesis, and protease activity in the mural ameloblastoma, ascertained by the expression of these markers, confirm its aggressive phenotype. The intraluminal and luminal subtype exhibiting decreased expression are compatible with their indolent clinical behavior.

journal_name

Dis Markers

journal_title

Disease markers

authors

Sah P,Menon A,Kamath A,Chandrashekar C,Carnelio S,Radhakrishnan R

doi

10.1155/2013/517834

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

481-8

issue

5

eissn

0278-0240

issn

1875-8630

journal_volume

35

pub_type

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