当前位置： SCI文献检索 > DISEASE MARKERS期刊下所有文献 > The use of plasma and urine neutrophil gelatinase associated lipocalin (NGAL) and Cystatin C in early diagnosis of septic acute kidney injury in critically ill patients.

The use of plasma and urine neutrophil gelatinase associated lipocalin (NGAL) and Cystatin C in early diagnosis of septic acute kidney injury in critically ill patients.

Abstract：

AIM:To assess and compare the roles of plasma and urine concentrations of neutrophil gelatinase associated lipocalin (NGAL) and Cystatin C for early diagnosis of septic acute kidney injury (AKI) in adult critically ill patients. METHODS:Patients were divided into three groups as sepsis-non AKI, sepsis-AKI and non sepsis-non AKI. Plasma samples for NGAL and Cystatin C were determined on admission and on alternate days and urinary samples were collected for every day until ICU discharge. RESULTS:One hundred fifty one patients were studied; 66 in sepsis-non AKI, 63 in sepsis-AKI, 22 in non-sepsis-non-AKI groups. Although plasma NGAL performed less well (AUC 0.44), urinary NGAL showed significant discrimination for AKI diagnosis (AUC 0.80) with a threshold value of 29.5 ng/ml (88% sensitivity, 73% specificity). Both plasma and urine Cystatin C worked well for the diagnosis of AKI (AUC 0.82 and 0.86, thresholds 1.5 and 0.106 mg/L respectively). CONCLUSION:Plasma and urinary Cystatin C and urinary NGAL are useful markers in predicting AKI in septic critically ill patients. Plasma NGAL raises in patients with sepsis in the absence of AKI and should be used with caution as a marker of AKI in septic ICU patients.

journal_name

Dis Markers

journal_title

Disease markers

authors

Aydoğdu M,Gürsel G,Sancak B,Yeni S,Sarı G,Taşyürek S,Türk M,Yüksel S,Senes M,Ozis TN

doi

10.3233/DMA-130966

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

237-46

issue

4

eissn

0278-0240

issn

1875-8630

pii

1017M24640ML2419

journal_volume

34

pub_type

杂志文章

相关文献

DISEASE MARKERS文献大全
  • Peritransplant Soluble CD30 as a Risk Factor for Slow Kidney Allograft Function, Early Acute Rejection, Worse Long-Term Allograft Function, and Patients' Survival.

    abstract：BACKGROUND:We aimed to determine whether serum soluble CD30 (sCD30) could identify recipients at high risk for unfavorable early and late kidney transplant outcomes. METHODS:Serum sCD30 was measured on the day of kidney transplantation and on the 4th day posttransplant. We assessed the value of these measurements in p...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2017/9264904

    authors： Trailin AV,Ostapenko TI,Nykonenko TN,Nesterenko SN,Nykonenko OS

    更新日期：2017-01-01 00:00:00

  • HFE gene polymorphisms and the risk for autism in Egyptian children and impact on the effect of oxidative stress.

    abstract：BACKGROUND:Autism is among the commonest neurodevelopmental childhood disorders worldwide; its aetiology is still unknown. Iron metabolism alteration in the central nervous system is recently implicated as a risk factor for several neurodegenerative disorders. Haemochromatosis HFE gene polymorphisms (p.H63D and p.C282Y...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.3233/DMA-2011-0830

    authors： Gebril OH,Meguid NA

    更新日期：2011-01-01 00:00:00

  • Promoter methylation of SFRP3 is frequent in hepatocellular carcinoma.

    abstract：:Oncogenic activation of the Wnt/ β -catenin signaling pathway is common in human cancers. The secreted frizzled-related proteins (SFRPs) function as negative regulators of Wnt signaling and have important implications in carcinogenesis. Because there have been no reports about the role of SFRP3 in hepatocellular carci...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2014/351863

    authors： Lin YW,Shih YL,Lien GS,Suk FM,Hsieh CB,Yan MD

    更新日期：2014-01-01 00:00:00

  • Hepatic Subcapsular Flow as a Significant Diagnostic Marker for Biliary Atresia: A Meta-Analysis.

    abstract：Aim:Increasing evidence indicates that hepatic subcapsular flow (HSF) can serve as a noninvasive ultrasonographic marker for the early diagnosis of biliary atresia (BA). However, results regarding its diagnostic accuracy are inconsistent and inconclusive. We conducted this meta-analysis with an aim to systematically ev...

    journal_title：Disease markers

    pub_type： 杂志文章,评审

    doi：10.1155/2020/5262565

    authors： Sun C,Wu B,Pan J,Chen L,Zhi W,Tang R,Zhao D,Guo W,Wang J,Huang S

    更新日期：2020-03-01 00:00:00

  • Cyclin-Dependent Kinase Regulatory Subunit 2 Indicated Poor Prognosis and Facilitated Aggressive Phenotype of Hepatocellular Carcinoma.

    abstract：:Cyclin-dependent kinase regulatory subunit 2 (CKS2) is a member of the cell cycle-dependent protein kinase subunit family, which is implicated as an oncogene in various malignancies. However, the clinical significance, oncogenic functions, and related mechanisms of CKS2 in hepatocellular carcinoma (HCC) remain largely...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2019/8964015

    authors： Zhang J,Song Q,Liu J,Lu L,Xu Y,Zheng W

    更新日期：2019-10-22 00:00:00

  • Toward Noninvasive Diagnosis of IgA Nephropathy: A Pilot Urinary Metabolomic and Proteomic Study.

    abstract：:IgA nephropathy is diagnosed by renal biopsy, an invasive procedure with a risk of significant complications. Noninvasive approaches are needed for possible diagnostic purposes and especially for monitoring disease activity or responses to treatment. In this pilot project, we assessed the utility of urine samples as s...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2016/3650909

    authors： Neprasova M,Maixnerova D,Novak J,Reily C,Julian BA,Boron J,Novotny P,Suchanek M,Tesar V,Kacer P

    更新日期：2016-01-01 00:00:00

  • Corrigendum to "RANTES Gene Polymorphisms Associated with HIV-1 Infections in Kenyan Population".

    abstract：:[This corrects the article DOI: 10.1155/2016/4703854.]. ...

    journal_title：Disease markers

    pub_type： 杂志文章,已发布勘误

    doi：10.1155/2017/6230176

    authors： Mutuiri SPM,Kutima HL,Mwapagha LM,Munyao JK,Kebira AN,Wanjiru I,Khamadi SA

    更新日期：2017-01-01 00:00:00

  • Susceptibility to toxoplasmic retinochoroiditis is associated with HLA alleles reported to be implicated with rapid progression to AIDS.

    abstract：BACKGROUND/AIMS:The frequency of HLA markers associated with rapid progression to AIDS was evaluated in Brazilian patients with AIDS exhibiting or not toxoplasmic retinochoroiditis (TRC). METHODS:98 AIDS patients (25 with TRC, 43 with anti-T. gondii antibodies but without TCR, and 30 without anti-T. gondii antibodies ...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.3233/DMA-2012-00935

    authors： Demarco AL,Rodrigues Mde L,Figueiredo JF,Deghaide NH,de Menezes MB,Demarco LA,Fernandes AP,Donadi EA

    更新日期：2012-01-01 00:00:00

  • A Case-Control Study of the Association between Polymorphisms in the Fibrinogen Alpha Chain Gene and Schizophrenia.

    abstract：:Our previous studies using the mass spectrum analysis provided evidence that fibrinopeptide A (FPA) could be a potential biomarker for schizophrenia diagnosis. We sought further to demonstrate that variants in the fibrinogen alpha chain gene (FGA) coded FPA might confer vulnerability to schizophrenia. 1,145 patients w...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2017/3104180

    authors： Rao W,Zhou N,Zhang H,Liu R,Zhang S,Su Y,Yang G,Ma Y,Shi J,Yu Y,Yu Q

    更新日期：2017-01-01 00:00:00

  • The CCR5Δ32 polymorphism in Brazilian patients with sickle cell disease.

    abstract：BACKGROUND:Previous studies on the role of inflammation in the pathophysiology of sickle cell disease (SCD) suggested that the CCR5Δ32 allele, which is responsible for the production of truncated C-C chemokine receptor type 5 (CCR5), could confer a selective advantage on patients with SCD because it leads to a less eff...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2014/678246

    authors： Lopes MP,Santos MN,Faber EW,Bezerra MA,Hatzlhofer BL,Albuquerque DM,Zaccariotto TR,Ribeiro DM,Araújo Ada S,Costa FF,Sonati Mde F

    更新日期：2014-01-01 00:00:00

  • Identification of Pathogenic Genes of Nonsyndromic Hearing Loss in Uyghur Families Using Massively Parallel DNA Sequencing Technique.

    abstract：:We aim to identify the mutations of deafness genes using massively parallel DNA sequencing in the 12 Uyghur families. SNPscan method was used to screen against the 124 sites in the common deafness genes in probands. Subjects with SNPscan negativity were subject to massively parallel DNA sequencing for the sequencing o...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2018/5298057

    authors： Chen Y,Lu Y,Kuyaxi P,Cheng J,Zhao J,Zhao Q,Musha P,Zhang H,Yuan H

    更新日期：2018-03-05 00:00:00

  • KIF20A Predicts Poor Survival of Patients and Promotes Colorectal Cancer Tumor Progression through the JAK/STAT3 Signaling Pathway.

    abstract：:Kinesin family member 20A (KIF20A) has been recently reported to be upregulated and associated with increased invasiveness and metastasis in several malignancies. However, the role of KIF20A in colorectal cancer (CRC) is still unclear. This study is aimed at investigating the potential roles of KIF20A in the developme...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2020/2032679

    authors： Zhang Q,Di J,Ji Z,Mi A,Li Q,Du X,Wang A,Wang A,Qin C

    更新日期：2020-07-08 00:00:00

  • Effects of Apelin on Left Ventricular-Arterial Coupling and Mechanical Efficiency in Rats with Ischemic Heart Failure.

    abstract：:Apelin plays important roles in cardiovascular homeostasis. However, its effects on the mechanoenergetics of heart failure (HF) are unavailable. We attempted to investigate the effects of apelin on the left ventricular-arterial coupling (VAC) and mechanical efficiency in rats with HF. HF was induced in rats by the lig...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2019/4823156

    authors： Ouyang Q,You T,Guo J,Xu R,Guo Q,Lin J,Zhao H

    更新日期：2019-06-17 00:00:00

  • Adverse Cardiac Remodelling after Acute Myocardial Infarction: Old and New Biomarkers.

    abstract：:The prevalence of heart failure (HF) due to cardiac remodelling after acute myocardial infarction (AMI) does not decrease regardless of implementation of new technologies supporting opening culprit coronary artery and solving of ischemia-relating stenosis with primary percutaneous coronary intervention (PCI). Numerous...

    journal_title：Disease markers

    pub_type： 杂志文章,评审

    doi：10.1155/2020/1215802

    authors： Berezin AE,Berezin AA

    更新日期：2020-06-12 00:00:00

  • Malignant Mesothelioma, BAP1 Immunohistochemistry, and VEGFA: Does BAP1 Have Potential for Early Diagnosis and Assessment of Prognosis?

    abstract：:Malignant mesothelioma (MM) is an aggressive malignancy of the serosal membranes. Early diagnosis and accurate prognostication remain problematic. BAP1 is a tumour suppressor gene commonly mutated in MM. Germline BAP1 mutation has been associated with early onset and less aggressive disease compared with sporadic MM. ...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2017/1310478

    authors： Pulford E,Huilgol K,Moffat D,Henderson DW,Klebe S

    更新日期：2017-01-01 00:00:00

  • Single-cell elastography: probing for disease with the atomic force microscope.

    abstract：:The atomic force microscope (AFM) is emerging as a powerful tool in cell biology. Originally developed for high-resolution imaging purposes, the AFM also has unique capabilities as a nano-indenter to probe the dynamic viscoelastic material properties of living cells in culture. In particular, AFM elastography combines...

    journal_title：Disease markers

    pub_type： 杂志文章,评审

    doi：10.1155/2004/482680

    authors： Costa KD

    更新日期：2003-01-01 00:00:00

  • Diagnostic implications of an elevated troponin in the emergency department.

    abstract：OBJECTIVE:To determine the proportion of initial troponin (cTn) elevations associated with Type I MI versus other cardiovascular and noncardiovascular diagnoses in an emergency department (ED) and whether or not a relationship exists between the cTn level and the likelihood of Type I MI. BACKGROUND:In the ED, cTn is u...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2015/157812

    authors： Yiadom MY,Jarolim P,Jenkins C,Melanson SE,Conrad M,Kosowsky JM

    更新日期：2015-01-01 00:00:00

  • Monoclonal antibodies against partially deglycosylated colon cancer mucin that recognize Tn antigen.

    abstract：:In order to develop reagents that can detect the exposed core carbohydrate antigens of mucins, we have prepared monoclonal antibodies against partially deglycosylated LS174T human colon cancer mucin. The three monoclonal antibodies, 10F4, 15D3a, and 91S8, stained cancers of the colon, pancreas, stomach, breast, prosta...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：

    authors： Huang J,Byrd JC,Siddiki B,Yuan M,Lau E,Kim YS

    更新日期：1992-03-01 00:00:00

  • The apolipoprotein B/apolipoprotein A-I ratio as a potential marker of plasma atherogenicity.

    abstract：BACKGROUND:The apolipoprotein (apo) B/apoA-I ratio represents the balance between apoB-rich atherogenic particles and apoA-I-rich antiatherogenic particles, and this ratio is considered to be a marker of cardiovascular risk. Although many studies have demonstrated the importance of the apoB/apoA-I ratio in predicting t...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2015/591454

    authors： Kaneva AM,Potolitsyna NN,Bojko ER,Odland JØ

    更新日期：2015-01-01 00:00:00

  • HLA-DQ molecular heterogeneity in HLA-DR4-Dw4 consanguineous cell lines.

    abstract：:Two-dimensional gel analysis (NEPHGE) of the molecules precipitated by the HLA-DR monomorphic antibody L243 showed a single and identical alpha chain spot from two consanguineous cell lines, BM14 and MCF. The latter was derived from a rheumatoid arthritis patient. No apparent structural polymorphism of the HLA-DR beta...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：

    authors： Fernandez N,Labeta M,Kurpisz M,Solana R,Festenstein H

    更新日期：1986-06-01 00:00:00

  • Could high levels of tissue polypeptide specific antigen, a marker of apoptosis detected in nonalcoholic steatohepatitis, improve after weight loss?

    abstract：BACKGROUND:Tissue Polypeptide Specific antigen has recently been proposed as diagnostic marker of apoptosis in NonAlcoholic SteatoHepatitis. The aim of this study was to validate in patients suffering from NonAlcoholic SteatoHepatitis the clinical utility of this marker after different programs of weight reduction. ME...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.3233/DMA-2009-0607

    authors： Tarantino G,Mazzarella C,Tarantino M,Di Minno MN,Conca P

    更新日期：2009-01-01 00:00:00

  • High Expression of LTBP2 Contributes to Poor Prognosis in Colorectal Cancer Patients and Correlates with the Mesenchymal Colorectal Cancer Subtype.

    abstract：:Colorectal cancer (CRC) is a complex and heterogeneous disease with four consensus molecular subtypes (CMS1-4). LTBP2 is a member of the fibrillin/LTBP super family and plays a critical role in tumorigenesis by activating TGF-β in the CMS4 CRC subtype. So far, the expression and prognostic significance of LTBP2 in CRC...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2019/5231269

    authors： Huang Y,Wang G,Zhao C,Geng R,Zhang S,Wang W,Chen J,Liu H,Wang X

    更新日期：2019-03-10 00:00:00

  • Infection as a risk factor in the pathogenesis of primary biliary cirrhosis: pros and cons.

    abstract：:Primary biliary cirrhosis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology, characterized by injury of the intrahepatic bile ducts that may eventually lead to cirrhosis and liver failure. Evidence suggests cardinal roles for both environmental factors and genetic susceptibilit...

    journal_title：Disease markers

    pub_type： 杂志文章,评审

    doi：10.3233/DMA-2010-0747

    authors： Kumagi T,Abe M,Ikeda Y,Hiasa Y

    更新日期：2010-01-01 00:00:00

  • The Relation between eNOS -786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, -384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease.

    abstract：AIM:The purpose of this study is to determine the association between eotaxin 426 C/T, -384 A/G, 67 G/A, eNOS -786 T/C, 4 a/b, and MMP-13 rs640198 G/T and prognosis of patients with known CAD. METHODS:From total of 1161 patients referred to coronary angiography, 532 patients with angiographically confirmed CAD were se...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2015/232048

    authors： Kincl V,Máchal J,Drozdová A,Panovský R,Vašků A

    更新日期：2015-01-01 00:00:00

  • The search for a genetic factor associating with immune restoration disease in HIV patients co-infected with Mycobacterium tuberculosis.

    abstract：BACKGROUND:Up to 43% of HIV-infected patients co-infected with Mycobacterium tuberculosis experience exacerbations of tuberculosis (TB) after commencing antiretroviral therapy (ART). These are termed immune restoration disease (IRD). It is unclear why individual susceptibility varies. OBJECTIVE:We investigate if singl...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.3233/DMA-130991

    authors： Affandi JS,Kumar M,Agarwal U,Singh S,Price P

    更新日期：2013-01-01 00:00:00

  • Immunological markers of lung disease due to non-tuberculous mycobacteria.

    abstract：:Lung disease due to non-tuberculous mycobacteria (NTM) is a poorly understood condition that is difficult to treat. Treatment remains problematic as few tools are available to help clinicians monitor disease progression or predict treatment outcome. In this study, plasma levels of several inflammatory molecules and th...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.3233/DMA-2010-0732

    authors： Lim A,Allison C,Tan DB,Oliver B,Price P,Waterer G

    更新日期：2010-01-01 00:00:00

  • Expression Concordance of 325 Novel RNA Biomarkers between Data Generated by NanoString nCounter and Affymetrix GeneChip.

    abstract：Background:With the development of new drug combinations and targeted treatments for multiple types of cancer, the ability to stratify categories of patient populations and to develop companion diagnostics has become increasingly important. A panel of 325 RNA biomarkers was selected based on cancer-related biological p...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2019/1940347

    authors： Delmonico L,Attiya S,Chen JW,Obenauer JC,Goodwin EC,Fournier MV

    更新日期：2019-05-14 00:00:00

  • Expression of Spindle and Kinetochore-Associated Protein 1 Is Associated with Poor Prognosis in Papillary Thyroid Carcinoma.

    abstract：AIM:Spindle and kinetochore-associated protein 1 (SKA1) is one subtype of SKA, whose protein can make spindle microtubules attach steadily to the kinetochore in the middle of mitosis. At present, there are fewer researches on the relationship between SKA1 expression and tumor development. METHODS:In this study, immuno...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2015/616541

    authors： Dong C,Wang XL,Ma BL

    更新日期：2015-01-01 00:00:00

  • Genetic Polymorphisms of MMP1, MMP9, COL1A1, and COL1A2 in Polish Patients with Thoracic Aortopathy.

    abstract：Background:The pathogenesis of thoracic aortopathy is complex, and much evidence suggests the influence of genetic factors. Some genes with polymorphisms are widely considered critical factors in the initiation and development of aortic aneurysm. The aim of our study was to analyze the association of genetic polymorphi...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2020/9567239

    authors： Gorący I,Grudniewicz S,Safranow K,Ciechanowicz A,Jakubiszyn P,Gorący A,Brykczyński M

    更新日期：2020-09-24 00:00:00

  • Baseline Serum Cystatin C Is a Potential Predictor for Acute Kidney Injury in Patients with Acute Pancreatitis.

    abstract：Aims:The study is aimed at studying the incidence of acute kidney injury (AKI) and exploring the potential predictor for AKI in patients with acute pancreatitis. Methods:A retrospective study adopting a stratified cohort sampling design was performed in a cohort of patients (n = 237) diagnosed with acute pancreatitis ...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2018/8431219

    authors： Chai X,Huang HB,Feng G,Cao YH,Cheng QS,Li SH,He CY,Lu WH,Qin MM

    更新日期：2018-11-19 00:00:00