当前位置： SCI文献检索 > DISEASE MARKERS期刊下所有文献 > A Case-Control Study of the Association between Polymorphisms in the Fibrinogen Alpha Chain Gene and Schizophrenia.

A Case-Control Study of the Association between Polymorphisms in the Fibrinogen Alpha Chain Gene and Schizophrenia.

Abstract：

:Our previous studies using the mass spectrum analysis provided evidence that fibrinopeptide A (FPA) could be a potential biomarker for schizophrenia diagnosis. We sought further to demonstrate that variants in the fibrinogen alpha chain gene (FGA) coded FPA might confer vulnerability to schizophrenia. 1,145 patients with schizophrenia and 1,016 healthy volunteers from the Han population in Northeast China were recruited. The association of three tag single nucleotide polymorphisms (SNPs) (rs2070011 in the 5'UTR, rs2070016 in intron 4, and rs2070022 in the 3'UTR) in FGA and schizophrenia was examined using a case-control study design. Genotypic distributions of these three SNPs were not found to be significantly different between cases and controls (rs2070011: χ2 = 1.28, P = 0.528; rs2070016: χ2 = 4.11, P = 0.128; rs2070022: χ2 = 1.23, P = 0.541). There were also no significant differences in SNP allelic frequencies between cases and controls (all P > 0.05). Additionally, the frequency of haplotypes consisting of alleles of these three SNPs was not significantly different between cases and healthy control subjects (global χ2 = 9.27, P = 0.159). Our study did not show a significant association of FGA SNPs with schizophrenia. Future studies may need to test more FGA SNPs in a larger sample to identify those SNPs with a minor or moderate effect on schizophrenia.

journal_name

Dis Markers

journal_title

Disease markers

authors

Rao W,Zhou N,Zhang H,Liu R,Zhang S,Su Y,Yang G,Ma Y,Shi J,Yu Y,Yu Q

doi

10.1155/2017/3104180

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

3104180

eissn

0278-0240

issn

1875-8630

journal_volume

2017

pub_type

杂志文章

相关文献

DISEASE MARKERS文献大全
  • TLR-4 and CD14 polymorphisms in respiratory syncytial virus associated disease.

    abstract：:Respiratory syncytial virus (RSV) is the most common viral respiratory pathogen during infancy world wide. It induces innate and adaptive immune response in host cells. The toll like receptor 4 (TLR4)/CD14 complex is particularly important for the initiation of an innate immune response to RSV. Thus we were interested...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2006/865890

    authors： Puthothu B,Forster J,Heinzmann A,Krueger M

    更新日期：2006-01-01 00:00:00

  • The clinical significance of PR, ER, NF- κ B, and TNF- α in breast cancer.

    abstract：OBJECTIVES:To investigate the expression of estrogen (ER), progesterone receptors (PR), nuclear factor- κ B (NF- κ B), and tumor necrosis factor- α (TNF- α ) in human breast cancer (BC), and the correlation of these four parameters with clinicopathological features of BC. METHODS AND RESULTS:We performed an immunohist...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2014/494581

    authors： Zhou XL,Fan W,Yang G,Yu MX

    更新日期：2014-01-01 00:00:00

  • Serum Soluble ST2 and Diastolic Dysfunction in Hypertensive Patients.

    abstract：BACKGROUND:Echocardiographic evaluation of left ventricular (LV) structural and functional alterations in hypertension has some limitations, potentially overcome by using biomarkers. ST2, a prognostic biomarker for heart failure and myocardial infarction patients, was less studied in hypertension. AIM:To analyze the r...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2017/2714095

    authors： Farcaş AD,Anton FP,Goidescu CM,Gavrilă IL,Vida-Simiti LA,Stoia MA

    更新日期：2017-01-01 00:00:00

  • High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma.

    abstract：BACKGROUND:Despite the many studies examining thyroid cancers, the effect of thyroid autoantibodies on differentiated thyroid carcinoma (DTC) remains unclear. OBJECTIVE:To investigate the association between serologic thyroid autoantibodies (ATAs) and DTC, we retrospectively evaluated data of thyroid nodules obtained ...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2015/648670

    authors： Qin J,Yu Z,Guan H,Shi L,Liu Y,Zhao N,Shan Z,Han C,Li Y,Teng W

    更新日期：2015-01-01 00:00:00

  • Clinical Value of Combined Determination of Serum B7-H4 with Carcinoembryonic Antigen, Osteopontin, or Tissue Polypeptide-Specific Antigen for the Diagnosis of Colorectal Cancer.

    abstract：Aim:B7-H4 is member of the B7 family that negatively regulates the immune response, which are associated with tumor development and prognosis. The present study is aimed at examining serum B7-H4 expression and exploring its contribution to diagnosis in patients with colorectal cancer. Methods:We determined serum expre...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2018/4310790

    authors： Wang P,Li C,Zhang F,Ma X,Gai X

    更新日期：2018-09-27 00:00:00

  • Impact of renin-angiotensin-aldosterone system gene polymorphisms on left ventricular dysfunction in coronary artery disease patients.

    abstract：BACKGROUND:Left ventricular dysfunction (LVD), followed by fall in cardiac output is one of the major complications in some coronary artery disease (CAD) patients. The decreased cardiac output over time leads to activation of the renin-angiotensin-aldosterone system which results in vasoconstriction by influencing salt...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.3233/DMA-2012-0858

    authors： Mishra A,Srivastava A,Mittal T,Garg N,Mittal B

    更新日期：2012-01-01 00:00:00

  • Identification of human papilloma virus DNA sequence in the hyperplastic epithelium of an oral denture fibroma.

    abstract：:The human papilloma virus (HPV) associated with hyperplastic epithelium in an oral denture fibroma was examined by southern blot hybridization. Extracted DNA was hybridized with full length linear HPV type 2a, 6b, 11, 16, 18, 31 and 33 DNAs as a mixed probe only under low stringent conditions. The hybridized bands dig...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：

    authors： Yamaguchi T,Shindoh M,Amemiya A,Notani K,Fukuda H,Sakaoka H,Inoue M,Fujinaga K

    更新日期：1997-04-01 00:00:00

  • Corrigendum to "RANTES Gene Polymorphisms Associated with HIV-1 Infections in Kenyan Population".

    abstract：:[This corrects the article DOI: 10.1155/2016/4703854.]. ...

    journal_title：Disease markers

    pub_type： 杂志文章,已发布勘误

    doi：10.1155/2017/6230176

    authors： Mutuiri SPM,Kutima HL,Mwapagha LM,Munyao JK,Kebira AN,Wanjiru I,Khamadi SA

    更新日期：2017-01-01 00:00:00

  • Human papillomaviruses and non-melanoma skin cancer: basic virology and clinical manifestations.

    abstract：:Human papillomaviruses (HPV) infect cutaneous and mucosal epithelia and induce benign and malignant lesions. Non-melanoma skin cancer (NMSC), encompassing basal cell carcinoma and squamous cell carcinoma (SCC), is the most frequent cancer in the Caucasian population, and the incidence has increased dramatically worldw...

    journal_title：Disease markers

    pub_type： 杂志文章,评审

    doi：10.1155/2007/942650

    authors： Nindl I,Gottschling M,Stockfleth E

    更新日期：2007-01-01 00:00:00

  • Association of WISP1/CCN4 with Risk of Overweight and Gestational Diabetes Mellitus in Chinese Pregnant Women.

    abstract：Background:Obese women with gestational diabetes mellitus (GDM) have a higher risk of adverse outcomes than women with obesity or GDM alone. Our study is aimed at investigating the discriminatory power of circulatory Wnt1-inducible signaling pathway protein-1 (WISP1), a novel adipocytokine, on the copresence of prepreg...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2020/4934206

    authors： Liu L,Hu J,Yang L,Wang N,Liu Y,Wei X,Gao M,Wang Y,Ma Y,Wen D

    更新日期：2020-04-14 00:00:00

  • Effects of Apelin on Left Ventricular-Arterial Coupling and Mechanical Efficiency in Rats with Ischemic Heart Failure.

    abstract：:Apelin plays important roles in cardiovascular homeostasis. However, its effects on the mechanoenergetics of heart failure (HF) are unavailable. We attempted to investigate the effects of apelin on the left ventricular-arterial coupling (VAC) and mechanical efficiency in rats with HF. HF was induced in rats by the lig...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2019/4823156

    authors： Ouyang Q,You T,Guo J,Xu R,Guo Q,Lin J,Zhao H

    更新日期：2019-06-17 00:00:00

  • Diagnostic implications of an elevated troponin in the emergency department.

    abstract：OBJECTIVE:To determine the proportion of initial troponin (cTn) elevations associated with Type I MI versus other cardiovascular and noncardiovascular diagnoses in an emergency department (ED) and whether or not a relationship exists between the cTn level and the likelihood of Type I MI. BACKGROUND:In the ED, cTn is u...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2015/157812

    authors： Yiadom MY,Jarolim P,Jenkins C,Melanson SE,Conrad M,Kosowsky JM

    更新日期：2015-01-01 00:00:00

  • MMP-9, homocysteine and CRP circulating levels are associated with intraluminal thrombus thickness of abdominal aortic aneurysms: new implication of the old biomarkers.

    abstract：BACKGROUND:Abdominal aortic aneurysms (AAAs) are characterized by presence of high proteolytic activity, atherosclerotic lesions, extensive transmural inflammation and the presence of variably sized and shaped intraluminal thrombus (ILT). Therefore, we evaluated a possible association between plasma matrix metalloprote...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.3233/DMA-2011-0799

    authors： Wiernicki I,Millo B,Safranow K,Gorecka-Szyld B,Gutowski P

    更新日期：2011-01-01 00:00:00

  • Relationship between Serum Levels of Metalloproteinase-8 and Tissue Inhibitor of Metalloproteinases-1 and Exercise Test Results in Postmenopausal Women.

    abstract：:Physical activity as a part of the lifestyle is a significant factor influencing health condition. Exercises that require stamina are of particular importance. Oxygen metabolism, which is a significant part of all longer training processes, has an influence on cardiovascular and respiratory system functioning as well ...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2016/7169531

    authors： Mieczkowska J,Rutkowska E,Mosiewicz J,Mosiewicz B

    更新日期：2016-01-01 00:00:00

  • Evaluation of Metabolic Defects in Fatty Acid Oxidation Using Peripheral Blood Mononuclear Cells Loaded with Deuterium-Labeled Fatty Acids.

    abstract：:Because tandem mass spectrometry- (MS/MS-) based newborn screening identifies many suspicious cases of fatty acid oxidation and carnitine cycle disorders, a simple, noninvasive test is required to confirm the diagnosis. We have developed a novel method to evaluate the metabolic defects in peripheral blood mononuclear ...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2019/2984747

    authors： Yuasa M,Hata I,Sugihara K,Isozaki Y,Ohshima Y,Hara K,Tajima G,Shigematsu Y

    更新日期：2019-02-07 00:00:00

  • SREBP-2 1784 G/C genotype is associated with non-alcoholic fatty liver disease in north Indians.

    abstract：BACKGROUND:Genetics of non-alcoholic fatty liver (NAFLD) in Asian Indians has been inadequately investigated. This study aims to determine the association of the 1784G>C polymorphism in the SREBP-2 gene with NAFLD in Asian Indians in north India. METHODS:In this study, (n=335); 162 obese with NAFLD, 91 obese without N...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.3233/DMA-2011-0852

    authors： Bhatt SP,Nigam P,Misra A,Guleria R,Luthra K,Vaidya M,Jain SK,Pasha MA

    更新日期：2011-01-01 00:00:00

  • A Simplified Diagnostic Classification Scheme of Chemotherapy-Induced Peripheral Neuropathy.

    abstract：:Background and Objective. The main purpose of this study was to develop a simple automatic diagnostic classification scheme for chemotherapy-induced peripheral neuropathy. Methods:This was a prospective cohort study that enrolled patients with colorectal or gynecologic cancer post chemotherapy for more than 1 year. T...

    journal_title：Disease markers

    pub_type： 临床试验,杂志文章

    doi：10.1155/2020/3402108

    authors： Huang HW,Wu PY,Su PF,Li CI,Yeh YM,Lin PC,Hsu KF,Shen MR,Chang JY,Lin CK

    更新日期：2020-01-25 00:00:00

  • Polymorphism on Chromosome 9p21.3 Is Associated with Severity and Early-Onset CAD in Type 2 Diabetic Tunisian Population.

    abstract：:Multiple association studies found that the human 9p21.3 chromosome locus is a risk factor for atherosclerosis. The purpose of this study was to investigate the association of the severity and early-onset of coronary artery disease with variant rs1333049 on chromosome 9p21.3 polymorphism and the impact of this variant...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2015/792679

    authors： Abid K,Mili D,Kenani A

    更新日期：2015-01-01 00:00:00

  • CD99 and HLA-II immunostaining in breast cancer tissue and their correlation with lymph node metastasis.

    abstract：:In an attempt to better unfold the antitumor immune response and invasion strategies perused by tumor cells, markers such as CD99 and HLA-II have been stained in breast tumors, some of them turned out to be important for prognosis and its outcome. CD99 is involved in the intracellular transport of HLA-II proteins. The...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.3233/DMA-130982

    authors： Baccar A,Ferchichi I,Troudi W,Marrakchi R,Ben Hmida N,Jebini S,Mrad K,Ben Romdhane K,Benammar Elgaaied A

    更新日期：2013-01-01 00:00:00

  • Diagnostic Markers for Nonspecific Inflammatory Bowel Diseases.

    abstract：:The nonspecific inflammatory bowel diseases (IBD) represent a heterogeneous group of chronic inflammatory disorders of the gastrointestinal tract, and Leśniowski-Crohn's disease (CD) and ulcerative colitis (UC) are among the two major clinical forms. Despite the great progress in understanding the pathogenesis of thes...

    journal_title：Disease markers

    pub_type： 杂志文章,评审

    doi：10.1155/2018/7451946

    authors： Derkacz A,Olczyk P,Komosinska-Vassev K

    更新日期：2018-06-11 00:00:00

  • Alanine Aminotransferase and Body Composition in Obese Men and Women.

    abstract：:There is a known relationship between serum alanine aminotransferase (ALT) and obesity in humans, but the mechanism(s) are not clarified. This study investigated the associations between serum ALT and body composition in an overweight and obese population. The results are based on data from a previous randomized contr...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2019/1695874

    authors： Bekkelund SI,Jorde R

    更新日期：2019-08-26 00:00:00

  • Effect of periodontal surgery on osteoprotegerin levels in gingival crevicular fluid, saliva, and gingival tissues of chronic periodontitis patients.

    abstract：OBJECTIVES:This study was undertaken to investigate the OPG profiles in gingival crevicular fluid (GCF), saliva, and gingival tissues of chronic periodontitis (CP) patients in response to open flap debridement (OFD). SUBJECTS AND METHODS:The study included 30 subjects divided into 2 groups: 20 CP patients and 10 perio...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2015/341259

    authors： Hassan SH,El-Refai MI,Ghallab NA,Kasem RF,Shaker OG

    更新日期：2015-01-01 00:00:00

  • Investigating the impact of the Down syndrome related common MTHFR 677C>T polymorphism in the Danish population.

    abstract：:Chromosomal aneuploidy consists the leading cause of fetal death in our species. Around 50% of spontaneous abortions until 15 weeks of gestational age are chromosomally aneuploid, with trisomies accounting for 50% of the abnormal abortions. Trisomy 21 is the most common chromosome abnormality in liveborns and is usual...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.3233/DMA-2009-0673

    authors： Kokotas H,Grigoriadou M,Mikkelsen M,Giannoulia-Karantana A,Petersen MB

    更新日期：2009-01-01 00:00:00

  • Association of Galectin-3 and Soluble ST2, and Their Changes, with Echocardiographic Parameters and Development of Heart Failure after ST-Segment Elevation Myocardial Infarction.

    abstract：Purpose:To investigate the association of galectin-3 (Gal-3) and soluble ST2 (sST2) and their follow-up changes with the development of heart failure (HF) and echocardiographic parameters of HF (ejection fraction, atrial and ventricular size, left ventricular hypertrophy, e', and E/e') in patients with ST-segment eleva...

    journal_title：Disease markers

    pub_type： 临床试验,杂志文章

    doi：10.1155/2019/9529053

    authors： Tymińska A,Kapłon-Cieślicka A,Ozierański K,Budnik M,Wancerz A,Sypień P,Peller M,Balsam P,Opolski G,Filipiak KJ

    更新日期：2019-10-10 00:00:00

  • A Panel of CA19-9, Ca125, and Ca15-3 as the Enhanced Test for the Differential Diagnosis of the Pancreatic Lesion.

    abstract：:Background. Proper diagnosis of pancreatic lesion etiology is a challenging clinical dilemma. Studies suggest that surgery for suspected pancreatic ductal adenocarcinoma (PDAC) reveals a benign lesion in 5% to 13% of cases. The aim of our study was to assess whether routinely used biomarkers such as CA19-9, Ca125, Ca1...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2017/8629712

    authors： Hogendorf P,Skulimowski A,Durczyński A,Kumor A,Poznańska G,Oleśna A,Rut J,Strzelczyk J

    更新日期：2017-01-01 00:00:00

  • Corrigendum to "Proteomic-Based Approaches for the Study of Cytokines in Lung Cancer".

    abstract：:[This corrects the article DOI: 10.1155/2016/2138627.]. ...

    journal_title：Disease markers

    pub_type： 杂志文章,已发布勘误

    doi：10.1155/2018/1404780

    authors： Marrugal Á,Ojeda L,Paz-Ares L,Molina-Pinelo S,Ferrer I

    更新日期：2018-07-08 00:00:00

  • Apolipoprotein E genotypes in Mexican patients with Parkinson's disease.

    abstract：BACKGROUND:The association of the apolipoprotein (Apo E) -epsilon4 allele to neurodegenerative diseases such as Parkinson's disease (PD) has been analyzed in several studies. This association has been identified by amyloid deposits and neurofibrillary tangles in the brains of patients with neurodegenerative diseases. ...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.3233/DMA-2009-0667

    authors： Gallegos-Arreola MP,Figuera LE,Ortiz GG,Jiménez-Gil FJ,Ramírez-Vega J,Ruíz-Sandoval JL,Puebla-Pérez AM,Troyo-Sanroman R,García-Ortiz JE,Sanchez-Corona J,Zúñiga-González GM

    更新日期：2009-01-01 00:00:00

  • SOD2 V16A SNP in the mitochondrial targeting sequence is associated with noise induced hearing loss in Chinese workers.

    abstract：OBJECTIVE:To investigate whether single nucleotide polymorphisms (SNPs) in the Mn-superoxide dismutase gene (SOD2) underlie the susceptibility to noise-induced hearing loss (NIHL). METHODS:Audiometric data from 2400 Chinese Han workers who exposed to occupational noise were analyzed. DNA samples were collected from th...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.3233/DMA-2010-0693

    authors： Liu YM,Li XD,Guo X,Liu B,Lin AH,Ding YL,Rao SQ

    更新日期：2010-01-01 00:00:00

  • Optimized CyberKnife Lung Treatment: Effect of Fractionated Tracking Volume Change on Tracking Results.

    abstract：Objectives:To explore the impact of volume change in the fractionated tracking of stereotactic radiotherapy on the results of synchronous, respiratory tracking algorithm using CyberKnife. Methods:A total of 38 lung tumor patients receiving stereotactic radiotherapy at our center from March 2018 to October 2019 were co...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2020/9298263

    authors： Li GQ,Wang Y,Qiu MJ,Yang J,Peng ZJ,Zhang S,Fang X,Yang SL

    更新日期：2020-01-11 00:00:00

  • Serum Levels of Kisspeptin Are Elevated in Patients with Pancreatic Cancer.

    abstract：:Pancreatic adenocarcinoma (PDAC) still represents a devastating disease associated with a very limited survival. Novel biomarkers allowing an early diagnosis as well as an optimal selection of suitable treatment options for individual patients are urgently needed to improve the dismal outcome of PDAC patients. Recentl...

    journal_title：Disease markers

    pub_type： 杂志文章

    doi：10.1155/2019/5603474

    authors： Loosen SH,Luedde M,Lurje G,Spehlmann M,Paffenholz P,Ulmer TF,Tacke F,Vucur M,Trautwein C,Neumann UP,Luedde T,Roderburg C

    更新日期：2019-10-20 00:00:00