Abstract:
:Primary biliary cirrhosis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology, characterized by injury of the intrahepatic bile ducts that may eventually lead to cirrhosis and liver failure. Evidence suggests cardinal roles for both environmental factors and genetic susceptibility. Nevertheless, the absolute etiology of PBC is unclear, despite recent well-designed case-control studies that reported environmental risk factors, including infectious agents, for PBC. Of the reported infectious agents, some of them are not reproducible and remain controversial. However, infection is no doubt one of the major risks among the environmental factors. This is supported by the fact that infectious agents in autoimmune diseases express antigens resulting in molecular mimicry and xenobiotics that play a role in breaking tolerance. Taken together, recent findings from genome wide assays as well as novel animal models may enable us to better understand the mechanism of pathogenesis responsible for this disease.
journal_name
Dis Markersjournal_title
Disease markersauthors
Kumagi T,Abe M,Ikeda Y,Hiasa Ydoi
10.3233/DMA-2010-0747subject
Has Abstractpub_date
2010-01-01 00:00:00pages
313-21issue
6eissn
0278-0240issn
1875-8630pii
7047536943637377journal_volume
29pub_type
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