Abstract:
:There is increasing evidence to support the use of CA125 in the follow-up and management of patients with ovarian cancer and several commercial kits are now available for its measurement. This study investigated and compared the performance of three of them: an enzyme immunoassay (EIA) and an immunoradiometric assay (IRMA) from Abbott Diagnostics, and an IRMA from CIS, U.K. One hundred and thirty-two serum samples from 42 patients with advanced epithelial ovarian cancer were thawed once and assayed for CA125 using each kit. Both IRMAs performed better than the EIA in terms of CV, sensitivity, specificity, and accuracy. The results confirm the usefulness of CA125 as a marker for ovarian cancer. However, discrepancies between results using different kits suggest the need for improved standardization.
journal_name
Dis Markersjournal_title
Disease markersauthors
Fisken J,Leonard RC,Roulston JEsubject
Has Abstractpub_date
1989-01-01 00:00:00pages
61-7issue
1eissn
0278-0240issn
1875-8630journal_volume
7pub_type
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