Abstract:
:Alcohol abuse is one of the most common risk factor for chronic pancreatitis, but the underlying pathophysiological mechanisms remain unclear. The aim of this study was to identify genes that contribute to susceptibility or resistance for alcoholic chronic pancreatitis by screening the whole genome. Sixty-five patients with alcoholic chronic pancreatitis (63 men and 2 women, mean age 55.2 years) and 99 healthy Japanese controls were enrolled in this study. This was an association study using 400 polymorphic microsatellite markers with an average spacing of 10.8 cM distributed throughout the whole genome. This search revealed 10 candidate susceptibility regions and 5 candidate resistant regions throughout the genome. No specific microsatellite markers were detected in association with previously reported susceptibility genes for chronic pancreatitis, such as PRSS1, PRSS2, CTRC, SPINK1, CFTR, ALDH2, and CYP2E1. Among the statistically significant markers, D15S1007 on chromosome 15q14 showed strong evidence for disease susceptibility (70.8% vs. 35.1%, Pc = 0.0001). Within 500 kb of D15S1007, several genes were candidate genes for susceptibility, including FMN1, DKFZP686C2281, LOC440268, RYR3, and AVEN, This study identified 10 candidate susceptibility and 5 candidate resistant regions that may contain genes involved in ACP pathogenesis.
journal_name
Dis Markersjournal_title
Disease markersauthors
Kitahara K,Kawa S,Katsuyama Y,Umemura T,Ozaki Y,Takayama M,Arakura N,Ota Mdoi
10.1155/2008/426764subject
Has Abstractpub_date
2008-01-01 00:00:00pages
175-80issue
3eissn
0278-0240issn
1875-8630journal_volume
25pub_type
杂志文章相关文献
DISEASE MARKERS文献大全abstract::IgA nephropathy (IgAN) is a kidney disease with a varying renal prognosis. Recently, many studies have demonstrated that renal alpha-smooth muscle actin (alpha-SMA) and transforming growth factor (TGF-beta1) expression, as well interstitial mast cell infiltrates could represent a prognostic marker in several renal dis...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2008/725408
更新日期:2008-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2016/2138627.]. ...
journal_title:Disease markers
pub_type: 杂志文章,已发布勘误
doi:10.1155/2018/1404780
更新日期:2018-07-08 00:00:00
abstract::The cell surface glycoprotein KAI1/CD82 suppresses tumor growth and metastasis in animal models. This study aimed to evaluate the prognostic relevance of KAI1/CD82 protein expression in human gastric cancer. Primary gastric carcinomas (n=271) with a mean clinical follow-up time of 48 months were immunostained using th...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2012-0896
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:A possible association between the TACC3 rs798766 polymorphism and urinary bladder cancer risk has been indicated in published literature. We performed this meta-analysis as a synthesis of all relevant data to summarize currently available evidence and to provide estimation with increased precision. METHODS...
journal_title:Disease markers
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2017/7850708
更新日期:2017-01-01 00:00:00
abstract::The prevalence of heart failure (HF) due to cardiac remodelling after acute myocardial infarction (AMI) does not decrease regardless of implementation of new technologies supporting opening culprit coronary artery and solving of ischemia-relating stenosis with primary percutaneous coronary intervention (PCI). Numerous...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2020/1215802
更新日期:2020-06-12 00:00:00
abstract:BACKGROUND:Cystic fibrosis is a monogenic recessive disorder found predominantly in Caucasian population. This disease arises from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. In this study we consider poly T polymorphism c.1210-12T[5], c.1210-12T[7], c.1210-12T[9] (T{5}, T{7}, T{9}...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2011-0880
更新日期:2012-01-01 00:00:00
abstract::In view of the potential uses of cell surface tumour associated antigens in novel anticancer treatment, a study was designed to investigate whether the biological response modifiers interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) could effect the expression of an epitope on the tumour associa...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/1994/480236
更新日期:1994-10-01 00:00:00
abstract::Ultrasound has been a popular clinical imaging modality for decades. It is well established as a means of displaying the macroscopic anatomy of soft-tissue structures. While conventional ultrasound methodologies (i.e., B-mode and Doppler methods) are well proven and continue to advance technically on a daily basis, e....
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2002/167104
更新日期:2002-01-01 00:00:00
abstract::INHBA-encoded inhibin β A is a member of the transforming growth factor-β (TGF-β) superfamily. INHBA has been reported to be implicated in the progression of multiple types of cancer including ovarian cancer (OC). However, the mechanisms by which INHBA affects OC progression are not well-characterized. The aim of our ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/7275289
更新日期:2019-11-11 00:00:00
abstract::Introduction. Chronic Periodontitis (CP) is suggested to be related to gene variations. Present study aims to quantitatively estimate the association between interleukin-6- (IL-6-) 174G/C polymorphism and CP susceptibility. Materials and Methods. Pubmed, Embase, and Web of Science were searched up to May 2016. The met...
journal_title:Disease markers
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2016/9612421
更新日期:2016-01-01 00:00:00
abstract::Studies have shown that the maternal risk for Down syndrome (DS) may be modulated by alterations in folate metabolism. The aim of this study was to evaluate the influence of 12 genetic polymorphisms involved in folate metabolism on maternal risk for DS. In addition, we evaluated the impact of these polymorphisms on se...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2011-0869
更新日期:2012-01-01 00:00:00
abstract::Restriction fragment length polymorphism (RFLP) analyses of DR1 positive peripheral blood leukocytes DNA was carried out. The Taq I digested DNA was hybridized with cDNA probes for HLA-DR and -DQ beta genes. The DR probe detected fragments commonly observed in the DR1 specificity, whereas a new DQ-beta fragment was de...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1991-09-01 00:00:00
abstract::Keloids are benign fibroproliferative tumors of the skin which commonly occur after injury mainly in darker skinned patients. Medical treatment is fraught with high recurrence rates mainly because of an incomplete understanding of the biological mechanisms that lead to keloids. The purpose of this project was to exami...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/943176
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Evidence indicates that microRNAs (miRNA) play a role in the pathogenesis of chronic kidney diseases (CKD). We explored the possibility of using urinary miRNA as non-invasive biomarkers for CKD. METHODS:We quantified miRNA expression in urinary sediment of 56 CKD patients who underwent kidney biopsy. Patien...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2012/842764
更新日期:2012-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/1202710.]. ...
journal_title:Disease markers
pub_type: 已发布勘误
doi:10.1155/2020/1245645
更新日期:2020-10-14 00:00:00
abstract:Objective:To systematically evaluate the significance of squamous cell carcinoma antigen (SCC-Ag) in the prognosis of cervical cancer. Methods:Literature from Pubmed, Embase, and Cochrane Library was retrieved to collect all English literature on the correlation between SCC-Ag and cervical cancer prognosis, and the qu...
journal_title:Disease markers
pub_type: 杂志文章,meta分析
doi:10.1155/2019/6710352
更新日期:2019-06-02 00:00:00
abstract:BACKGROUND:Stroke subtype diagnosis leads to specific therapies to reduce recurrences. Because nearly one third of patients remain with unknown etiology after a complete screening workup, we aim to investigate whether molecular markers of myocardial damage were associated with cardioembolic stroke and if they were usef...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2009-0630
更新日期:2009-01-01 00:00:00
abstract::Cyclin Y (CCNY) is a novel cyclin and almost nothing is known about its role in human cancers. To investigate the clinical significance of serum anti-CCNY autoantibodies in nonsmall-cell lung carcinoma (NSCLC), the serum levels of CCNY protein in 264 patients with NSCLC, 103 patients with tuberculosis, and 89 healthy ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/935943
更新日期:2013-01-01 00:00:00
abstract:Background and Objective:Reduced expression of syndecan-1 (CD138), increased proliferation index, and modifications in the expression of the molecular RANK/RANKL/OPG triad are related to an intensified potential of aggressiveness and invasion of diverse tumors and cysts. The aim was to compare the expression of Ki-67, ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/7048531
更新日期:2018-07-29 00:00:00
abstract::There is increasing evidence to support the use of CA125 in the follow-up and management of patients with ovarian cancer and several commercial kits are now available for its measurement. This study investigated and compared the performance of three of them: an enzyme immunoassay (EIA) and an immunoradiometric assay (...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::The eukaryotic initiation factor 3 (eIF3) is the largest and most complex translation initiation factor in mammalian cells. It consists of 13 subunits and among which several were implicated to have significant prognostic effects on multiple human cancer entities. To examine the expression profiles of eIF3 subunits an...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/6019637
更新日期:2019-12-07 00:00:00
abstract::Recent experiments have shown that when specific biomolecular interactions are confined to one surface of a microcantilever beam, changes in intermolecular nanomechanical forces provide sufficient differential torque to bend the cantilever beam. This has been used to detect single base pair mismatches during DNA hybri...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2002/856032
更新日期:2002-01-01 00:00:00
abstract::IgA nephropathy is diagnosed by renal biopsy, an invasive procedure with a risk of significant complications. Noninvasive approaches are needed for possible diagnostic purposes and especially for monitoring disease activity or responses to treatment. In this pilot project, we assessed the utility of urine samples as s...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2016/3650909
更新日期:2016-01-01 00:00:00
abstract:Background:The pathogenesis of thoracic aortopathy is complex, and much evidence suggests the influence of genetic factors. Some genes with polymorphisms are widely considered critical factors in the initiation and development of aortic aneurysm. The aim of our study was to analyze the association of genetic polymorphi...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/9567239
更新日期:2020-09-24 00:00:00
abstract::Prognostic markers of compensated cirrhosis should mainly investigate factors involved with progression to decompensation because death in cirrhosis is related with decompensation. Portal hypertension plays a crucial role in the pathophysiology of most complications of cirrhosis. Accordingly, HVPG monitoring has stron...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.3233/DMA-2011-0837
更新日期:2011-01-01 00:00:00
abstract::Objective. To determine active TGF-β1 (aTGF-β1) levels in serum, skin, and peripheral blood mononuclear cell (PBMC) culture supernatants and to understand their associations with clinical parameters in systemic sclerosis (SSc) patients. Methods. We evaluated serum samples from 56 SSc patients and 24 healthy controls (...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2016/6064830
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The association of the apolipoprotein (Apo E) -epsilon4 allele to neurodegenerative diseases such as Parkinson's disease (PD) has been analyzed in several studies. This association has been identified by amyloid deposits and neurofibrillary tangles in the brains of patients with neurodegenerative diseases. ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2009-0667
更新日期:2009-01-01 00:00:00
abstract::Apolipoprotein E (apoE) plays an important role in lipid metabolism. Its epsilon4 allele has been consistently associated with lipoprotein disorders but its connection to myocardial infarction (MI) is controversial. Because epsilon4 frequency decreases with age we thought that the contradictory results in different st...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2005/381657
更新日期:2005-01-01 00:00:00
abstract::In recent researches, high expression of nesfatin-1/nucleobindin-2 (NUCB2) is linked to poor prognosis in prostate and colon cancer due to the enhancement in proliferation, migration, and invasion. However, the role of nesfatin-1 in bladder cancer is not clear. In this study, we examined the expression of NUCB2 in bla...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/4272064
更新日期:2018-09-19 00:00:00
abstract:Background:The ratio of early mitral inflow velocity to the global diastolic strain rate (E/E'sr) and global longitudinal systolic strain (GLS) of the left ventricle (LV) are emerging indices of diastolic and systolic functions, respectively, for the LV. Their prognostic significance in the prediction of mortality and ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/7512805
更新日期:2019-09-05 00:00:00