High serum levels of pro-brain natriuretic peptide (pro BNP) identify cardioembolic origin in undetermined stroke.

abstract：:Primary biliary cirrhosis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology, characterized by injury of the intrahepatic bile ducts that may eventually lead to cirrhosis and liver failure. Evidence suggests cardinal roles for both environmental factors and genetic susceptibilit...

journal_title：Disease markers

authors： Kumagi T,Abe M,Ikeda Y,Hiasa Y

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Particularly interesting new cysteine-histidine rich protein (PINCH) is an important component of the local adhesion complexes and upregulated in several types of malignancies, and involved in the incidence and development of tumours. PINCH expression is also independently correlated with poorer survival in p...

journal_title：Disease markers

authors： Zhu ZL,Yan BY,Zhang Y,Yang YH,Wang ZM,Zhang HZ,Wang MW,Zhang XH,Sun XF

更新日期：2012-01-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) is the body fluid closest to the pathology of multiple sclerosis (MS). For many candidate biomarkers CSF is the only fluid that can be investigated. Several factors need to be standardized when sampling CSF for biomarker research: time/volume of CSF collection, sample processing/storage, and ...

journal_title：Disease markers

authors： Giovannoni G

更新日期：2006-01-01 00:00:00

abstract：:The surface and cytoplasmic expression of CD1a molecules was analysed by indirect immunofluorescence (IIF) and dot blot assay (DBA) in a panel of 40 acute and chronic leukaemias. Thirty-two per cent of the samples were positive by IIF but, surprisingly, 72 per cent of the patients were positive by DBA, suggesting the ...

journal_title：Disease markers

authors： Salamone MC,Roisman FR,Morelli AE,Noli MI,Fainboim L

更新日期：1990-09-01 00:00:00

abstract：:Colorectal cancer is one of the most common cancers in the world. Due to its still undetermined pathogenesis, we are searching for signaling pathways that are important in the development of colorectal cancer. In this article, we present results of study on the role of ADAM proteins in colorectal cancer. The study inc...

journal_title：Disease markers

authors： Walkiewicz K,Strzelczyk J,Waniczek D,Biernacki K,Muc-Wierzgoń M,Copija A,Nowakowska-Zajdel E

更新日期：2019-09-02 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the most common viral respiratory pathogen during infancy world wide. It induces innate and adaptive immune response in host cells. The toll like receptor 4 (TLR4)/CD14 complex is particularly important for the initiation of an innate immune response to RSV. Thus we were interested...

journal_title：Disease markers

authors： Puthothu B,Forster J,Heinzmann A,Krueger M

更新日期：2006-01-01 00:00:00

abstract：:CD4+ T cells of patients with B cell non-Hodgkin's lymphoma (NHL) were analysed for expression of CD45RA and CD29. It was found that CD45RA expression was significantly lower, and CD29 expression significantly higher, in lymphoma patients compared to normal controls. Moreover absolute numbers of CD4+ T cells were sign...

journal_title：Disease markers

authors： Sewell HF,MacKenzie RH,Dawson AA,Ratcliffe MA,King DJ,Bennett NB

更新日期：1990-05-01 00:00:00

abstract：:S-100 protein was demonstrated in 28/31 melanoma tissue sections that had been previously stained by hematoxylin and eosin, including 17 from 19 primary melanomas and 11 from 12 metastases. Additional H & E stained sections from 11 metastatic and 13 primary melanomas were reacted with the monoclonal antibody NKI/C-3 a...

journal_title：Disease markers

authors： Paul E,Cochran AJ

更新日期：1988-10-01 00:00:00

abstract：INTRODUCTION:Amongst the genitourinary cancers, carcinoma of the urinary bladder is one of the leading causes of death in India. Hypermethylation of the CpG islands of gene promoter is one of the earliest and most frequent epigenetic alterations leading to cancer as well as in its development. Several studies have sugg...

journal_title：Disease markers

authors： Ali Hosseini S,Sobti RC,Malekzadeh K,Singh SK,Joshi K

更新日期：2010-01-01 00:00:00

abstract：:Microsatellite instability (MSI) analysis is becoming more and more important to detect sporadic primary tumors of the MSI phenotype as well as in helping to determine Hereditary Non-Polyposis Colorectal Cancer (HNPCC) cases. After some years of conflicting data due to the absence of consensus markers for the MSI phen...

journal_title：Disease markers

authors： Buhard O,Suraweera N,Lectard A,Duval A,Hamelin R

更新日期：2004-01-01 00:00:00

abstract：:In view of the potential uses of cell surface tumour associated antigens in novel anticancer treatment, a study was designed to investigate whether the biological response modifiers interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) could effect the expression of an epitope on the tumour associa...

journal_title：Disease markers

authors： Clark S,McGuckin MA,Hurst T,Ward BG

更新日期：1994-10-01 00:00:00

abstract：Background:Lactate has been widely used as a risk indicator of outcomes in critically ill patients due to its ready measurement and good predictive ability. However, the interconnections between lactate metabolism and glucose metabolism have not been sufficiently explored, yet. In this study, we aimed to investigate wh...

journal_title：Disease markers

authors： Chen X,Bi J,Zhang J,Du Z,Ren Y,Wei S,Ren F,Wu Z,Lv Y,Wu R

更新日期：2019-11-26 00:00:00

abstract：BACKGROUND:Left ventricular dysfunction (LVD), followed by fall in cardiac output is one of the major complications in some coronary artery disease (CAD) patients. The decreased cardiac output over time leads to activation of the renin-angiotensin-aldosterone system which results in vasoconstriction by influencing salt...

journal_title：Disease markers

authors： Mishra A,Srivastava A,Mittal T,Garg N,Mittal B

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AND AIM:Because B-type natriuretic peptide is a powerful predictor of heart failure, its capability to predict a fatal outcome in stroke might be limited to the cardioembolic stroke subtype. In this study, we attempt to ascertain the difference in the prognostic value of N-terminal pro-B-type natriuretic pep...

journal_title：Disease markers

authors： Lee SJ,Lee DG,Lim DS,Hong S,Park JS

更新日期：2015-01-01 00:00:00

abstract：:IGF2 is the first gene discovered to be imprinted and expressed exclusively from the paternal allele in both human and mouse. IGF2 is also the first imprinted gene displaying loss of imprinting (LOI) or aberrant imprinting in human cancers. Evidently, LOI or reactivation of the maternal allele of IGF2 is associated wi...

journal_title：Disease markers

authors： Cui H

更新日期：2007-01-01 00:00:00

abstract：AIM:In this study, we aimed to investigate the relationship between the histological fibrosis stage of nonalcoholic fatty liver disease (NAFLD) and serum connective tissue growth factor (CTGF) to determine the usefulness of this relationship in clinical practice. METHODS:Serum samples were collected from 51 patients w...

journal_title：Disease markers

authors： Colak Y,Senates E,Coskunpinar E,Oltulu YM,Zemheri E,Ozturk O,Doganay L,Mesci B,Yilmaz Y,Enc FY,Kiziltas S,Ulasoglu C,Tuncer I

更新日期：2012-01-01 00:00:00

abstract：:Ovarian cancer is complex disease composed of different histological grades and types. However, the underlying molecular mechanisms involved in the development of different phenotypes remain largely unknown. Epidemiological studies identified multiple exogenous and endogenous risk factors for ovarian cancer developmen...

journal_title：Disease markers

authors： Mok SC,Kwong J,Welch WR,Samimi G,Ozbun L,Bonome T,Birrer MJ,Berkowitz RS,Wong KK

更新日期：2007-01-01 00:00:00

abstract：Objective:In order to further study the changes of cerebral functional connectivity in patients with toothache (TA), this study used the resting-state functional magnetic resonance imaging (rs-fMRI) technique and degree centrality (DC) analysis method. Methods:Eighteen TA patients (8 males, 10 females) and 18 healthy ...

journal_title：Disease markers

authors： Wu SN,Zhang MY,Shu HY,Liang RB,Ge QM,Pan YC,Zhang LJ,Li QY,Shao Y

更新日期：2020-12-28 00:00:00

abstract：:Background. Proper diagnosis of pancreatic lesion etiology is a challenging clinical dilemma. Studies suggest that surgery for suspected pancreatic ductal adenocarcinoma (PDAC) reveals a benign lesion in 5% to 13% of cases. The aim of our study was to assess whether routinely used biomarkers such as CA19-9, Ca125, Ca1...

journal_title：Disease markers

authors： Hogendorf P,Skulimowski A,Durczyński A,Kumor A,Poznańska G,Oleśna A,Rut J,Strzelczyk J

更新日期：2017-01-01 00:00:00

abstract：:SIRT6 has been demonstrated to exert protective effects on endothelial cells and is closely associated with lipid metabolism, glucose metabolism, and obesity, indicating an important role in the pathogenesis and progression of coronary artery disease (CAD). Nonetheless, the biological significance of SIRT6 variants on...

journal_title：Disease markers

authors： Tang SS,Xu S,Cheng J,Cai MY,Chen L,Liang LL,Yang XL,Chen C,Liu XG,Xiong XD

更新日期：2016-01-01 00:00:00

abstract：:Background and Objective. The main purpose of this study was to develop a simple automatic diagnostic classification scheme for chemotherapy-induced peripheral neuropathy. Methods:This was a prospective cohort study that enrolled patients with colorectal or gynecologic cancer post chemotherapy for more than 1 year. T...

journal_title：Disease markers

authors： Huang HW,Wu PY,Su PF,Li CI,Yeh YM,Lin PC,Hsu KF,Shen MR,Chang JY,Lin CK

更新日期：2020-01-25 00:00:00

abstract：:Prosthetic joint infection (PJI) is the most common cause of failure of total joint arthroplasty, but a gold standard for PJI diagnosis is still lacking. Advanced glycation end products (AGEs) are proinflammatory molecules inducing intracellular oxidative stress (OS) after binding to their cell membrane receptors (RAG...

journal_title：Disease markers

authors： Massaccesi L,Bonomelli B,Marazzi MG,Drago L,Romanelli MMC,Erba D,Papini N,Barassi A,Goi G,Galliera E

更新日期：2017-01-01 00:00:00

abstract：:We first investigated the difference in microRNA expression between normal NP cells and degenerative NP cells using gene chip. We have found that the expression of ERK1/2 was decreased with overexpression of miR-155 in normal nucleus pulposus cell. Expression of ERK1/2 was increased with inhibition of miR-155. Overexp...

journal_title：Disease markers

authors： Ye D,Dai L,Yao Y,Qin S,Xie H,Wang W,Liang W

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Tumor cells show alterations in their glycosylation patterns when compared to normal cells. Lectins can be used to evaluate these glycocode changes. Chemiluminescence assay is an effective technique for quantitative analysis of proteins, nucleic acids, and carbohydrates due to its high sensitivity, specifici...

journal_title：Disease markers

authors： Lima LR,Bezerra MF,Almeida SM,Silva LP,Beltrão EI,Carvalho Júnior LB

更新日期：2013-01-01 00:00:00

abstract：Objective:Several serum markers were reported to reflect the severity of pulmonary alveolar proteinosis (PAP). The aim of this study is to investigate a reliable and facile marker to access and monitor the clinical course of PAP in a large cohort. Methods:PAP patients from January 2010 to June 2018 were enrolled. Hosp...

journal_title：Disease markers

authors： Shi S,Chen L,Qiu X,Zhao Q,Xiao Y,Yan X

更新日期：2019-11-11 00:00:00

abstract：PURPOSE:The clinical behavior of unicystic ameloblastoma varies according to its subtype. The assessment of its proliferative capacity, neovascularization, and invasiveness using relevant immunomarkers may aid in appropriate surgical therapeutic protocol. METHODS:18 cases of clinically and histologically confirmed uni...

journal_title：Disease markers

authors： Sah P,Menon A,Kamath A,Chandrashekar C,Carnelio S,Radhakrishnan R

更新日期：2013-01-01 00:00:00

abstract：AIM:Spindle and kinetochore-associated protein 1 (SKA1) is one subtype of SKA, whose protein can make spindle microtubules attach steadily to the kinetochore in the middle of mitosis. At present, there are fewer researches on the relationship between SKA1 expression and tumor development. METHODS:In this study, immuno...

journal_title：Disease markers

authors： Dong C,Wang XL,Ma BL

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:To evaluate serum chemerin levels in patients with osteoporosis and healthy controls and to investigate the relationship between serum chemerin levels and bone mineral density (BMD). METHODS:An age- and gender-matched case-control study was conducted. Pearson's correlation test was performed to investigate ...

journal_title：Disease markers

authors： He J,Li JC,Xie H,Xu ZH,Sun YW,Shan Q

更新日期：2015-01-01 00:00:00

abstract：:Nevirapine (NVP) is an effective nonnucleoside reverse transcriptase inhibitor (NNRTI) of particular interest as it is often used in resource limited countries. However, one of the main concerns with the use of NVP is hepatotoxicity and elevation of liver enzymes as a consequence of highly active antiretroviral therap...

journal_title：Disease markers

authors： Wongtrakul J,Thongtan T,Roytrakul S,Kumrapich B,Janphen K,Praparattanapan J,Supparatpinyo K,Smith DR

更新日期：2014-01-01 00:00:00

abstract：:Recent experiments have shown that when specific biomolecular interactions are confined to one surface of a microcantilever beam, changes in intermolecular nanomechanical forces provide sufficient differential torque to bend the cantilever beam. This has been used to detect single base pair mismatches during DNA hybri...

journal_title：Disease markers

authors： Majumdar A

更新日期：2002-01-01 00:00:00