Abstract:
:Restriction fragment length polymorphism (RFLP) analyses of DR1 positive peripheral blood leukocytes DNA was carried out. The Taq I digested DNA was hybridized with cDNA probes for HLA-DR and -DQ beta genes. The DR probe detected fragments commonly observed in the DR1 specificity, whereas a new DQ-beta fragment was detected in some DR1 haplotypes when the DQ-beta probe was used. This fragment had an RFLP pattern identical to the DQ-beta fragment typically associated with most DR2 and some DRw6 specificities.
journal_name
Dis Markersjournal_title
Disease markersauthors
Redford A,Magalong D,Onohara-Toyoda M,Tyan D,Riley WJ,Maclaren NK,Rotter JI,Toyoda Hsubject
Has Abstractpub_date
1991-09-01 00:00:00pages
257-63issue
5eissn
0278-0240issn
1875-8630journal_volume
9pub_type
杂志文章相关文献
DISEASE MARKERS文献大全abstract:Aims:The impact of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 Lys45Glu (A/G), MMP-7 -181A/G, and MMP-12 -82A/G variants and plasma MMP levels on obesity and microvascular reactivity in Tunisians. Methods:Our population included 202 nonobese and 168 obese subjects. Anthropometric, biochemical, and microvascular parameters wer...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2017/6198526
更新日期:2017-01-01 00:00:00
abstract::Abnormal phenotypic switch of vascular smooth muscle cell (VSMC) is a hallmark of vascular disorders such as atherosclerosis and restenosis. And this process has been related to remodeling of L-type calcium channel (LTCC). We attempted to investigate whether fluvastatin has any effect on VSMC proliferation and LTCCα 1...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/237067
更新日期:2014-01-01 00:00:00
abstract:Materials and Methods:Relative expression of lncRNAs CARMN, LUCAT1, SMILR, and MALAT1 was tested in clinical aortic tissue and blood plasma samples from TAA and non-TAA patients using the qRT-PCR method. The Mann-Whitney U test was used to compare ΔCt values between the study groups. ROC curve analysis was performed to...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/8521899
更新日期:2020-06-17 00:00:00
abstract:Background:Determination of neonate serum's N-acetyl-β-hexosaminidase (HEX) activity and correlation results with Apgar scale and factors routinely determined in newborn serum. Aims:Providing reference values of neonates serum HEX activities, and indicate their diagnostic significance. Study design:The study was perf...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/6187245
更新日期:2018-07-02 00:00:00
abstract::Chromosomal aneuploidy consists the leading cause of fetal death in our species. Around 50% of spontaneous abortions until 15 weeks of gestational age are chromosomally aneuploid, with trisomies accounting for 50% of the abnormal abortions. Trisomy 21 is the most common chromosome abnormality in liveborns and is usual...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2009-0673
更新日期:2009-01-01 00:00:00
abstract:Objective:To systematically evaluate the significance of squamous cell carcinoma antigen (SCC-Ag) in the prognosis of cervical cancer. Methods:Literature from Pubmed, Embase, and Cochrane Library was retrieved to collect all English literature on the correlation between SCC-Ag and cervical cancer prognosis, and the qu...
journal_title:Disease markers
pub_type: 杂志文章,meta分析
doi:10.1155/2019/6710352
更新日期:2019-06-02 00:00:00
abstract::As the most common neoplasm arising from the kidney, renal cell carcinoma (RCC) continues to have a significant impact on global health. Conventional cross-sectional imaging has always served an important role in the staging of RCC. However, with recent advances in imaging techniques and postprocessing analysis, magne...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2015/648495
更新日期:2015-01-01 00:00:00
abstract::Renal cell carcinoma (RCC) is one of the most common genitourinary cancers worldwide. Previous evidence shows that long noncoding RNA (LncRNA) APOC1P1 plays an important role in cancer development. However, the role of LncRNA APOC1P1 in ccRCC remains to be explored. LncRNA APOC1P1 expression in 283 ccRCC tissues and 3...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/2814058
更新日期:2019-12-01 00:00:00
abstract::Ovarian cancer is complex disease composed of different histological grades and types. However, the underlying molecular mechanisms involved in the development of different phenotypes remain largely unknown. Epidemiological studies identified multiple exogenous and endogenous risk factors for ovarian cancer developmen...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2007/474320
更新日期:2007-01-01 00:00:00
abstract::The present study evaluated diurnal variations and day-to-day fluctuations of salivary oxidative stress (OS) markers in healthy adult individuals. Whole unstimulated saliva was collected at 2 time intervals over 3 consecutive days. Glutathione peroxidase (GPX), superoxide dismutase (SOD), total antioxidant capacity (T...
journal_title:Disease markers
pub_type: 临床试验,杂志文章
doi:10.1155/2017/2697464
更新日期:2017-01-01 00:00:00
abstract:Background:It is reported that miRNAs are aberrantly expressed in patients with pancreatic cancer. However, the diagnostic value of miRNAs in pancreatic cancer remains controversial. The meta-analysis was to access diagnostic accuracy of miRNAs in pancreatic cancer. Methods:PubMed, Scopus, Web of Science, Chinese Nati...
journal_title:Disease markers
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2018/6292396
更新日期:2018-05-15 00:00:00
abstract::S-100 protein was demonstrated in 28/31 melanoma tissue sections that had been previously stained by hematoxylin and eosin, including 17 from 19 primary melanomas and 11 from 12 metastases. Additional H & E stained sections from 11 metastatic and 13 primary melanomas were reacted with the monoclonal antibody NKI/C-3 a...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00
abstract::The terminal portion of the pol gene and the entire env gene of the human endogenous retrovirus ERV3 was screened for polymorphic nucleotides. For this purpose fragments amplified from the desired regions of ERV3 were subjected to single strand conformational analysis (SSCP analysis). Using this approach, we detected ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/1998/958379
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND:Paraoxonase-1 (PON1) activity is suggested to be altered in individuals infected with human immunodeficiency virus type-1 (HIV-1). We investigated PON1 activity in individuals receiving different regimens of highly active antiretroviral therapy (HAART). METHODS:PON1 activity was evaluated in 91 HIV-1 serone...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/480201
更新日期:2014-01-01 00:00:00
abstract:Background:Few previous studies have comprehensively explored the level of DNA methylation and gene expression in ccRCC. The purpose of this study was to identify the key clear cell renal cell carcinoma- (ccRCC-) related DNA methylation-driven genes (MDG) and to build a prognostic model based on the level of DNA methyl...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/8817652
更新日期:2020-07-11 00:00:00
abstract::GROβ (CXCL2) is a chemokine produced by endotoxin-treated macrophages that mediates inflammation and tumor development. However, little is known about GROβ expression in gastrointestinal stromal tumors (GIST) or the relationship between GROβ expression and clinical attributes of GIST. GROβ expression was examined via ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/171035
更新日期:2015-01-01 00:00:00
abstract::Traditional lipid measures are the cornerstone of risk assessment and treatment goals in cardiovascular prevention. Whereas the association between total, LDL-, HDL-cholesterol and cardiovascular disease risk has been generally acknowledged, the rather poor capacity to distinguish between patients who will and those w...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.3233/DMA-2009-0636
更新日期:2009-01-01 00:00:00
abstract:Background:Epithelial ovarian cancer (EOC) is highly lethal worldwide. Factors involved in the inflammation and hormone-associated signaling pathway play vital roles in EOC carcinogenesis. The transforming growth factor-β- (TGF-β-) activated kinase 1 (MAP3K7) binding protein 2 (TAB2), mediating convergence of inflammat...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/8012979
更新日期:2019-08-14 00:00:00
abstract::Gamma-glutamyltransferase (GGT) is a well-established serum marker for alcohol-related liver disease. However, GGT's predictive utility applies well beyond liver disease: elevated GGT is linked to increased risk to a multitude of diseases and conditions, including cardiovascular disease, diabetes, metabolic syndrome (...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2015/818570
更新日期:2015-01-01 00:00:00
abstract::A multitude of host genetic factors plays a crucial role in susceptibility to HIV-1 infection and progression to AIDS, which is highly variable among individuals and populations. This review focuses on the chemokine-receptor and chemokine genes, which were extensively studied because of their role as HIV co-receptor o...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.3233/DMA-2011-0874
更新日期:2012-01-01 00:00:00
abstract:Backgrounds:Both pretreatment serum CRP (C-reactive protein) level and ALB (albumin) level have been found to be predictive of survival for multiple malignancies including sarcoma. Since both of the GPS (Glasgow prognostic score) and CAR (C-reactive protein to albumin ratio) are based on the combination of CRP and ALB,...
journal_title:Disease markers
pub_type: 杂志文章,meta分析
doi:10.1155/2020/8736509
更新日期:2020-01-07 00:00:00
abstract::soluble urokinase Plasminogen Activator Receptor (suPAR) levels reflect inflammation and elevated suPAR levels are found in several infectious diseases and cancer. suPAR exists in three forms; suPAR(I-III), suPAR(II-III) and suPAR(I) which show different properties due to structural differences. Studies suggest that f...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.3233/DMA-2009-0657
更新日期:2009-01-01 00:00:00
abstract::Physical activity as a part of the lifestyle is a significant factor influencing health condition. Exercises that require stamina are of particular importance. Oxygen metabolism, which is a significant part of all longer training processes, has an influence on cardiovascular and respiratory system functioning as well ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2016/7169531
更新日期:2016-01-01 00:00:00
abstract::The prevalence of heart failure (HF) due to cardiac remodelling after acute myocardial infarction (AMI) does not decrease regardless of implementation of new technologies supporting opening culprit coronary artery and solving of ischemia-relating stenosis with primary percutaneous coronary intervention (PCI). Numerous...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2020/1215802
更新日期:2020-06-12 00:00:00
abstract::The clinical distinction of frontotemporal dementia (FTD) and Alzheimer's disease (AD) may be difficult. In this narrative review we summarize and discuss the most relevant electroencephalography (EEG) studies which have been applied to demented patients with the aim of distinguishing the various types of cognitive im...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2018/6581490
更新日期:2018-09-03 00:00:00
abstract::Background. Early identification of high risk subjects for cardiovascular disease in health check-up is still unmet medical need. Cardiovascular disease is characterized by the superior increase in aspartate aminotransferase (AST) to alanine aminotransferase (ALT). However, the association of AST/ALT ratio with brain ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2016/4857917
更新日期:2016-01-01 00:00:00
abstract::Over the last few years the interest in diagnostic markers for specific diseases has increased continuously. It is expected that they not only improve a patient's medical treatment but also contribute to accelerating the process of drug development. This demand for new biomarkers is caused by a lack of specific and se...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2006/174849
更新日期:2006-01-01 00:00:00
abstract::The discovery that PSA exists in serum in both free and complexed forms led to development of immunoassays specific for different PSA forms. This helped in measuring free PSA in the presence of PSA-ACT (PSA-alpha antichymotrypsin), hence it was possible to calculate the percent free PSA or free to total PSA ratio, mea...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2004/913870
更新日期:2003-01-01 00:00:00
abstract::A growing interest in the usability of saliva has been observed recently. Using saliva as a diagnostic material is possible because it contains a varied range of composites, organic and inorganic like proteins, carbohydrates, and lipids, which are secreted into saliva. Moreover, this applies to drugs and their metabol...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2019/4360612
更新日期:2019-05-02 00:00:00
abstract:BACKGROUND:We aimed to determine whether serum soluble CD30 (sCD30) could identify recipients at high risk for unfavorable early and late kidney transplant outcomes. METHODS:Serum sCD30 was measured on the day of kidney transplantation and on the 4th day posttransplant. We assessed the value of these measurements in p...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2017/9264904
更新日期:2017-01-01 00:00:00