Prognostic Value of DNA Methylation-Driven Genes in Clear Cell Renal Cell Carcinoma: A Study Based on Methylation and Transcriptome Analyses.

abstract：:Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide due to latent liver disease, late diagnosis, and nonresponse to systemic treatments. Till now, surgical and/or biopsy specimens are still generally used as a gold standard by the clinicians for clinical decision-making. Howeve...

journal_title：Disease markers

authors： Yin CQ,Yuan CH,Qu Z,Guan Q,Chen H,Wang FB

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:Both adaptive and innate immune systems are involved in coronary artery disease (CAD). The aim of this study was to evaluate TH17 cytokines expression profiles in un-stimulated peripheral blood lymphocytes (PBMCs) of patients with coronary artery disease. METHODS:Expression profiles of IL-17, IL-23, and TGF-...

journal_title：Disease markers

authors： Khojasteh-Fard M,Abolhalaj M,Amiri P,Zaki M,Taheri Z,Qorbani M,Bazzaz JT,Amoli MM

更新日期：2012-01-01 00:00:00

abstract：:Nevirapine (NVP) is an effective nonnucleoside reverse transcriptase inhibitor (NNRTI) of particular interest as it is often used in resource limited countries. However, one of the main concerns with the use of NVP is hepatotoxicity and elevation of liver enzymes as a consequence of highly active antiretroviral therap...

journal_title：Disease markers

authors： Wongtrakul J,Thongtan T,Roytrakul S,Kumrapich B,Janphen K,Praparattanapan J,Supparatpinyo K,Smith DR

更新日期：2014-01-01 00:00:00

abstract：:PD1/PDL1 inhibitors have been adopted for the treatment of advanced non-small-cell lung cancer, and PDL1 expression has been investigated as a predictive biomarker for PD1/PDL1 inhibitor therapy. However, PDL1 lacks diagnostic accuracy in differentiating patients who are likely or unlikely to benefit. So, it is urgent...

journal_title：Disease markers

authors： Wu Y,Lin L,Liu X

更新日期：2020-06-09 00:00:00

abstract：:Transforming growth factor β1 (TGF-β1) is an important mediator in Chagas disease. Furthermore, patients with higher TGF-β1 serum levels show a worse clinical outcome. Gene polymorphism may account for differences in cytokine production during infectious diseases. We tested whether TGFB1 polymorphisms could be associa...

journal_title：Disease markers

authors： Ferreira RR,Madeira FDS,Alves GF,Chambela MDC,Curvo EOV,Moreira ADS,Almeida de Sá R,Mendonça-Lima L,Cabello PH,Bailly S,Feige JJ,Araujo-Jorge TC,Saraiva RM,Waghabi MC

更新日期：2018-02-18 00:00:00

abstract：:This report describes the production and characterization of two new monoclonal antibodies (MoAb), WM-53 and WM-54, reacting with a human myeloid differentiation antigen, which has recently been assigned by the Third International Leucocyte Workshop on Human Differentiation Antigens into cluster CD-33 ('gp67'). To dat...

journal_title：Disease markers

authors： Favaloro EJ,Bradstock KF,Kabral A,Grimsley P,Berndt MC

更新日期：1987-12-01 00:00:00

abstract：:Two-dimensional gel analysis (NEPHGE) of the molecules precipitated by the HLA-DR monomorphic antibody L243 showed a single and identical alpha chain spot from two consanguineous cell lines, BM14 and MCF. The latter was derived from a rheumatoid arthritis patient. No apparent structural polymorphism of the HLA-DR beta...

journal_title：Disease markers

authors： Fernandez N,Labeta M,Kurpisz M,Solana R,Festenstein H

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND:Microarray technology shows great potential but previous studies were limited by small number of samples in the colorectal cancer (CRC) research. The aims of this study are to investigate gene expression profile of CRCs by pooling cDNA microarrays using PAM, ANN, and decision trees (CART and C5.0). METHODS:...

journal_title：Disease markers

authors： Chu CM,Yao CT,Chang YT,Chou HL,Chou YC,Chen KH,Terng HJ,Huang CS,Lee CC,Su SL,Liu YC,Lin FG,Wetter T,Chang CW

更新日期：2014-01-01 00:00:00

abstract：Objectives:We investigated the influence of spinal cord stimulation (SCS) on IFN-γ, IL-1β, IL-6, TNF-α, IL-10, and TGF-β serum levels in failed back surgery syndrome (FBSS) patients. The study will try to give new insights into the mechanism of SCS action and the role of IFN-γ and other cytokines in neuropathic pain (N...

journal_title：Disease markers

authors： Kamieniak P,Bielewicz J,Grochowski C,Litak J,Bojarska-Junak A,Daniluk B,Trojanowski T

更新日期：2019-01-14 00:00:00

abstract：:Recent experiments have shown that when specific biomolecular interactions are confined to one surface of a microcantilever beam, changes in intermolecular nanomechanical forces provide sufficient differential torque to bend the cantilever beam. This has been used to detect single base pair mismatches during DNA hybri...

journal_title：Disease markers

authors： Majumdar A

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Autism is among the commonest neurodevelopmental childhood disorders worldwide; its aetiology is still unknown. Iron metabolism alteration in the central nervous system is recently implicated as a risk factor for several neurodegenerative disorders. Haemochromatosis HFE gene polymorphisms (p.H63D and p.C282Y...

journal_title：Disease markers

authors： Gebril OH,Meguid NA

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Tissue Polypeptide Specific antigen has recently been proposed as diagnostic marker of apoptosis in NonAlcoholic SteatoHepatitis. The aim of this study was to validate in patients suffering from NonAlcoholic SteatoHepatitis the clinical utility of this marker after different programs of weight reduction. ME...

journal_title：Disease markers

authors： Tarantino G,Mazzarella C,Tarantino M,Di Minno MN,Conca P

更新日期：2009-01-01 00:00:00

abstract：Background:Syndecan-1 (SDC1/CD138) is a key cell surface adhesion molecule essential for maintaining cell morphology and the interactions with the surrounding microenvironment. SDC1 tumor immunoexpression may be increased or decreased in epithelial malignant neoplasms compared to that in adjacent non-neoplastic tissue,...

journal_title：Disease markers

authors： Li K,Li L,Wu X,Yu J,Ma H,Zhang R,Li Y,Wang W

更新日期：2019-04-30 00:00:00

abstract：Purpose:To investigate the association of galectin-3 (Gal-3) and soluble ST2 (sST2) and their follow-up changes with the development of heart failure (HF) and echocardiographic parameters of HF (ejection fraction, atrial and ventricular size, left ventricular hypertrophy, e', and E/e') in patients with ST-segment eleva...

journal_title：Disease markers

authors： Tymińska A,Kapłon-Cieślicka A,Ozierański K,Budnik M,Wancerz A,Sypień P,Peller M,Balsam P,Opolski G,Filipiak KJ

更新日期：2019-10-10 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of small, non-coding RNA molecules that can regulate gene expression, thereby affecting crucial processes in cancer development. miRNAs offer great potential as biomarkers for cancer detection because of their remarkable stability in blood and their characteristic expression in different...

journal_title：Disease markers

authors： Mar-Aguilar F,Mendoza-Ramírez JA,Malagón-Santiago I,Espino-Silva PK,Santuario-Facio SK,Ruiz-Flores P,Rodríguez-Padilla C,Reséndez-Pérez D

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:This study was undertaken to investigate the OPG profiles in gingival crevicular fluid (GCF), saliva, and gingival tissues of chronic periodontitis (CP) patients in response to open flap debridement (OFD). SUBJECTS AND METHODS:The study included 30 subjects divided into 2 groups: 20 CP patients and 10 perio...

journal_title：Disease markers

authors： Hassan SH,El-Refai MI,Ghallab NA,Kasem RF,Shaker OG

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The association of the apolipoprotein (Apo E) -epsilon4 allele to neurodegenerative diseases such as Parkinson's disease (PD) has been analyzed in several studies. This association has been identified by amyloid deposits and neurofibrillary tangles in the brains of patients with neurodegenerative diseases. ...

journal_title：Disease markers

authors： Gallegos-Arreola MP,Figuera LE,Ortiz GG,Jiménez-Gil FJ,Ramírez-Vega J,Ruíz-Sandoval JL,Puebla-Pérez AM,Troyo-Sanroman R,García-Ortiz JE,Sanchez-Corona J,Zúñiga-González GM

更新日期：2009-01-01 00:00:00

abstract：AIM:This study was conducted to find out the optimal vitamin D cutoff point in predicting activity of RA disease. MATERIALS AND METHODS:One hundred and two rheumatoid arthritis Saudi patients of both genders were recruited in this study. Vitamin D as 25-hydroxy-vitamin D [25(OH)D] was measured and serum level less tha...

journal_title：Disease markers

authors： Azzeh FS,Kensara OA

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Tumor cells show alterations in their glycosylation patterns when compared to normal cells. Lectins can be used to evaluate these glycocode changes. Chemiluminescence assay is an effective technique for quantitative analysis of proteins, nucleic acids, and carbohydrates due to its high sensitivity, specifici...

journal_title：Disease markers

authors： Lima LR,Bezerra MF,Almeida SM,Silva LP,Beltrão EI,Carvalho Júnior LB

更新日期：2013-01-01 00:00:00

abstract：:We evaluated the occurrence of mutations in P53, K-RAS, COX-2, expression of COX-2 and hTERT and relations among clinicopathological signs. P53 mutations were identified in 34.4% of tumours, the majority of them occurring in SCC (squamous cell carcinoma, 55.6%). K-RAS was mutated in 12.2% of NSCLC tumours, the majorit...

journal_title：Disease markers

authors： Strazisar M,Rott T,Glavac D

更新日期：2008-01-01 00:00:00

abstract：:The clinical distinction of frontotemporal dementia (FTD) and Alzheimer's disease (AD) may be difficult. In this narrative review we summarize and discuss the most relevant electroencephalography (EEG) studies which have been applied to demented patients with the aim of distinguishing the various types of cognitive im...

journal_title：Disease markers

authors： Nardone R,Sebastianelli L,Versace V,Saltuari L,Lochner P,Frey V,Golaszewski S,Brigo F,Trinka E,Höller Y

更新日期：2018-09-03 00:00:00

abstract：:Lung disease due to non-tuberculous mycobacteria (NTM) is a poorly understood condition that is difficult to treat. Treatment remains problematic as few tools are available to help clinicians monitor disease progression or predict treatment outcome. In this study, plasma levels of several inflammatory molecules and th...

journal_title：Disease markers

authors： Lim A,Allison C,Tan DB,Oliver B,Price P,Waterer G

更新日期：2010-01-01 00:00:00

abstract：:Ultrasound has been a popular clinical imaging modality for decades. It is well established as a means of displaying the macroscopic anatomy of soft-tissue structures. While conventional ultrasound methodologies (i.e., B-mode and Doppler methods) are well proven and continue to advance technically on a daily basis, e....

journal_title：Disease markers

authors： Feleppa EJ,Alam SK,Deng CX

更新日期：2002-01-01 00:00:00

abstract：:In view of the potential uses of cell surface tumour associated antigens in novel anticancer treatment, a study was designed to investigate whether the biological response modifiers interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) could effect the expression of an epitope on the tumour associa...

journal_title：Disease markers

authors： Clark S,McGuckin MA,Hurst T,Ward BG

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Some studies have suggested a relation of plasma fibrinogen to the severity of coronary artery disease (CAD). However, whether plasma fibrinogen can predict the presence and severity of CAD in patients with diabetes mellitus has not been determined. METHODS:A total of consecutive 373 diabetic patients with ...

journal_title：Disease markers

authors： Hong LF,Li XL,Luo SH,Guo YL,Zhu CG,Qing P,Wu NQ,Li JJ

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:High serum MBL level as well as polymorphisms in the mannose-binding lectin 2 (MBL2) gene resulting in MBL deficiency are involved in the mechanism of a number of non-infectious diseases such as asthma, conferring either risk or protection in different population studies. MBL being the first reactant of the ...

journal_title：Disease markers

authors： Birbian N,Singh J,Jindal SK,Joshi A,Batra N,Singla N

更新日期：2012-01-01 00:00:00

abstract：:Basal cell carcinoma (BCC) is the world's leading skin cancer in terms of frequency at the moment and its incidence continues to rise each year, leading to profound negative psychosocial and economic consequences. UV exposure is the most important environmental factor in the development of BCC in genetically predispos...

journal_title：Disease markers

authors： Lupu M,Caruntu C,Ghita MA,Voiculescu V,Voiculescu S,Rosca AE,Caruntu A,Moraru L,Popa IM,Calenic B,Greabu M,Costea DE

更新日期：2016-01-01 00:00:00

abstract：Objectives:Periodontal disease is prevalent and has an inflammation associated with not only oral but also systemic pathologies. The diagnosis by biomarkers is required for clinical practice on periodontal disease. The lactoferrin and α1-antitrypsin were both inflammation-related molecules. The present study investigat...

journal_title：Disease markers

authors： Koshi R,Kotani K,Ohtsu M,Yoshinuma N,Sugano N

更新日期：2018-11-07 00:00:00

abstract：:Objective. To determine active TGF-β1 (aTGF-β1) levels in serum, skin, and peripheral blood mononuclear cell (PBMC) culture supernatants and to understand their associations with clinical parameters in systemic sclerosis (SSc) patients. Methods. We evaluated serum samples from 56 SSc patients and 24 healthy controls (...

journal_title：Disease markers

authors： Dantas AT,Gonçalves SM,de Almeida AR,Gonçalves RS,Sampaio MC,Vilar KM,Pereira MC,Rêgo MJ,Pitta ID,Marques CD,Duarte AL,Pitta MG

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:To investigate the expression of estrogen (ER), progesterone receptors (PR), nuclear factor- κ B (NF- κ B), and tumor necrosis factor- α (TNF- α ) in human breast cancer (BC), and the correlation of these four parameters with clinicopathological features of BC. METHODS AND RESULTS:We performed an immunohist...

journal_title：Disease markers

authors： Zhou XL,Fan W,Yang G,Yu MX

更新日期：2014-01-01 00:00:00