Abstract:
BACKGROUND:Some studies have suggested a relation of plasma fibrinogen to the severity of coronary artery disease (CAD). However, whether plasma fibrinogen can predict the presence and severity of CAD in patients with diabetes mellitus has not been determined. METHODS:A total of consecutive 373 diabetic patients with typical angina pectoris who received coronary angiography were enrolled and classified into three groups by tertiles of Gensini score (GS, low group <8; intermediate group 8~28; high group >28). The relationship between fibrinogen and GS was evaluated. RESULTS:There were correlations of fibrinogen with hemoglobin A1c, C-reactive protein, and GS (r = 0.17, r = 0.52, and r = 0.21, resp.; all P < 0.001). Area under the receivers operating characteristic curve of fibrinogen was 0.62 (95% CI 0.56-0.68, P < 0.001) for predicting a high GS. Multivariate analysis suggested that plasma fibrinogen was an independent predictor of a high GS for diabetic patients (OR = 1.40, 95% CI 1.04-1.88, and P = 0.026) after adjusting for traditional risk factors of CAD. CONCLUSIONS:The present data indicated that plasma fibrinogen, a readily measurable systematic inflammatory marker, appeared to be an independent predictor for the severity of CAD in diabetic patients.
journal_name
Dis Markersjournal_title
Disease markersauthors
Hong LF,Li XL,Luo SH,Guo YL,Zhu CG,Qing P,Wu NQ,Li JJdoi
10.1155/2014/485687subject
Has Abstractpub_date
2014-01-01 00:00:00pages
485687eissn
0278-0240issn
1875-8630journal_volume
2014pub_type
杂志文章相关文献
DISEASE MARKERS文献大全abstract::Current problems in obtaining suitable monoclonal antibodies (MoAbs) for in vivo imaging and therapy can now be bypassed using protein-engineering rather than conventional hybridoma technology. Rodent antibody binding sites can be grafted onto human acceptor antibodies thus reshaping the human MoAbs into reagents with...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00
abstract::INHBA-encoded inhibin β A is a member of the transforming growth factor-β (TGF-β) superfamily. INHBA has been reported to be implicated in the progression of multiple types of cancer including ovarian cancer (OC). However, the mechanisms by which INHBA affects OC progression are not well-characterized. The aim of our ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/7275289
更新日期:2019-11-11 00:00:00
abstract::Antibodies against myelin oligodendrocyte antigens have been found in the immunoreactive brain lesions of Multiple Sclerosis (MS) patients. Recently it has been proposed that these antibodies can be used as a prognostic marker in the course of disease. However, the serum levels of these autoantibodies during different...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2005/826817
更新日期:2005-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/1202710.]. ...
journal_title:Disease markers
pub_type: 已发布勘误
doi:10.1155/2020/1245645
更新日期:2020-10-14 00:00:00
abstract::Keloids are benign fibroproliferative tumors of the skin which commonly occur after injury mainly in darker skinned patients. Medical treatment is fraught with high recurrence rates mainly because of an incomplete understanding of the biological mechanisms that lead to keloids. The purpose of this project was to exami...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/943176
更新日期:2015-01-01 00:00:00
abstract:Background:Lactate has been widely used as a risk indicator of outcomes in critically ill patients due to its ready measurement and good predictive ability. However, the interconnections between lactate metabolism and glucose metabolism have not been sufficiently explored, yet. In this study, we aimed to investigate wh...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/1578502
更新日期:2019-11-26 00:00:00
abstract::Kinesin family member 20A (KIF20A) has been recently reported to be upregulated and associated with increased invasiveness and metastasis in several malignancies. However, the role of KIF20A in colorectal cancer (CRC) is still unclear. This study is aimed at investigating the potential roles of KIF20A in the developme...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/2032679
更新日期:2020-07-08 00:00:00
abstract::Prosthetic joint infection (PJI) is the most common cause of failure of total joint arthroplasty, but a gold standard for PJI diagnosis is still lacking. Advanced glycation end products (AGEs) are proinflammatory molecules inducing intracellular oxidative stress (OS) after binding to their cell membrane receptors (RAG...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2017/6140896
更新日期:2017-01-01 00:00:00
abstract::Clinical variables contribute to the severity of Kashin-Beck disease (KBD). However, it is unclear if there is a correlation between gene expression and clinical variables. Peripheral blood samples were collected from 100 patients with KBD and 100 healthy controls from KBD-endemic areas to identify differentially expr...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/3736198
更新日期:2019-01-03 00:00:00
abstract::To identify the novel, noninvasive biomarkers to assess the outcome and prognosis of breast cancer (BC), patients with high sensitivity and specificity are greatly desired. Herein, the miRNA expression profile and matched clinical features of BC patients were extracted from The Cancer Genome Atlas (TCGA) database. The...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/3815952
更新日期:2019-12-30 00:00:00
abstract::Two-dimensional gel analysis (NEPHGE) of the molecules precipitated by the HLA-DR monomorphic antibody L243 showed a single and identical alpha chain spot from two consanguineous cell lines, BM14 and MCF. The latter was derived from a rheumatoid arthritis patient. No apparent structural polymorphism of the HLA-DR beta...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1986-06-01 00:00:00
abstract:BACKGROUND:Impaired fasting glucose (IFG) through the nondiabetic range (100-125 mg/dL) is not considered in the cardiovascular (CV) risk profile. AIM:To compare the clustering of CV risk factors (RFs) in nondiabetic subjects with normal fasting glucose (NFG) and IFG. MATERIAL AND METHODS:Cross-sectional study in 373...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/804739
更新日期:2015-01-01 00:00:00
abstract::This report describes the production and characterization of two new monoclonal antibodies (MoAb), WM-53 and WM-54, reacting with a human myeloid differentiation antigen, which has recently been assigned by the Third International Leucocyte Workshop on Human Differentiation Antigens into cluster CD-33 ('gp67'). To dat...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1987-12-01 00:00:00
abstract::A study of MHC class I, II, and III markers in a group of southern Chinese in Hong Kong is reported. HLA antigen frequencies and complement allele frequencies are given, together with statistically significant pair-wise co-occurrences. Over half of the statistically significant positive and negative linkage disequilib...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00
abstract::Epithelial ovarian cancer (EOC) is the sixth most common cause of cancer deaths in women because the diagnosis occurs mostly when the disease is in its late-stage. Current diagnostic methods of EOC show only a moderate sensitivity, especially at an early-stage of the disease; hence, novel biomarkers are needed to impr...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/238197
更新日期:2014-01-01 00:00:00
abstract::The aim of this study was to assess the expression of MMP-9 and TIMP-1 in cancerous tissue as well as in the serum and plasma concentrations of these proteins in patients with laryngeal cancer and compare the results to the inflammatory reaction in healthy subjects. Twenty-seven patients who were diagnosed with laryng...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/3136792
更新日期:2019-04-18 00:00:00
abstract:Purpose:Liver metastasis is the final stage of cancer progression and is associated with poor prognosis. Although numerous indicators have been identified as having prognostic value for lung cancer and liver metastasis, liver metastases are still not diagnosed by imaging in many patients. To provide a more accurate met...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/8850873
更新日期:2020-12-09 00:00:00
abstract::Renal cell carcinoma (RCC) is one of the most common genitourinary cancers worldwide. Previous evidence shows that long noncoding RNA (LncRNA) APOC1P1 plays an important role in cancer development. However, the role of LncRNA APOC1P1 in ccRCC remains to be explored. LncRNA APOC1P1 expression in 283 ccRCC tissues and 3...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/2814058
更新日期:2019-12-01 00:00:00
abstract::The terminal portion of the pol gene and the entire env gene of the human endogenous retrovirus ERV3 was screened for polymorphic nucleotides. For this purpose fragments amplified from the desired regions of ERV3 were subjected to single strand conformational analysis (SSCP analysis). Using this approach, we detected ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/1998/958379
更新日期:1998-11-01 00:00:00
abstract::Age-related macular degeneration (AMD) is the most common cause of blindness in elderly people worldwide and the major degenerative disease of the retina that leads to progressive impairment of central vision. Several polymorphisms in different genes have been proposed as factors that increase the disease susceptibili...
journal_title:Disease markers
pub_type: 杂志文章,meta分析
doi:10.1155/2016/8486406
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Genetics of non-alcoholic fatty liver (NAFLD) in Asian Indians has been inadequately investigated. This study aims to determine the association of the 1784G>C polymorphism in the SREBP-2 gene with NAFLD in Asian Indians in north India. METHODS:In this study, (n=335); 162 obese with NAFLD, 91 obese without N...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2011-0852
更新日期:2011-01-01 00:00:00
abstract::Because tandem mass spectrometry- (MS/MS-) based newborn screening identifies many suspicious cases of fatty acid oxidation and carnitine cycle disorders, a simple, noninvasive test is required to confirm the diagnosis. We have developed a novel method to evaluate the metabolic defects in peripheral blood mononuclear ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/2984747
更新日期:2019-02-07 00:00:00
abstract::Lung disease due to non-tuberculous mycobacteria (NTM) is a poorly understood condition that is difficult to treat. Treatment remains problematic as few tools are available to help clinicians monitor disease progression or predict treatment outcome. In this study, plasma levels of several inflammatory molecules and th...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2010-0732
更新日期:2010-01-01 00:00:00
abstract::This study evaluated the in vitro sensitivity of paired Leishmania braziliensis samples isolated from the same patient before pentavalent antimonial treatment (Sample A) and after treatment failure or cutaneous leishmaniasis reactivation (Sample B) in patients undergoing intralesional administration or injections (5 m...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/943236
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:During progression of gastric cancer (GC), degradation of the extracellular matrix is mediated by the matrix metalloproteases (MMPs) and their tissue inhibitors (TIMPs): changes in the expression of these have been related to unfavorable prognosis in GC. OBJECTIVE:To analyze the expression of certain MMPs a...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/285906
更新日期:2014-01-01 00:00:00
abstract::Colorectal cancer (CRC) is a complex and heterogeneous disease with four consensus molecular subtypes (CMS1-4). LTBP2 is a member of the fibrillin/LTBP super family and plays a critical role in tumorigenesis by activating TGF-β in the CMS4 CRC subtype. So far, the expression and prognostic significance of LTBP2 in CRC...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/5231269
更新日期:2019-03-10 00:00:00
abstract::PIZ allele frequencies were defined by PCR amplification and hybridization using a PIZ SSO (sequence specific oligonucleotide) probe. The groups studied included 64 normal controls, 104 subjects with rheumatoid arthritis (RA) without any extra-articular features, 29 of whom had severe arthritis and 31 of whom had mild...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1992-05-01 00:00:00
abstract:Aim:Increasing evidence indicates that hepatic subcapsular flow (HSF) can serve as a noninvasive ultrasonographic marker for the early diagnosis of biliary atresia (BA). However, results regarding its diagnostic accuracy are inconsistent and inconclusive. We conducted this meta-analysis with an aim to systematically ev...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2020/5262565
更新日期:2020-03-01 00:00:00
abstract::Lung cancer remains a major cause of cancer-related lethality because of high incidence and recurrence in spite of significant advances in staging and therapies. Recent data indicates that stem cells situated throughout the airways may initiate cancer formation. These putative stem cells maintain protumorigenic charac...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2008/396281
更新日期:2008-01-01 00:00:00
abstract::The human papilloma virus (HPV) associated with hyperplastic epithelium in an oral denture fibroma was examined by southern blot hybridization. Extracted DNA was hybridized with full length linear HPV type 2a, 6b, 11, 16, 18, 31 and 33 DNAs as a mixed probe only under low stringent conditions. The hybridized bands dig...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00