Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China.

abstract：:In an attempt to better unfold the antitumor immune response and invasion strategies perused by tumor cells, markers such as CD99 and HLA-II have been stained in breast tumors, some of them turned out to be important for prognosis and its outcome. CD99 is involved in the intracellular transport of HLA-II proteins. The...

journal_title：Disease markers

authors： Baccar A,Ferchichi I,Troudi W,Marrakchi R,Ben Hmida N,Jebini S,Mrad K,Ben Romdhane K,Benammar Elgaaied A

更新日期：2013-01-01 00:00:00

abstract：:The adenosine deaminase gene frequencies were calculated in 405 subjects randomly chosen from the Bigouden district. A rather high frequency (0.0765 +/- 0.0093) was found for the ADA2 gene. The possible effect of Celtic influences is considered. ...

journal_title：Disease markers

authors： Youinou P,Seger J,Salmon D,Jouquan J,le Menn G,Ruffie J,Salmon C

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:Soluble vascular endothelial growth factor (VEGF) is a promising biomarker in monitoring rheumatoid arthritis (RA), but studies of pre-analytical and biologic variability are few. METHODS:VEGF was measured by ELISA methods in serum and plasma from healthy persons and RA patients. Pre-analytical factors were...

journal_title：Disease markers

authors： Hetland ML,Christensen IJ,Lottenburger T,Johansen JS,Svendsen MN,Hørslev-Petersen K,Nielsen L,Nielsen HJ

更新日期：2008-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder that accounts for nearly 70% of the more than 46 million dementia cases estimated worldwide. Although there is no cure for AD, early diagnosis and an accurate characterization of the disease progression can improve the quality of life of AD patients and their ca...

journal_title：Disease markers

authors： Cassani R,Estarellas M,San-Martin R,Fraga FJ,Falk TH

更新日期：2018-10-04 00:00:00

abstract：:In this work we explored the role of the 3'UTR of the MECP2 gene in patients with clinical diagnosis of RTT and mental retardation; focusing on regions of the 3'UTR with almost 100% conservation at the nucleotide level among mouse and human. By mutation scanning (DOVAM-S technique) the MECP2 3'UTR of a total of 66 aff...

journal_title：Disease markers

authors： Santos M,Yan J,Temudo T,Oliveira G,Vieira JP,Fen J,Sommer S,Maciel P

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:To investigate the expression of estrogen (ER), progesterone receptors (PR), nuclear factor- κ B (NF- κ B), and tumor necrosis factor- α (TNF- α ) in human breast cancer (BC), and the correlation of these four parameters with clinicopathological features of BC. METHODS AND RESULTS:We performed an immunohist...

journal_title：Disease markers

authors： Zhou XL,Fan W,Yang G,Yu MX

更新日期：2014-01-01 00:00:00

abstract：:Oncogenic activation of the Wnt/ β -catenin signaling pathway is common in human cancers. The secreted frizzled-related proteins (SFRPs) function as negative regulators of Wnt signaling and have important implications in carcinogenesis. Because there have been no reports about the role of SFRP3 in hepatocellular carci...

journal_title：Disease markers

authors： Lin YW,Shih YL,Lien GS,Suk FM,Hsieh CB,Yan MD

更新日期：2014-01-01 00:00:00

abstract：:The terminal portion of the pol gene and the entire env gene of the human endogenous retrovirus ERV3 was screened for polymorphic nucleotides. For this purpose fragments amplified from the desired regions of ERV3 were subjected to single strand conformational analysis (SSCP analysis). Using this approach, we detected ...

journal_title：Disease markers

authors： Rasmussen HB,Clausen J

更新日期：1998-11-01 00:00:00

abstract：Objective:To systematically evaluate the significance of squamous cell carcinoma antigen (SCC-Ag) in the prognosis of cervical cancer. Methods:Literature from Pubmed, Embase, and Cochrane Library was retrieved to collect all English literature on the correlation between SCC-Ag and cervical cancer prognosis, and the qu...

journal_title：Disease markers

authors： Liu Z,Shi H

更新日期：2019-06-02 00:00:00

abstract：:Involvement of the ets-1 proto-oncogene located at chromosome band 11q23 was studied in six tumors and in a congenital chromosome abnormality affecting the 11q23 region, in order to determine whether the breakpoint of these rearrangements was identical at the molecular level. In multiple restriction digestions a 5.4 k...

journal_title：Disease markers

authors： Koduru PR,Offit K,Jhanwar SC

更新日期：1989-07-01 00:00:00

abstract：:Basal cell carcinoma (BCC) is the world's leading skin cancer in terms of frequency at the moment and its incidence continues to rise each year, leading to profound negative psychosocial and economic consequences. UV exposure is the most important environmental factor in the development of BCC in genetically predispos...

journal_title：Disease markers

authors： Lupu M,Caruntu C,Ghita MA,Voiculescu V,Voiculescu S,Rosca AE,Caruntu A,Moraru L,Popa IM,Calenic B,Greabu M,Costea DE

更新日期：2016-01-01 00:00:00

abstract：:IgA nephropathy is diagnosed by renal biopsy, an invasive procedure with a risk of significant complications. Noninvasive approaches are needed for possible diagnostic purposes and especially for monitoring disease activity or responses to treatment. In this pilot project, we assessed the utility of urine samples as s...

journal_title：Disease markers

authors： Neprasova M,Maixnerova D,Novak J,Reily C,Julian BA,Boron J,Novotny P,Suchanek M,Tesar V,Kacer P

更新日期：2016-01-01 00:00:00

abstract：:Several hemolytic markers are available to guide the differential diagnosis and to monitor treatment of hemolytic conditions. They include increased reticulocytes, an indicator of marrow compensatory response, elevated lactate dehydrogenase, a marker of intravascular hemolysis, reduced haptoglobin, and unconjugated hy...

journal_title：Disease markers

authors： Barcellini W,Fattizzo B

更新日期：2015-01-01 00:00:00

abstract：Objectives:To explore the impact of volume change in the fractionated tracking of stereotactic radiotherapy on the results of synchronous, respiratory tracking algorithm using CyberKnife. Methods:A total of 38 lung tumor patients receiving stereotactic radiotherapy at our center from March 2018 to October 2019 were co...

journal_title：Disease markers

authors： Li GQ,Wang Y,Qiu MJ,Yang J,Peng ZJ,Zhang S,Fang X,Yang SL

更新日期：2020-01-11 00:00:00

abstract：:Some polymorphisms in genes codifying for fibrinogen have been correlated with plasma levels of this protein, and several studies reported their associations with acute cardiovascular events. In the present study, 118 subjects with unstable and stable coronary diseases were enrolled to determinate the associations amo...

journal_title：Disease markers

authors： Canseco-Avila LM,Lopez-Roblero A,Serrano-Guzman E,Aguilar-Fuentes J,Jerjes-Sanchez C,Rojas-Martinez A,Ortiz-Lopez R

更新日期：2019-07-01 00:00:00

abstract：Materials and Methods:Relative expression of lncRNAs CARMN, LUCAT1, SMILR, and MALAT1 was tested in clinical aortic tissue and blood plasma samples from TAA and non-TAA patients using the qRT-PCR method. The Mann-Whitney U test was used to compare ΔCt values between the study groups. ROC curve analysis was performed to...

journal_title：Disease markers

authors： Patamsytė V,Žukovas G,Gečys D,Žaliaduonytė D,Jakuška P,Benetis R,Lesauskaitė V

更新日期：2020-06-17 00:00:00

abstract：:Cyclin Y (CCNY) is a novel cyclin and almost nothing is known about its role in human cancers. To investigate the clinical significance of serum anti-CCNY autoantibodies in nonsmall-cell lung carcinoma (NSCLC), the serum levels of CCNY protein in 264 patients with NSCLC, 103 patients with tuberculosis, and 89 healthy ...

journal_title：Disease markers

authors： Ma L,Yue W,Teng Y,Zhang L,Gu M,Wang Y

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the combined effects of MMP-2 and TIMP-2 protein immunoreactivities on the prognosis in endometrial carcinoma. METHODS:Paraffin-embedded tissue samples from 225 primary endometrioid adenocarcinomas and 13 histologies other than endometrioid adenocarcinoma were immunohist...

journal_title：Disease markers

authors： Honkavuori-Toivola M,Santala M,Soini Y,Turpeenniemi-Hujanen T,Talvensaari-Mattila A

更新日期：2013-01-01 00:00:00

abstract：Objective:Recent studies have demonstrated that miRNA-155 is involved in the occurrence and development of atherosclerosis. Furthermore, miRNA-155 has emerged as a new indirect marker for inflammation associated with adverse outcomes in oncology and cardiovascular diseases. This study investigated the correlation betwe...

journal_title：Disease markers

authors： Su Q,Yang H,Li L

更新日期：2018-06-25 00:00:00

abstract：:Prognostic markers of compensated cirrhosis should mainly investigate factors involved with progression to decompensation because death in cirrhosis is related with decompensation. Portal hypertension plays a crucial role in the pathophysiology of most complications of cirrhosis. Accordingly, HVPG monitoring has stron...

journal_title：Disease markers

authors： Poca M,Puente A,Graupera I,Villanueva C

更新日期：2011-01-01 00:00:00

abstract：:The HLA system is deeply involved in susceptibility to a variety of diseases. Relationships between HLA and diseases are of considerable interest and importance, as they provide new tools for studying the inheritance, classification, and pathogenesis of these diseases. Studies on the distribution of HLA antigens in di...

journal_title：Disease markers

authors： Jabbar AA

更新日期：1993-11-01 00:00:00

abstract：Aim:To evaluate the diagnosis value of serum human epididymis protein 4 (HE4), cancer antigen 125 (CA125), the Risk of Ovarian Malignancy Algorithm (ROMA), and Copenhagen Index (CPH-I) at early stages for differentiating borderline ovarian tumors from epithelial ovarian cancer. Methods:We recruited 144 borderline ovar...

journal_title：Disease markers

authors： Wang Z,Tao X,Ying C

更新日期：2019-10-13 00:00:00

abstract：Background:In patients admitted with chest pain and suspected acute coronary syndrome (ACS), it is crucial to early identify those who are at higher risk of adverse events. The study aim was to assess the predictive value of copeptin in patients admitted to the emergency department with chest pain and nonconclusive ECG...

journal_title：Disease markers

authors： Morawiec B,Kawecki D,Przywara-Chowaniec B,Opara M,Muzyk P,Ho L,Tat LC,Gabrysiak A,Muller O,Nowalany-Kozielska E

更新日期：2018-01-24 00:00:00

abstract：:Microtubule-associated protein 4 (MAP4) plays an important role in microtubule assembly and stabilization. The purpose of this study was to investigate the level of expression of MAP4 in lung adenocarcinoma (LADC) samples and to evaluate its prognostic value and the influence on cancer progression in LADC patients. Th...

journal_title：Disease markers

authors： Xia X,He C,Wu A,Zhou J,Wu J

更新日期：2018-03-18 00:00:00

abstract：:Purpose. The aim of this study was to evaluate the sensitivity of pleural C-reactive protein (CRP) biomarker levels in identifying parapneumonic effusions. Methods. A single-center, retrospective review of 244 patients diagnosed with pleural effusions was initiated among patients at the Rabin Medical Center, Petah Tik...

journal_title：Disease markers

authors： Izhakian S,Wasser WG,Fox BD,Vainshelboim B,Kramer MR

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Liver cirrhosis (LC) is the final stage of most of chronic liver diseases and is almost caused by chronic hepatitis B (CHB) in China. Liver biopsy is the reference method for the evaluation of liver cirrhosis. However, it is an invasive procedure with inherent risk. The aim of this study was to construct a n...

journal_title：Disease markers

authors： Cao Y,Hu ZD,Liu XF,Deng AM,Hu CJ

更新日期：2013-01-01 00:00:00

abstract：:Regulatory T cells (Tregs) play an essential role in acute coronary syndrome (ACS). However, there is debate about which Treg subsets are truly critical to ACS. Helios, a transcription factor, was recently reported to be a bona fide marker for natural Tregs or activated Tregs with a suppression function, but little is...

journal_title：Disease markers

authors： Jiang L,Chen F,Hu X,Hu Y,Wang Y,Zhang W,Peng Y,Cheng L

更新日期：2017-01-01 00:00:00

abstract：:Deficiency alleles at the C4 loci within the MHC are associated with autoimmune diseases in Caucasoids and possibly other races. We therefore studied the relationship between relevant C4 alleles and other MHC markers in a random Thai/Chinese population. Over 90 per cent of C4AQO occurs within two supratypes (HLA Aw33,...

journal_title：Disease markers

authors： Kay PH,Grimsley G,Dawkins RL,Charoenwong P

更新日期：1987-03-01 00:00:00

abstract：OBJECTIVE:In this study, we sought to investigate the dynamic changes in the levels of TNF-α, IL-1β and LPS in the gingival crevicular fluid (GCF) in a rat model of diabetes mellitus (DM) and periodontitis (PD). Additionally, we evaluated alveolar bone loss and the histopathological response associated with experimenta...

journal_title：Disease markers

authors： Jiang ZL,Cui YQ,Gao R,Li Y,Fu ZC,Zhang B,Guan CC

更新日期：2013-01-01 00:00:00

abstract：Objectives:We investigated the influence of spinal cord stimulation (SCS) on IFN-γ, IL-1β, IL-6, TNF-α, IL-10, and TGF-β serum levels in failed back surgery syndrome (FBSS) patients. The study will try to give new insights into the mechanism of SCS action and the role of IFN-γ and other cytokines in neuropathic pain (N...

journal_title：Disease markers

authors： Kamieniak P,Bielewicz J,Grochowski C,Litak J,Bojarska-Junak A,Daniluk B,Trojanowski T

更新日期：2019-01-14 00:00:00