Large number of polymorphic nucleotides and a termination codon in the env gene of the endogenous human retrovirus ERV3.

Abstract:

:The terminal portion of the pol gene and the entire env gene of the human endogenous retrovirus ERV3 was screened for polymorphic nucleotides. For this purpose fragments amplified from the desired regions of ERV3 were subjected to single strand conformational analysis (SSCP analysis). Using this approach, we detected 13 polymorphic nucleotides, namely four in the pol gene and nine in the env gene. Three of the nucleotide substitutions were synonymous (not affecting the amino acid code). One of the non-synonymous nucleotide substitutions changed an arginine codon to a termination codon. The alleles at the different polymorphic sites could be arranged into five ERV3 haplotypes, two of which were new. To evaluate the possible significance of the termination codon, which precludes expression of a putative immunoregulatory factor, we examined samples of DNA from patients with multiple sclerosis, a demyelinating disease of presumed autoimmune etiology. We did not find an association between the ERV3 allele with the termination codon and this disease. Perhaps the presence of a stop codon combined with the high number of non-synonymous nucleotide substitutions in the reading frame of the env gene reflects absence of selective constraints during evolution. Obviously, our findings contradict the assumption that the reading frame of the ERV3 env gene has been conserved throughout evolution.

journal_name

Dis Markers

journal_title

Disease markers

authors

Rasmussen HB,Clausen J

doi

10.1155/1998/958379

subject

Has Abstract

pub_date

1998-11-01 00:00:00

pages

127-33

issue

3

eissn

0278-0240

issn

1875-8630

journal_volume

14

pub_type

杂志文章
  • Assessment of the Relationship between Carotid Intima-Media Thickening and Early-Stage Diabetic Kidney Disease Coupled with Helicobacter pylori Infection.

    abstract:Objective:This study aimed to explore the associations between carotid intima-media thickness (CIMT) and early-stage diabetic kidney disease (DKD) coupled with Helicobacter pylori (H. pylori) infection in type 2 diabetic patients. Methods:A cross-sectional study including 180 type 2 diabetic participants was conducted...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2018/3793768

    authors: Feng L,Deng C,Li Y

    更新日期:2018-04-16 00:00:00

  • Limited value of KAI1/CD82 protein expression as a prognostic marker in human gastric cancer.

    abstract::The cell surface glycoprotein KAI1/CD82 suppresses tumor growth and metastasis in animal models. This study aimed to evaluate the prognostic relevance of KAI1/CD82 protein expression in human gastric cancer. Primary gastric carcinomas (n=271) with a mean clinical follow-up time of 48 months were immunostained using th...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.3233/DMA-2012-0896

    authors: Knoener M,Krech T,Puls F,Lehmann U,Kreipe H,Christgen M

    更新日期:2012-01-01 00:00:00

  • The Impact of Serum Glucose on the Predictive Value of Serum Lactate for Hospital Mortality in Critically Ill Surgical Patients.

    abstract:Background:Lactate has been widely used as a risk indicator of outcomes in critically ill patients due to its ready measurement and good predictive ability. However, the interconnections between lactate metabolism and glucose metabolism have not been sufficiently explored, yet. In this study, we aimed to investigate wh...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2019/1578502

    authors: Chen X,Bi J,Zhang J,Du Z,Ren Y,Wei S,Ren F,Wu Z,Lv Y,Wu R

    更新日期:2019-11-26 00:00:00

  • HLA B-27 subtypes in Turkish patients with spondyloarthropathy and healthy controls.

    abstract::The frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients and controls were investigated in a sample Turkish population. B27 subtyping was performed by PCR-SSP method in two groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of SpA according to the European Spon...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2004/565270

    authors: Oguz FS,Ocal L,Diler AS,Ozkul H,Asicioglu F,Kasapoglu E,Bozkurt G,Konice M,Carin M

    更新日期:2004-01-01 00:00:00

  • Identification of Featured Metabolism-Related Genes in Patients with Acute Myocardial Infarction.

    abstract:Objective:A growing body of emerging evidence indicates that metabolic processes play a pivotal role in the biological processes underlying acute myocardial infarction (AMI). The aim of the current study was to identify featured metabolism-related genes in patients with AMI using a support vector machine (SVM) and to f...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2020/8880004

    authors: Xie H,Zha E,Zhang Y

    更新日期:2020-11-28 00:00:00

  • Valuable Serum Markers in Pulmonary Alveolar Proteinosis.

    abstract:Objective:Several serum markers were reported to reflect the severity of pulmonary alveolar proteinosis (PAP). The aim of this study is to investigate a reliable and facile marker to access and monitor the clinical course of PAP in a large cohort. Methods:PAP patients from January 2010 to June 2018 were enrolled. Hosp...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2019/9709531

    authors: Shi S,Chen L,Qiu X,Zhao Q,Xiao Y,Yan X

    更新日期:2019-11-11 00:00:00

  • The Prognostic Role of Glasgow Prognostic Score and C-reactive Protein to Albumin Ratio for Sarcoma: A System Review and Meta-Analysis.

    abstract:Backgrounds:Both pretreatment serum CRP (C-reactive protein) level and ALB (albumin) level have been found to be predictive of survival for multiple malignancies including sarcoma. Since both of the GPS (Glasgow prognostic score) and CAR (C-reactive protein to albumin ratio) are based on the combination of CRP and ALB,...

    journal_title:Disease markers

    pub_type: 杂志文章,meta分析

    doi:10.1155/2020/8736509

    authors: Fang E,Wang X,Feng J,Zhao X

    更新日期:2020-01-07 00:00:00

  • Prognostic Role of Squamous Cell Carcinoma Antigen in Cervical Cancer: A Meta-analysis.

    abstract:Objective:To systematically evaluate the significance of squamous cell carcinoma antigen (SCC-Ag) in the prognosis of cervical cancer. Methods:Literature from Pubmed, Embase, and Cochrane Library was retrieved to collect all English literature on the correlation between SCC-Ag and cervical cancer prognosis, and the qu...

    journal_title:Disease markers

    pub_type: 杂志文章,meta分析

    doi:10.1155/2019/6710352

    authors: Liu Z,Shi H

    更新日期:2019-06-02 00:00:00

  • Positive Correlation of Serum N-Acetyl-β-hexosaminidase with Markers of Atherosclerosis in Diabetes Type 2 Patients with Mild Symptoms of Depression and Anxiety.

    abstract:Background:Analysis of the correlation between diabetes type 2 (DT2) and serum N-acetyl-β-hexosaminidase (HEX) activity with parameters of fat metabolism and symptoms of anxiety and depression. Material and Method:The study was performed using a random sample of 40 DT2 patients (22 women and 18 men) between the ages o...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2018/1760592

    authors: Chojnowska S,Cabaj-Wiater I,Mikulska-Baran A,Zalewska-Szajda B,Waszkiewicz N

    更新日期:2018-06-20 00:00:00

  • IL-23 gene expression in PBMCs of patients with coronary artery disease.

    abstract:OBJECTIVE:Both adaptive and innate immune systems are involved in coronary artery disease (CAD). The aim of this study was to evaluate TH17 cytokines expression profiles in un-stimulated peripheral blood lymphocytes (PBMCs) of patients with coronary artery disease. METHODS:Expression profiles of IL-17, IL-23, and TGF-...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.3233/DMA-2012-00933

    authors: Khojasteh-Fard M,Abolhalaj M,Amiri P,Zaki M,Taheri Z,Qorbani M,Bazzaz JT,Amoli MM

    更新日期:2012-01-01 00:00:00

  • Prospecting for Breast Cancer Blood Biomarkers: Death-Associated Protein Kinase 1 (DAPK1) as a Potential Candidate.

    abstract:Background:Breast cancer is the commonest malignancy in women worldwide. It is estimated to affect approximately 1.5 million women annually and responsible for the greatest number of cancer-related mortalities among women. In 2018, breast cancer mortalities stood at 627,000 women representing approximately 15% of all c...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2020/6848703

    authors: Arko-Boham B,Owusu BA,Aryee NA,Blay RM,Owusu EDA,Tagoe EA,Adams AR,Gyasi RK,Adu-Aryee NA,Mahmood S

    更新日期:2020-05-24 00:00:00

  • Associations between TAB2 Gene Polymorphisms and Epithelial Ovarian Cancer in a Chinese Population.

    abstract:Background:Epithelial ovarian cancer (EOC) is highly lethal worldwide. Factors involved in the inflammation and hormone-associated signaling pathway play vital roles in EOC carcinogenesis. The transforming growth factor-β- (TGF-β-) activated kinase 1 (MAP3K7) binding protein 2 (TAB2), mediating convergence of inflammat...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2019/8012979

    authors: Huang X,Shen C,Zhang Y,Li Q,Li K,Wang Y,Song Y,Su M,Zhou B,Wang W

    更新日期:2019-08-14 00:00:00

  • Intestinal Alkaline Phosphatase Deficiency Is Associated with Ischemic Heart Disease.

    abstract:Background:We have previously shown that the deficiency of the gut enzyme intestinal alkaline phosphatase (IAP) is associated with type 2 diabetes mellitus (T2DM) in humans, and mice deficient in IAP develop the metabolic syndrome, a precipitant of T2DM and ischemic heart disease (IHD). We hypothesized that IAP deficie...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2019/8473565

    authors: Malo J,Alam MJ,Shahnaz M,Kaliannan K,Chandra G,Aziz T,Sarker T,Bala M,Paul R,Saha CK,Karmakar PK,Malo MS

    更新日期:2019-12-13 00:00:00

  • Gamma-Glutamyltransferase: A Predictive Biomarker of Cellular Antioxidant Inadequacy and Disease Risk.

    abstract::Gamma-glutamyltransferase (GGT) is a well-established serum marker for alcohol-related liver disease. However, GGT's predictive utility applies well beyond liver disease: elevated GGT is linked to increased risk to a multitude of diseases and conditions, including cardiovascular disease, diabetes, metabolic syndrome (...

    journal_title:Disease markers

    pub_type: 杂志文章,评审

    doi:10.1155/2015/818570

    authors: Koenig G,Seneff S

    更新日期:2015-01-01 00:00:00

  • Adverse Cardiac Remodelling after Acute Myocardial Infarction: Old and New Biomarkers.

    abstract::The prevalence of heart failure (HF) due to cardiac remodelling after acute myocardial infarction (AMI) does not decrease regardless of implementation of new technologies supporting opening culprit coronary artery and solving of ischemia-relating stenosis with primary percutaneous coronary intervention (PCI). Numerous...

    journal_title:Disease markers

    pub_type: 杂志文章,评审

    doi:10.1155/2020/1215802

    authors: Berezin AE,Berezin AA

    更新日期:2020-06-12 00:00:00

  • Interleukin-6-174G/C Polymorphism Contributes to Periodontitis Susceptibility: An Updated Meta-Analysis of 21 Case-Control Studies.

    abstract::Introduction. Chronic Periodontitis (CP) is suggested to be related to gene variations. Present study aims to quantitatively estimate the association between interleukin-6- (IL-6-) 174G/C polymorphism and CP susceptibility. Materials and Methods. Pubmed, Embase, and Web of Science were searched up to May 2016. The met...

    journal_title:Disease markers

    pub_type: 杂志文章,meta分析,评审

    doi:10.1155/2016/9612421

    authors: Zhu J,Guo B,Fu M,Guo W,Yuan Y,Yuan H,Zhang S,Yu H

    更新日期:2016-01-01 00:00:00

  • Difference in the prognostic significance of N-terminal pro-B-type natriuretic peptide between cardioembolic and noncardioembolic ischemic strokes.

    abstract:BACKGROUND AND AIM:Because B-type natriuretic peptide is a powerful predictor of heart failure, its capability to predict a fatal outcome in stroke might be limited to the cardioembolic stroke subtype. In this study, we attempt to ascertain the difference in the prognostic value of N-terminal pro-B-type natriuretic pep...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2015/597570

    authors: Lee SJ,Lee DG,Lim DS,Hong S,Park JS

    更新日期:2015-01-01 00:00:00

  • Serum levels of anti-myelin antibodies in relapsing-remitting multiple sclerosis patients during different phases of disease activity and immunomodulatory therapy.

    abstract::Antibodies against myelin oligodendrocyte antigens have been found in the immunoreactive brain lesions of Multiple Sclerosis (MS) patients. Recently it has been proposed that these antibodies can be used as a prognostic marker in the course of disease. However, the serum levels of these autoantibodies during different...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2005/826817

    authors: Angelucci F,Mirabella M,Frisullo G,Caggiula M,Tonali PA,Batocchi AP

    更新日期:2005-01-01 00:00:00

  • Susceptibility to toxoplasmic retinochoroiditis is associated with HLA alleles reported to be implicated with rapid progression to AIDS.

    abstract:BACKGROUND/AIMS:The frequency of HLA markers associated with rapid progression to AIDS was evaluated in Brazilian patients with AIDS exhibiting or not toxoplasmic retinochoroiditis (TRC). METHODS:98 AIDS patients (25 with TRC, 43 with anti-T. gondii antibodies but without TCR, and 30 without anti-T. gondii antibodies ...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.3233/DMA-2012-00935

    authors: Demarco AL,Rodrigues Mde L,Figueiredo JF,Deghaide NH,de Menezes MB,Demarco LA,Fernandes AP,Donadi EA

    更新日期:2012-01-01 00:00:00

  • HLA-DQ molecular heterogeneity in HLA-DR4-Dw4 consanguineous cell lines.

    abstract::Two-dimensional gel analysis (NEPHGE) of the molecules precipitated by the HLA-DR monomorphic antibody L243 showed a single and identical alpha chain spot from two consanguineous cell lines, BM14 and MCF. The latter was derived from a rheumatoid arthritis patient. No apparent structural polymorphism of the HLA-DR beta...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:

    authors: Fernandez N,Labeta M,Kurpisz M,Solana R,Festenstein H

    更新日期:1986-06-01 00:00:00

  • The Elevated Serum Level of IFN-γ in Patients with Failed Back Surgery Syndrome Remains Unchanged after Spinal Cord Stimulation.

    abstract:Objectives:We investigated the influence of spinal cord stimulation (SCS) on IFN-γ, IL-1β, IL-6, TNF-α, IL-10, and TGF-β serum levels in failed back surgery syndrome (FBSS) patients. The study will try to give new insights into the mechanism of SCS action and the role of IFN-γ and other cytokines in neuropathic pain (N...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2019/2606808

    authors: Kamieniak P,Bielewicz J,Grochowski C,Litak J,Bojarska-Junak A,Daniluk B,Trojanowski T

    更新日期:2019-01-14 00:00:00

  • Association of fibrinogen with severity of stable coronary artery disease in patients with type 2 diabetic mellitus.

    abstract:BACKGROUND:Some studies have suggested a relation of plasma fibrinogen to the severity of coronary artery disease (CAD). However, whether plasma fibrinogen can predict the presence and severity of CAD in patients with diabetes mellitus has not been determined. METHODS:A total of consecutive 373 diabetic patients with ...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2014/485687

    authors: Hong LF,Li XL,Luo SH,Guo YL,Zhu CG,Qing P,Wu NQ,Li JJ

    更新日期:2014-01-01 00:00:00

  • Predictive value of admission N-terminal pro-B-type natriuretic peptide and renal function in older people hospitalized for dyspnoea.

    abstract:BACKGROUND:We investigated the relationship between NT-pro-BNP, glomerular filtration rate (GFR), and all-cause mortality rates in a cohort of older people discharged from an internal medicine unit after admission for dyspnoea. PATIENTS AND METHODS:NT-pro-BNP was evaluated in serum samples of 134 patients aged 80 ± 6 ...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2013/687467

    authors: Fabbian F,De Giorgi A,Pala M,Volpato S,Portaluppi F,Zuliani G,Manfredini R

    更新日期:2013-01-01 00:00:00

  • Gene Expression and Proteome Analysis as Sources of Biomarkers in Basal Cell Carcinoma.

    abstract::Basal cell carcinoma (BCC) is the world's leading skin cancer in terms of frequency at the moment and its incidence continues to rise each year, leading to profound negative psychosocial and economic consequences. UV exposure is the most important environmental factor in the development of BCC in genetically predispos...

    journal_title:Disease markers

    pub_type: 杂志文章,评审

    doi:10.1155/2016/9831237

    authors: Lupu M,Caruntu C,Ghita MA,Voiculescu V,Voiculescu S,Rosca AE,Caruntu A,Moraru L,Popa IM,Calenic B,Greabu M,Costea DE

    更新日期:2016-01-01 00:00:00

  • High serum levels of pro-brain natriuretic peptide (pro BNP) identify cardioembolic origin in undetermined stroke.

    abstract:BACKGROUND:Stroke subtype diagnosis leads to specific therapies to reduce recurrences. Because nearly one third of patients remain with unknown etiology after a complete screening workup, we aim to investigate whether molecular markers of myocardial damage were associated with cardioembolic stroke and if they were usef...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.3233/DMA-2009-0630

    authors: Rodríguez-Yáñez M,Sobrino T,Blanco M,de la Ossa NP,Brea D,Rodríguez-González R,Leira R,Dávalos A,Castillo J

    更新日期:2009-01-01 00:00:00

  • Crevicular fluid and serum concentrations of progranulin and high sensitivity CRP in chronic periodontitis and type 2 diabetes.

    abstract:INTRODUCTION:This study was designed to correlate the serum and gingival crevicular fluid (GCF) levels of progranulin (PGRN) and high sensitivity C-reactive protein (hs CRP) in chronic periodontitis and type 2 diabetes mellitus (DM). DESIGN:PGRN and hs CRP levels were estimated in 3 groups: healthy, chronic periodonti...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2013/803240

    authors: Priyanka N,Kumari M,Kalra N,Arjun P,Naik SB,Pradeep AR

    更新日期:2013-01-01 00:00:00

  • Clinical Value of Combined Determination of Serum B7-H4 with Carcinoembryonic Antigen, Osteopontin, or Tissue Polypeptide-Specific Antigen for the Diagnosis of Colorectal Cancer.

    abstract:Aim:B7-H4 is member of the B7 family that negatively regulates the immune response, which are associated with tumor development and prognosis. The present study is aimed at examining serum B7-H4 expression and exploring its contribution to diagnosis in patients with colorectal cancer. Methods:We determined serum expre...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2018/4310790

    authors: Wang P,Li C,Zhang F,Ma X,Gai X

    更新日期:2018-09-27 00:00:00

  • Reassessing the Role of the Active TGF-β1 as a Biomarker in Systemic Sclerosis: Association of Serum Levels with Clinical Manifestations.

    abstract::Objective. To determine active TGF-β1 (aTGF-β1) levels in serum, skin, and peripheral blood mononuclear cell (PBMC) culture supernatants and to understand their associations with clinical parameters in systemic sclerosis (SSc) patients. Methods. We evaluated serum samples from 56 SSc patients and 24 healthy controls (...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2016/6064830

    authors: Dantas AT,Gonçalves SM,de Almeida AR,Gonçalves RS,Sampaio MC,Vilar KM,Pereira MC,Rêgo MJ,Pitta ID,Marques CD,Duarte AL,Pitta MG

    更新日期:2016-01-01 00:00:00

  • Changes in Functional Connectivity of Specific Cerebral Regions in Patients with Toothache: A Resting-State Functional Magnetic Resonance Imaging Study.

    abstract:Objective:In order to further study the changes of cerebral functional connectivity in patients with toothache (TA), this study used the resting-state functional magnetic resonance imaging (rs-fMRI) technique and degree centrality (DC) analysis method. Methods:Eighteen TA patients (8 males, 10 females) and 18 healthy ...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2020/6683161

    authors: Wu SN,Zhang MY,Shu HY,Liang RB,Ge QM,Pan YC,Zhang LJ,Li QY,Shao Y

    更新日期:2020-12-28 00:00:00

  • Baseline Serum Cystatin C Is a Potential Predictor for Acute Kidney Injury in Patients with Acute Pancreatitis.

    abstract:Aims:The study is aimed at studying the incidence of acute kidney injury (AKI) and exploring the potential predictor for AKI in patients with acute pancreatitis. Methods:A retrospective study adopting a stratified cohort sampling design was performed in a cohort of patients (n = 237) diagnosed with acute pancreatitis ...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2018/8431219

    authors: Chai X,Huang HB,Feng G,Cao YH,Cheng QS,Li SH,He CY,Lu WH,Qin MM

    更新日期:2018-11-19 00:00:00