The serum glycome to discriminate between early-stage epithelial ovarian cancer and benign ovarian diseases.

Abstract:

:Epithelial ovarian cancer (EOC) is the sixth most common cause of cancer deaths in women because the diagnosis occurs mostly when the disease is in its late-stage. Current diagnostic methods of EOC show only a moderate sensitivity, especially at an early-stage of the disease; hence, novel biomarkers are needed to improve the diagnosis. We recently reported that serum glycome modifications observed in late-stage EOC patients by MALDI-TOF-MS could be combined as a glycan score named GLYCOV that was calculated from the relative areas of the 11 N-glycan structures that were significantly modulated. Here, we evaluated the ability of GLYCOV to recognize early-stage EOC in a cohort of 73 individuals comprised of 20 early-stage primary serous EOC, 20 benign ovarian diseases (BOD), and 33 age-matched healthy controls. GLYCOV was able to recognize stage I EOC whereas CA125 values were statistically significant only for stage II EOC patients. In addition, GLYCOV was more sensitive and specific compared to CA125 in distinguishing early-stage EOC from BOD patients, which is of high relevance to clinicians as it is difficult for them to diagnose malignancy prior to operation.

journal_name

Dis Markers

journal_title

Disease markers

authors

Biskup K,Braicu EI,Sehouli J,Tauber R,Blanchard V

doi

10.1155/2014/238197

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

238197

eissn

0278-0240

issn

1875-8630

journal_volume

2014

pub_type

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