Abstract:
OBJECTIVE:Both adaptive and innate immune systems are involved in coronary artery disease (CAD). The aim of this study was to evaluate TH17 cytokines expression profiles in un-stimulated peripheral blood lymphocytes (PBMCs) of patients with coronary artery disease. METHODS:Expression profiles of IL-17, IL-23, and TGF-β1 were determined in individuals with and without CAD using Real-time PCR. RESULTS:A significant decrease in IL-23 gene expression in un-stimulated PBMCs of patients with CAD compared to those without CAD was found (p=0.003, OR=0.045, 95% CI: 0.006-0.355). CONCLUSION:Our data reinforce the potential role of the IL-23 as a critical regulatory molecule that bridges the innate and adaptive arms of the immune system in the complex mechanisms associated with the development of atherosclerosis.
journal_name
Dis Markersjournal_title
Disease markersauthors
Khojasteh-Fard M,Abolhalaj M,Amiri P,Zaki M,Taheri Z,Qorbani M,Bazzaz JT,Amoli MMdoi
10.3233/DMA-2012-00933subject
Has Abstractpub_date
2012-01-01 00:00:00pages
289-93issue
6eissn
0278-0240issn
1875-8630pii
8X55613417WV6307journal_volume
33pub_type
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