Abstract:
Purpose:To determine the frequency of the genotype of signal transducer and activator of transcription protein 3 (STAT3) rs744166, sirtuin (SIRT1) rs12778366, fibroblast growth factor (FGFR2) rs2981582, and advanced glycosylation end product-specific receptor (RAGE) rs1800625 gene polymorphisms in patients with laryngeal squamous cell carcinoma (LSCC). Methods:A total of 944 subjects were evaluated, which includes 144 patients with LSCC and 800 healthy controls. The genotyping of STAT3 rs744166, SIRT1 rs12778366, FGFR2 rs2981582, and RAGE rs1800625 was carried out using the RT-PCR. Results:The analysis of STAT3 rs744166, SIRT1 rs12778366, and FGFR2 rs2981582 gene polymorphisms did not reveal any differences in genotype distribution between the patients with LSCC and the control subjects. However, statistical analysis revealed that genotypes (AA, AG, and GG) of rs1800625 in RAGE gene were distributed statistically significantly differently between patients and controls (61.1%, 30.6%, and 23.6% vs. 72.5%, 25.8%, and 1.8%, respectively; p < 0.001). Additionally, statistical significance was observed in allele distribution between these two groups, i.e., allele G at rs1800625 was more frequently observed in the patient group than in controls (23.6% vs. 14.6%; p < 0.001). Conclusion:RAGE rs1800625 gene polymorphism may play a significant role in laryngeal squamous cell carcinoma development.
journal_name
Dis Markersjournal_title
Disease markersauthors
Uloza V,Tamauskaite T,Vilkeviciute A,Pasvenskaite A,Liutkevicius V,Liutkeviciene Rdoi
10.1155/2019/3907232subject
Has Abstractpub_date
2019-11-12 00:00:00pages
3907232eissn
0278-0240issn
1875-8630journal_volume
2019pub_type
杂志文章相关文献
DISEASE MARKERS文献大全abstract::There is a known relationship between serum alanine aminotransferase (ALT) and obesity in humans, but the mechanism(s) are not clarified. This study investigated the associations between serum ALT and body composition in an overweight and obese population. The results are based on data from a previous randomized contr...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/1695874
更新日期:2019-08-26 00:00:00
abstract::Regulatory T cells (Tregs) play an essential role in acute coronary syndrome (ACS). However, there is debate about which Treg subsets are truly critical to ACS. Helios, a transcription factor, was recently reported to be a bona fide marker for natural Tregs or activated Tregs with a suppression function, but little is...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2017/7909407
更新日期:2017-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/1202710.]. ...
journal_title:Disease markers
pub_type: 已发布勘误
doi:10.1155/2020/1245645
更新日期:2020-10-14 00:00:00
abstract:BACKGROUND:To evaluate serum chemerin levels in patients with osteoporosis and healthy controls and to investigate the relationship between serum chemerin levels and bone mineral density (BMD). METHODS:An age- and gender-matched case-control study was conducted. Pearson's correlation test was performed to investigate ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/786708
更新日期:2015-01-01 00:00:00
abstract::Changes of glycosylation pattern in serum proteins have been linked to various diseases including cancer, suggesting possible development of novel biomarkers based on the glycomic analysis. In this study, N-linked glycans from human serum were quantitatively profiled by matrix-assisted laser desorption ionization time...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/634289
更新日期:2014-01-01 00:00:00
abstract::Kinesin family member 20A (KIF20A) has been recently reported to be upregulated and associated with increased invasiveness and metastasis in several malignancies. However, the role of KIF20A in colorectal cancer (CRC) is still unclear. This study is aimed at investigating the potential roles of KIF20A in the developme...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/2032679
更新日期:2020-07-08 00:00:00
abstract::Ultrasound has been a popular clinical imaging modality for decades. It is well established as a means of displaying the macroscopic anatomy of soft-tissue structures. While conventional ultrasound methodologies (i.e., B-mode and Doppler methods) are well proven and continue to advance technically on a daily basis, e....
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2002/167104
更新日期:2002-01-01 00:00:00
abstract::Extra-nodal natural killer T-Cell (NK/T-cell) lymphoma is a progressive cancer with poor prognosis due to the lack of disease specific treatment. To develop specific therapeutic strategies, it is essential to identify tumor markers. Recent studies show that circulating microRNA (miRNA) may serve as diagnostic and/or p...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2010-0755
更新日期:2010-01-01 00:00:00
abstract::This study evaluated the in vitro sensitivity of paired Leishmania braziliensis samples isolated from the same patient before pentavalent antimonial treatment (Sample A) and after treatment failure or cutaneous leishmaniasis reactivation (Sample B) in patients undergoing intralesional administration or injections (5 m...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/943236
更新日期:2015-01-01 00:00:00
abstract::Alcohol abuse is one of the most common risk factor for chronic pancreatitis, but the underlying pathophysiological mechanisms remain unclear. The aim of this study was to identify genes that contribute to susceptibility or resistance for alcoholic chronic pancreatitis by screening the whole genome. Sixty-five patient...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2008/426764
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:We investigated the relationship between NT-pro-BNP, glomerular filtration rate (GFR), and all-cause mortality rates in a cohort of older people discharged from an internal medicine unit after admission for dyspnoea. PATIENTS AND METHODS:NT-pro-BNP was evaluated in serum samples of 134 patients aged 80 ± 6 ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/687467
更新日期:2013-01-01 00:00:00
abstract::Cytoskeletal rearrangement occurs in variety of cellular processes and involves a wide spectrum of proteins. Gelsolin super family proteins control actin organization by severing and capping filament ends and nucleating actin assembly. Gelsolin is the founding member of this family and plays important role in pathogen...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-120952
更新日期:2013-01-01 00:00:00
abstract::IgA nephropathy is diagnosed by renal biopsy, an invasive procedure with a risk of significant complications. Noninvasive approaches are needed for possible diagnostic purposes and especially for monitoring disease activity or responses to treatment. In this pilot project, we assessed the utility of urine samples as s...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2016/3650909
更新日期:2016-01-01 00:00:00
abstract:Background:Determination of neonate serum's N-acetyl-β-hexosaminidase (HEX) activity and correlation results with Apgar scale and factors routinely determined in newborn serum. Aims:Providing reference values of neonates serum HEX activities, and indicate their diagnostic significance. Study design:The study was perf...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/6187245
更新日期:2018-07-02 00:00:00
abstract:OBJECTIVES:This study was undertaken to investigate the OPG profiles in gingival crevicular fluid (GCF), saliva, and gingival tissues of chronic periodontitis (CP) patients in response to open flap debridement (OFD). SUBJECTS AND METHODS:The study included 30 subjects divided into 2 groups: 20 CP patients and 10 perio...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/341259
更新日期:2015-01-01 00:00:00
abstract::Over the last two decades, significant data has been accumulated linking Glutatione S-Transferases (GSTs) with the development of several diseases. Contemporary studies have demonstrated the impact of ethnicity on GST allele frequencies. The aim is to verify if the variability of GST genes reflects population demograp...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2011-0821
更新日期:2011-01-01 00:00:00
abstract::Transforming growth factor β1 (TGF-β1) is an important mediator in Chagas disease. Furthermore, patients with higher TGF-β1 serum levels show a worse clinical outcome. Gene polymorphism may account for differences in cytokine production during infectious diseases. We tested whether TGFB1 polymorphisms could be associa...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/4579198
更新日期:2018-02-18 00:00:00
abstract:BACKGROUND:Papillary thyroid carcinoma (PTC), follicular thyroid adenoma (FTA), and thyroid nodular hyperplasia (TNH) are the most frequent diseases of the thyroid gland. Previous studies described the involvement of dipeptidyl-peptidase IV (DPPIV/CD26) in the development of thyroid neoplasia and proposed it as an addi...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/970736
更新日期:2013-01-01 00:00:00
abstract::Objective. To determine active TGF-β1 (aTGF-β1) levels in serum, skin, and peripheral blood mononuclear cell (PBMC) culture supernatants and to understand their associations with clinical parameters in systemic sclerosis (SSc) patients. Methods. We evaluated serum samples from 56 SSc patients and 24 healthy controls (...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2016/6064830
更新日期:2016-01-01 00:00:00
abstract:Background:Epithelial ovarian cancer (EOC) is highly lethal worldwide. Factors involved in the inflammation and hormone-associated signaling pathway play vital roles in EOC carcinogenesis. The transforming growth factor-β- (TGF-β-) activated kinase 1 (MAP3K7) binding protein 2 (TAB2), mediating convergence of inflammat...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/8012979
更新日期:2019-08-14 00:00:00
abstract::We evaluated the occurrence of mutations in P53, K-RAS, COX-2, expression of COX-2 and hTERT and relations among clinicopathological signs. P53 mutations were identified in 34.4% of tumours, the majority of them occurring in SCC (squamous cell carcinoma, 55.6%). K-RAS was mutated in 12.2% of NSCLC tumours, the majorit...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2008/232743
更新日期:2008-01-01 00:00:00
abstract::The prevalence of heart failure (HF) due to cardiac remodelling after acute myocardial infarction (AMI) does not decrease regardless of implementation of new technologies supporting opening culprit coronary artery and solving of ischemia-relating stenosis with primary percutaneous coronary intervention (PCI). Numerous...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2020/1215802
更新日期:2020-06-12 00:00:00
abstract::This study was undertaken to assess the biochemical changes induced in chronic schistosomiasis and/or chronic HCV, as well as to pinpoint the most significant parameters which could be used as dependable indices for the differentiation of single and coupled infections with or without liver cirrhosis. The selected pati...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2000/732754
更新日期:2000-01-01 00:00:00
abstract::As the most common neoplasm arising from the kidney, renal cell carcinoma (RCC) continues to have a significant impact on global health. Conventional cross-sectional imaging has always served an important role in the staging of RCC. However, with recent advances in imaging techniques and postprocessing analysis, magne...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2015/648495
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:High serum MBL level as well as polymorphisms in the mannose-binding lectin 2 (MBL2) gene resulting in MBL deficiency are involved in the mechanism of a number of non-infectious diseases such as asthma, conferring either risk or protection in different population studies. MBL being the first reactant of the ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2012-0892
更新日期:2012-01-01 00:00:00
abstract::Microtubule-associated protein 4 (MAP4) plays an important role in microtubule assembly and stabilization. The purpose of this study was to investigate the level of expression of MAP4 in lung adenocarcinoma (LADC) samples and to evaluate its prognostic value and the influence on cancer progression in LADC patients. Th...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/8956072
更新日期:2018-03-18 00:00:00
abstract:BACKGROUND:Echocardiographic evaluation of left ventricular (LV) structural and functional alterations in hypertension has some limitations, potentially overcome by using biomarkers. ST2, a prognostic biomarker for heart failure and myocardial infarction patients, was less studied in hypertension. AIM:To analyze the r...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2017/2714095
更新日期:2017-01-01 00:00:00
abstract::Alterations of the retinoblastoma (Rb) gene have been described in several human neoplasms and recently, it has been suggested that these alterations may play a role in the development of endometrial carcinomas. Paraffin sections from 31 cases of normal endometrium (16 proliferative, 15 secretory), 35 hyperplastic les...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2002/496345
更新日期:2002-01-01 00:00:00
abstract::Some polymorphisms in genes codifying for fibrinogen have been correlated with plasma levels of this protein, and several studies reported their associations with acute cardiovascular events. In the present study, 118 subjects with unstable and stable coronary diseases were enrolled to determinate the associations amo...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/5769514
更新日期:2019-07-01 00:00:00
abstract::The genetic variation at the Apolipoprotein E locus (APOE) is an important determinant of plasma lipids and has been implicated in various human pathological conditions. The objective of the present study was to estimate the distribution of APOE alleles in five Venezuelan communities: two Amerindian tribes (Bari and Y...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2005/625182
更新日期:2005-01-01 00:00:00