Abstract:
:Chronic infection with the hepatitis B virus (HBV) is a known risk factor in the development of human hepatocellular carcinoma (HCC). The HBV-encoded X protein, HBx, has been investigated for properties that may explain its cancer cofactor role in transgenic mouse lines. We discuss here recent data showing that HBx is able to induce hepatocellular proliferation in vitro and in vivo. This property of HBx is predicted to sensitize hepatocytes to other HCC cofactors, including exposure to carcinogens and to other hepatitis viruses. Cellular proliferation is intimately linked to the mechanism(s) by which most tumor-associated viruses transform virus-infected cells. The HBx alteration of the cell cycle provides an additional mechanism by which chronic HBV infection may contribute to HCC.
journal_name
Dis Markersjournal_title
Disease markersauthors
Madden CR,Slagle BLdoi
10.1155/2001/571254subject
Has Abstractpub_date
2001-01-01 00:00:00pages
153-7issue
3eissn
0278-0240issn
1875-8630journal_volume
17pub_type
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