Abstract:
Purpose:To investigate the association of galectin-3 (Gal-3) and soluble ST2 (sST2) and their follow-up changes with the development of heart failure (HF) and echocardiographic parameters of HF (ejection fraction, atrial and ventricular size, left ventricular hypertrophy, e', and E/e') in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). Methods:A prospective, observational study, BIOSTRAT (Biomarkers for Risk Stratification After STEMI), enrolled 117 patients between October 2014 and April 2017. Gal-3 and sST2 serum collection and echocardiography were performed twice (during index hospitalization and on a control visit at one-year follow-up). The primary endpoint was HF onset at one-year follow-up. Secondary assessments included associations of biomarker concentration with echocardiographic indices of systolic and diastolic dysfunction at baseline and at one year. Results:Mean baseline concentrations of Gal-3 and sST2 (7.5 and 26.4 ng/mL, respectively) were significantly increased at one-year follow-up (8.5 ng/mL and p < 0.001 and 31.4 ng/mL and p = 0.001, respectively). Patients who reached the primary endpoint (50 patients (48%)) had significantly higher baseline concentrations of both biomarkers and a higher Gal-3 level at one year compared to patients who did not. Both Gal-3 and sST2 were predictors of the primary endpoint in univariate logistic regression analysis, but only Gal-3 remained significant in multivariate analysis. There was no clear association between both biomarkers and echocardiographic parameters. Conclusions:Baseline, but not one-year, changes of Gal-3 and sST2 concentrations may be useful for risk stratification after STEMI. However, only Gal-3 was the independent predictor of HF development at one-year observation. This trial is registered with NCT03735719.
journal_name
Dis Markersjournal_title
Disease markersauthors
Tymińska A,Kapłon-Cieślicka A,Ozierański K,Budnik M,Wancerz A,Sypień P,Peller M,Balsam P,Opolski G,Filipiak KJdoi
10.1155/2019/9529053subject
Has Abstractpub_date
2019-10-10 00:00:00pages
9529053eissn
0278-0240issn
1875-8630journal_volume
2019pub_type
临床试验,杂志文章相关文献
DISEASE MARKERS文献大全abstract:BACKGROUND:The molecular work-up of thyroid nodules from fine needle aspiration samples has given clinicians a new level of diagnostic information. The aim of the present study was to evaluate the utility of molecular analysis in thyroid fine needle aspiration samples from a Chinese population. METHODS:Specimens were ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/912182
更新日期:2014-01-01 00:00:00
abstract::In a study of multicase RA families, significantly raised frequencies of the HLA antigens DR4, DR1, Bw62, Cw3, A2, A31 and significantly lower frequencies of DR2, DR3, and B8 were found in probands compared to normal controls. When haplotype frequencies were compared between probands and controls, two haplotypes A2-B4...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:
更新日期:1986-06-01 00:00:00
abstract::Lung disease due to non-tuberculous mycobacteria (NTM) is a poorly understood condition that is difficult to treat. Treatment remains problematic as few tools are available to help clinicians monitor disease progression or predict treatment outcome. In this study, plasma levels of several inflammatory molecules and th...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2010-0732
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:specific polymorphisms of genes regulating intracellular redox balance and oxidative stress are related to atherogenesis. Some studies have identified a relationship between progression of atherosclerosis and C242T mutation in CYBA gene coding for p22phox, a subunit of the NADH/NADPH oxidase system. DESIGN:...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2006/458587
更新日期:2006-01-01 00:00:00
abstract:AIM:Spindle and kinetochore-associated protein 1 (SKA1) is one subtype of SKA, whose protein can make spindle microtubules attach steadily to the kinetochore in the middle of mitosis. At present, there are fewer researches on the relationship between SKA1 expression and tumor development. METHODS:In this study, immuno...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/616541
更新日期:2015-01-01 00:00:00
abstract::Nonenzymatic glycosylation or glycation of macromolecules, especially proteins leading to their oxidation, play an important role in diseases. Glycation of proteins primarily results in the formation of an early stage and stable Amadori-lysine product which undergo further irreversible chemical reactions to form advan...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.3233/DMA-2011-0791
更新日期:2011-01-01 00:00:00
abstract::A growing interest in the usability of saliva has been observed recently. Using saliva as a diagnostic material is possible because it contains a varied range of composites, organic and inorganic like proteins, carbohydrates, and lipids, which are secreted into saliva. Moreover, this applies to drugs and their metabol...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2019/4360612
更新日期:2019-05-02 00:00:00
abstract::We evaluated the occurrence of mutations in P53, K-RAS, COX-2, expression of COX-2 and hTERT and relations among clinicopathological signs. P53 mutations were identified in 34.4% of tumours, the majority of them occurring in SCC (squamous cell carcinoma, 55.6%). K-RAS was mutated in 12.2% of NSCLC tumours, the majorit...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2008/232743
更新日期:2008-01-01 00:00:00
abstract::Transforming growth factor β1 (TGF-β1) is an important mediator in Chagas disease. Furthermore, patients with higher TGF-β1 serum levels show a worse clinical outcome. Gene polymorphism may account for differences in cytokine production during infectious diseases. We tested whether TGFB1 polymorphisms could be associa...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/4579198
更新日期:2018-02-18 00:00:00
abstract::There is increasing evidence to support the use of CA125 in the follow-up and management of patients with ovarian cancer and several commercial kits are now available for its measurement. This study investigated and compared the performance of three of them: an enzyme immunoassay (EIA) and an immunoradiometric assay (...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::Over the last two decades, significant data has been accumulated linking Glutatione S-Transferases (GSTs) with the development of several diseases. Contemporary studies have demonstrated the impact of ethnicity on GST allele frequencies. The aim is to verify if the variability of GST genes reflects population demograp...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2011-0821
更新日期:2011-01-01 00:00:00
abstract::Microtubule-associated protein 4 (MAP4) plays an important role in microtubule assembly and stabilization. The purpose of this study was to investigate the level of expression of MAP4 in lung adenocarcinoma (LADC) samples and to evaluate its prognostic value and the influence on cancer progression in LADC patients. Th...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/8956072
更新日期:2018-03-18 00:00:00
abstract:Materials and Methods:Relative expression of lncRNAs CARMN, LUCAT1, SMILR, and MALAT1 was tested in clinical aortic tissue and blood plasma samples from TAA and non-TAA patients using the qRT-PCR method. The Mann-Whitney U test was used to compare ΔCt values between the study groups. ROC curve analysis was performed to...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/8521899
更新日期:2020-06-17 00:00:00
abstract:BACKGROUND:Paraoxonase-1 (PON1) activity is suggested to be altered in individuals infected with human immunodeficiency virus type-1 (HIV-1). We investigated PON1 activity in individuals receiving different regimens of highly active antiretroviral therapy (HAART). METHODS:PON1 activity was evaluated in 91 HIV-1 serone...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/480201
更新日期:2014-01-01 00:00:00
abstract::soluble urokinase Plasminogen Activator Receptor (suPAR) levels reflect inflammation and elevated suPAR levels are found in several infectious diseases and cancer. suPAR exists in three forms; suPAR(I-III), suPAR(II-III) and suPAR(I) which show different properties due to structural differences. Studies suggest that f...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.3233/DMA-2009-0657
更新日期:2009-01-01 00:00:00
abstract::INHBA-encoded inhibin β A is a member of the transforming growth factor-β (TGF-β) superfamily. INHBA has been reported to be implicated in the progression of multiple types of cancer including ovarian cancer (OC). However, the mechanisms by which INHBA affects OC progression are not well-characterized. The aim of our ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/7275289
更新日期:2019-11-11 00:00:00
abstract:Background and Objective:Reduced expression of syndecan-1 (CD138), increased proliferation index, and modifications in the expression of the molecular RANK/RANKL/OPG triad are related to an intensified potential of aggressiveness and invasion of diverse tumors and cysts. The aim was to compare the expression of Ki-67, ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/7048531
更新日期:2018-07-29 00:00:00
abstract::Vitamin D plays a role in central nervous system (CNS) development. Recent literature focused on vitamin D status in children and adolescents with autism spectrum disorder (ASD), but with inconsistent results. Our case-control study is aimed at evaluating serum 25-hydroxyl-vitamin D (25(OH)D) concentration in children...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/9292560
更新日期:2020-09-18 00:00:00
abstract::In this work we explored the role of the 3'UTR of the MECP2 gene in patients with clinical diagnosis of RTT and mental retardation; focusing on regions of the 3'UTR with almost 100% conservation at the nucleotide level among mouse and human. By mutation scanning (DOVAM-S technique) the MECP2 3'UTR of a total of 66 aff...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2008/738401
更新日期:2008-01-01 00:00:00
abstract:Background:We have previously shown that the deficiency of the gut enzyme intestinal alkaline phosphatase (IAP) is associated with type 2 diabetes mellitus (T2DM) in humans, and mice deficient in IAP develop the metabolic syndrome, a precipitant of T2DM and ischemic heart disease (IHD). We hypothesized that IAP deficie...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/8473565
更新日期:2019-12-13 00:00:00
abstract:AIM:To determine the implication of the polymorphism, namely, A(TA)nTAA of UGT1A1 in lithogenesis for the first time in Tunisia among sickle cell anemia (SCA) children patients. MATERIAL AND METHODS:Our study was performed in 2010 and it involved 76 subjects chosen as control group characterized with normal hemoglobin...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/173474
更新日期:2013-01-01 00:00:00
abstract::Basal cell carcinoma (BCC) is the world's leading skin cancer in terms of frequency at the moment and its incidence continues to rise each year, leading to profound negative psychosocial and economic consequences. UV exposure is the most important environmental factor in the development of BCC in genetically predispos...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2016/9831237
更新日期:2016-01-01 00:00:00
abstract::Pancreatic adenocarcinoma (PDAC) still represents a devastating disease associated with a very limited survival. Novel biomarkers allowing an early diagnosis as well as an optimal selection of suitable treatment options for individual patients are urgently needed to improve the dismal outcome of PDAC patients. Recentl...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/5603474
更新日期:2019-10-20 00:00:00
abstract::Abnormal phenotypic switch of vascular smooth muscle cell (VSMC) is a hallmark of vascular disorders such as atherosclerosis and restenosis. And this process has been related to remodeling of L-type calcium channel (LTCC). We attempted to investigate whether fluvastatin has any effect on VSMC proliferation and LTCCα 1...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/237067
更新日期:2014-01-01 00:00:00
abstract::Background and Objective. The main purpose of this study was to develop a simple automatic diagnostic classification scheme for chemotherapy-induced peripheral neuropathy. Methods:This was a prospective cohort study that enrolled patients with colorectal or gynecologic cancer post chemotherapy for more than 1 year. T...
journal_title:Disease markers
pub_type: 临床试验,杂志文章
doi:10.1155/2020/3402108
更新日期:2020-01-25 00:00:00
abstract:Objective:Long noncoding RNAs (lncRNAs) have been strongly associated with various types of cancer. The present study aimed at exploring the diagnostic and prognostic value of lncRNA Zinc finger protein 667-antisense RNA 1 (ZNF667-AS1) in glioma patients. Patients and Methods. The expressions of ZNF667-AS1 were detecte...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/8895968
更新日期:2020-11-16 00:00:00
abstract::Antibodies against myelin oligodendrocyte antigens have been found in the immunoreactive brain lesions of Multiple Sclerosis (MS) patients. Recently it has been proposed that these antibodies can be used as a prognostic marker in the course of disease. However, the serum levels of these autoantibodies during different...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2005/826817
更新日期:2005-01-01 00:00:00
abstract::Epithelial cancers, including those of the skin and cervix, are the most common type of cancers in humans. Many recent studies have attempted to use Raman spectroscopy to diagnose these cancers. In this paper, Raman spectral markers related to the temporal and spatial effects of cervical and skin cancers are examined ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2008/230307
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Previous studies on the role of inflammation in the pathophysiology of sickle cell disease (SCD) suggested that the CCR5Δ32 allele, which is responsible for the production of truncated C-C chemokine receptor type 5 (CCR5), could confer a selective advantage on patients with SCD because it leads to a less eff...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/678246
更新日期:2014-01-01 00:00:00
abstract::The atomic force microscope (AFM) is emerging as a powerful tool in cell biology. Originally developed for high-resolution imaging purposes, the AFM also has unique capabilities as a nano-indenter to probe the dynamic viscoelastic material properties of living cells in culture. In particular, AFM elastography combines...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2004/482680
更新日期:2003-01-01 00:00:00