Abstract:
:Transforming growth factor β1 (TGF-β1) is an important mediator in Chagas disease. Furthermore, patients with higher TGF-β1 serum levels show a worse clinical outcome. Gene polymorphism may account for differences in cytokine production during infectious diseases. We tested whether TGFB1 polymorphisms could be associated with Chagas disease susceptibility and severity in a Brazilian population. We investigated five single-nucleotide polymorphisms (-800 G>A, -509 C>T, +10 T>C, +25 G>C, and +263 C>T). 152 patients with Chagas disease (53 with the indeterminate form and 99 with the cardiac form) and 48 noninfected subjects were included. Genotypes CT and TT at position -509 of the TGFB1 gene were more frequent in Chagas disease patients than in noninfected subjects. Genotypes TC and CC at codon +10 of the TGFB1 gene were also more frequent in Chagas disease patients than in noninfected subjects. We found no significant differences in the distribution of the studied TGFB1 polymorphisms between patients with the indeterminate or cardiac form of Chagas disease. Therefore, -509 C>T and +10 T>C TGFB1 polymorphisms are associated with Chagas disease susceptibility in a Brazilian population.
journal_name
Dis Markersjournal_title
Disease markersauthors
Ferreira RR,Madeira FDS,Alves GF,Chambela MDC,Curvo EOV,Moreira ADS,Almeida de Sá R,Mendonça-Lima L,Cabello PH,Bailly S,Feige JJ,Araujo-Jorge TC,Saraiva RM,Waghabi MCdoi
10.1155/2018/4579198subject
Has Abstractpub_date
2018-02-18 00:00:00pages
4579198eissn
0278-0240issn
1875-8630journal_volume
2018pub_type
杂志文章相关文献
DISEASE MARKERS文献大全abstract::Exposure to asbestos is the main cause of malignant pleural mesothelioma (MPM), a highly aggressive cancer of the pleura. Since the only tools for early detection are based on radiological tests, some authors focused on serum markers (i.e., mesothelin). The aim of this study was the evaluation of new serum biomarkers ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2017/3510984
更新日期:2017-01-01 00:00:00
abstract::Exhaled breath condensate (EBC) has been increasingly used as a new and non-invasive method to study airway inflammation. In this study we have compared the concentrations of lipid mediators in EBC with concentrations in bronchoalveolar lavage fluid (BALF). We included 37 patients undergoing bronchoscopy (12 sarcoidos...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2011-0776
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Up to 43% of HIV-infected patients co-infected with Mycobacterium tuberculosis experience exacerbations of tuberculosis (TB) after commencing antiretroviral therapy (ART). These are termed immune restoration disease (IRD). It is unclear why individual susceptibility varies. OBJECTIVE:We investigate if singl...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-130991
更新日期:2013-01-01 00:00:00
abstract::S-100 protein was demonstrated in 28/31 melanoma tissue sections that had been previously stained by hematoxylin and eosin, including 17 from 19 primary melanomas and 11 from 12 metastases. Additional H & E stained sections from 11 metastatic and 13 primary melanomas were reacted with the monoclonal antibody NKI/C-3 a...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00
abstract::Clinical variables contribute to the severity of Kashin-Beck disease (KBD). However, it is unclear if there is a correlation between gene expression and clinical variables. Peripheral blood samples were collected from 100 patients with KBD and 100 healthy controls from KBD-endemic areas to identify differentially expr...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/3736198
更新日期:2019-01-03 00:00:00
abstract:Purpose:To investigate the association of galectin-3 (Gal-3) and soluble ST2 (sST2) and their follow-up changes with the development of heart failure (HF) and echocardiographic parameters of HF (ejection fraction, atrial and ventricular size, left ventricular hypertrophy, e', and E/e') in patients with ST-segment eleva...
journal_title:Disease markers
pub_type: 临床试验,杂志文章
doi:10.1155/2019/9529053
更新日期:2019-10-10 00:00:00
abstract::Microtubule-associated protein 4 (MAP4) plays an important role in microtubule assembly and stabilization. The purpose of this study was to investigate the level of expression of MAP4 in lung adenocarcinoma (LADC) samples and to evaluate its prognostic value and the influence on cancer progression in LADC patients. Th...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/8956072
更新日期:2018-03-18 00:00:00
abstract:Methods:We collected 732 samples from Liaoning Province, China, and three polymorphisms in long noncoding RNA H19 were genotyped using the KASP platform. Results:Our data showed that H19 rs2735971 and rs3024270 variant genotypes were associated with a decreased risk of CAD (rs2735971, P = 0.003, odds ratio (OR) = 0.61...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/9839612
更新日期:2020-05-10 00:00:00
abstract::There is increasing evidence to support the use of CA125 in the follow-up and management of patients with ovarian cancer and several commercial kits are now available for its measurement. This study investigated and compared the performance of three of them: an enzyme immunoassay (EIA) and an immunoradiometric assay (...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::In recent researches, high expression of nesfatin-1/nucleobindin-2 (NUCB2) is linked to poor prognosis in prostate and colon cancer due to the enhancement in proliferation, migration, and invasion. However, the role of nesfatin-1 in bladder cancer is not clear. In this study, we examined the expression of NUCB2 in bla...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/4272064
更新日期:2018-09-19 00:00:00
abstract::Alzheimer's disease (AD) is a neurodegenerative disorder that accounts for nearly 70% of the more than 46 million dementia cases estimated worldwide. Although there is no cure for AD, early diagnosis and an accurate characterization of the disease progression can improve the quality of life of AD patients and their ca...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/5174815
更新日期:2018-10-04 00:00:00
abstract::Cardiovascular diseases are the main causes of mortality. Sudden cardiac death may also appear in athletes, due to underlying congenital or inherited cardiac abnormalities. The electrocardiogram is used in clinical practice and clinical trials, as a valid, reliable, accessible, inexpensive method. The aim of the prese...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2015/727401
更新日期:2015-01-01 00:00:00
abstract::A limited number of studies have been performed so far on the polymorphism in the transmembrane region (exon 5) of the major histocompatibility complex class I chain-related gene A (MICA) in patients with melanoma. However, the influence of MICA polymorphism in extracellular domains (exons 2, 3, and 4) has not been in...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/831864
更新日期:2015-01-01 00:00:00
abstract::In this study, we aim to investigate the correlation between circulating tumor cells (CTCs) and the T lymphocyte subsets and NK cells in peripheral blood in non-small-cell lung cancer (NSCLC). The peripheral blood CTCs were determined by SET-iFISH. Flow cytometry was used to determine the distribution of T lymphocyte ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2017/5727815
更新日期:2017-01-01 00:00:00
abstract::Apolipoprotein E (apoE) plays an important role in lipid metabolism. Its epsilon4 allele has been consistently associated with lipoprotein disorders but its connection to myocardial infarction (MI) is controversial. Because epsilon4 frequency decreases with age we thought that the contradictory results in different st...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2005/381657
更新日期:2005-01-01 00:00:00
abstract::Epithelial ovarian cancer (EOC) is the sixth most common cause of cancer deaths in women because the diagnosis occurs mostly when the disease is in its late-stage. Current diagnostic methods of EOC show only a moderate sensitivity, especially at an early-stage of the disease; hence, novel biomarkers are needed to impr...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/238197
更新日期:2014-01-01 00:00:00
abstract::Age-related macular degeneration (AMD) is the most common cause of blindness in elderly people worldwide and the major degenerative disease of the retina that leads to progressive impairment of central vision. Several polymorphisms in different genes have been proposed as factors that increase the disease susceptibili...
journal_title:Disease markers
pub_type: 杂志文章,meta分析
doi:10.1155/2016/8486406
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:In this study, we sought to investigate the dynamic changes in the levels of TNF-α, IL-1β and LPS in the gingival crevicular fluid (GCF) in a rat model of diabetes mellitus (DM) and periodontitis (PD). Additionally, we evaluated alveolar bone loss and the histopathological response associated with experimenta...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-130974
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Impaired fasting glucose (IFG) through the nondiabetic range (100-125 mg/dL) is not considered in the cardiovascular (CV) risk profile. AIM:To compare the clustering of CV risk factors (RFs) in nondiabetic subjects with normal fasting glucose (NFG) and IFG. MATERIAL AND METHODS:Cross-sectional study in 373...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/804739
更新日期:2015-01-01 00:00:00
abstract::As the most common neoplasm arising from the kidney, renal cell carcinoma (RCC) continues to have a significant impact on global health. Conventional cross-sectional imaging has always served an important role in the staging of RCC. However, with recent advances in imaging techniques and postprocessing analysis, magne...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2015/648495
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:A novel swine-origin influenza A H1N1 virus (S-OIV) caused human infection and acute respiratory illness in 2009, resulting in an influenza pandemic. OBJECTIVES:This study characterized the immune responses of S-OIV infection in pediatric patients at risk of pulmonary complications. METHODS:All enrolled pe...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/195453
更新日期:2014-01-01 00:00:00
abstract::Background. Proper diagnosis of pancreatic lesion etiology is a challenging clinical dilemma. Studies suggest that surgery for suspected pancreatic ductal adenocarcinoma (PDAC) reveals a benign lesion in 5% to 13% of cases. The aim of our study was to assess whether routinely used biomarkers such as CA19-9, Ca125, Ca1...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2017/8629712
更新日期:2017-01-01 00:00:00
abstract::Vitamin D plays a role in central nervous system (CNS) development. Recent literature focused on vitamin D status in children and adolescents with autism spectrum disorder (ASD), but with inconsistent results. Our case-control study is aimed at evaluating serum 25-hydroxyl-vitamin D (25(OH)D) concentration in children...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/9292560
更新日期:2020-09-18 00:00:00
abstract::Multiple association studies found that the human 9p21.3 chromosome locus is a risk factor for atherosclerosis. The purpose of this study was to investigate the association of the severity and early-onset of coronary artery disease with variant rs1333049 on chromosome 9p21.3 polymorphism and the impact of this variant...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/792679
更新日期:2015-01-01 00:00:00
abstract::Epithelial cancers, including those of the skin and cervix, are the most common type of cancers in humans. Many recent studies have attempted to use Raman spectroscopy to diagnose these cancers. In this paper, Raman spectral markers related to the temporal and spatial effects of cervical and skin cancers are examined ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2008/230307
更新日期:2008-01-01 00:00:00
abstract:Background:With the development of new drug combinations and targeted treatments for multiple types of cancer, the ability to stratify categories of patient populations and to develop companion diagnostics has become increasingly important. A panel of 325 RNA biomarkers was selected based on cancer-related biological p...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/1940347
更新日期:2019-05-14 00:00:00
abstract:OBJECTIVES:This study was undertaken to investigate the OPG profiles in gingival crevicular fluid (GCF), saliva, and gingival tissues of chronic periodontitis (CP) patients in response to open flap debridement (OFD). SUBJECTS AND METHODS:The study included 30 subjects divided into 2 groups: 20 CP patients and 10 perio...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/341259
更新日期:2015-01-01 00:00:00
abstract::Nevirapine (NVP) is an effective nonnucleoside reverse transcriptase inhibitor (NNRTI) of particular interest as it is often used in resource limited countries. However, one of the main concerns with the use of NVP is hepatotoxicity and elevation of liver enzymes as a consequence of highly active antiretroviral therap...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/315824
更新日期:2014-01-01 00:00:00
abstract:Background:The C-reactive protein (CRP)/albumin ratio is a useful index used to represent patient inflammation and nutritional status. Elderly patients are at the highest risk for acute kidney injury (AKI). We clarified the impact of the preoperative CRP/albumin ratio on AKI and evaluated the impact of postoperative AK...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/8818445
更新日期:2020-10-27 00:00:00
abstract:Background:Syndecan-1 (SDC1/CD138) is a key cell surface adhesion molecule essential for maintaining cell morphology and the interactions with the surrounding microenvironment. SDC1 tumor immunoexpression may be increased or decreased in epithelial malignant neoplasms compared to that in adjacent non-neoplastic tissue,...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/3768708
更新日期:2019-04-30 00:00:00