Abstract:
Background:Syndecan-1 (SDC1/CD138) is a key cell surface adhesion molecule essential for maintaining cell morphology and the interactions with the surrounding microenvironment. SDC1 tumor immunoexpression may be increased or decreased in epithelial malignant neoplasms compared to that in adjacent non-neoplastic tissue, depending on the type of carcinoma, and it has been correlated with various clinicopathological parameters and patient prognosis. SDC1 expression is decreased in colorectal cancer (CRC) tissue, but the relationship between prognosis and SDC1 expression in CRC patients is controversial. Methods:In this study, SDC1 expression was detected in 65 adjacent non-neoplastic colorectal tissues, 477 CRCs, and 79 metastatic lymph nodes using tissue microarray. Results:The data show that SDC1 decreased in CRC tissues (p ≤ 0.001) and metastatic lymph node tissues (p ≤ 0.001) compared to that in adjacent non-neoplastic colorectal tissues. Loss of SDC1 protein expression is associated with poor overall (p < 0.0001) and disease-free survival (p < 0.0001), differentiation (p = 0.017), stage (p ≤ 0.001), and lymph node metastasis (p ≤ 0.001) in CRC patients. Conclusions:These data suggest that the loss of SDC1 plays an important role in CRC malignant progression. Loss of SDC1 expression indicates poor prognosis in patients from northern China with CRC.
journal_name
Dis Markersjournal_title
Disease markersauthors
Li K,Li L,Wu X,Yu J,Ma H,Zhang R,Li Y,Wang Wdoi
10.1155/2019/3768708subject
Has Abstractpub_date
2019-04-30 00:00:00pages
3768708eissn
0278-0240issn
1875-8630journal_volume
2019pub_type
杂志文章相关文献
DISEASE MARKERS文献大全abstract:Purpose:Modern neuroimaging techniques allow investigating brain structures and substances involved in the pathophysiology of mental disorders, trying to find new markers of these disorders. To better understanding of the pathophysiology and differential diagnosis of schizophrenia and bipolar disorder, this study was c...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/3654894
更新日期:2018-11-25 00:00:00
abstract:BACKGROUND:During progression of gastric cancer (GC), degradation of the extracellular matrix is mediated by the matrix metalloproteases (MMPs) and their tissue inhibitors (TIMPs): changes in the expression of these have been related to unfavorable prognosis in GC. OBJECTIVE:To analyze the expression of certain MMPs a...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/285906
更新日期:2014-01-01 00:00:00
abstract::Tumor-induced osteomalacia (TIO) is a rare acquired paraneoplastic disorder and fibroblast growth factor 23 (FGF23) plays a key role in its pathogenesis. This study was conducted to describe a novel FGF23 detecting procedure and describe clinical features of the disease. Fourteen TIO cases were retrieved and FGF23 exp...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2016/3176978
更新日期:2016-01-01 00:00:00
abstract::RARβ plays a critical role in cancer progression and is associated with several types of human cancer. It remains unclear, however, whether it is linked to the clinicopathological parameters of colorectal cancer (CRC). We therefore determined the expression of RARβ protein in patients with primary CRC and examined its...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/7138754
更新日期:2019-03-03 00:00:00
abstract:OBJECTIVE:To investigate whether single nucleotide polymorphisms (SNPs) in the Mn-superoxide dismutase gene (SOD2) underlie the susceptibility to noise-induced hearing loss (NIHL). METHODS:Audiometric data from 2400 Chinese Han workers who exposed to occupational noise were analyzed. DNA samples were collected from th...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2010-0693
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Soluble vascular endothelial growth factor (VEGF) is a promising biomarker in monitoring rheumatoid arthritis (RA), but studies of pre-analytical and biologic variability are few. METHODS:VEGF was measured by ELISA methods in serum and plasma from healthy persons and RA patients. Pre-analytical factors were...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2008/707864
更新日期:2008-01-01 00:00:00
abstract:Objective:A growing body of emerging evidence indicates that metabolic processes play a pivotal role in the biological processes underlying acute myocardial infarction (AMI). The aim of the current study was to identify featured metabolism-related genes in patients with AMI using a support vector machine (SVM) and to f...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/8880004
更新日期:2020-11-28 00:00:00
abstract::High recurrence rate is one representative characteristic of bladder cancer. Intravesical therapy after transurethral resection is often performed in patients with nonmuscle invasive bladder cancer (NMIBC) to prevent recurrence. Bacillus Calmette-Guérin (BCG) and several anticancer/antibiotic agents, such as mitomycin...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2015/857416
更新日期:2015-01-01 00:00:00
abstract::Basal cell carcinoma (BCC) is the world's leading skin cancer in terms of frequency at the moment and its incidence continues to rise each year, leading to profound negative psychosocial and economic consequences. UV exposure is the most important environmental factor in the development of BCC in genetically predispos...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2016/9831237
更新日期:2016-01-01 00:00:00
abstract:Objective:Recent studies have demonstrated that miRNA-155 is involved in the occurrence and development of atherosclerosis. Furthermore, miRNA-155 has emerged as a new indirect marker for inflammation associated with adverse outcomes in oncology and cardiovascular diseases. This study investigated the correlation betwe...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/6345284
更新日期:2018-06-25 00:00:00
abstract::Gamma-glutamyltransferase (GGT) is a well-established serum marker for alcohol-related liver disease. However, GGT's predictive utility applies well beyond liver disease: elevated GGT is linked to increased risk to a multitude of diseases and conditions, including cardiovascular disease, diabetes, metabolic syndrome (...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2015/818570
更新日期:2015-01-01 00:00:00
abstract::Cardiovascular diseases are the main causes of mortality. Sudden cardiac death may also appear in athletes, due to underlying congenital or inherited cardiac abnormalities. The electrocardiogram is used in clinical practice and clinical trials, as a valid, reliable, accessible, inexpensive method. The aim of the prese...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2015/727401
更新日期:2015-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide due to latent liver disease, late diagnosis, and nonresponse to systemic treatments. Till now, surgical and/or biopsy specimens are still generally used as a gold standard by the clinicians for clinical decision-making. Howeve...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2016/1427849
更新日期:2016-01-01 00:00:00
abstract::INHBA-encoded inhibin β A is a member of the transforming growth factor-β (TGF-β) superfamily. INHBA has been reported to be implicated in the progression of multiple types of cancer including ovarian cancer (OC). However, the mechanisms by which INHBA affects OC progression are not well-characterized. The aim of our ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/7275289
更新日期:2019-11-11 00:00:00
abstract:AIM:To determine the implication of the polymorphism, namely, A(TA)nTAA of UGT1A1 in lithogenesis for the first time in Tunisia among sickle cell anemia (SCA) children patients. MATERIAL AND METHODS:Our study was performed in 2010 and it involved 76 subjects chosen as control group characterized with normal hemoglobin...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/173474
更新日期:2013-01-01 00:00:00
abstract::Human papillomaviruses (HPV) infect cutaneous and mucosal epithelia and induce benign and malignant lesions. Non-melanoma skin cancer (NMSC), encompassing basal cell carcinoma and squamous cell carcinoma (SCC), is the most frequent cancer in the Caucasian population, and the incidence has increased dramatically worldw...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2007/942650
更新日期:2007-01-01 00:00:00
abstract::Chromosomal aneuploidy consists the leading cause of fetal death in our species. Around 50% of spontaneous abortions until 15 weeks of gestational age are chromosomally aneuploid, with trisomies accounting for 50% of the abnormal abortions. Trisomy 21 is the most common chromosome abnormality in liveborns and is usual...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2009-0673
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:The purpose of the present study is to explore the correlation between nuclear expression of cyclin-dependent kinase inhibitor 1B (p27) and clinicopathologic features in nasopharyngeal carcinoma (NPC), including patient survival. METHODS:Immunohistochemistry was used to examine the expression of p27 in 130 p...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/251209
更新日期:2013-01-01 00:00:00
abstract::SIRT6 has been demonstrated to exert protective effects on endothelial cells and is closely associated with lipid metabolism, glucose metabolism, and obesity, indicating an important role in the pathogenesis and progression of coronary artery disease (CAD). Nonetheless, the biological significance of SIRT6 variants on...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2016/1628041
更新日期:2016-01-01 00:00:00
abstract::In an attempt to better unfold the antitumor immune response and invasion strategies perused by tumor cells, markers such as CD99 and HLA-II have been stained in breast tumors, some of them turned out to be important for prognosis and its outcome. CD99 is involved in the intracellular transport of HLA-II proteins. The...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-130982
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the combined effects of MMP-2 and TIMP-2 protein immunoreactivities on the prognosis in endometrial carcinoma. METHODS:Paraffin-embedded tissue samples from 225 primary endometrioid adenocarcinomas and 13 histologies other than endometrioid adenocarcinoma were immunohist...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/416870
更新日期:2013-01-01 00:00:00
abstract::Immunological and immunogenetic investigations are described in a group of 28 women with a history of unexplained recurrent (greater than or equal to 3 consecutive) spontaneous abortions (RSA). Compared with female blood donor controls, recurrent aborters had significantly elevated mean serum complement C4 (p less tha...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract:Aim:B7-H4 is member of the B7 family that negatively regulates the immune response, which are associated with tumor development and prognosis. The present study is aimed at examining serum B7-H4 expression and exploring its contribution to diagnosis in patients with colorectal cancer. Methods:We determined serum expre...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/4310790
更新日期:2018-09-27 00:00:00
abstract::The total plasma concentration of homocysteine is a marker of this amino acid's atherogenic potential. However, the homocysteine pool exists almost entirely as oxidized homocysteine equivalents (OHcyE), composed of homocystine and cysteine-homocysteine disulphides (20-30%), and protein-bound disulphide (70-80%). We ha...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2009-0649
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The association of the apolipoprotein (Apo E) -epsilon4 allele to neurodegenerative diseases such as Parkinson's disease (PD) has been analyzed in several studies. This association has been identified by amyloid deposits and neurofibrillary tangles in the brains of patients with neurodegenerative diseases. ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2009-0667
更新日期:2009-01-01 00:00:00
abstract:Background:The pathogenesis of thoracic aortopathy is complex, and much evidence suggests the influence of genetic factors. Some genes with polymorphisms are widely considered critical factors in the initiation and development of aortic aneurysm. The aim of our study was to analyze the association of genetic polymorphi...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/9567239
更新日期:2020-09-24 00:00:00
abstract::MicroRNAs (miRNAs) are a class of small, non-coding RNA molecules that can regulate gene expression, thereby affecting crucial processes in cancer development. miRNAs offer great potential as biomarkers for cancer detection because of their remarkable stability in blood and their characteristic expression in different...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-120957
更新日期:2013-01-01 00:00:00
abstract::Chronic infection with the hepatitis B virus (HBV) is a known risk factor in the development of human hepatocellular carcinoma (HCC). The HBV-encoded X protein, HBx, has been investigated for properties that may explain its cancer cofactor role in transgenic mouse lines. We discuss here recent data showing that HBx is...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2001/571254
更新日期:2001-01-01 00:00:00
abstract::Alterations of the retinoblastoma (Rb) gene have been described in several human neoplasms and recently, it has been suggested that these alterations may play a role in the development of endometrial carcinomas. Paraffin sections from 31 cases of normal endometrium (16 proliferative, 15 secretory), 35 hyperplastic les...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2002/496345
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:To evaluate serum chemerin levels in patients with osteoporosis and healthy controls and to investigate the relationship between serum chemerin levels and bone mineral density (BMD). METHODS:An age- and gender-matched case-control study was conducted. Pearson's correlation test was performed to investigate ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/786708
更新日期:2015-01-01 00:00:00