Abstract:
OBJECTIVE:The purpose of the present study is to explore the correlation between nuclear expression of cyclin-dependent kinase inhibitor 1B (p27) and clinicopathologic features in nasopharyngeal carcinoma (NPC), including patient survival. METHODS:Immunohistochemistry was used to examine the expression of p27 in 130 primary NPC tissues. The relationship between the levels of p27 expression and clinicopathologic characteristics was analyzed. Survival curves were plotted using the Kaplan-Meier method and compared using the log-rank test. The significance of various survival variables was analyzed using multivariate Cox proportional hazards model. RESULTS:p27 was expressed in both nuclear and cytoplasmic compartments. Nuclear expression of p27 was inversely correlated with T classification and clinical stage. Patients with nuclear p27 expression had better overall survival rates than those without nuclear expression of p27. Further, we observed that nuclear expression of p27 was positively associated with survival time of NPC patients not only in N0-1 and M0 classifications but also in radiotherapy and chemotherapy treatment groups. Finally, we found that nuclear expression of p27 was not an independent prognostic factor for patients with NPC. CONCLUSIONS:Our findings hint that nuclear expression of p27 is a potentially favorable factor in the progression and prognosis of NPC.
journal_name
Dis Markersjournal_title
Disease markersauthors
Liu Z,Long Y,Zhang Y,Huang W,Long X,Yang H,Long J,Cheng C,Fang Wdoi
10.1155/2013/251209subject
Has Abstractpub_date
2013-01-01 00:00:00pages
925-32issue
6eissn
0278-0240issn
1875-8630journal_volume
35pub_type
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