The clinical significance of PR, ER, NF- κ B, and TNF- α in breast cancer.

abstract：:There is increasing evidence to support the use of CA125 in the follow-up and management of patients with ovarian cancer and several commercial kits are now available for its measurement. This study investigated and compared the performance of three of them: an enzyme immunoassay (EIA) and an immunoradiometric assay (...

journal_title：Disease markers

authors： Fisken J,Leonard RC,Roulston JE

更新日期：1989-01-01 00:00:00

abstract：:The clinical distinction of frontotemporal dementia (FTD) and Alzheimer's disease (AD) may be difficult. In this narrative review we summarize and discuss the most relevant electroencephalography (EEG) studies which have been applied to demented patients with the aim of distinguishing the various types of cognitive im...

journal_title：Disease markers

authors： Nardone R,Sebastianelli L,Versace V,Saltuari L,Lochner P,Frey V,Golaszewski S,Brigo F,Trinka E,Höller Y

更新日期：2018-09-03 00:00:00

abstract：Aims:The impact of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 Lys45Glu (A/G), MMP-7 -181A/G, and MMP-12 -82A/G variants and plasma MMP levels on obesity and microvascular reactivity in Tunisians. Methods:Our population included 202 nonobese and 168 obese subjects. Anthropometric, biochemical, and microvascular parameters wer...

journal_title：Disease markers

authors： Boumiza S,Bchir S,Ben Nasr H,Abbassi A,Jacob MP,Norel X,Tabka Z,Chahed K

更新日期：2017-01-01 00:00:00

abstract：:The total plasma concentration of homocysteine is a marker of this amino acid's atherogenic potential. However, the homocysteine pool exists almost entirely as oxidized homocysteine equivalents (OHcyE), composed of homocystine and cysteine-homocysteine disulphides (20-30%), and protein-bound disulphide (70-80%). We ha...

journal_title：Disease markers

authors： Iuliano M,De Tommaso G,Ragone R

更新日期：2009-01-01 00:00:00

abstract：:This report describes the production and characterization of two new monoclonal antibodies (MoAb), WM-53 and WM-54, reacting with a human myeloid differentiation antigen, which has recently been assigned by the Third International Leucocyte Workshop on Human Differentiation Antigens into cluster CD-33 ('gp67'). To dat...

journal_title：Disease markers

authors： Favaloro EJ,Bradstock KF,Kabral A,Grimsley P,Berndt MC

更新日期：1987-12-01 00:00:00

abstract：:soluble urokinase Plasminogen Activator Receptor (suPAR) levels reflect inflammation and elevated suPAR levels are found in several infectious diseases and cancer. suPAR exists in three forms; suPAR(I-III), suPAR(II-III) and suPAR(I) which show different properties due to structural differences. Studies suggest that f...

journal_title：Disease markers

authors： Thunø M,Macho B,Eugen-Olsen J

更新日期：2009-01-01 00:00:00

abstract：:IGF2 is the first gene discovered to be imprinted and expressed exclusively from the paternal allele in both human and mouse. IGF2 is also the first imprinted gene displaying loss of imprinting (LOI) or aberrant imprinting in human cancers. Evidently, LOI or reactivation of the maternal allele of IGF2 is associated wi...

journal_title：Disease markers

authors： Cui H

更新日期：2007-01-01 00:00:00

abstract：:A study of MHC class I, II, and III markers in a group of southern Chinese in Hong Kong is reported. HLA antigen frequencies and complement allele frequencies are given, together with statistically significant pair-wise co-occurrences. Over half of the statistically significant positive and negative linkage disequilib...

journal_title：Disease markers

authors： Hawkins BR,Serjeantson SW,Higgins DA

更新日期：1988-10-01 00:00:00

abstract：BACKGROUND:The apolipoprotein (apo) B/apoA-I ratio represents the balance between apoB-rich atherogenic particles and apoA-I-rich antiatherogenic particles, and this ratio is considered to be a marker of cardiovascular risk. Although many studies have demonstrated the importance of the apoB/apoA-I ratio in predicting t...

journal_title：Disease markers

authors： Kaneva AM,Potolitsyna NN,Bojko ER,Odland JØ

更新日期：2015-01-01 00:00:00

abstract：Background:The ratio of early mitral inflow velocity to the global diastolic strain rate (E/E'sr) and global longitudinal systolic strain (GLS) of the left ventricle (LV) are emerging indices of diastolic and systolic functions, respectively, for the LV. Their prognostic significance in the prediction of mortality and ...

journal_title：Disease markers

authors： Huang JC,Su HM,Wu PY,Lee JJ,Lee WH,Chen SC,Chiu YW,Hsu YL,Chang JM,Chen HC

更新日期：2019-09-05 00:00:00

abstract：Objective:Recent studies have demonstrated that miRNA-155 is involved in the occurrence and development of atherosclerosis. Furthermore, miRNA-155 has emerged as a new indirect marker for inflammation associated with adverse outcomes in oncology and cardiovascular diseases. This study investigated the correlation betwe...

journal_title：Disease markers

authors： Su Q,Yang H,Li L

更新日期：2018-06-25 00:00:00

abstract：:Familial Amyloidotic Polyneuropathy (FAP) is a disorder characterized by the extracellular deposition of fibrillar Transthyretin (TTR) amyloid, with a special involvement of the peripheral nerve. Several extracellular matrix proteins have been found elevated in tissues from FAP patients, namely metalloproteinase-9 (MM...

journal_title：Disease markers

authors： Cardoso I,Brito M,Saraiva MJ

更新日期：2008-01-01 00:00:00

abstract：:The role of pro-fibrogenic cytokines in the outcome of infections with hepatitis C virus (HCV) and the response to treatment with pegylated interferon-alpha (pegIFNalpha) and ribavirin remains unclear. To address this issue, we assessed hepatic fibrosis and plasma markers pertinent to T-cell mediated fibrogenesis and ...

journal_title：Disease markers

authors： Lee S,Varano J,Flexman JP,Cheng W,Watson MW,Rossi E,Adams LA,Bulsara M,Price P

更新日期：2010-01-01 00:00:00

abstract：Purpose:To investigate the association of galectin-3 (Gal-3) and soluble ST2 (sST2) and their follow-up changes with the development of heart failure (HF) and echocardiographic parameters of HF (ejection fraction, atrial and ventricular size, left ventricular hypertrophy, e', and E/e') in patients with ST-segment eleva...

journal_title：Disease markers

authors： Tymińska A,Kapłon-Cieślicka A,Ozierański K,Budnik M,Wancerz A,Sypień P,Peller M,Balsam P,Opolski G,Filipiak KJ

更新日期：2019-10-10 00:00:00

abstract：BACKGROUND:Evidence indicates that microRNAs (miRNA) play a role in the pathogenesis of chronic kidney diseases (CKD). We explored the possibility of using urinary miRNA as non-invasive biomarkers for CKD. METHODS:We quantified miRNA expression in urinary sediment of 56 CKD patients who underwent kidney biopsy. Patien...

journal_title：Disease markers

authors： Szeto CC,Ching-Ha KB,Ka-Bik L,Mac-Moune LF,Cheung-Lung CP,Gang W,Kai-Ming C,Kam-Tao LP

更新日期：2012-01-01 00:00:00

abstract：:The eukaryotic initiation factor 3 (eIF3) is the largest and most complex translation initiation factor in mammalian cells. It consists of 13 subunits and among which several were implicated to have significant prognostic effects on multiple human cancer entities. To examine the expression profiles of eIF3 subunits an...

journal_title：Disease markers

authors： Wang D,Jia Y,Zheng W,Li C,Cui W

更新日期：2019-12-07 00:00:00

abstract：AIMS:To study the changes of the metabolic profile during the pathogenesis in monocrotaline (MCT) induced pulmonary arterial hypertension (PAH). METHODS:Forty male Sprague-Dawley (SD) rats were randomly divided into 5 groups (n = 8, each). PAH rats were induced by a single dose intraperitoneal injection of 60 mg/kg MC...

journal_title：Disease markers

authors： Lin T,Gu J,Huang C,Zheng S,Lin X,Xie L,Lin D

更新日期：2016-01-01 00:00:00

abstract：:Kidney insufficiency is a hallmark of nephropathia epidemica (NE). Little is known about the mechanisms of the NE kidney pathology, with current knowledge mainly based on findings in postmortem tissue. We have analyzed kidney damage biomarkers in urine collected from early- and late-phase NE using Bio-Plex kidney toxi...

journal_title：Disease markers

authors： Martynova EV,Maksudova AN,Shakirova VG,Abdulkhakov SR,Khaertynova IM,Anokhin VA,Ivanova VV,Abiola IM,Garanina EE,Tazetdinova LG,Valiullina AH,Khaiboullina SF

更新日期：2018-02-26 00:00:00

abstract：:The human papilloma virus (HPV) associated with hyperplastic epithelium in an oral denture fibroma was examined by southern blot hybridization. Extracted DNA was hybridized with full length linear HPV type 2a, 6b, 11, 16, 18, 31 and 33 DNAs as a mixed probe only under low stringent conditions. The hybridized bands dig...

journal_title：Disease markers

authors： Yamaguchi T,Shindoh M,Amemiya A,Notani K,Fukuda H,Sakaoka H,Inoue M,Fujinaga K

更新日期：1997-04-01 00:00:00

abstract：:We aim to identify the mutations of deafness genes using massively parallel DNA sequencing in the 12 Uyghur families. SNPscan method was used to screen against the 124 sites in the common deafness genes in probands. Subjects with SNPscan negativity were subject to massively parallel DNA sequencing for the sequencing o...

journal_title：Disease markers

authors： Chen Y,Lu Y,Kuyaxi P,Cheng J,Zhao J,Zhao Q,Musha P,Zhang H,Yuan H

更新日期：2018-03-05 00:00:00

abstract：:Colorectal cancer is one of the most common cancers in the world. Due to its still undetermined pathogenesis, we are searching for signaling pathways that are important in the development of colorectal cancer. In this article, we present results of study on the role of ADAM proteins in colorectal cancer. The study inc...

journal_title：Disease markers

authors： Walkiewicz K,Strzelczyk J,Waniczek D,Biernacki K,Muc-Wierzgoń M,Copija A,Nowakowska-Zajdel E

更新日期：2019-09-02 00:00:00

abstract：:The phenotype of cytosolic Low Molecular Weight Protein Tyrosine Phosphatase (cLMWPTP or ACP1), an enzyme involved in signal transduction of insulin, PDGF and T-cell receptors, has been determined in 71 patients with Crohn's Disease (CD: 37 males and 34 females), 49 patients with Ulcerative Colitis (UC: 27 males and 2...

journal_title：Disease markers

authors： Bottini N,Gloria-Bottini F,Lucarini N,Ronchetti PG,Fontana L

更新日期：2000-01-01 00:00:00

abstract：:PD1/PDL1 inhibitors have been adopted for the treatment of advanced non-small-cell lung cancer, and PDL1 expression has been investigated as a predictive biomarker for PD1/PDL1 inhibitor therapy. However, PDL1 lacks diagnostic accuracy in differentiating patients who are likely or unlikely to benefit. So, it is urgent...

journal_title：Disease markers

authors： Wu Y,Lin L,Liu X

更新日期：2020-06-09 00:00:00

abstract：:Vitamin D plays a role in central nervous system (CNS) development. Recent literature focused on vitamin D status in children and adolescents with autism spectrum disorder (ASD), but with inconsistent results. Our case-control study is aimed at evaluating serum 25-hydroxyl-vitamin D (25(OH)D) concentration in children...

journal_title：Disease markers

authors： Petruzzelli MG,Marzulli L,Margari F,De Giacomo A,Gabellone A,Giannico OV,Margari L

更新日期：2020-09-18 00:00:00

abstract：:The cell surface glycoprotein KAI1/CD82 suppresses tumor growth and metastasis in animal models. This study aimed to evaluate the prognostic relevance of KAI1/CD82 protein expression in human gastric cancer. Primary gastric carcinomas (n=271) with a mean clinical follow-up time of 48 months were immunostained using th...

journal_title：Disease markers

authors： Knoener M,Krech T,Puls F,Lehmann U,Kreipe H,Christgen M

更新日期：2012-01-01 00:00:00

abstract：:Over the last two decades, significant data has been accumulated linking Glutatione S-Transferases (GSTs) with the development of several diseases. Contemporary studies have demonstrated the impact of ethnicity on GST allele frequencies. The aim is to verify if the variability of GST genes reflects population demograp...

journal_title：Disease markers

authors： Polimanti R,Piacentini S,De Angelis F,De Stefano GF,Fuciarelli M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:To evaluate serum chemerin levels in patients with osteoporosis and healthy controls and to investigate the relationship between serum chemerin levels and bone mineral density (BMD). METHODS:An age- and gender-matched case-control study was conducted. Pearson's correlation test was performed to investigate ...

journal_title：Disease markers

authors： He J,Li JC,Xie H,Xu ZH,Sun YW,Shan Q

更新日期：2015-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is a complex and heterogeneous disease with four consensus molecular subtypes (CMS1-4). LTBP2 is a member of the fibrillin/LTBP super family and plays a critical role in tumorigenesis by activating TGF-β in the CMS4 CRC subtype. So far, the expression and prognostic significance of LTBP2 in CRC...

journal_title：Disease markers

authors： Huang Y,Wang G,Zhao C,Geng R,Zhang S,Wang W,Chen J,Liu H,Wang X

更新日期：2019-03-10 00:00:00

abstract：:Two-dimensional gel analysis (NEPHGE) of the molecules precipitated by the HLA-DR monomorphic antibody L243 showed a single and identical alpha chain spot from two consanguineous cell lines, BM14 and MCF. The latter was derived from a rheumatoid arthritis patient. No apparent structural polymorphism of the HLA-DR beta...

journal_title：Disease markers

authors： Fernandez N,Labeta M,Kurpisz M,Solana R,Festenstein H

更新日期：1986-06-01 00:00:00

abstract：:Kinesin family member 20A (KIF20A) has been recently reported to be upregulated and associated with increased invasiveness and metastasis in several malignancies. However, the role of KIF20A in colorectal cancer (CRC) is still unclear. This study is aimed at investigating the potential roles of KIF20A in the developme...

journal_title：Disease markers

authors： Zhang Q,Di J,Ji Z,Mi A,Li Q,Du X,Wang A,Wang A,Qin C

更新日期：2020-07-08 00:00:00