Abstract:
BACKGROUND:Paraoxonase-1 (PON1) activity is suggested to be altered in individuals infected with human immunodeficiency virus type-1 (HIV-1). We investigated PON1 activity in individuals receiving different regimens of highly active antiretroviral therapy (HAART). METHODS:PON1 activity was evaluated in 91 HIV-1 seronegative and 624 HIV-1 infected individuals (115 were not undergoing therapy (ART-naïve), and 509 were receiving HAART). HIV-1 infected individuals were treated with the following: efavirenz (EFV; n = 195) or nevirapine (NVP; n = 95) or lopinavir/ritonavir (LOP/r; n = 219). Serum levels of total cholesterol (TC), HDL, and low-density lipoprotein (LDL) fractions and the atherogenic indices (AI, TC : HDL, and LDL : HDL ratios) were determined. RESULTS:PON1 activity (U/L) was lower in the ART-naïve group compared with the other groups. PON1 activity correlated with CD4+ T-cell number of ART-naïve group (r = 0,121; P = 0,014). The LOP/r group showed a reduction in HDL and an increase in AI (TC : HDL ratio) in comparison with other groups. CONCLUSION:PON1 activity was reduced in untreated individuals, but not in individuals receiving HAART. PON1 activity correlated with the number of CD4+ T-cells. The findings suggest that the activity of PON1 is associated with the immune status of HIV-1 infected individuals.
journal_name
Dis Markersjournal_title
Disease markersauthors
Maselli LM,da Cunha J,Gutierrez EB,Maranhão RC,Spada C,Bydlowski SPdoi
10.1155/2014/480201subject
Has Abstractpub_date
2014-01-01 00:00:00pages
480201eissn
0278-0240issn
1875-8630journal_volume
2014pub_type
杂志文章相关文献
DISEASE MARKERS文献大全abstract:Background:Obese women with gestational diabetes mellitus (GDM) have a higher risk of adverse outcomes than women with obesity or GDM alone. Our study is aimed at investigating the discriminatory power of circulatory Wnt1-inducible signaling pathway protein-1 (WISP1), a novel adipocytokine, on the copresence of prepreg...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/4934206
更新日期:2020-04-14 00:00:00
abstract:Backgrounds:Both pretreatment serum CRP (C-reactive protein) level and ALB (albumin) level have been found to be predictive of survival for multiple malignancies including sarcoma. Since both of the GPS (Glasgow prognostic score) and CAR (C-reactive protein to albumin ratio) are based on the combination of CRP and ALB,...
journal_title:Disease markers
pub_type: 杂志文章,meta分析
doi:10.1155/2020/8736509
更新日期:2020-01-07 00:00:00
abstract::The genetic variation at the Apolipoprotein E locus (APOE) is an important determinant of plasma lipids and has been implicated in various human pathological conditions. The objective of the present study was to estimate the distribution of APOE alleles in five Venezuelan communities: two Amerindian tribes (Bari and Y...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2005/625182
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:The apolipoprotein (apo) B/apoA-I ratio represents the balance between apoB-rich atherogenic particles and apoA-I-rich antiatherogenic particles, and this ratio is considered to be a marker of cardiovascular risk. Although many studies have demonstrated the importance of the apoB/apoA-I ratio in predicting t...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/591454
更新日期:2015-01-01 00:00:00
abstract::Restriction fragment length polymorphism (RFLP) analyses of DR1 positive peripheral blood leukocytes DNA was carried out. The Taq I digested DNA was hybridized with cDNA probes for HLA-DR and -DQ beta genes. The DR probe detected fragments commonly observed in the DR1 specificity, whereas a new DQ-beta fragment was de...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND AND AIM:Because B-type natriuretic peptide is a powerful predictor of heart failure, its capability to predict a fatal outcome in stroke might be limited to the cardioembolic stroke subtype. In this study, we attempt to ascertain the difference in the prognostic value of N-terminal pro-B-type natriuretic pep...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/597570
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Stroke subtype diagnosis leads to specific therapies to reduce recurrences. Because nearly one third of patients remain with unknown etiology after a complete screening workup, we aim to investigate whether molecular markers of myocardial damage were associated with cardioembolic stroke and if they were usef...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2009-0630
更新日期:2009-01-01 00:00:00
abstract::The role of pro-fibrogenic cytokines in the outcome of infections with hepatitis C virus (HCV) and the response to treatment with pegylated interferon-alpha (pegIFNalpha) and ribavirin remains unclear. To address this issue, we assessed hepatic fibrosis and plasma markers pertinent to T-cell mediated fibrogenesis and ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2010-0699
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To investigate whether single nucleotide polymorphisms (SNPs) in the Mn-superoxide dismutase gene (SOD2) underlie the susceptibility to noise-induced hearing loss (NIHL). METHODS:Audiometric data from 2400 Chinese Han workers who exposed to occupational noise were analyzed. DNA samples were collected from th...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2010-0693
更新日期:2010-01-01 00:00:00
abstract::The eukaryotic initiation factor 3 (eIF3) is the largest and most complex translation initiation factor in mammalian cells. It consists of 13 subunits and among which several were implicated to have significant prognostic effects on multiple human cancer entities. To examine the expression profiles of eIF3 subunits an...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/6019637
更新日期:2019-12-07 00:00:00
abstract:INTRODUCTION:Vitamin D deficiency is associated with the onset and progression of hypertension and cardiovascular disease (CVD). However, mechanisms underlying vitamin D deficiency-mediated increased risk of CVD remain unknown. We sought to examine the differential effect of high-dose versus low-dose vitamin D suppleme...
journal_title:Disease markers
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/918968
更新日期:2015-01-01 00:00:00
abstract::Human papillomaviruses (HPV) infect cutaneous and mucosal epithelia and induce benign and malignant lesions. Non-melanoma skin cancer (NMSC), encompassing basal cell carcinoma and squamous cell carcinoma (SCC), is the most frequent cancer in the Caucasian population, and the incidence has increased dramatically worldw...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2007/942650
更新日期:2007-01-01 00:00:00
abstract::Over the last two decades, significant data has been accumulated linking Glutatione S-Transferases (GSTs) with the development of several diseases. Contemporary studies have demonstrated the impact of ethnicity on GST allele frequencies. The aim is to verify if the variability of GST genes reflects population demograp...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2011-0821
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:This study was undertaken to investigate the OPG profiles in gingival crevicular fluid (GCF), saliva, and gingival tissues of chronic periodontitis (CP) patients in response to open flap debridement (OFD). SUBJECTS AND METHODS:The study included 30 subjects divided into 2 groups: 20 CP patients and 10 perio...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/341259
更新日期:2015-01-01 00:00:00
abstract:Background:The role of miR-200c in gastric cancer remains controversial. This study is aimed at clarifying the diagnostic and prognostic value of miR-200c in gastric cancer through a meta-analysis. Methods:A comprehensive literature search of PubMed, Embase, and Ovid library databases was conducted. The studies includ...
journal_title:Disease markers
pub_type: 杂志文章,meta分析
doi:10.1155/2019/8949618
更新日期:2019-04-04 00:00:00
abstract::Physical activity as a part of the lifestyle is a significant factor influencing health condition. Exercises that require stamina are of particular importance. Oxygen metabolism, which is a significant part of all longer training processes, has an influence on cardiovascular and respiratory system functioning as well ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2016/7169531
更新日期:2016-01-01 00:00:00
abstract::Because tandem mass spectrometry- (MS/MS-) based newborn screening identifies many suspicious cases of fatty acid oxidation and carnitine cycle disorders, a simple, noninvasive test is required to confirm the diagnosis. We have developed a novel method to evaluate the metabolic defects in peripheral blood mononuclear ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/2984747
更新日期:2019-02-07 00:00:00
abstract:BACKGROUND:High serum MBL level as well as polymorphisms in the mannose-binding lectin 2 (MBL2) gene resulting in MBL deficiency are involved in the mechanism of a number of non-infectious diseases such as asthma, conferring either risk or protection in different population studies. MBL being the first reactant of the ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2012-0892
更新日期:2012-01-01 00:00:00
abstract::Our previous studies using the mass spectrum analysis provided evidence that fibrinopeptide A (FPA) could be a potential biomarker for schizophrenia diagnosis. We sought further to demonstrate that variants in the fibrinogen alpha chain gene (FGA) coded FPA might confer vulnerability to schizophrenia. 1,145 patients w...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2017/3104180
更新日期:2017-01-01 00:00:00
abstract::IGF2 is the first gene discovered to be imprinted and expressed exclusively from the paternal allele in both human and mouse. IGF2 is also the first imprinted gene displaying loss of imprinting (LOI) or aberrant imprinting in human cancers. Evidently, LOI or reactivation of the maternal allele of IGF2 is associated wi...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2007/363464
更新日期:2007-01-01 00:00:00
abstract:Objective:Recent studies have demonstrated that miRNA-155 is involved in the occurrence and development of atherosclerosis. Furthermore, miRNA-155 has emerged as a new indirect marker for inflammation associated with adverse outcomes in oncology and cardiovascular diseases. This study investigated the correlation betwe...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/6345284
更新日期:2018-06-25 00:00:00
abstract::Abnormal phenotypic switch of vascular smooth muscle cell (VSMC) is a hallmark of vascular disorders such as atherosclerosis and restenosis. And this process has been related to remodeling of L-type calcium channel (LTCC). We attempted to investigate whether fluvastatin has any effect on VSMC proliferation and LTCCα 1...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/237067
更新日期:2014-01-01 00:00:00
abstract::Cyclin-dependent kinase regulatory subunit 2 (CKS2) is a member of the cell cycle-dependent protein kinase subunit family, which is implicated as an oncogene in various malignancies. However, the clinical significance, oncogenic functions, and related mechanisms of CKS2 in hepatocellular carcinoma (HCC) remain largely...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/8964015
更新日期:2019-10-22 00:00:00
abstract::Background. Early identification of high risk subjects for cardiovascular disease in health check-up is still unmet medical need. Cardiovascular disease is characterized by the superior increase in aspartate aminotransferase (AST) to alanine aminotransferase (ALT). However, the association of AST/ALT ratio with brain ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2016/4857917
更新日期:2016-01-01 00:00:00
abstract::IgA nephropathy (IgAN) is a kidney disease with a varying renal prognosis. Recently, many studies have demonstrated that renal alpha-smooth muscle actin (alpha-SMA) and transforming growth factor (TGF-beta1) expression, as well interstitial mast cell infiltrates could represent a prognostic marker in several renal dis...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2008/725408
更新日期:2008-01-01 00:00:00
abstract::Thirty-six coeliac children on gluten-containing diet were studied for AGA IgA and IgG levels. Patients were typed for HLA-A, -B, -C, -DR, -DQ antigens and data were analysed for any correlation between HLA-DR phenotype and AGA levels. AGA IgA and/or IgG were present in all these children. Subjects negative for DR3 or...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1991-11-01 00:00:00
abstract::Introduction. Chronic Periodontitis (CP) is suggested to be related to gene variations. Present study aims to quantitatively estimate the association between interleukin-6- (IL-6-) 174G/C polymorphism and CP susceptibility. Materials and Methods. Pubmed, Embase, and Web of Science were searched up to May 2016. The met...
journal_title:Disease markers
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2016/9612421
更新日期:2016-01-01 00:00:00
abstract::Background and Objective. The main purpose of this study was to develop a simple automatic diagnostic classification scheme for chemotherapy-induced peripheral neuropathy. Methods:This was a prospective cohort study that enrolled patients with colorectal or gynecologic cancer post chemotherapy for more than 1 year. T...
journal_title:Disease markers
pub_type: 临床试验,杂志文章
doi:10.1155/2020/3402108
更新日期:2020-01-25 00:00:00
abstract::Heart disease is the leading cause of mortality and morbidity in the world. As such, biomarkers are needed for the diagnosis, prognosis, therapeutic monitoring and risk stratification of acute injury (acute myocardial infarction (AMI)) and chronic disease (heart failure). The procedure for biomarker development involv...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2004/965261
更新日期:2004-01-01 00:00:00
abstract:Objective:Long noncoding RNAs (lncRNAs) have been strongly associated with various types of cancer. The present study aimed at exploring the diagnostic and prognostic value of lncRNA Zinc finger protein 667-antisense RNA 1 (ZNF667-AS1) in glioma patients. Patients and Methods. The expressions of ZNF667-AS1 were detecte...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/8895968
更新日期:2020-11-16 00:00:00