Heart disease, clinical proteomics and mass spectrometry.

abstract：:MicroRNAs (miRNAs) are a class of small, non-coding RNA molecules that can regulate gene expression, thereby affecting crucial processes in cancer development. miRNAs offer great potential as biomarkers for cancer detection because of their remarkable stability in blood and their characteristic expression in different...

journal_title：Disease markers

authors： Mar-Aguilar F,Mendoza-Ramírez JA,Malagón-Santiago I,Espino-Silva PK,Santuario-Facio SK,Ruiz-Flores P,Rodríguez-Padilla C,Reséndez-Pérez D

更新日期：2013-01-01 00:00:00

abstract：Aim:B7-H4 is member of the B7 family that negatively regulates the immune response, which are associated with tumor development and prognosis. The present study is aimed at examining serum B7-H4 expression and exploring its contribution to diagnosis in patients with colorectal cancer. Methods:We determined serum expre...

journal_title：Disease markers

authors： Wang P,Li C,Zhang F,Ma X,Gai X

更新日期：2018-09-27 00:00:00

abstract：Background:The role of the NFKB1 gene rs28362491 polymorphism and NFKBIA gene rs2233406 polymorphism in the development of head and neck cancer (HNC) remains controversial. This meta-analysis was performed to assess the relationship between the gene polymorphisms and HNC quantitatively. Methods:PubMed, Embase, Web of ...

journal_title：Disease markers

authors： Li L,Zhang ZT

更新日期：2019-09-12 00:00:00

abstract：:Chronic infection with the hepatitis B virus (HBV) is a known risk factor in the development of human hepatocellular carcinoma (HCC). The HBV-encoded X protein, HBx, has been investigated for properties that may explain its cancer cofactor role in transgenic mouse lines. We discuss here recent data showing that HBx is...

journal_title：Disease markers

authors： Madden CR,Slagle BL

更新日期：2001-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide due to latent liver disease, late diagnosis, and nonresponse to systemic treatments. Till now, surgical and/or biopsy specimens are still generally used as a gold standard by the clinicians for clinical decision-making. Howeve...

journal_title：Disease markers

authors： Yin CQ,Yuan CH,Qu Z,Guan Q,Chen H,Wang FB

更新日期：2016-01-01 00:00:00

abstract：Objective:Several serum markers were reported to reflect the severity of pulmonary alveolar proteinosis (PAP). The aim of this study is to investigate a reliable and facile marker to access and monitor the clinical course of PAP in a large cohort. Methods:PAP patients from January 2010 to June 2018 were enrolled. Hosp...

journal_title：Disease markers

authors： Shi S,Chen L,Qiu X,Zhao Q,Xiao Y,Yan X

更新日期：2019-11-11 00:00:00

abstract：:Background. Early identification of high risk subjects for cardiovascular disease in health check-up is still unmet medical need. Cardiovascular disease is characterized by the superior increase in aspartate aminotransferase (AST) to alanine aminotransferase (ALT). However, the association of AST/ALT ratio with brain ...

journal_title：Disease markers

authors： Yokoyama M,Watanabe T,Otaki Y,Takahashi H,Arimoto T,Shishido T,Miyamoto T,Konta T,Shibata Y,Daimon M,Ueno Y,Kato T,Kayama T,Kubota I

更新日期：2016-01-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a head and neck cancer that is highly found in distinct geographic areas, such as Southeast Asia. The management of NPC remains burdensome as the prognosis is poor due to the late presentation of the disease and the complex nature of NPC pathogenesis. Therefore, it is necessary to fin...

journal_title：Disease markers

authors： Janvilisri T

更新日期：2015-01-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the most common viral respiratory pathogen during infancy world wide. It induces innate and adaptive immune response in host cells. The toll like receptor 4 (TLR4)/CD14 complex is particularly important for the initiation of an innate immune response to RSV. Thus we were interested...

journal_title：Disease markers

authors： Puthothu B,Forster J,Heinzmann A,Krueger M

更新日期：2006-01-01 00:00:00

abstract：:We evaluated the occurrence of mutations in P53, K-RAS, COX-2, expression of COX-2 and hTERT and relations among clinicopathological signs. P53 mutations were identified in 34.4% of tumours, the majority of them occurring in SCC (squamous cell carcinoma, 55.6%). K-RAS was mutated in 12.2% of NSCLC tumours, the majorit...

journal_title：Disease markers

authors： Strazisar M,Rott T,Glavac D

更新日期：2008-01-01 00:00:00

abstract：:Tumor markers and antigens are normally highly expressed in malignant tissue, but not in the surrounding normal tissue. Serial Analysis of Gene Expression (SAGE) is a technology that counts mRNA transcripts and can be used to find those genes most highly induced in malignant tissues. SAGE produces a comprehensive prof...

journal_title：Disease markers

authors： Riggins GJ

更新日期：2001-01-01 00:00:00

abstract：:Chromosomal aneuploidy consists the leading cause of fetal death in our species. Around 50% of spontaneous abortions until 15 weeks of gestational age are chromosomally aneuploid, with trisomies accounting for 50% of the abnormal abortions. Trisomy 21 is the most common chromosome abnormality in liveborns and is usual...

journal_title：Disease markers

authors： Kokotas H,Grigoriadou M,Mikkelsen M,Giannoulia-Karantana A,Petersen MB

更新日期：2009-01-01 00:00:00

abstract：:High levels of cardiovascular fitness (CRF) and physical activity (PA) are associated with decreased mortality and risk to develop metabolic diseases. The independent contributions of CRF and PA to metabolic disease risk factors are unknown. We tested the hypothesis that runners who run consistently >50 km/wk and/or >...

journal_title：Disease markers

authors： Laye MJ,Nielsen MB,Hansen LS,Knudsen T,Pedersen BK

更新日期：2015-01-01 00:00:00

abstract：:SIRT6 has been demonstrated to exert protective effects on endothelial cells and is closely associated with lipid metabolism, glucose metabolism, and obesity, indicating an important role in the pathogenesis and progression of coronary artery disease (CAD). Nonetheless, the biological significance of SIRT6 variants on...

journal_title：Disease markers

authors： Tang SS,Xu S,Cheng J,Cai MY,Chen L,Liang LL,Yang XL,Chen C,Liu XG,Xiong XD

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:The present study investigated the prevalence of the IL-28B polymorphisms rs12979860 and rs8099917 in chronic hepatitis B patients from a case study in Eastern Amazonia. METHODS:In total, 65 chronically infected HBV patients and 97 healthy subjects who were anti-HBc and anti-HBs positive (control group) were...

journal_title：Disease markers

authors： Conde SR,Rocha LL,Ferreira VM,Monteiro JC,Filgueiras NK,Lins PA,dos Santos BT,Freitas FB,Graça Eda S,Demachki S,de Araújo MT,Ishak R,Vallinoto AC

更新日期：2014-01-01 00:00:00

abstract：:Lung cancer remains a major cause of cancer-related lethality because of high incidence and recurrence in spite of significant advances in staging and therapies. Recent data indicates that stem cells situated throughout the airways may initiate cancer formation. These putative stem cells maintain protumorigenic charac...

journal_title：Disease markers

authors： Pine SR,Marshall B,Varticovski L

更新日期：2008-01-01 00:00:00

abstract：:Keloids are benign fibroproliferative tumors of the skin which commonly occur after injury mainly in darker skinned patients. Medical treatment is fraught with high recurrence rates mainly because of an incomplete understanding of the biological mechanisms that lead to keloids. The purpose of this project was to exami...

journal_title：Disease markers

authors： Jones LR,Young W,Divine G,Datta I,Chen KM,Ozog D,Worsham MJ

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Abdominal aortic aneurysms (AAAs) are characterized by presence of high proteolytic activity, atherosclerotic lesions, extensive transmural inflammation and the presence of variably sized and shaped intraluminal thrombus (ILT). Therefore, we evaluated a possible association between plasma matrix metalloprote...

journal_title：Disease markers

authors： Wiernicki I,Millo B,Safranow K,Gorecka-Szyld B,Gutowski P

更新日期：2011-01-01 00:00:00

abstract：:The nonspecific inflammatory bowel diseases (IBD) represent a heterogeneous group of chronic inflammatory disorders of the gastrointestinal tract, and Leśniowski-Crohn's disease (CD) and ulcerative colitis (UC) are among the two major clinical forms. Despite the great progress in understanding the pathogenesis of thes...

journal_title：Disease markers

authors： Derkacz A,Olczyk P,Komosinska-Vassev K

更新日期：2018-06-11 00:00:00

abstract：:The total plasma concentration of homocysteine is a marker of this amino acid's atherogenic potential. However, the homocysteine pool exists almost entirely as oxidized homocysteine equivalents (OHcyE), composed of homocystine and cysteine-homocysteine disulphides (20-30%), and protein-bound disulphide (70-80%). We ha...

journal_title：Disease markers

authors： Iuliano M,De Tommaso G,Ragone R

更新日期：2009-01-01 00:00:00

abstract：Objectives:To explore the impact of volume change in the fractionated tracking of stereotactic radiotherapy on the results of synchronous, respiratory tracking algorithm using CyberKnife. Methods:A total of 38 lung tumor patients receiving stereotactic radiotherapy at our center from March 2018 to October 2019 were co...

journal_title：Disease markers

authors： Li GQ,Wang Y,Qiu MJ,Yang J,Peng ZJ,Zhang S,Fang X,Yang SL

更新日期：2020-01-11 00:00:00

abstract：BACKGROUND:Tumor cells show alterations in their glycosylation patterns when compared to normal cells. Lectins can be used to evaluate these glycocode changes. Chemiluminescence assay is an effective technique for quantitative analysis of proteins, nucleic acids, and carbohydrates due to its high sensitivity, specifici...

journal_title：Disease markers

authors： Lima LR,Bezerra MF,Almeida SM,Silva LP,Beltrão EI,Carvalho Júnior LB

更新日期：2013-01-01 00:00:00

abstract：:Regulatory T cells (Tregs) play an essential role in acute coronary syndrome (ACS). However, there is debate about which Treg subsets are truly critical to ACS. Helios, a transcription factor, was recently reported to be a bona fide marker for natural Tregs or activated Tregs with a suppression function, but little is...

journal_title：Disease markers

authors： Jiang L,Chen F,Hu X,Hu Y,Wang Y,Zhang W,Peng Y,Cheng L

更新日期：2017-01-01 00:00:00

abstract：AIM:Spindle and kinetochore-associated protein 1 (SKA1) is one subtype of SKA, whose protein can make spindle microtubules attach steadily to the kinetochore in the middle of mitosis. At present, there are fewer researches on the relationship between SKA1 expression and tumor development. METHODS:In this study, immuno...

journal_title：Disease markers

authors： Dong C,Wang XL,Ma BL

更新日期：2015-01-01 00:00:00

abstract：:Cytoskeletal rearrangement occurs in variety of cellular processes and involves a wide spectrum of proteins. Gelsolin super family proteins control actin organization by severing and capping filament ends and nucleating actin assembly. Gelsolin is the founding member of this family and plays important role in pathogen...

journal_title：Disease markers

authors： Baig RM,Mahjabeen I,Sabir M,Masood N,Ali K,Malik FA,Kayani MA

更新日期：2013-01-01 00:00:00

abstract：Aim:To explore the diagnostic efficacy of des-gamma-carboxy prothrombin (DCP) in hepatitis B virus- (HBV-) related hepatocellular carcinoma (HCC). Methods:A retrospective study of 459 cases from June 2016 to March 2018 was undertaken, and records of the DCP levels were extracted. The sensitivity, specificity, and cuto...

journal_title：Disease markers

authors： Chen J,Wu G,Li Y

更新日期：2018-10-04 00:00:00

abstract：:A major subtype of childhood lymphoblastic leukemia has been previously defined on the basis of expression of a cell surface marker referred to as the common acute lymphoblastic leukemia antigen. In this study we provide evidence that leukemic cells from most of the patients with common acute lymphoblastic leukemia co...

journal_title：Disease markers

authors： Hanash SM,Kuick R,Nichols D,Stoolman L

更新日期：1988-10-01 00:00:00

abstract：:In this study, we aim to investigate the correlation between circulating tumor cells (CTCs) and the T lymphocyte subsets and NK cells in peripheral blood in non-small-cell lung cancer (NSCLC). The peripheral blood CTCs were determined by SET-iFISH. Flow cytometry was used to determine the distribution of T lymphocyte ...

journal_title：Disease markers

authors： Ye L,Zhang F,Li H,Yang L,Lv T,Gu W,Song Y

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Autism is among the commonest neurodevelopmental childhood disorders worldwide; its aetiology is still unknown. Iron metabolism alteration in the central nervous system is recently implicated as a risk factor for several neurodegenerative disorders. Haemochromatosis HFE gene polymorphisms (p.H63D and p.C282Y...

journal_title：Disease markers

authors： Gebril OH,Meguid NA

更新日期：2011-01-01 00:00:00

abstract：:Ovarian cancer is complex disease composed of different histological grades and types. However, the underlying molecular mechanisms involved in the development of different phenotypes remain largely unknown. Epidemiological studies identified multiple exogenous and endogenous risk factors for ovarian cancer developmen...

journal_title：Disease markers

authors： Mok SC,Kwong J,Welch WR,Samimi G,Ozbun L,Bonome T,Birrer MJ,Berkowitz RS,Wong KK

更新日期：2007-01-01 00:00:00