Abstract:
:Respiratory syncytial virus (RSV) is the most common viral respiratory pathogen during infancy world wide. It induces innate and adaptive immune response in host cells. The toll like receptor 4 (TLR4)/CD14 complex is particularly important for the initiation of an innate immune response to RSV. Thus we were interested whether an association exists between severe RSV associated diseases and polymorphisms within TLR4 and CD14. We genotyped the CD14 promotor polymorphism -C159T and the two common TLR4 amino acid variants (D259G, and T359I) in 131 infants with severe RSV associated diseases and 270 controls. Statistical analyses of single polymorphisms made use of the Armitage's trend test, haplotypes were calculated by FAMHAP, FASTEHPLUS and Arlequin. All polymorphisms were in Hardy Weinberg Equilibrium. We found marginal association between amino acid exchange D259G in TLR4 with RSV infection p=0.0545). Furthermore, haplotypes analysis of the two TLR4 polymorphisms by three independent programs revealed association of haplotypes with severe RSV infection (p journal_name journal_title authors doi subject pub_date pages issue eissn issn journal_volume pub_type
相关文献
DISEASE MARKERS文献大全abstract::Cytoskeletal rearrangement occurs in variety of cellular processes and involves a wide spectrum of proteins. Gelsolin super family proteins control actin organization by severing and capping filament ends and nucleating actin assembly. Gelsolin is the founding member of this family and plays important role in pathogen...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-120952
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Genetics of non-alcoholic fatty liver (NAFLD) in Asian Indians has been inadequately investigated. This study aims to determine the association of the 1784G>C polymorphism in the SREBP-2 gene with NAFLD in Asian Indians in north India. METHODS:In this study, (n=335); 162 obese with NAFLD, 91 obese without N...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2011-0852
更新日期:2011-01-01 00:00:00
abstract:Background:The role of the NFKB1 gene rs28362491 polymorphism and NFKBIA gene rs2233406 polymorphism in the development of head and neck cancer (HNC) remains controversial. This meta-analysis was performed to assess the relationship between the gene polymorphisms and HNC quantitatively. Methods:PubMed, Embase, Web of ...
journal_title:Disease markers
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2019/6523837
更新日期:2019-09-12 00:00:00
abstract:Aim:Increasing evidence indicates that hepatic subcapsular flow (HSF) can serve as a noninvasive ultrasonographic marker for the early diagnosis of biliary atresia (BA). However, results regarding its diagnostic accuracy are inconsistent and inconclusive. We conducted this meta-analysis with an aim to systematically ev...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2020/5262565
更新日期:2020-03-01 00:00:00
abstract:Background:Lactate has been widely used as a risk indicator of outcomes in critically ill patients due to its ready measurement and good predictive ability. However, the interconnections between lactate metabolism and glucose metabolism have not been sufficiently explored, yet. In this study, we aimed to investigate wh...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/1578502
更新日期:2019-11-26 00:00:00
abstract:Background:The systemic immune-inflammation index (SII), based on peripheral lymphocytes, neutrophils, and platelet count, has been used as a prognostic marker for several tumors. However, use of the SII has not been reported for gastric cancer. Methods:We evaluated the prognostic value of the SII in primary and valid...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/1787424
更新日期:2018-12-02 00:00:00
abstract::Tumor markers and antigens are normally highly expressed in malignant tissue, but not in the surrounding normal tissue. Serial Analysis of Gene Expression (SAGE) is a technology that counts mRNA transcripts and can be used to find those genes most highly induced in malignant tissues. SAGE produces a comprehensive prof...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2001/185929
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Despite the many studies examining thyroid cancers, the effect of thyroid autoantibodies on differentiated thyroid carcinoma (DTC) remains unclear. OBJECTIVE:To investigate the association between serologic thyroid autoantibodies (ATAs) and DTC, we retrospectively evaluated data of thyroid nodules obtained ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/648670
更新日期:2015-01-01 00:00:00
abstract:Objectives:We investigated the influence of spinal cord stimulation (SCS) on IFN-γ, IL-1β, IL-6, TNF-α, IL-10, and TGF-β serum levels in failed back surgery syndrome (FBSS) patients. The study will try to give new insights into the mechanism of SCS action and the role of IFN-γ and other cytokines in neuropathic pain (N...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/2606808
更新日期:2019-01-14 00:00:00
abstract::The recent advances in high-throughput data acquisition have driven a revolution in the study of human disease and determination of molecular biomarkers of disease states. It has become increasingly clear that many of the most important human diseases arise as the result of a complex interplay between several factors ...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.3233/DMA-2010-0695
更新日期:2010-01-01 00:00:00
abstract::S-100 protein was demonstrated in 28/31 melanoma tissue sections that had been previously stained by hematoxylin and eosin, including 17 from 19 primary melanomas and 11 from 12 metastases. Additional H & E stained sections from 11 metastatic and 13 primary melanomas were reacted with the monoclonal antibody NKI/C-3 a...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00
abstract::Prognostic markers of compensated cirrhosis should mainly investigate factors involved with progression to decompensation because death in cirrhosis is related with decompensation. Portal hypertension plays a crucial role in the pathophysiology of most complications of cirrhosis. Accordingly, HVPG monitoring has stron...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.3233/DMA-2011-0837
更新日期:2011-01-01 00:00:00
abstract:Background:Obese women with gestational diabetes mellitus (GDM) have a higher risk of adverse outcomes than women with obesity or GDM alone. Our study is aimed at investigating the discriminatory power of circulatory Wnt1-inducible signaling pathway protein-1 (WISP1), a novel adipocytokine, on the copresence of prepreg...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/4934206
更新日期:2020-04-14 00:00:00
abstract:OBJECTIVE:The purpose of the present study is to explore the correlation between nuclear expression of cyclin-dependent kinase inhibitor 1B (p27) and clinicopathologic features in nasopharyngeal carcinoma (NPC), including patient survival. METHODS:Immunohistochemistry was used to examine the expression of p27 in 130 p...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/251209
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:This study was undertaken to investigate the OPG profiles in gingival crevicular fluid (GCF), saliva, and gingival tissues of chronic periodontitis (CP) patients in response to open flap debridement (OFD). SUBJECTS AND METHODS:The study included 30 subjects divided into 2 groups: 20 CP patients and 10 perio...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/341259
更新日期:2015-01-01 00:00:00
abstract::This report describes the production and characterization of two new monoclonal antibodies (MoAb), WM-53 and WM-54, reacting with a human myeloid differentiation antigen, which has recently been assigned by the Third International Leucocyte Workshop on Human Differentiation Antigens into cluster CD-33 ('gp67'). To dat...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1987-12-01 00:00:00
abstract:Objective:This study aimed to explore the associations between carotid intima-media thickness (CIMT) and early-stage diabetic kidney disease (DKD) coupled with Helicobacter pylori (H. pylori) infection in type 2 diabetic patients. Methods:A cross-sectional study including 180 type 2 diabetic participants was conducted...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/3793768
更新日期:2018-04-16 00:00:00
abstract::Alzheimer's disease (AD) is a neurodegenerative disorder that accounts for nearly 70% of the more than 46 million dementia cases estimated worldwide. Although there is no cure for AD, early diagnosis and an accurate characterization of the disease progression can improve the quality of life of AD patients and their ca...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/5174815
更新日期:2018-10-04 00:00:00
abstract:Background:Epithelial ovarian cancer (EOC) is highly lethal worldwide. Factors involved in the inflammation and hormone-associated signaling pathway play vital roles in EOC carcinogenesis. The transforming growth factor-β- (TGF-β-) activated kinase 1 (MAP3K7) binding protein 2 (TAB2), mediating convergence of inflammat...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/8012979
更新日期:2019-08-14 00:00:00
abstract::CD4+ T cells of patients with B cell non-Hodgkin's lymphoma (NHL) were analysed for expression of CD45RA and CD29. It was found that CD45RA expression was significantly lower, and CD29 expression significantly higher, in lymphoma patients compared to normal controls. Moreover absolute numbers of CD4+ T cells were sign...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1990-05-01 00:00:00
abstract:BACKGROUND:Impaired fasting glucose (IFG) through the nondiabetic range (100-125 mg/dL) is not considered in the cardiovascular (CV) risk profile. AIM:To compare the clustering of CV risk factors (RFs) in nondiabetic subjects with normal fasting glucose (NFG) and IFG. MATERIAL AND METHODS:Cross-sectional study in 373...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/804739
更新日期:2015-01-01 00:00:00
abstract::A limited number of studies have been performed so far on the polymorphism in the transmembrane region (exon 5) of the major histocompatibility complex class I chain-related gene A (MICA) in patients with melanoma. However, the influence of MICA polymorphism in extracellular domains (exons 2, 3, and 4) has not been in...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/831864
更新日期:2015-01-01 00:00:00
abstract::HLA typing for antigens of the A, B, C, and DR loci was carried out on lymphocytes from a haemophilic (Type A) family which included four siblings with arthritis. No single haplotype was found to relate to the presence of haemophilia or haemophilic arthritis. ...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1986-10-01 00:00:00
abstract::The surface and cytoplasmic expression of CD1a molecules was analysed by indirect immunofluorescence (IIF) and dot blot assay (DBA) in a panel of 40 acute and chronic leukaemias. Thirty-two per cent of the samples were positive by IIF but, surprisingly, 72 per cent of the patients were positive by DBA, suggesting the ...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1990-09-01 00:00:00
abstract::Accumulating evidence suggests that the tumor microenvironment has a profound influence on tumor initiation and progression, opening a new avenue for studying tumor biology. Nonetheless, the prognostic values of the peritumoral expression of EpCAM and CD13 remain to be elucidated in hepatocellular carcinoma (HCC) pati...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2017/8495326
更新日期:2017-01-01 00:00:00
abstract::SIRT6 has been demonstrated to exert protective effects on endothelial cells and is closely associated with lipid metabolism, glucose metabolism, and obesity, indicating an important role in the pathogenesis and progression of coronary artery disease (CAD). Nonetheless, the biological significance of SIRT6 variants on...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2016/1628041
更新日期:2016-01-01 00:00:00
abstract::Restriction fragment length polymorphism (RFLP) analyses of DR1 positive peripheral blood leukocytes DNA was carried out. The Taq I digested DNA was hybridized with cDNA probes for HLA-DR and -DQ beta genes. The DR probe detected fragments commonly observed in the DR1 specificity, whereas a new DQ-beta fragment was de...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1991-09-01 00:00:00
abstract::Microsatellite instability (MSI) analysis is becoming more and more important to detect sporadic primary tumors of the MSI phenotype as well as in helping to determine Hereditary Non-Polyposis Colorectal Cancer (HNPCC) cases. After some years of conflicting data due to the absence of consensus markers for the MSI phen...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2004/159347
更新日期:2004-01-01 00:00:00
abstract::Inflammatory diseases are accompanied by numerous changes at the site of inflammation as well as many systemic physiological and biochemical changes. In the past two decades more and more attention is being paid to changes in glycosylation and in this review we describe some of the changes found on main serum proteins...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2008/493289
更新日期:2008-01-01 00:00:00
abstract::A major subtype of childhood lymphoblastic leukemia has been previously defined on the basis of expression of a cell surface marker referred to as the common acute lymphoblastic leukemia antigen. In this study we provide evidence that leukemic cells from most of the patients with common acute lymphoblastic leukemia co...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00