A Simplified Diagnostic Classification Scheme of Chemotherapy-Induced Peripheral Neuropathy.

abstract：:We aim to identify the mutations of deafness genes using massively parallel DNA sequencing in the 12 Uyghur families. SNPscan method was used to screen against the 124 sites in the common deafness genes in probands. Subjects with SNPscan negativity were subject to massively parallel DNA sequencing for the sequencing o...

journal_title：Disease markers

authors： Chen Y,Lu Y,Kuyaxi P,Cheng J,Zhao J,Zhao Q,Musha P,Zhang H,Yuan H

更新日期：2018-03-05 00:00:00

abstract：BACKGROUND:High serum MBL level as well as polymorphisms in the mannose-binding lectin 2 (MBL2) gene resulting in MBL deficiency are involved in the mechanism of a number of non-infectious diseases such as asthma, conferring either risk or protection in different population studies. MBL being the first reactant of the ...

journal_title：Disease markers

authors： Birbian N,Singh J,Jindal SK,Joshi A,Batra N,Singla N

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Liver cirrhosis (LC) is the final stage of most of chronic liver diseases and is almost caused by chronic hepatitis B (CHB) in China. Liver biopsy is the reference method for the evaluation of liver cirrhosis. However, it is an invasive procedure with inherent risk. The aim of this study was to construct a n...

journal_title：Disease markers

authors： Cao Y,Hu ZD,Liu XF,Deng AM,Hu CJ

更新日期：2013-01-01 00:00:00

abstract：Objective:To evaluate the performance of serum and urinary sCD163 concentrations as possible biomarker in systemic sclerosis (SSc). Methods:Urine and serum samples were obtained from SSc patients and age- and sex-matched controls. Serum and urinary sCD163 concentrations were measured by commercially available ELISA ki...

journal_title：Disease markers

authors： Frantz C,Pezet S,Avouac J,Allanore Y

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Left ventricular dysfunction (LVD), followed by fall in cardiac output is one of the major complications in some coronary artery disease (CAD) patients. The decreased cardiac output over time leads to activation of the renin-angiotensin-aldosterone system which results in vasoconstriction by influencing salt...

journal_title：Disease markers

authors： Mishra A,Srivastava A,Mittal T,Garg N,Mittal B

更新日期：2012-01-01 00:00:00

abstract：:Apelin plays important roles in cardiovascular homeostasis. However, its effects on the mechanoenergetics of heart failure (HF) are unavailable. We attempted to investigate the effects of apelin on the left ventricular-arterial coupling (VAC) and mechanical efficiency in rats with HF. HF was induced in rats by the lig...

journal_title：Disease markers

authors： Ouyang Q,You T,Guo J,Xu R,Guo Q,Lin J,Zhao H

更新日期：2019-06-17 00:00:00

abstract：:Recent experiments have shown that when specific biomolecular interactions are confined to one surface of a microcantilever beam, changes in intermolecular nanomechanical forces provide sufficient differential torque to bend the cantilever beam. This has been used to detect single base pair mismatches during DNA hybri...

journal_title：Disease markers

authors： Majumdar A

更新日期：2002-01-01 00:00:00

abstract：Methods:We collected 732 samples from Liaoning Province, China, and three polymorphisms in long noncoding RNA H19 were genotyped using the KASP platform. Results:Our data showed that H19 rs2735971 and rs3024270 variant genotypes were associated with a decreased risk of CAD (rs2735971, P = 0.003, odds ratio (OR) = 0.61...

journal_title：Disease markers

authors： Hu WN,Ding HX,Xu Q,Zhang XY,Yang DT,Jin YZ

更新日期：2020-05-10 00:00:00

abstract：:Our previous studies using the mass spectrum analysis provided evidence that fibrinopeptide A (FPA) could be a potential biomarker for schizophrenia diagnosis. We sought further to demonstrate that variants in the fibrinogen alpha chain gene (FGA) coded FPA might confer vulnerability to schizophrenia. 1,145 patients w...

journal_title：Disease markers

authors： Rao W,Zhou N,Zhang H,Liu R,Zhang S,Su Y,Yang G,Ma Y,Shi J,Yu Y,Yu Q

更新日期：2017-01-01 00:00:00

abstract：:Objective. To determine active TGF-β1 (aTGF-β1) levels in serum, skin, and peripheral blood mononuclear cell (PBMC) culture supernatants and to understand their associations with clinical parameters in systemic sclerosis (SSc) patients. Methods. We evaluated serum samples from 56 SSc patients and 24 healthy controls (...

journal_title：Disease markers

authors： Dantas AT,Gonçalves SM,de Almeida AR,Gonçalves RS,Sampaio MC,Vilar KM,Pereira MC,Rêgo MJ,Pitta ID,Marques CD,Duarte AL,Pitta MG

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The molecular work-up of thyroid nodules from fine needle aspiration samples has given clinicians a new level of diagnostic information. The aim of the present study was to evaluate the utility of molecular analysis in thyroid fine needle aspiration samples from a Chinese population. METHODS:Specimens were ...

journal_title：Disease markers

authors： Guo HQ,Zhao H,Zhang ZH,Zhu YL,Xiao T,Pan QJ

更新日期：2014-01-01 00:00:00

abstract：:Studies have shown that the maternal risk for Down syndrome (DS) may be modulated by alterations in folate metabolism. The aim of this study was to evaluate the influence of 12 genetic polymorphisms involved in folate metabolism on maternal risk for DS. In addition, we evaluated the impact of these polymorphisms on se...

journal_title：Disease markers

authors： Zampieri BL,Biselli JM,Goloni-Bertollo EM,Vannucchi H,Carvalho VM,Cordeiro JA,Pavarino EC

更新日期：2012-01-01 00:00:00

abstract：:We have previously identified an allele of the human SP-A2 gene that occurs with greater frequency in an RDS population [12]. Because of the importance of SP-A in normal lung function and its newly emerging role in innate host defense and regulation of inflammatory processes, we wish to better characterize genotypes o...

journal_title：Disease markers

authors： DiAngelo S,Lin Z,Wang G,Phillips S,Ramet M,Luo J,Floros J

更新日期：1999-12-01 00:00:00

abstract：Objective:To systematically evaluate the significance of squamous cell carcinoma antigen (SCC-Ag) in the prognosis of cervical cancer. Methods:Literature from Pubmed, Embase, and Cochrane Library was retrieved to collect all English literature on the correlation between SCC-Ag and cervical cancer prognosis, and the qu...

journal_title：Disease markers

authors： Liu Z,Shi H

更新日期：2019-06-02 00:00:00

abstract：BACKGROUND:Evidence indicates that microRNAs (miRNA) play a role in the pathogenesis of chronic kidney diseases (CKD). We explored the possibility of using urinary miRNA as non-invasive biomarkers for CKD. METHODS:We quantified miRNA expression in urinary sediment of 56 CKD patients who underwent kidney biopsy. Patien...

journal_title：Disease markers

authors： Szeto CC,Ching-Ha KB,Ka-Bik L,Mac-Moune LF,Cheung-Lung CP,Gang W,Kai-Ming C,Kam-Tao LP

更新日期：2012-01-01 00:00:00

abstract：:Ultrasound has been a popular clinical imaging modality for decades. It is well established as a means of displaying the macroscopic anatomy of soft-tissue structures. While conventional ultrasound methodologies (i.e., B-mode and Doppler methods) are well proven and continue to advance technically on a daily basis, e....

journal_title：Disease markers

authors： Feleppa EJ,Alam SK,Deng CX

更新日期：2002-01-01 00:00:00

abstract：:Alterations of the retinoblastoma (Rb) gene have been described in several human neoplasms and recently, it has been suggested that these alterations may play a role in the development of endometrial carcinomas. Paraffin sections from 31 cases of normal endometrium (16 proliferative, 15 secretory), 35 hyperplastic les...

journal_title：Disease markers

authors： Ioachim EE,Goussia AC,Kitsiou EG,Charalabopoulos K,Mermiga E,Stefanaki S

更新日期：2002-01-01 00:00:00

abstract：:Extra-nodal natural killer T-Cell (NK/T-cell) lymphoma is a progressive cancer with poor prognosis due to the lack of disease specific treatment. To develop specific therapeutic strategies, it is essential to identify tumor markers. Recent studies show that circulating microRNA (miRNA) may serve as diagnostic and/or p...

journal_title：Disease markers

authors： Guo HQ,Huang GL,Guo CC,Pu XX,Lin TY

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Amongst the genitourinary cancers, carcinoma of the urinary bladder is one of the leading causes of death in India. Hypermethylation of the CpG islands of gene promoter is one of the earliest and most frequent epigenetic alterations leading to cancer as well as in its development. Several studies have sugg...

journal_title：Disease markers

authors： Ali Hosseini S,Sobti RC,Malekzadeh K,Singh SK,Joshi K

更新日期：2010-01-01 00:00:00

abstract：Aim:To evaluate the diagnosis value of serum human epididymis protein 4 (HE4), cancer antigen 125 (CA125), the Risk of Ovarian Malignancy Algorithm (ROMA), and Copenhagen Index (CPH-I) at early stages for differentiating borderline ovarian tumors from epithelial ovarian cancer. Methods:We recruited 144 borderline ovar...

journal_title：Disease markers

authors： Wang Z,Tao X,Ying C

更新日期：2019-10-13 00:00:00

abstract：:Background. Early identification of high risk subjects for cardiovascular disease in health check-up is still unmet medical need. Cardiovascular disease is characterized by the superior increase in aspartate aminotransferase (AST) to alanine aminotransferase (ALT). However, the association of AST/ALT ratio with brain ...

journal_title：Disease markers

authors： Yokoyama M,Watanabe T,Otaki Y,Takahashi H,Arimoto T,Shishido T,Miyamoto T,Konta T,Shibata Y,Daimon M,Ueno Y,Kato T,Kayama T,Kubota I

更新日期：2016-01-01 00:00:00

abstract：:Twelve multiplex families with isolated congenital heart diseases (CHD) were included in the study. In 9 families the types of CHD in the living sibs were concordant and in the other 3 were discordant. All families were subjected to the following: (1) Pedigree construction, (2) clinical examination of the parents, aff...

journal_title：Disease markers

authors： Hafez M,Abdalla A,el-Shennawy F,Tawfik SH

更新日期：1986-12-01 00:00:00

abstract：:We evaluated the occurrence of mutations in P53, K-RAS, COX-2, expression of COX-2 and hTERT and relations among clinicopathological signs. P53 mutations were identified in 34.4% of tumours, the majority of them occurring in SCC (squamous cell carcinoma, 55.6%). K-RAS was mutated in 12.2% of NSCLC tumours, the majorit...

journal_title：Disease markers

authors： Strazisar M,Rott T,Glavac D

更新日期：2008-01-01 00:00:00

abstract：:Kinesin family member 20A (KIF20A) has been recently reported to be upregulated and associated with increased invasiveness and metastasis in several malignancies. However, the role of KIF20A in colorectal cancer (CRC) is still unclear. This study is aimed at investigating the potential roles of KIF20A in the developme...

journal_title：Disease markers

authors： Zhang Q,Di J,Ji Z,Mi A,Li Q,Du X,Wang A,Wang A,Qin C

更新日期：2020-07-08 00:00:00

abstract：:Oncogenic activation of the Wnt/ β -catenin signaling pathway is common in human cancers. The secreted frizzled-related proteins (SFRPs) function as negative regulators of Wnt signaling and have important implications in carcinogenesis. Because there have been no reports about the role of SFRP3 in hepatocellular carci...

journal_title：Disease markers

authors： Lin YW,Shih YL,Lien GS,Suk FM,Hsieh CB,Yan MD

更新日期：2014-01-01 00:00:00

abstract：Background:With the development of new drug combinations and targeted treatments for multiple types of cancer, the ability to stratify categories of patient populations and to develop companion diagnostics has become increasingly important. A panel of 325 RNA biomarkers was selected based on cancer-related biological p...

journal_title：Disease markers

authors： Delmonico L,Attiya S,Chen JW,Obenauer JC,Goodwin EC,Fournier MV

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:The apolipoprotein (apo) B/apoA-I ratio represents the balance between apoB-rich atherogenic particles and apoA-I-rich antiatherogenic particles, and this ratio is considered to be a marker of cardiovascular risk. Although many studies have demonstrated the importance of the apoB/apoA-I ratio in predicting t...

journal_title：Disease markers

authors： Kaneva AM,Potolitsyna NN,Bojko ER,Odland JØ

更新日期：2015-01-01 00:00:00

abstract：:The adenosine deaminase gene frequencies were calculated in 405 subjects randomly chosen from the Bigouden district. A rather high frequency (0.0765 +/- 0.0093) was found for the ADA2 gene. The possible effect of Celtic influences is considered. ...

journal_title：Disease markers

authors： Youinou P,Seger J,Salmon D,Jouquan J,le Menn G,Ruffie J,Salmon C

更新日期：1988-03-01 00:00:00

abstract：:Accumulating evidence suggests that the tumor microenvironment has a profound influence on tumor initiation and progression, opening a new avenue for studying tumor biology. Nonetheless, the prognostic values of the peritumoral expression of EpCAM and CD13 remain to be elucidated in hepatocellular carcinoma (HCC) pati...

journal_title：Disease markers

authors： Dai XM,Huang T,Yang SL,Zheng XM,Chen GG,Zhang T

更新日期：2017-01-01 00:00:00

abstract：:The aim of this study was to assess the expression of MMP-9 and TIMP-1 in cancerous tissue as well as in the serum and plasma concentrations of these proteins in patients with laryngeal cancer and compare the results to the inflammatory reaction in healthy subjects. Twenty-seven patients who were diagnosed with laryng...

journal_title：Disease markers

authors： Matulka M,Konopka A,Mroczko B,Pryczynicz A,Kemona A,Groblewska M,Sieskiewicz A,Olszewska E

更新日期：2019-04-18 00:00:00