Abstract：
:We have previously identified an allele of the human SP-A2 gene that occurs with greater frequency in an RDS population [12]. Because of the importance of SP-A in normal lung function and its newly emerging role in innate host defense and regulation of inflammatory processes, we wish to better characterize genotypes of both SP-A1 and SP-A2 genes. It has been determined that SP-D shares similar roles in immune response. Therefore, in this report we 1) describe a novel, non radioactive PCR based-cRFLP method for genotyping both SP-A and SP-D; 2) describe two previously unpublished biallelic polymorphisms within the SP-D gene; 3) present the partial sequence of one new SP-A1 allele (6A14) and describe other new SP-A1 and SP-A2 alleles; and 4) describe additional methodologies for SP-A genotype assessment. The ability to more accurately and efficiently genotype samples from individuals with various pulmonary diseases will facilitate population and family based association studies. Genetic polymorphisms may be identified that partially explain individual disease susceptibility and/or treatment effectiveness.
journal_name
Dis Markersjournal_title
Disease markersauthors
DiAngelo S,Lin Z,Wang G,Phillips S,Ramet M,Luo J,Floros Jdoi
10.1155/1999/961430subject
Has Abstractpub_date
1999-12-01 00:00:00pages
269-81issue
4eissn
0278-0240issn
1875-8630journal_volume
15pub_type
杂志文章相关文献
DISEASE MARKERS文献大全abstract：:Salivary oxidative stress markers represent a promising tool for monitoring of oral diseases. Saliva can often be contaminated by blood, especially in patients with periodontitis. The aim of our study was to examine the impact of blood contamination on the measurement of salivary oxidative stress markers. Saliva sampl...
journal_title：Disease markers
pub_type： 杂志文章
doi：10.1155/2015/479251
更新日期：2015-01-01 00:00:00
abstract：:A major subtype of childhood lymphoblastic leukemia has been previously defined on the basis of expression of a cell surface marker referred to as the common acute lymphoblastic leukemia antigen. In this study we provide evidence that leukemic cells from most of the patients with common acute lymphoblastic leukemia co...
journal_title：Disease markers
pub_type： 杂志文章
doi：
更新日期：1988-10-01 00:00:00
abstract：:Hepatitis C virus (HCV) infection prevalence was determined in 34 hepatocellular carcinoma (HCC) patients with underlying liver cirrhosis. Serum alfa-fetoprotein level was found to be more than 1000 ng/ml (3153 +/- 1451) in those patients. Anti-HCV antibodies were detected in 84% of patients sera negative for hepatiti...
journal_title：Disease markers
pub_type： 杂志文章
doi：
更新日期：1997-11-01 00:00:00
abstract：OBJECTIVE:Particularly interesting new cysteine-histidine rich protein (PINCH) is an important component of the local adhesion complexes and upregulated in several types of malignancies, and involved in the incidence and development of tumours. PINCH expression is also independently correlated with poorer survival in p...
journal_title：Disease markers
pub_type： 杂志文章
doi：10.3233/DMA-2012-0930
更新日期：2012-01-01 00:00:00
abstract：Objective:Recent studies have demonstrated that miRNA-155 is involved in the occurrence and development of atherosclerosis. Furthermore, miRNA-155 has emerged as a new indirect marker for inflammation associated with adverse outcomes in oncology and cardiovascular diseases. This study investigated the correlation betwe...
journal_title：Disease markers
pub_type： 杂志文章
doi：10.1155/2018/6345284
更新日期：2018-06-25 00:00:00
abstract：BACKGROUND:Echocardiographic evaluation of left ventricular (LV) structural and functional alterations in hypertension has some limitations, potentially overcome by using biomarkers. ST2, a prognostic biomarker for heart failure and myocardial infarction patients, was less studied in hypertension. AIM:To analyze the r...
journal_title：Disease markers
pub_type： 杂志文章
doi：10.1155/2017/2714095
更新日期：2017-01-01 00:00:00
abstract：:CD4+ T cells of patients with B cell non-Hodgkin's lymphoma (NHL) were analysed for expression of CD45RA and CD29. It was found that CD45RA expression was significantly lower, and CD29 expression significantly higher, in lymphoma patients compared to normal controls. Moreover absolute numbers of CD4+ T cells were sign...
journal_title：Disease markers
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
abstract：:A multitude of host genetic factors plays a crucial role in susceptibility to HIV-1 infection and progression to AIDS, which is highly variable among individuals and populations. This review focuses on the chemokine-receptor and chemokine genes, which were extensively studied because of their role as HIV co-receptor o...
journal_title：Disease markers
pub_type： 杂志文章,评审
doi：10.3233/DMA-2011-0874
更新日期：2012-01-01 00:00:00
abstract：:Microtubule-associated protein 4 (MAP4) plays an important role in microtubule assembly and stabilization. The purpose of this study was to investigate the level of expression of MAP4 in lung adenocarcinoma (LADC) samples and to evaluate its prognostic value and the influence on cancer progression in LADC patients. Th...
journal_title：Disease markers
pub_type： 杂志文章
doi：10.1155/2018/8956072
更新日期：2018-03-18 00:00:00
abstract：AIM:Spindle and kinetochore-associated protein 1 (SKA1) is one subtype of SKA, whose protein can make spindle microtubules attach steadily to the kinetochore in the middle of mitosis. At present, there are fewer researches on the relationship between SKA1 expression and tumor development. METHODS:In this study, immuno...
journal_title：Disease markers
pub_type： 杂志文章
doi：10.1155/2015/616541
更新日期：2015-01-01 00:00:00
abstract：:Prognostic markers of compensated cirrhosis should mainly investigate factors involved with progression to decompensation because death in cirrhosis is related with decompensation. Portal hypertension plays a crucial role in the pathophysiology of most complications of cirrhosis. Accordingly, HVPG monitoring has stron...
journal_title：Disease markers
pub_type： 杂志文章,评审
doi：10.3233/DMA-2011-0837
更新日期：2011-01-01 00:00:00
abstract：:Keloids are benign fibroproliferative tumors of the skin which commonly occur after injury mainly in darker skinned patients. Medical treatment is fraught with high recurrence rates mainly because of an incomplete understanding of the biological mechanisms that lead to keloids. The purpose of this project was to exami...
journal_title：Disease markers
pub_type： 杂志文章
doi：10.1155/2015/943176
更新日期：2015-01-01 00:00:00
abstract：:Colorectal cancer is one of the most common cancers in the world. Due to its still undetermined pathogenesis, we are searching for signaling pathways that are important in the development of colorectal cancer. In this article, we present results of study on the role of ADAM proteins in colorectal cancer. The study inc...
journal_title：Disease markers
pub_type： 杂志文章
doi：10.1155/2019/5035234
更新日期：2019-09-02 00:00:00
abstract：Background:In patients admitted with chest pain and suspected acute coronary syndrome (ACS), it is crucial to early identify those who are at higher risk of adverse events. The study aim was to assess the predictive value of copeptin in patients admitted to the emergency department with chest pain and nonconclusive ECG...
journal_title：Disease markers
pub_type： 临床试验,杂志文章
doi：10.1155/2018/6597387
更新日期：2018-01-24 00:00:00
abstract：:Primary biliary cirrhosis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology, characterized by injury of the intrahepatic bile ducts that may eventually lead to cirrhosis and liver failure. Evidence suggests cardinal roles for both environmental factors and genetic susceptibilit...
journal_title：Disease markers
pub_type： 杂志文章,评审
doi：10.3233/DMA-2010-0747
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Cystic fibrosis is a monogenic recessive disorder found predominantly in Caucasian population. This disease arises from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. In this study we consider poly T polymorphism c.1210-12T[5], c.1210-12T[7], c.1210-12T[9] (T{5}, T{7}, T{9}...
journal_title：Disease markers
pub_type： 杂志文章
doi：10.3233/DMA-2011-0880
更新日期：2012-01-01 00:00:00
abstract：Aim:Increasing evidence indicates that hepatic subcapsular flow (HSF) can serve as a noninvasive ultrasonographic marker for the early diagnosis of biliary atresia (BA). However, results regarding its diagnostic accuracy are inconsistent and inconclusive. We conducted this meta-analysis with an aim to systematically ev...
journal_title：Disease markers
pub_type： 杂志文章,评审
doi：10.1155/2020/5262565
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVE:Both adaptive and innate immune systems are involved in coronary artery disease (CAD). The aim of this study was to evaluate TH17 cytokines expression profiles in un-stimulated peripheral blood lymphocytes (PBMCs) of patients with coronary artery disease. METHODS:Expression profiles of IL-17, IL-23, and TGF-...
journal_title：Disease markers
pub_type： 杂志文章
doi：10.3233/DMA-2012-00933
更新日期：2012-01-01 00:00:00
abstract：:Transforming growth factor β1 (TGF-β1) is an important mediator in Chagas disease. Furthermore, patients with higher TGF-β1 serum levels show a worse clinical outcome. Gene polymorphism may account for differences in cytokine production during infectious diseases. We tested whether TGFB1 polymorphisms could be associa...
journal_title：Disease markers
pub_type： 杂志文章
doi：10.1155/2018/4579198
更新日期：2018-02-18 00:00:00
abstract：:The atomic force microscope (AFM) is emerging as a powerful tool in cell biology. Originally developed for high-resolution imaging purposes, the AFM also has unique capabilities as a nano-indenter to probe the dynamic viscoelastic material properties of living cells in culture. In particular, AFM elastography combines...
journal_title：Disease markers
pub_type： 杂志文章,评审
doi：10.1155/2004/482680
更新日期：2003-01-01 00:00:00
abstract：:The HLA system is deeply involved in susceptibility to a variety of diseases. Relationships between HLA and diseases are of considerable interest and importance, as they provide new tools for studying the inheritance, classification, and pathogenesis of these diseases. Studies on the distribution of HLA antigens in di...
journal_title：Disease markers
pub_type： 杂志文章,评审
doi：10.1155/1993/192019
更新日期：1993-11-01 00:00:00
abstract：BACKGROUND:To evaluate serum chemerin levels in patients with osteoporosis and healthy controls and to investigate the relationship between serum chemerin levels and bone mineral density (BMD). METHODS:An age- and gender-matched case-control study was conducted. Pearson's correlation test was performed to investigate ...
journal_title：Disease markers
pub_type： 杂志文章
doi：10.1155/2015/786708
更新日期：2015-01-01 00:00:00
abstract：Background:Few previous studies have comprehensively explored the level of DNA methylation and gene expression in ccRCC. The purpose of this study was to identify the key clear cell renal cell carcinoma- (ccRCC-) related DNA methylation-driven genes (MDG) and to build a prognostic model based on the level of DNA methyl...
journal_title：Disease markers
pub_type： 杂志文章
doi：10.1155/2020/8817652
更新日期：2020-07-11 00:00:00
abstract：BACKGROUND:Up to 43% of HIV-infected patients co-infected with Mycobacterium tuberculosis experience exacerbations of tuberculosis (TB) after commencing antiretroviral therapy (ART). These are termed immune restoration disease (IRD). It is unclear why individual susceptibility varies. OBJECTIVE:We investigate if singl...
journal_title：Disease markers
pub_type： 杂志文章
doi：10.3233/DMA-130991
更新日期：2013-01-01 00:00:00
abstract：:Apolipoprotein E (apoE) plays an important role in lipid metabolism. Its epsilon4 allele has been consistently associated with lipoprotein disorders but its connection to myocardial infarction (MI) is controversial. Because epsilon4 frequency decreases with age we thought that the contradictory results in different st...
journal_title：Disease markers
pub_type： 杂志文章
doi：10.1155/2005/381657
更新日期：2005-01-01 00:00:00
abstract：:A study of MHC class I, II, and III markers in a group of southern Chinese in Hong Kong is reported. HLA antigen frequencies and complement allele frequencies are given, together with statistically significant pair-wise co-occurrences. Over half of the statistically significant positive and negative linkage disequilib...
journal_title：Disease markers
pub_type： 杂志文章
doi：
更新日期：1988-10-01 00:00:00
abstract：:High levels of cardiovascular fitness (CRF) and physical activity (PA) are associated with decreased mortality and risk to develop metabolic diseases. The independent contributions of CRF and PA to metabolic disease risk factors are unknown. We tested the hypothesis that runners who run consistently >50 km/wk and/or >...
journal_title：Disease markers
pub_type： 杂志文章
doi：10.1155/2015/806418
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:We aimed to determine whether serum soluble CD30 (sCD30) could identify recipients at high risk for unfavorable early and late kidney transplant outcomes. METHODS:Serum sCD30 was measured on the day of kidney transplantation and on the 4th day posttransplant. We assessed the value of these measurements in p...
journal_title：Disease markers
pub_type： 杂志文章
doi：10.1155/2017/9264904
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVE:The purpose of the present study is to explore the correlation between nuclear expression of cyclin-dependent kinase inhibitor 1B (p27) and clinicopathologic features in nasopharyngeal carcinoma (NPC), including patient survival. METHODS:Immunohistochemistry was used to examine the expression of p27 in 130 p...
journal_title：Disease markers
pub_type： 杂志文章
doi：10.1155/2013/251209
更新日期：2013-01-01 00:00:00
abstract：:Increasingly women at high risk of breast cancer are opting for prophylactic surgery to reduce their risks. Data from 10 European centres that offer a risk counselling and screening service to women at risk show different approaches to the option of preventive surgery, although most centres adhere to a protocol includ...
journal_title：Disease markers
pub_type： 杂志文章,多中心研究
doi：10.1155/1999/605917
更新日期：1999-10-01 00:00:00
