Abstract:
:The cell surface glycoprotein KAI1/CD82 suppresses tumor growth and metastasis in animal models. This study aimed to evaluate the prognostic relevance of KAI1/CD82 protein expression in human gastric cancer. Primary gastric carcinomas (n=271) with a mean clinical follow-up time of 48 months were immunostained using the monoclonal anti-KAI1/CD82 antibody G2. Staining was evaluated as negative versus positive for statistical analysis. KAI1/CD82 immunoreactivity was absent in 103/271 (38%) cases. There was a trend towards KAI1/CD82 negativity in poorly differentiated cases (p=0.0679). Moreover, KAI1/CD82-negative carcinomas were associated with a higher pT status (p=0.0222), metastatic lymph node involvement (p=0.0018) and a higher clinical tumor stage (p=0.0050). The median overall survival times of KAI1/CD82-negative and KAI1/CD82-positive gastric carcinomas were 20 and 37 months, respectively (p=0.2305). These results are in line with the proposed function of KAI1/CD82 as a suppressor of tumor growth and metastasis. However, these data suggest that KAI1/CD82, as detected by immunohistochemistry, is of limited value as a prognostic marker for gastric cancer in routine histological workup.
journal_name
Dis Markersjournal_title
Disease markersauthors
Knoener M,Krech T,Puls F,Lehmann U,Kreipe H,Christgen Mdoi
10.3233/DMA-2012-0896subject
Has Abstractpub_date
2012-01-01 00:00:00pages
337-42issue
6eissn
0278-0240issn
1875-8630pii
0J330H8066270474journal_volume
32pub_type
杂志文章相关文献
DISEASE MARKERS文献大全abstract:Objective:Several serum markers were reported to reflect the severity of pulmonary alveolar proteinosis (PAP). The aim of this study is to investigate a reliable and facile marker to access and monitor the clinical course of PAP in a large cohort. Methods:PAP patients from January 2010 to June 2018 were enrolled. Hosp...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/9709531
更新日期:2019-11-11 00:00:00
abstract::Cyclin-dependent kinase regulatory subunit 2 (CKS2) is a member of the cell cycle-dependent protein kinase subunit family, which is implicated as an oncogene in various malignancies. However, the clinical significance, oncogenic functions, and related mechanisms of CKS2 in hepatocellular carcinoma (HCC) remain largely...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/8964015
更新日期:2019-10-22 00:00:00
abstract:BACKGROUND:Papillary thyroid carcinoma (PTC), follicular thyroid adenoma (FTA), and thyroid nodular hyperplasia (TNH) are the most frequent diseases of the thyroid gland. Previous studies described the involvement of dipeptidyl-peptidase IV (DPPIV/CD26) in the development of thyroid neoplasia and proposed it as an addi...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/970736
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Despite the many studies examining thyroid cancers, the effect of thyroid autoantibodies on differentiated thyroid carcinoma (DTC) remains unclear. OBJECTIVE:To investigate the association between serologic thyroid autoantibodies (ATAs) and DTC, we retrospectively evaluated data of thyroid nodules obtained ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/648670
更新日期:2015-01-01 00:00:00
abstract::Oncogenic activation of the Wnt/ β -catenin signaling pathway is common in human cancers. The secreted frizzled-related proteins (SFRPs) function as negative regulators of Wnt signaling and have important implications in carcinogenesis. Because there have been no reports about the role of SFRP3 in hepatocellular carci...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/351863
更新日期:2014-01-01 00:00:00
abstract::Cardiovascular diseases are the main causes of mortality. Sudden cardiac death may also appear in athletes, due to underlying congenital or inherited cardiac abnormalities. The electrocardiogram is used in clinical practice and clinical trials, as a valid, reliable, accessible, inexpensive method. The aim of the prese...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2015/727401
更新日期:2015-01-01 00:00:00
abstract::In order to develop reagents that can detect the exposed core carbohydrate antigens of mucins, we have prepared monoclonal antibodies against partially deglycosylated LS174T human colon cancer mucin. The three monoclonal antibodies, 10F4, 15D3a, and 91S8, stained cancers of the colon, pancreas, stomach, breast, prosta...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1992-03-01 00:00:00
abstract:OBJECTIVE:Particularly interesting new cysteine-histidine rich protein (PINCH) is an important component of the local adhesion complexes and upregulated in several types of malignancies, and involved in the incidence and development of tumours. PINCH expression is also independently correlated with poorer survival in p...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2012-0930
更新日期:2012-01-01 00:00:00
abstract::Microsatellite instability (MSI) analysis is becoming more and more important to detect sporadic primary tumors of the MSI phenotype as well as in helping to determine Hereditary Non-Polyposis Colorectal Cancer (HNPCC) cases. After some years of conflicting data due to the absence of consensus markers for the MSI phen...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2004/159347
更新日期:2004-01-01 00:00:00
abstract::Prosthetic joint infection (PJI) is the most common cause of failure of total joint arthroplasty, but a gold standard for PJI diagnosis is still lacking. Advanced glycation end products (AGEs) are proinflammatory molecules inducing intracellular oxidative stress (OS) after binding to their cell membrane receptors (RAG...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2017/6140896
更新日期:2017-01-01 00:00:00
abstract::Gamma-glutamyltransferase (GGT) is a well-established serum marker for alcohol-related liver disease. However, GGT's predictive utility applies well beyond liver disease: elevated GGT is linked to increased risk to a multitude of diseases and conditions, including cardiovascular disease, diabetes, metabolic syndrome (...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2015/818570
更新日期:2015-01-01 00:00:00
abstract::Over the last few years the interest in diagnostic markers for specific diseases has increased continuously. It is expected that they not only improve a patient's medical treatment but also contribute to accelerating the process of drug development. This demand for new biomarkers is caused by a lack of specific and se...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2006/174849
更新日期:2006-01-01 00:00:00
abstract::Ultrasound has been a popular clinical imaging modality for decades. It is well established as a means of displaying the macroscopic anatomy of soft-tissue structures. While conventional ultrasound methodologies (i.e., B-mode and Doppler methods) are well proven and continue to advance technically on a daily basis, e....
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2002/167104
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Echocardiographic evaluation of left ventricular (LV) structural and functional alterations in hypertension has some limitations, potentially overcome by using biomarkers. ST2, a prognostic biomarker for heart failure and myocardial infarction patients, was less studied in hypertension. AIM:To analyze the r...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2017/2714095
更新日期:2017-01-01 00:00:00
abstract::The role of pro-fibrogenic cytokines in the outcome of infections with hepatitis C virus (HCV) and the response to treatment with pegylated interferon-alpha (pegIFNalpha) and ribavirin remains unclear. To address this issue, we assessed hepatic fibrosis and plasma markers pertinent to T-cell mediated fibrogenesis and ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2010-0699
更新日期:2010-01-01 00:00:00
abstract::The present study evaluated diurnal variations and day-to-day fluctuations of salivary oxidative stress (OS) markers in healthy adult individuals. Whole unstimulated saliva was collected at 2 time intervals over 3 consecutive days. Glutathione peroxidase (GPX), superoxide dismutase (SOD), total antioxidant capacity (T...
journal_title:Disease markers
pub_type: 临床试验,杂志文章
doi:10.1155/2017/2697464
更新日期:2017-01-01 00:00:00
abstract::Colorectal cancer is one of the most common cancers in the world. Due to its still undetermined pathogenesis, we are searching for signaling pathways that are important in the development of colorectal cancer. In this article, we present results of study on the role of ADAM proteins in colorectal cancer. The study inc...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/5035234
更新日期:2019-09-02 00:00:00
abstract:Aims:The study is aimed at studying the incidence of acute kidney injury (AKI) and exploring the potential predictor for AKI in patients with acute pancreatitis. Methods:A retrospective study adopting a stratified cohort sampling design was performed in a cohort of patients (n = 237) diagnosed with acute pancreatitis ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/8431219
更新日期:2018-11-19 00:00:00
abstract:Background:Syndecan-1 (SDC1/CD138) is a key cell surface adhesion molecule essential for maintaining cell morphology and the interactions with the surrounding microenvironment. SDC1 tumor immunoexpression may be increased or decreased in epithelial malignant neoplasms compared to that in adjacent non-neoplastic tissue,...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/3768708
更新日期:2019-04-30 00:00:00
abstract::A growing interest in the usability of saliva has been observed recently. Using saliva as a diagnostic material is possible because it contains a varied range of composites, organic and inorganic like proteins, carbohydrates, and lipids, which are secreted into saliva. Moreover, this applies to drugs and their metabol...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2019/4360612
更新日期:2019-05-02 00:00:00
abstract:BACKGROUND:Up to 43% of HIV-infected patients co-infected with Mycobacterium tuberculosis experience exacerbations of tuberculosis (TB) after commencing antiretroviral therapy (ART). These are termed immune restoration disease (IRD). It is unclear why individual susceptibility varies. OBJECTIVE:We investigate if singl...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-130991
更新日期:2013-01-01 00:00:00
abstract::We aim to identify the mutations of deafness genes using massively parallel DNA sequencing in the 12 Uyghur families. SNPscan method was used to screen against the 124 sites in the common deafness genes in probands. Subjects with SNPscan negativity were subject to massively parallel DNA sequencing for the sequencing o...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/5298057
更新日期:2018-03-05 00:00:00
abstract::Malignant mesothelioma (MM) is an aggressive malignancy of the serosal membranes. Early diagnosis and accurate prognostication remain problematic. BAP1 is a tumour suppressor gene commonly mutated in MM. Germline BAP1 mutation has been associated with early onset and less aggressive disease compared with sporadic MM. ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2017/1310478
更新日期:2017-01-01 00:00:00
abstract::The total plasma concentration of homocysteine is a marker of this amino acid's atherogenic potential. However, the homocysteine pool exists almost entirely as oxidized homocysteine equivalents (OHcyE), composed of homocystine and cysteine-homocysteine disulphides (20-30%), and protein-bound disulphide (70-80%). We ha...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2009-0649
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:Elevated humoral responses to cytomegalovirus (CMV) associate with increased risk of cardiovascular disease (CVD) in HIV patients on antiretroviral therapy (ART). To better understand the persistence of CMV humoral responses in relation to CVD, we determined trends in CMV antibody levels over the first 10 ye...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/947432
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Amongst the genitourinary cancers, carcinoma of the urinary bladder is one of the leading causes of death in India. Hypermethylation of the CpG islands of gene promoter is one of the earliest and most frequent epigenetic alterations leading to cancer as well as in its development. Several studies have sugg...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2010-0716
更新日期:2010-01-01 00:00:00
abstract::Background. Proper diagnosis of pancreatic lesion etiology is a challenging clinical dilemma. Studies suggest that surgery for suspected pancreatic ductal adenocarcinoma (PDAC) reveals a benign lesion in 5% to 13% of cases. The aim of our study was to assess whether routinely used biomarkers such as CA19-9, Ca125, Ca1...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2017/8629712
更新日期:2017-01-01 00:00:00
abstract::Purpose. The aim of this study was to evaluate the sensitivity of pleural C-reactive protein (CRP) biomarker levels in identifying parapneumonic effusions. Methods. A single-center, retrospective review of 244 patients diagnosed with pleural effusions was initiated among patients at the Rabin Medical Center, Petah Tik...
journal_title:Disease markers
pub_type: 临床试验,杂志文章
doi:10.1155/2016/7539780
更新日期:2016-01-01 00:00:00
abstract::The aim of this study was to assess the expression of MMP-9 and TIMP-1 in cancerous tissue as well as in the serum and plasma concentrations of these proteins in patients with laryngeal cancer and compare the results to the inflammatory reaction in healthy subjects. Twenty-seven patients who were diagnosed with laryng...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/3136792
更新日期:2019-04-18 00:00:00
abstract:Objective:Long noncoding RNAs (lncRNAs) have been strongly associated with various types of cancer. The present study aimed at exploring the diagnostic and prognostic value of lncRNA Zinc finger protein 667-antisense RNA 1 (ZNF667-AS1) in glioma patients. Patients and Methods. The expressions of ZNF667-AS1 were detecte...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/8895968
更新日期:2020-11-16 00:00:00