Abstract:
:IgA nephropathy is diagnosed by renal biopsy, an invasive procedure with a risk of significant complications. Noninvasive approaches are needed for possible diagnostic purposes and especially for monitoring disease activity or responses to treatment. In this pilot project, we assessed the utility of urine samples as source of biomarkers of IgA nephropathy. We used spot urine specimens from 19 healthy controls, 11 patients with IgA nephropathy, and 8 renal-disease controls collected on day of renal biopsy. Urine samples were analyzed using untargeted metabolomic and targeted proteomic analyses by several experimental techniques: liquid chromatography coupled with mass spectrometry, immunomagnetic isolation of target proteins coupled with quantitation by mass spectrometry, and protein arrays. No single individual biomarker completely differentiated the three groups. Therefore, we tested the utility of several markers combined in a panel. Discriminant analysis revealed that combination of seven markers, three metabolites (dodecanal, 8-hydroxyguanosine, and leukotriene C4), three proteins (α1-antitrypsin, IgA-uromodulin complex, and galactose-deficient IgA1), and heparan sulfate, differentiated patients with IgA nephropathy from patients with other renal diseases and healthy controls. Future studies are needed to validate these preliminary findings and to determine the power of these urinary markers for assessment of responses to therapy.
journal_name
Dis Markersjournal_title
Disease markersauthors
Neprasova M,Maixnerova D,Novak J,Reily C,Julian BA,Boron J,Novotny P,Suchanek M,Tesar V,Kacer Pdoi
10.1155/2016/3650909subject
Has Abstractpub_date
2016-01-01 00:00:00pages
3650909eissn
0278-0240issn
1875-8630journal_volume
2016pub_type
杂志文章相关文献
DISEASE MARKERS文献大全abstract:Background:The role of the NFKB1 gene rs28362491 polymorphism and NFKBIA gene rs2233406 polymorphism in the development of head and neck cancer (HNC) remains controversial. This meta-analysis was performed to assess the relationship between the gene polymorphisms and HNC quantitatively. Methods:PubMed, Embase, Web of ...
journal_title:Disease markers
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2019/6523837
更新日期:2019-09-12 00:00:00
abstract::Restriction fragment length polymorphism (RFLP) analyses of DR1 positive peripheral blood leukocytes DNA was carried out. The Taq I digested DNA was hybridized with cDNA probes for HLA-DR and -DQ beta genes. The DR probe detected fragments commonly observed in the DR1 specificity, whereas a new DQ-beta fragment was de...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1991-09-01 00:00:00
abstract::We have previously identified an allele of the human SP-A2 gene that occurs with greater frequency in an RDS population [12]. Because of the importance of SP-A in normal lung function and its newly emerging role in innate host defense and regulation of inflammatory processes, we wish to better characterize genotypes o...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/1999/961430
更新日期:1999-12-01 00:00:00
abstract::Immunological and immunogenetic investigations are described in a group of 28 women with a history of unexplained recurrent (greater than or equal to 3 consecutive) spontaneous abortions (RSA). Compared with female blood donor controls, recurrent aborters had significantly elevated mean serum complement C4 (p less tha...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract:BACKGROUND:During progression of gastric cancer (GC), degradation of the extracellular matrix is mediated by the matrix metalloproteases (MMPs) and their tissue inhibitors (TIMPs): changes in the expression of these have been related to unfavorable prognosis in GC. OBJECTIVE:To analyze the expression of certain MMPs a...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/285906
更新日期:2014-01-01 00:00:00
abstract::As the most common neoplasm arising from the kidney, renal cell carcinoma (RCC) continues to have a significant impact on global health. Conventional cross-sectional imaging has always served an important role in the staging of RCC. However, with recent advances in imaging techniques and postprocessing analysis, magne...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2015/648495
更新日期:2015-01-01 00:00:00
abstract::The genetic variation at the Apolipoprotein E locus (APOE) is an important determinant of plasma lipids and has been implicated in various human pathological conditions. The objective of the present study was to estimate the distribution of APOE alleles in five Venezuelan communities: two Amerindian tribes (Bari and Y...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2005/625182
更新日期:2005-01-01 00:00:00
abstract::Pancreatic adenocarcinoma (PDAC) still represents a devastating disease associated with a very limited survival. Novel biomarkers allowing an early diagnosis as well as an optimal selection of suitable treatment options for individual patients are urgently needed to improve the dismal outcome of PDAC patients. Recentl...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/5603474
更新日期:2019-10-20 00:00:00
abstract::Exhaled breath condensate (EBC) has been increasingly used as a new and non-invasive method to study airway inflammation. In this study we have compared the concentrations of lipid mediators in EBC with concentrations in bronchoalveolar lavage fluid (BALF). We included 37 patients undergoing bronchoscopy (12 sarcoidos...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2011-0776
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Some studies have suggested a relation of plasma fibrinogen to the severity of coronary artery disease (CAD). However, whether plasma fibrinogen can predict the presence and severity of CAD in patients with diabetes mellitus has not been determined. METHODS:A total of consecutive 373 diabetic patients with ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/485687
更新日期:2014-01-01 00:00:00
abstract::Objective. To determine active TGF-β1 (aTGF-β1) levels in serum, skin, and peripheral blood mononuclear cell (PBMC) culture supernatants and to understand their associations with clinical parameters in systemic sclerosis (SSc) patients. Methods. We evaluated serum samples from 56 SSc patients and 24 healthy controls (...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2016/6064830
更新日期:2016-01-01 00:00:00
abstract:Background:The ratio of early mitral inflow velocity to the global diastolic strain rate (E/E'sr) and global longitudinal systolic strain (GLS) of the left ventricle (LV) are emerging indices of diastolic and systolic functions, respectively, for the LV. Their prognostic significance in the prediction of mortality and ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/7512805
更新日期:2019-09-05 00:00:00
abstract::Deficiency alleles at the C4 loci within the MHC are associated with autoimmune diseases in Caucasoids and possibly other races. We therefore studied the relationship between relevant C4 alleles and other MHC markers in a random Thai/Chinese population. Over 90 per cent of C4AQO occurs within two supratypes (HLA Aw33,...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1987-03-01 00:00:00
abstract::Oncogenic activation of the Wnt/ β -catenin signaling pathway is common in human cancers. The secreted frizzled-related proteins (SFRPs) function as negative regulators of Wnt signaling and have important implications in carcinogenesis. Because there have been no reports about the role of SFRP3 in hepatocellular carci...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/351863
更新日期:2014-01-01 00:00:00
abstract::Inflammatory diseases are accompanied by numerous changes at the site of inflammation as well as many systemic physiological and biochemical changes. In the past two decades more and more attention is being paid to changes in glycosylation and in this review we describe some of the changes found on main serum proteins...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2008/493289
更新日期:2008-01-01 00:00:00
abstract::MicroRNAs (miRNAs) are a class of small, non-coding RNA molecules that can regulate gene expression, thereby affecting crucial processes in cancer development. miRNAs offer great potential as biomarkers for cancer detection because of their remarkable stability in blood and their characteristic expression in different...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-120957
更新日期:2013-01-01 00:00:00
abstract::The aim of this study was to assess the expression of MMP-9 and TIMP-1 in cancerous tissue as well as in the serum and plasma concentrations of these proteins in patients with laryngeal cancer and compare the results to the inflammatory reaction in healthy subjects. Twenty-seven patients who were diagnosed with laryng...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/3136792
更新日期:2019-04-18 00:00:00
abstract::Tumor-induced osteomalacia (TIO) is a rare acquired paraneoplastic disorder and fibroblast growth factor 23 (FGF23) plays a key role in its pathogenesis. This study was conducted to describe a novel FGF23 detecting procedure and describe clinical features of the disease. Fourteen TIO cases were retrieved and FGF23 exp...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2016/3176978
更新日期:2016-01-01 00:00:00
abstract::A growing interest in the usability of saliva has been observed recently. Using saliva as a diagnostic material is possible because it contains a varied range of composites, organic and inorganic like proteins, carbohydrates, and lipids, which are secreted into saliva. Moreover, this applies to drugs and their metabol...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2019/4360612
更新日期:2019-05-02 00:00:00
abstract::Respiratory syncytial virus (RSV) is the most common viral respiratory pathogen during infancy world wide. It induces innate and adaptive immune response in host cells. The toll like receptor 4 (TLR4)/CD14 complex is particularly important for the initiation of an innate immune response to RSV. Thus we were interested...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2006/865890
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:In this study, we sought to investigate the dynamic changes in the levels of TNF-α, IL-1β and LPS in the gingival crevicular fluid (GCF) in a rat model of diabetes mellitus (DM) and periodontitis (PD). Additionally, we evaluated alveolar bone loss and the histopathological response associated with experimenta...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-130974
更新日期:2013-01-01 00:00:00
abstract::The HLA system is deeply involved in susceptibility to a variety of diseases. Relationships between HLA and diseases are of considerable interest and importance, as they provide new tools for studying the inheritance, classification, and pathogenesis of these diseases. Studies on the distribution of HLA antigens in di...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/1993/192019
更新日期:1993-11-01 00:00:00
abstract::The present study evaluated diurnal variations and day-to-day fluctuations of salivary oxidative stress (OS) markers in healthy adult individuals. Whole unstimulated saliva was collected at 2 time intervals over 3 consecutive days. Glutathione peroxidase (GPX), superoxide dismutase (SOD), total antioxidant capacity (T...
journal_title:Disease markers
pub_type: 临床试验,杂志文章
doi:10.1155/2017/2697464
更新日期:2017-01-01 00:00:00
abstract::The prevalence of heart failure (HF) due to cardiac remodelling after acute myocardial infarction (AMI) does not decrease regardless of implementation of new technologies supporting opening culprit coronary artery and solving of ischemia-relating stenosis with primary percutaneous coronary intervention (PCI). Numerous...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2020/1215802
更新日期:2020-06-12 00:00:00
abstract:BACKGROUND:The molecular work-up of thyroid nodules from fine needle aspiration samples has given clinicians a new level of diagnostic information. The aim of the present study was to evaluate the utility of molecular analysis in thyroid fine needle aspiration samples from a Chinese population. METHODS:Specimens were ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/912182
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Evidence indicates that microRNAs (miRNA) play a role in the pathogenesis of chronic kidney diseases (CKD). We explored the possibility of using urinary miRNA as non-invasive biomarkers for CKD. METHODS:We quantified miRNA expression in urinary sediment of 56 CKD patients who underwent kidney biopsy. Patien...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2012/842764
更新日期:2012-01-01 00:00:00
abstract::CD4+ T cells of patients with B cell non-Hodgkin's lymphoma (NHL) were analysed for expression of CD45RA and CD29. It was found that CD45RA expression was significantly lower, and CD29 expression significantly higher, in lymphoma patients compared to normal controls. Moreover absolute numbers of CD4+ T cells were sign...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1990-05-01 00:00:00
abstract::The clinical distinction of frontotemporal dementia (FTD) and Alzheimer's disease (AD) may be difficult. In this narrative review we summarize and discuss the most relevant electroencephalography (EEG) studies which have been applied to demented patients with the aim of distinguishing the various types of cognitive im...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2018/6581490
更新日期:2018-09-03 00:00:00
abstract:BACKGROUND:Impaired fasting glucose (IFG) through the nondiabetic range (100-125 mg/dL) is not considered in the cardiovascular (CV) risk profile. AIM:To compare the clustering of CV risk factors (RFs) in nondiabetic subjects with normal fasting glucose (NFG) and IFG. MATERIAL AND METHODS:Cross-sectional study in 373...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/804739
更新日期:2015-01-01 00:00:00
abstract:AIM:The purpose of this study is to determine the association between eotaxin 426 C/T, -384 A/G, 67 G/A, eNOS -786 T/C, 4 a/b, and MMP-13 rs640198 G/T and prognosis of patients with known CAD. METHODS:From total of 1161 patients referred to coronary angiography, 532 patients with angiographically confirmed CAD were se...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/232048
更新日期:2015-01-01 00:00:00