Abstract:
:RFLP HLA-DRB1 analysis was performed on a total of 83 children born from HIV-infected mothers, 35 of whom were shown to be HIV-infected, while 48 reverted from seropositivity to seronegativity, indicating that they were not infected. Moreover, 89 healthy children were used as controls. It has been found that DRB1-14a and DRB1-13a.4 alleles were not present in the HIV-infected children, but were found in the sero-reverted (HIV-uninfected) children (in the proportion of 9.6 per cent and 5.3 per cent, respectively), and in the controls (5.6 per cent and 3.9 per cent, respectively). The possible correlation between DR and risk of HIV transmission from mother to baby was analysed considering every single allele, estimated by the ratio between the number of infected children and the number of all children born from seropositive mothers. There was also introduced a statistic G for the control of 'statistical validity' of data.
journal_name
Dis Markersjournal_title
Disease markersauthors
Greggio NA,Cameran M,Giaquinto C,Zacchello F,Koroliuk D,Colizzi Vdoi
10.1155/1993/292684subject
Has Abstractpub_date
1993-06-01 00:00:00pages
29-35issue
1eissn
0278-0240issn
1875-8630journal_volume
11pub_type
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