Abstract:
BACKGROUND:specific polymorphisms of genes regulating intracellular redox balance and oxidative stress are related to atherogenesis. Some studies have identified a relationship between progression of atherosclerosis and C242T mutation in CYBA gene coding for p22phox, a subunit of the NADH/NADPH oxidase system. DESIGN:we investigated whether the C242T nucleotide transition is associated with the presence of coronary artery disease (CAD) in a population of 494 Caucasian Italians undergoing coronary angiography to diagnose the cause of chest pain. RESULTS:the frequency of the T mutant allele that we found in 276 patients with angiographically documented CAD was significantly higher compared to what we observed in 218 subjects with normal coronary arteries (Controls) (respectively: 0.400 and 0.332, p<0.01). The prevalence of the T allele was even stronger when we compared: 1) early onset (age < or =55) vs late onset (age > or =65) single-vessel CAD patients (respectively: 0.75 and 0.48, p<0.05), and 2) the subgroup of CAD patients with at least one > or =98% stenosis in a coronary vessel vs those with no > or =98% stenosis in a coronary vessel (respectively: 0.425 and 0.365, p<0.05). CONCLUSIONS:these results support the increased risk of developing early CAD and of having rapid progression of coronary stenosis in subjects carrying the C242T nucleotide transition among the Italian population.
journal_name
Dis Markersjournal_title
Disease markersauthors
Nasti S,Spallarossa P,Altieri P,Garibaldi S,Fabbi P,Polito L,Bacino L,Brunelli M,Brunelli C,Barsotti A,Ghigliotti Gdoi
10.1155/2006/458587subject
Has Abstractpub_date
2006-01-01 00:00:00pages
167-73issue
3eissn
0278-0240issn
1875-8630journal_volume
22pub_type
杂志文章相关文献
DISEASE MARKERS文献大全abstract::[This corrects the article DOI: 10.1155/2017/1202710.]. ...
journal_title:Disease markers
pub_type: 已发布勘误
doi:10.1155/2020/1245645
更新日期:2020-10-14 00:00:00
abstract::In recent researches, high expression of nesfatin-1/nucleobindin-2 (NUCB2) is linked to poor prognosis in prostate and colon cancer due to the enhancement in proliferation, migration, and invasion. However, the role of nesfatin-1 in bladder cancer is not clear. In this study, we examined the expression of NUCB2 in bla...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/4272064
更新日期:2018-09-19 00:00:00
abstract::S-100 protein was demonstrated in 28/31 melanoma tissue sections that had been previously stained by hematoxylin and eosin, including 17 from 19 primary melanomas and 11 from 12 metastases. Additional H & E stained sections from 11 metastatic and 13 primary melanomas were reacted with the monoclonal antibody NKI/C-3 a...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00
abstract::In order to verify the role of CEA in the differential diagnosis of pancreatic cancer and to evaluate some influencing factors like age, tumor spread and liver dysfunction, this antigen was measured in the sera of 60 control subjects, 45 patients with pancreatic cancer, 37 with chronic pancreatitis, 67 with benign, an...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1988-07-01 00:00:00
abstract::Transforming growth factor β1 (TGF-β1) is an important mediator in Chagas disease. Furthermore, patients with higher TGF-β1 serum levels show a worse clinical outcome. Gene polymorphism may account for differences in cytokine production during infectious diseases. We tested whether TGFB1 polymorphisms could be associa...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/4579198
更新日期:2018-02-18 00:00:00
abstract::Regulatory T cells (Tregs) play an essential role in acute coronary syndrome (ACS). However, there is debate about which Treg subsets are truly critical to ACS. Helios, a transcription factor, was recently reported to be a bona fide marker for natural Tregs or activated Tregs with a suppression function, but little is...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2017/7909407
更新日期:2017-01-01 00:00:00
abstract::A limited number of studies have been performed so far on the polymorphism in the transmembrane region (exon 5) of the major histocompatibility complex class I chain-related gene A (MICA) in patients with melanoma. However, the influence of MICA polymorphism in extracellular domains (exons 2, 3, and 4) has not been in...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/831864
更新日期:2015-01-01 00:00:00
abstract::The frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients and controls were investigated in a sample Turkish population. B27 subtyping was performed by PCR-SSP method in two groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of SpA according to the European Spon...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2004/565270
更新日期:2004-01-01 00:00:00
abstract::In a study of multicase RA families, significantly raised frequencies of the HLA antigens DR4, DR1, Bw62, Cw3, A2, A31 and significantly lower frequencies of DR2, DR3, and B8 were found in probands compared to normal controls. When haplotype frequencies were compared between probands and controls, two haplotypes A2-B4...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:
更新日期:1986-06-01 00:00:00
abstract::Physical activity as a part of the lifestyle is a significant factor influencing health condition. Exercises that require stamina are of particular importance. Oxygen metabolism, which is a significant part of all longer training processes, has an influence on cardiovascular and respiratory system functioning as well ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2016/7169531
更新日期:2016-01-01 00:00:00
abstract::Cerebrospinal fluid (CSF) is the body fluid closest to the pathology of multiple sclerosis (MS). For many candidate biomarkers CSF is the only fluid that can be investigated. Several factors need to be standardized when sampling CSF for biomarker research: time/volume of CSF collection, sample processing/storage, and ...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2006/509476
更新日期:2006-01-01 00:00:00
abstract::The phenotype of cytosolic Low Molecular Weight Protein Tyrosine Phosphatase (cLMWPTP or ACP1), an enzyme involved in signal transduction of insulin, PDGF and T-cell receptors, has been determined in 71 patients with Crohn's Disease (CD: 37 males and 34 females), 49 patients with Ulcerative Colitis (UC: 27 males and 2...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2000/101739
更新日期:2000-01-01 00:00:00
abstract::Abnormal phenotypic switch of vascular smooth muscle cell (VSMC) is a hallmark of vascular disorders such as atherosclerosis and restenosis. And this process has been related to remodeling of L-type calcium channel (LTCC). We attempted to investigate whether fluvastatin has any effect on VSMC proliferation and LTCCα 1...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/237067
更新日期:2014-01-01 00:00:00
abstract::The aim of this study was to assess the expression of MMP-9 and TIMP-1 in cancerous tissue as well as in the serum and plasma concentrations of these proteins in patients with laryngeal cancer and compare the results to the inflammatory reaction in healthy subjects. Twenty-seven patients who were diagnosed with laryng...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/3136792
更新日期:2019-04-18 00:00:00
abstract::Thirty-six coeliac children on gluten-containing diet were studied for AGA IgA and IgG levels. Patients were typed for HLA-A, -B, -C, -DR, -DQ antigens and data were analysed for any correlation between HLA-DR phenotype and AGA levels. AGA IgA and/or IgG were present in all these children. Subjects negative for DR3 or...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:Liver cirrhosis (LC) is the final stage of most of chronic liver diseases and is almost caused by chronic hepatitis B (CHB) in China. Liver biopsy is the reference method for the evaluation of liver cirrhosis. However, it is an invasive procedure with inherent risk. The aim of this study was to construct a n...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/127962
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Left ventricular dysfunction (LVD), followed by fall in cardiac output is one of the major complications in some coronary artery disease (CAD) patients. The decreased cardiac output over time leads to activation of the renin-angiotensin-aldosterone system which results in vasoconstriction by influencing salt...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2012-0858
更新日期:2012-01-01 00:00:00
abstract:INTRODUCTION:Acute gangrenous appendicitis (AGA) is a common medical condition; however, the grade of appendicitis usually cannot be established preoperatively. We have attempted to identify some indicators, such as the mean platelet volume (MPV) and the platelet distribution width (PDW), to diagnose AGA. Aims. To eval...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/542013
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Stroke subtype diagnosis leads to specific therapies to reduce recurrences. Because nearly one third of patients remain with unknown etiology after a complete screening workup, we aim to investigate whether molecular markers of myocardial damage were associated with cardioembolic stroke and if they were usef...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2009-0630
更新日期:2009-01-01 00:00:00
abstract::Epithelial cancers, including those of the skin and cervix, are the most common type of cancers in humans. Many recent studies have attempted to use Raman spectroscopy to diagnose these cancers. In this paper, Raman spectral markers related to the temporal and spatial effects of cervical and skin cancers are examined ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2008/230307
更新日期:2008-01-01 00:00:00
abstract::Cytoplasmic islet cell antibodies (ICA) were determined in a group of non-diabetic Caucasian schoolchildren (n = 4208). The prevalence rate for ICA positivity was 1.05 per cent (95 per cent confidence interval: 0.8-1.4 per cent). Analysis of HLA risk factors revealed that HLA-DRB1*03 (p less than 0.01), HLA-DRB1*04 (p...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:The association of the apolipoprotein (Apo E) -epsilon4 allele to neurodegenerative diseases such as Parkinson's disease (PD) has been analyzed in several studies. This association has been identified by amyloid deposits and neurofibrillary tangles in the brains of patients with neurodegenerative diseases. ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2009-0667
更新日期:2009-01-01 00:00:00
abstract:AIM:This study was conducted to find out the optimal vitamin D cutoff point in predicting activity of RA disease. MATERIALS AND METHODS:One hundred and two rheumatoid arthritis Saudi patients of both genders were recruited in this study. Vitamin D as 25-hydroxy-vitamin D [25(OH)D] was measured and serum level less tha...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/260725
更新日期:2015-01-01 00:00:00
abstract::Vitamin D plays a role in central nervous system (CNS) development. Recent literature focused on vitamin D status in children and adolescents with autism spectrum disorder (ASD), but with inconsistent results. Our case-control study is aimed at evaluating serum 25-hydroxyl-vitamin D (25(OH)D) concentration in children...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/9292560
更新日期:2020-09-18 00:00:00
abstract:AIM:To assess and compare the roles of plasma and urine concentrations of neutrophil gelatinase associated lipocalin (NGAL) and Cystatin C for early diagnosis of septic acute kidney injury (AKI) in adult critically ill patients. METHODS:Patients were divided into three groups as sepsis-non AKI, sepsis-AKI and non seps...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-130966
更新日期:2013-01-01 00:00:00
abstract::GROβ (CXCL2) is a chemokine produced by endotoxin-treated macrophages that mediates inflammation and tumor development. However, little is known about GROβ expression in gastrointestinal stromal tumors (GIST) or the relationship between GROβ expression and clinical attributes of GIST. GROβ expression was examined via ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/171035
更新日期:2015-01-01 00:00:00
abstract::The adenosine deaminase gene frequencies were calculated in 405 subjects randomly chosen from the Bigouden district. A rather high frequency (0.0765 +/- 0.0093) was found for the ADA2 gene. The possible effect of Celtic influences is considered. ...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1988-03-01 00:00:00
abstract::Pancreatic adenocarcinoma (PDAC) still represents a devastating disease associated with a very limited survival. Novel biomarkers allowing an early diagnosis as well as an optimal selection of suitable treatment options for individual patients are urgently needed to improve the dismal outcome of PDAC patients. Recentl...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/5603474
更新日期:2019-10-20 00:00:00
abstract::There is increasing evidence to support the use of CA125 in the follow-up and management of patients with ovarian cancer and several commercial kits are now available for its measurement. This study investigated and compared the performance of three of them: an enzyme immunoassay (EIA) and an immunoradiometric assay (...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Tumor cells show alterations in their glycosylation patterns when compared to normal cells. Lectins can be used to evaluate these glycocode changes. Chemiluminescence assay is an effective technique for quantitative analysis of proteins, nucleic acids, and carbohydrates due to its high sensitivity, specifici...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/787130
更新日期:2013-01-01 00:00:00