Abstract:
:We first investigated the difference in microRNA expression between normal NP cells and degenerative NP cells using gene chip. We have found that the expression of ERK1/2 was decreased with overexpression of miR-155 in normal nucleus pulposus cell. Expression of ERK1/2 was increased with inhibition of miR-155. Overexpression or inhibition of miR-155 had no effects on the expression level of mRNA ERK1/2 in nucleus pulposus cell, which showed that miR-155 affected the expression of pERK1/2 after transcription of ERK1/2 mRNA indicating that ERK1/2 was a new target protein regulated by miR-155. In the degeneration of intervertebral disc, inhibited miR-155 decreased the expressions of extracellular main matrix collagen II and glycosaminoglycan and increased expression of ERK1/2. Taken together, our data suggested that miR-155 was the identified miRNA which regulated NP cells degenerated through directly targeting ERK1/2.
journal_name
Dis Markersjournal_title
Disease markersauthors
Ye D,Dai L,Yao Y,Qin S,Xie H,Wang W,Liang Wdoi
10.1155/2016/6984270subject
Has Abstractpub_date
2016-01-01 00:00:00pages
6984270eissn
0278-0240issn
1875-8630journal_volume
2016pub_type
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