Abstract:
:Cytoplasmic islet cell antibodies (ICA) were determined in a group of non-diabetic Caucasian schoolchildren (n = 4208). The prevalence rate for ICA positivity was 1.05 per cent (95 per cent confidence interval: 0.8-1.4 per cent). Analysis of HLA risk factors revealed that HLA-DRB1*03 (p less than 0.01), HLA-DRB1*04 (p less than 0.01) and HLA haplotypes with non-charged amino acids (non-Asp) at codon 57 of the HLA-DQ beta (p less than 0.01) chain were significantly increased when compared to controls. High levels of islet cell antibodies, i.e. Juvenile Diabetes Federation units (JDF units) equal to or greater than 30 JDF units were found to be associated with amino acids other than aspartic acid at codon 57 of the DQ beta chain molecule. Also the persistence of circulating ICA was found to be associated with non-Asp homozygosity of the proband (p less than 0.03).
journal_name
Dis Markersjournal_title
Disease markersauthors
Boehm BO,Seissler J,Glück M,Manfras BJ,Thomas H,Schmidt K,Rudert WA,Usadel KH,Trucco M,Scherbaum WAsubject
Has Abstractpub_date
1991-09-01 00:00:00pages
273-80issue
5eissn
0278-0240issn
1875-8630journal_volume
9pub_type
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