Molecular analysis of structural chromosome changes affecting chromosome band 11q23.


:Involvement of the ets-1 proto-oncogene located at chromosome band 11q23 was studied in six tumors and in a congenital chromosome abnormality affecting the 11q23 region, in order to determine whether the breakpoint of these rearrangements was identical at the molecular level. In multiple restriction digestions a 5.4 kb EcoRI genomic probe of the c-ets-1 gene did not detect rearrangements in any of these samples. Thus, in these tumors the break in DNA was not within the domain of c-ets-1 recognized by this probe. However, after digestion with XbaI enzyme the probe detected a 2.4 kb polymorphic allele in placental DNA. One tumor DNA sample showed homozygosity for this polymorphic allele. In order to determine the frequency of this polymorphic allele, DNA from 50 additional tumors and from the blood of nine healthy donors was analyzed. DNA from one tumor showed homozygosity for the polymorphic allele. In the 67 DNA samples studied, 17.9 per cent were heterozygous for the polymorphic site and 3 per cent were homozygous for the polymorphic site. Thus, the overall frequency of the polymorphic allele in these samples was 0.111.


Dis Markers


Disease markers


Koduru PR,Offit K,Jhanwar SC


Has Abstract


1989-07-01 00:00:00












  • Usefulness of Cathepsin S to Predict Risk for Obstructive Sleep Apnea among Patients with Type 2 Diabetes.

    abstract:Background:Obstructive sleep apnea (OSA) was highly prevalent in patients with type 2 diabetes (T2D). Cathepsin S (CTSS), a cysteine protease, is involved in the inflammatory activity in T2D and hypoxia conditions. The aim of the study was to evaluate whether CTSS could be involved in the inflammatory reaction of OSA i...

    journal_title:Disease markers

    pub_type: 杂志文章


    authors: Wen W,Sun H,Yang Y,Jia Y,Fang F,Qin Y,Zhang M,Wei Y

    更新日期:2020-09-25 00:00:00

  • Polymorphism on Chromosome 9p21.3 Is Associated with Severity and Early-Onset CAD in Type 2 Diabetic Tunisian Population.

    abstract::Multiple association studies found that the human 9p21.3 chromosome locus is a risk factor for atherosclerosis. The purpose of this study was to investigate the association of the severity and early-onset of coronary artery disease with variant rs1333049 on chromosome 9p21.3 polymorphism and the impact of this variant...

    journal_title:Disease markers

    pub_type: 杂志文章


    authors: Abid K,Mili D,Kenani A

    更新日期:2015-01-01 00:00:00

  • Large number of polymorphic nucleotides and a termination codon in the env gene of the endogenous human retrovirus ERV3.

    abstract::The terminal portion of the pol gene and the entire env gene of the human endogenous retrovirus ERV3 was screened for polymorphic nucleotides. For this purpose fragments amplified from the desired regions of ERV3 were subjected to single strand conformational analysis (SSCP analysis). Using this approach, we detected ...

    journal_title:Disease markers

    pub_type: 杂志文章


    authors: Rasmussen HB,Clausen J

    更新日期:1998-11-01 00:00:00

  • Clinical Applications of Hemolytic Markers in the Differential Diagnosis and Management of Hemolytic Anemia.

    abstract::Several hemolytic markers are available to guide the differential diagnosis and to monitor treatment of hemolytic conditions. They include increased reticulocytes, an indicator of marrow compensatory response, elevated lactate dehydrogenase, a marker of intravascular hemolysis, reduced haptoglobin, and unconjugated hy...

    journal_title:Disease markers

    pub_type: 杂志文章,评审


    authors: Barcellini W,Fattizzo B

    更新日期:2015-01-01 00:00:00

  • Identification of Pathogenic Genes of Nonsyndromic Hearing Loss in Uyghur Families Using Massively Parallel DNA Sequencing Technique.

    abstract::We aim to identify the mutations of deafness genes using massively parallel DNA sequencing in the 12 Uyghur families. SNPscan method was used to screen against the 124 sites in the common deafness genes in probands. Subjects with SNPscan negativity were subject to massively parallel DNA sequencing for the sequencing o...

    journal_title:Disease markers

    pub_type: 杂志文章


    authors: Chen Y,Lu Y,Kuyaxi P,Cheng J,Zhao J,Zhao Q,Musha P,Zhang H,Yuan H

    更新日期:2018-03-05 00:00:00

  • Diagnostic implications of an elevated troponin in the emergency department.

    abstract:OBJECTIVE:To determine the proportion of initial troponin (cTn) elevations associated with Type I MI versus other cardiovascular and noncardiovascular diagnoses in an emergency department (ED) and whether or not a relationship exists between the cTn level and the likelihood of Type I MI. BACKGROUND:In the ED, cTn is u...

    journal_title:Disease markers

    pub_type: 杂志文章


    authors: Yiadom MY,Jarolim P,Jenkins C,Melanson SE,Conrad M,Kosowsky JM

    更新日期:2015-01-01 00:00:00

  • Polymorphisms -455G/A and -148C/T and Fibrinogen Plasmatic Level as Risk Markers of Coronary Disease and Major Adverse Cardiovascular Events.

    abstract::Some polymorphisms in genes codifying for fibrinogen have been correlated with plasma levels of this protein, and several studies reported their associations with acute cardiovascular events. In the present study, 118 subjects with unstable and stable coronary diseases were enrolled to determinate the associations amo...

    journal_title:Disease markers

    pub_type: 杂志文章


    authors: Canseco-Avila LM,Lopez-Roblero A,Serrano-Guzman E,Aguilar-Fuentes J,Jerjes-Sanchez C,Rojas-Martinez A,Ortiz-Lopez R

    更新日期:2019-07-01 00:00:00

  • The serum glycome to discriminate between early-stage epithelial ovarian cancer and benign ovarian diseases.

    abstract::Epithelial ovarian cancer (EOC) is the sixth most common cause of cancer deaths in women because the diagnosis occurs mostly when the disease is in its late-stage. Current diagnostic methods of EOC show only a moderate sensitivity, especially at an early-stage of the disease; hence, novel biomarkers are needed to impr...

    journal_title:Disease markers

    pub_type: 杂志文章


    authors: Biskup K,Braicu EI,Sehouli J,Tauber R,Blanchard V

    更新日期:2014-01-01 00:00:00

  • Bioassays based on molecular nanomechanics.

    abstract::Recent experiments have shown that when specific biomolecular interactions are confined to one surface of a microcantilever beam, changes in intermolecular nanomechanical forces provide sufficient differential torque to bend the cantilever beam. This has been used to detect single base pair mismatches during DNA hybri...

    journal_title:Disease markers

    pub_type: 杂志文章,评审


    authors: Majumdar A

    更新日期:2002-01-01 00:00:00

  • Reshaping human monoclonal antibodies for imaging and therapy.

    abstract::Current problems in obtaining suitable monoclonal antibodies (MoAbs) for in vivo imaging and therapy can now be bypassed using protein-engineering rather than conventional hybridoma technology. Rodent antibody binding sites can be grafted onto human acceptor antibodies thus reshaping the human MoAbs into reagents with...

    journal_title:Disease markers

    pub_type: 杂志文章


    authors: Verhoeyen ME,Saunders JA,Broderick EL,Eida SJ,Badley RA

    更新日期:1991-05-01 00:00:00

  • Nuclear p27 expression confers a favorable outcome for nasopharyngeal carcinoma patients.

    abstract:OBJECTIVE:The purpose of the present study is to explore the correlation between nuclear expression of cyclin-dependent kinase inhibitor 1B (p27) and clinicopathologic features in nasopharyngeal carcinoma (NPC), including patient survival. METHODS:Immunohistochemistry was used to examine the expression of p27 in 130 p...

    journal_title:Disease markers

    pub_type: 杂志文章


    authors: Liu Z,Long Y,Zhang Y,Huang W,Long X,Yang H,Long J,Cheng C,Fang W

    更新日期:2013-01-01 00:00:00

  • Serum Chemerin Levels in relation to Osteoporosis and Bone Mineral Density: A Case-Control Study.

    abstract:BACKGROUND:To evaluate serum chemerin levels in patients with osteoporosis and healthy controls and to investigate the relationship between serum chemerin levels and bone mineral density (BMD). METHODS:An age- and gender-matched case-control study was conducted. Pearson's correlation test was performed to investigate ...

    journal_title:Disease markers

    pub_type: 杂志文章


    authors: He J,Li JC,Xie H,Xu ZH,Sun YW,Shan Q

    更新日期:2015-01-01 00:00:00

  • C242T polymorphism in CYBA gene (p22phox) and risk of coronary artery disease in a population of Caucasian Italians.

    abstract:BACKGROUND:specific polymorphisms of genes regulating intracellular redox balance and oxidative stress are related to atherogenesis. Some studies have identified a relationship between progression of atherosclerosis and C242T mutation in CYBA gene coding for p22phox, a subunit of the NADH/NADPH oxidase system. DESIGN:...

    journal_title:Disease markers

    pub_type: 杂志文章


    authors: Nasti S,Spallarossa P,Altieri P,Garibaldi S,Fabbi P,Polito L,Bacino L,Brunelli M,Brunelli C,Barsotti A,Ghigliotti G

    更新日期:2006-01-01 00:00:00

  • Chemokines and chemokine receptors in susceptibility to HIV-1 infection and progression to AIDS.

    abstract::A multitude of host genetic factors plays a crucial role in susceptibility to HIV-1 infection and progression to AIDS, which is highly variable among individuals and populations. This review focuses on the chemokine-receptor and chemokine genes, which were extensively studied because of their role as HIV co-receptor o...

    journal_title:Disease markers

    pub_type: 杂志文章,评审


    authors: Chatterjee A,Rathore A,Vidyant S,Kakkar K,Dhole TN

    更新日期:2012-01-01 00:00:00

  • Determination of SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, and RAGE rs1800625 Single Gene Polymorphisms in Patients with Laryngeal Squamous Cell Carcinoma.

    abstract:Purpose:To determine the frequency of the genotype of signal transducer and activator of transcription protein 3 (STAT3) rs744166, sirtuin (SIRT1) rs12778366, fibroblast growth factor (FGFR2) rs2981582, and advanced glycosylation end product-specific receptor (RAGE) rs1800625 gene polymorphisms in patients with larynge...

    journal_title:Disease markers

    pub_type: 杂志文章


    authors: Uloza V,Tamauskaite T,Vilkeviciute A,Pasvenskaite A,Liutkevicius V,Liutkeviciene R

    更新日期:2019-11-12 00:00:00

  • Microtubule-Associated Protein 4 Is a Prognostic Factor and Promotes Tumor Progression in Lung Adenocarcinoma.

    abstract::Microtubule-associated protein 4 (MAP4) plays an important role in microtubule assembly and stabilization. The purpose of this study was to investigate the level of expression of MAP4 in lung adenocarcinoma (LADC) samples and to evaluate its prognostic value and the influence on cancer progression in LADC patients. Th...

    journal_title:Disease markers

    pub_type: 杂志文章


    authors: Xia X,He C,Wu A,Zhou J,Wu J

    更新日期:2018-03-18 00:00:00

  • Adverse Cardiac Remodelling after Acute Myocardial Infarction: Old and New Biomarkers.

    abstract::The prevalence of heart failure (HF) due to cardiac remodelling after acute myocardial infarction (AMI) does not decrease regardless of implementation of new technologies supporting opening culprit coronary artery and solving of ischemia-relating stenosis with primary percutaneous coronary intervention (PCI). Numerous...

    journal_title:Disease markers

    pub_type: 杂志文章,评审


    authors: Berezin AE,Berezin AA

    更新日期:2020-06-12 00:00:00

  • Quantitative ELISA-Like Immunohistochemistry of Fibroblast Growth Factor 23 in Diagnosis of Tumor-Induced Osteomalacia and Clinical Characteristics of the Disease.

    abstract::Tumor-induced osteomalacia (TIO) is a rare acquired paraneoplastic disorder and fibroblast growth factor 23 (FGF23) plays a key role in its pathogenesis. This study was conducted to describe a novel FGF23 detecting procedure and describe clinical features of the disease. Fourteen TIO cases were retrieved and FGF23 exp...

    journal_title:Disease markers

    pub_type: 杂志文章


    authors: Hu F,Jiang C,Zhang Q,Shi H,Wei L,Wang Y

    更新日期:2016-01-01 00:00:00

  • Placental Expression of NEMO Protein in Normal Pregnancy and Preeclampsia.

    abstract:Background:Preeclamptic pregnancies often present an intensified inflammatory state associated with the nuclear activity of NFκB. NEMO is an essential regulator of nuclear factor kappa B (NFκB) in cytoplasmic and nuclear cellular compartments. The aim of the present study is to examine the level and localization of the...

    journal_title:Disease markers

    pub_type: 杂志文章


    authors: Sakowicz A,Lisowska M,Biesiada L,Płuciennik E,Gach A,Rybak-Krzyszkowska M,Huras H,Sakowicz B,Romanowicz H,Piastowska-Ciesielska AW,Grzesiak M,Pietrucha T

    更新日期:2019-01-02 00:00:00

  • TLR-4 and CD14 polymorphisms in respiratory syncytial virus associated disease.

    abstract::Respiratory syncytial virus (RSV) is the most common viral respiratory pathogen during infancy world wide. It induces innate and adaptive immune response in host cells. The toll like receptor 4 (TLR4)/CD14 complex is particularly important for the initiation of an innate immune response to RSV. Thus we were interested...

    journal_title:Disease markers

    pub_type: 杂志文章


    authors: Puthothu B,Forster J,Heinzmann A,Krueger M

    更新日期:2006-01-01 00:00:00

  • Cyclin-Dependent Kinase Regulatory Subunit 2 Indicated Poor Prognosis and Facilitated Aggressive Phenotype of Hepatocellular Carcinoma.

    abstract::Cyclin-dependent kinase regulatory subunit 2 (CKS2) is a member of the cell cycle-dependent protein kinase subunit family, which is implicated as an oncogene in various malignancies. However, the clinical significance, oncogenic functions, and related mechanisms of CKS2 in hepatocellular carcinoma (HCC) remain largely...

    journal_title:Disease markers

    pub_type: 杂志文章


    authors: Zhang J,Song Q,Liu J,Lu L,Xu Y,Zheng W

    更新日期:2019-10-22 00:00:00

  • Multiple sclerosis cerebrospinal fluid biomarkers.

    abstract::Cerebrospinal fluid (CSF) is the body fluid closest to the pathology of multiple sclerosis (MS). For many candidate biomarkers CSF is the only fluid that can be investigated. Several factors need to be standardized when sampling CSF for biomarker research: time/volume of CSF collection, sample processing/storage, and ...

    journal_title:Disease markers

    pub_type: 杂志文章,评审


    authors: Giovannoni G

    更新日期:2006-01-01 00:00:00

  • Analysis of highly conserved regions of the 3'UTR of MECP2 gene in patients with clinical diagnosis of Rett syndrome and other disorders associated with mental retardation.

    abstract::In this work we explored the role of the 3'UTR of the MECP2 gene in patients with clinical diagnosis of RTT and mental retardation; focusing on regions of the 3'UTR with almost 100% conservation at the nucleotide level among mouse and human. By mutation scanning (DOVAM-S technique) the MECP2 3'UTR of a total of 66 aff...

    journal_title:Disease markers

    pub_type: 杂志文章


    authors: Santos M,Yan J,Temudo T,Oliveira G,Vieira JP,Fen J,Sommer S,Maciel P

    更新日期:2008-01-01 00:00:00

  • Stimulation of cellular proliferation by hepatitis B virus X protein.

    abstract::Chronic infection with the hepatitis B virus (HBV) is a known risk factor in the development of human hepatocellular carcinoma (HCC). The HBV-encoded X protein, HBx, has been investigated for properties that may explain its cancer cofactor role in transgenic mouse lines. We discuss here recent data showing that HBx is...

    journal_title:Disease markers

    pub_type: 杂志文章,评审


    authors: Madden CR,Slagle BL

    更新日期:2001-01-01 00:00:00

  • Lung cancer stem cells.

    abstract::Lung cancer remains a major cause of cancer-related lethality because of high incidence and recurrence in spite of significant advances in staging and therapies. Recent data indicates that stem cells situated throughout the airways may initiate cancer formation. These putative stem cells maintain protumorigenic charac...

    journal_title:Disease markers

    pub_type: 杂志文章,评审


    authors: Pine SR,Marshall B,Varticovski L

    更新日期:2008-01-01 00:00:00

  • The Combination of CA125 and NSE Is Useful for Predicting Liver Metastasis of Lung Cancer.

    abstract:Purpose:Liver metastasis is the final stage of cancer progression and is associated with poor prognosis. Although numerous indicators have been identified as having prognostic value for lung cancer and liver metastasis, liver metastases are still not diagnosed by imaging in many patients. To provide a more accurate met...

    journal_title:Disease markers

    pub_type: 杂志文章


    authors: Wang CF,Peng SJ,Liu RQ,Yu YJ,Ge QM,Liang RB,Li QY,Li B,Shao Y

    更新日期:2020-12-09 00:00:00

  • Mean Platelet Volume and Platelet Distribution Width as Markers in the Diagnosis of Acute Gangrenous Appendicitis.

    abstract:INTRODUCTION:Acute gangrenous appendicitis (AGA) is a common medical condition; however, the grade of appendicitis usually cannot be established preoperatively. We have attempted to identify some indicators, such as the mean platelet volume (MPV) and the platelet distribution width (PDW), to diagnose AGA. Aims. To eval...

    journal_title:Disease markers

    pub_type: 杂志文章


    authors: Fan Z,Pan J,Zhang Y,Wang Z,Zhu M,Yang B,Shi L,Jing H

    更新日期:2015-01-01 00:00:00

  • Corrigendum to "Overexpression of GRK3, Promoting Tumor Proliferation, Is Predictive of Poor Prognosis in Colon Cancer".

    abstract::[This corrects the article DOI: 10.1155/2017/1202710.]. ...

    journal_title:Disease markers

    pub_type: 已发布勘误


    authors: Jiang T,Yang C,Ma L,Wu Z,Ye L,Ma X,Li H,Fan J,Yang Y

    更新日期:2020-10-14 00:00:00

  • Association of fibrinogen with severity of stable coronary artery disease in patients with type 2 diabetic mellitus.

    abstract:BACKGROUND:Some studies have suggested a relation of plasma fibrinogen to the severity of coronary artery disease (CAD). However, whether plasma fibrinogen can predict the presence and severity of CAD in patients with diabetes mellitus has not been determined. METHODS:A total of consecutive 373 diabetic patients with ...

    journal_title:Disease markers

    pub_type: 杂志文章


    authors: Hong LF,Li XL,Luo SH,Guo YL,Zhu CG,Qing P,Wu NQ,Li JJ

    更新日期:2014-01-01 00:00:00

  • Utilisation of prophylactic mastectomy in 10 European centres.

    abstract::Increasingly women at high risk of breast cancer are opting for prophylactic surgery to reduce their risks. Data from 10 European centres that offer a risk counselling and screening service to women at risk show different approaches to the option of preventive surgery, although most centres adhere to a protocol includ...

    journal_title:Disease markers

    pub_type: 杂志文章,多中心研究


    authors: Evans DG,Anderson E,Lalloo F,Vasen H,Beckmann M,Eccles D,Hodgson S,Møller P,Chang-Claude J,Morrison P,Stoppa-Lyonnet D,Steel M,Haites N

    更新日期:1999-10-01 00:00:00