Abstract：
BACKGROUND:The objective of this study was to assess how atypical diagnostic category (ADC) is followed up, its outcomes, and the predictors that are associated with subsequent diagnosis of neoplasm/malignancy. METHODS:We reviewed pancreatic endoscopic ultrasound fine-needle aspiration (EUS-FNA) with ADC and compared the rate of detection of neoplasms after a repeat FNA, a biopsy/resection, or a clinical follow-up following ADC. Logistic regression was used to determine the factors associated with the diagnosis of a neoplastic or a malignant lesion following ADC. Predictive probability for each case was calculated on the basis of the significant predictors, and whether it improved diagnostic performance was assessed. RESULTS:Of 3832 cases that received pancreatic EUS-FNAs, 187 (4.9%) were ADC. A total of 93 neoplasms (55%), including 61 carcinomas (36%), were detected after an atypical cytologic diagnosis. Similar rates of detecting neoplasms were observed after repeat FNA or biopsy/resection but higher than after clinical follow-up. The presence of a mass, history of alcohol use, and absence of a history of pancreatitis were significant predictors of a higher rate of diagnosis of neoplasm. Weight loss and bile flow obstruction were more likely to be associated with higher rates of carcinoma. Predictive probability demonstrated a wide range of risk and changed the ambiguous diagnosis to informative in 30% of cases. CONCLUSIONS:ADC of pancreas is associated with a high risk of benign and malignant neoplasms regardless of the method of follow-up. The presences of a mass, alcohol use, and absence of a history of pancreatitis are significant predictors of a diagnosis of neoplasm, whereas weight loss and bile duct obstruction are significant predictors of ductal carcinoma following an ADC.
journal_name
Cancer Cytopatholjournal_title
Cancer cytopathologyauthors
Alston E,Bae S,Eltoum IAdoi
10.1002/cncy.21389subject
Has Abstractpub_date
2014-06-01 00:00:00pages
428-34issue
6eissn
1934-662Xissn
1934-6638journal_volume
122pub_type
杂志文章abstract：BACKGROUND:The 2007 Bethesda classification for thyroid cytology defines follicular neoplasm as a category of cases with cellular specimens demonstrating abundant follicular cells arranged in a microfollicular pattern with little or no colloid. The current recommendation for the management of these cases is diagnostic ...
journal_title：Cancer cytopathology
pub_type： 杂志文章,评审
doi：10.1002/cncy.21425
更新日期：2014-07-01 00:00:00
abstract：:Cervical cancer and anal cancer share many similarities including causation by oncogenic human papillomaviruses; however, significant differences exist in their epidemiology, risk factors, biologic behavior, management, and treatment. Although rare, the incidence of anal cancer is alarmingly high and continues to incr...
journal_title：Cancer cytopathology
pub_type： 杂志文章,评审
doi：10.1002/cncy.20126
更新日期：2011-02-25 00:00:00
abstract：BACKGROUND:Germline and somatic mutations of DICER1 have been identified in various types of neoplastic lesions, with germline DICER1 mutation being linked to autosomal dominant hereditary pleiotropic tumor syndrome (DICER1 syndrome). Patients with DICER1 syndrome are at increased risk of developing thyroid disease, in...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.22329
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Much of the reluctance about using cytology specimens rather than histology specimens to assess programmed death ligand 1 (PD-L1) expression for guiding the use of immune modulating drugs in the management of non-small cell lung cancer (NSCLC) is based on the belief that the alcohol-based fixatives favored b...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.22216
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Fine-needle aspiration biopsy of spindled mesenchymal lesions, including schwannomas, are challenging because of overlapping cytomorphological features. The objective of the current study was to identify key diagnostic cytological criteria for the diagnosis of schwannoma and to distinguish it from its common...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.21506
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:The Paris System for Reporting Urinary Cytology (TPS) defines clear morphologic criteria to classify urinary specimens into 7 diagnostic categories. According to TPS, a nuclear-to-cytoplasmic ratio (N:C ratio) >0.7 and hyperchromasia must be observed to render a diagnosis of high-grade urothelial carcinoma (...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.22218
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:The current study was conducted to compare DNA yield, including normalization to nuclear area, DNA amplification functionality, and detection of KRAS mutations between matched fine-needle aspiration (FNA) specimens and pancreatic resections diagnostic of pancreatic ductal adenocarcinoma. METHODS:A retrospec...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.21935
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:Angiomyolipoma (AML), typically composed of smooth muscle, vessels, and fat, is generally a benign tumor in the kidneys. However, it occasionally occurs in extrarenal sites and behaves like a malignant tumor. AML is uncommonly encountered in fine-needle aspiration (FNA) samples and can cause diagnostic diffi...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.21824
更新日期：2017-04-01 00:00:00
abstract：:The evaluation of mediastinal and hilar lymph nodes for tissue diagnosis and staging of lung cancer is now commonly performed by minimally invasive, nonsurgical procedures such as computed tomography-guided fine-needle aspiration and endobronchial ultrasound-guided transbronchial needle aspiration. Ensuring that a suf...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.20166
更新日期：2011-12-25 00:00:00
abstract：BACKGROUND:Mutations of AT-rich interactive domain 1 (ARID1A) have been associated with a worse outcome after intravesical treatment with bacille Calmette-Guérin in patients with non-muscle-invasive bladder cancer (NMIBC). Loss of ARID1A protein expression in urine cytology may serve as an indication of an ARID1A mutat...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.22167
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:Although thyroid fine-needle aspiration (TFNA) is an excellent test in evaluating thyroid nodules, there are occasionally false negatives (FN). The clinical impact and pathologic features of FN TFNA is understudied in the peer-reviewed literature. METHODS:A cohort of patients with thyroid cancer was separat...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.21196
更新日期：2012-10-25 00:00:00
abstract：BACKGROUND:The aim of this study was to validate clinical utilization of routinely prepared cytology specimens for molecular testing to detect EGFR or KRAS mutations in lung cancer. METHODS:From September 2009 to April 2010, the authors collected 209 cytology specimens from patients with lung cancer at the MD Anderson...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.20151
更新日期：2011-04-25 00:00:00
abstract：BACKGROUND:Atypical glandular cells (AGC) is a very important diagnosis in gynecological cytology. In the current study, the authors investigated the usefulness of Cellient cell blocks (CB) for characterizing AGC on Papanicolaou (Pap) tests. METHODS:A total of 148 patients with an AGC diagnosis based on Pap tests by c...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.21343
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Fine-needle aspiration (FNA) is widely accepted in the preoperative management of salivary gland lesions. The proposed Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) aims to standardize reporting terminology. Studies regarding the risk of malignancy (ROM) for the proposed categories continu...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.22016
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:Fluorescence in situ hybridization (FISH) to identify specific DNA target sequences in the nuclei of nondividing cells of numerous solid neoplasms has contributed to the introduction of molecular cytogenetics as a useful adjunct to cytology, leading recently to the "marriage" of the 2 disciplines. Numerous c...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.21397
更新日期：2014-05-01 00:00:00
abstract：:Follicular cell-derived carcinomas of the thyroid gland comprise a heterogeneous group of malignant neoplasms of the thyroid gland with varied histologic appearance and molecular profiles. In most patients, these tumors represent relatively indolent neoplasms; however, certain subtypes/variants behave in an aggressive...
journal_title：Cancer cytopathology
pub_type： 杂志文章,评审
doi：10.1002/cncy.21417
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:SMARCB1 (INI-1)-deficient sinonasal carcinoma (IDSNC) is a newly described, poorly differentiated carcinoma. Herein, the authors describe the cytopathologic features of IDSNC in fine-needle aspiration (FNA) samples. METHODS:The pathology archives of 2 academic institutions were searched for cases of IDSNC w...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.22020
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:BRAF mutations are highly specific for papillary thyroid carcinoma (PTC) and many cytology specimens with BRAF mutations are expected to demonstrate cytologic features typical of PTC. However, indeterminate thyroid cytology cases are inevitable and understanding the significance of the BRAF mutation within t...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.21229
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:The Paris System (TPS) for Reporting Urinary Cytology aims to standardize urine cytology reporting. Per TPS, the diagnosis of "suspicious for high-grade urothelial carcinoma (SHGUC)" is applied in cases that have few urothelial cells with severe atypia but are quantitatively insufficient for a diagnosis of "...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.22357
更新日期：2021-02-01 00:00:00
abstract：BACKGROUND:Morphologic and genetic analysis of thyroid nodules may be performed from a single vial. Preanalytic variables that affect nucleic acid extracted from a single vial are evaluated. METHODS:Thyroid fine-needle aspiration (FNA) specimens collected in CytoLyt were evaluated. A ThinPrep slide was prepared. Extra...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.22270
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:Carbonic anhydrase IX (CAIX) is a hallmark of metabolic change in cancer cells. The aim was to evaluate the utility of CAIX expression for the detection of malignant pleural effusions by enzyme-linked immunosorbent assay (ELISA) and immunocytochemistry. METHODS:A total of 97 pleural effusions including 54 b...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.21191
更新日期：2012-08-25 00:00:00
abstract：BACKGROUND:The authors conducted an analysis of 2 telepathology systems with different resolutions to determine how resolution affects the pathologists' ability to provide preliminary diagnoses for fine-needle aspirations (FNA). METHODS:FNA cases evaluated by telepathology between February 1, 2011 and January 18, 2012...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.21404
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:Accurate fine-needle aspiration (FNA) diagnosis of metastatic melanoma is of therapeutic and prognostic significance and often requires ancillary studies. To the authors' knowledge, the reliability of immunostaining using a pan-melanoma cocktail, Sry-related HMG-BOX gene 10 (SOX10), and microphthalmia transc...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.21458
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:More accurate biomarkers in cervical cytology screening could reduce the number of women unnecessarily referred for biopsy. This study investigated the ability of p16/Ki-67 dual staining to predict high-grade cervical intraepithelial neoplasia (CIN) in human papillomavirus (HPV)-positive women from the Norwe...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.21807
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:The availability of suitable biospecimens is critical to the success of advanced genomic analyses. The objective of this study was to assess the sensitivity of fine-needle aspiration (FNA) compared with gross surgical sampling (GSS) from surgical specimens for the detection of somatic mutations in breast can...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.21599
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:The newly unveiled Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has proposed salivary gland neoplasm of uncertain malignant potential (SUMP) as an indeterminate category. The category is reserved for fine-needle aspiration (FNA) cases that are diagnostic of a salivary gland neoplasm but c...
journal_title：Cancer cytopathology
pub_type： 杂志文章,多中心研究
doi：10.1002/cncy.22066
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:The accumulation of cyclin-dependent kinase inhibitor 2A (p16ink4a ) protein in a cell is associated with neoplastic progression in precancerous cervical lesions. Dual staining for p16ink4a and Ki-67 has been proposed as a triage test in cervical cancer screening for women who test positive for human papillo...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.21800
更新日期：2017-03-01 00:00:00
abstract：:The practice of cytopathology has dramatically changed due to advances in genomics and information technology. Cytology laboratories have accordingly become increasingly dependent on pathology informatics support to meet the emerging demands of precision medicine. Pathology informatics deals with information technolog...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.21833
更新日期：2017-06-01 00:00:00
abstract：:Two-thirds of neuroendocrine neoplasms arising in the human body originate from the gastrointestinal system or pancreas. Gastroenteropancreatic neuroendocrine neoplasms are heterogeneous, comprising both well differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). The cl...
journal_title：Cancer cytopathology
pub_type： 杂志文章,评审
doi：10.1002/cncy.22073
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:The recent revision in terminology, with noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) replacing noninvasive follicular variant of papillary thyroid carcinoma, has reclassified the clinically indolent tumor as nonmalignant. The objective of this study was to evaluate th...
journal_title：Cancer cytopathology
pub_type： 杂志文章
doi：10.1002/cncy.21981
更新日期：2018-05-01 00:00:00
