Advances in the cytologic diagnosis of gastroenteropancreatic neuroendocrine neoplasms.

abstract：BACKGROUND:The Bethesda System for Reporting Thyroid Cytopathology category of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) includes fine-needle aspiration (FNA) specimens that cannot straightforwardly be classified as benign or malignant. To determine whether morphologi...

journal_title：Cancer cytopathology

authors： Bellevicine C,Sgariglia R,Migliatico I,Vigliar E,D'Anna M,Nacchio MA,Serra N,Malapelle U,Bongiovanni M,Troncone G

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Personalized oncology requires molecular analysis of tumor cells. Several studies have demonstrated that cytological material is suitable for DNA analysis, but to the authors' knowledge there are no systematic studies comparing how the yield and quality of extracted DNA is affected by the various techniques ...

journal_title：Cancer cytopathology

authors： Dejmek A,Zendehrokh N,Tomaszewska M,Edsjö A

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:The usefulness of GATA3 (GATA-binding protein 3 to DNA sequence [A/T]GATA[A/G]) as a marker for metastatic breast carcinoma in serous effusion specimens was investigated. METHODS:Cell block sections from 74 serous effusion specimens (32 ascitic, 2 pericardial, and 40 pleural fluids) were stained with an ant...

journal_title：Cancer cytopathology

authors： Shield PW,Papadimos DJ,Walsh MD

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Urine cytology results that are suspicious for urothelial carcinoma (UC) are challenging. The objective of this study was to elucidate the clinical significance of such results in patients who have a negative cystoscopy. METHODS:In this prospective study, 83 patients who had urine cytology that was suspicio...

journal_title：Cancer cytopathology

authors： Montalbo R,Izquierdo L,Ingelmo-Torres M,Galve P,Solé M,Franco A,Ribal MJ,Alcaraz A,Mengual L

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Angiomyolipoma (AML), typically composed of smooth muscle, vessels, and fat, is generally a benign tumor in the kidneys. However, it occasionally occurs in extrarenal sites and behaves like a malignant tumor. AML is uncommonly encountered in fine-needle aspiration (FNA) samples and can cause diagnostic diffi...

journal_title：Cancer cytopathology

authors： Zhou H,Guo M,Gong Y

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Mutations of AT-rich interactive domain 1 (ARID1A) have been associated with a worse outcome after intravesical treatment with bacille Calmette-Guérin in patients with non-muscle-invasive bladder cancer (NMIBC). Loss of ARID1A protein expression in urine cytology may serve as an indication of an ARID1A mutat...

journal_title：Cancer cytopathology

authors： Dugas SG,Müller DC,Le Magnen C,Federer-Gsponer J,Seifert HH,Ruiz C,Savic Prince S,Vlajnic T,Zellweger T,Mertz KD,Bacon JVW,Wyatt AW,Rentsch CA,Bubendorf L

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Diagnosing giant cell-rich bone tumors can be challenging on limited biopsies. H3 histone family member 3A (H3F3A) (G34W/V/R/L) mutations are present in the majority of giant cell tumors (GCTs) of bone and H3 histone family member 3B (H3F3B) (K36M) mutations are present in nearly all chondroblastomas, but ar...

journal_title：Cancer cytopathology

authors： Schaefer IM,Fletcher JA,Nielsen GP,Shih AR,Ferrone ML,Hornick JL,Qian X

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:The Paris System for Reporting Urinary Cytology (TPS) defines clear morphologic criteria to classify urinary specimens into 7 diagnostic categories. According to TPS, a nuclear-to-cytoplasmic ratio (N:C ratio) >0.7 and hyperchromasia must be observed to render a diagnosis of high-grade urothelial carcinoma (...

journal_title：Cancer cytopathology

authors： Richardson CJ,Pambuccian SE,Barkan GA

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:The current study was conducted to compare DNA yield, including normalization to nuclear area, DNA amplification functionality, and detection of KRAS mutations between matched fine-needle aspiration (FNA) specimens and pancreatic resections diagnostic of pancreatic ductal adenocarcinoma. METHODS:A retrospec...

journal_title：Cancer cytopathology

authors： Hartley CP,Mahajan AM,Selvaggi SM,Rehrauer WM

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Accurate fine-needle aspiration (FNA) diagnosis of metastatic melanoma is of therapeutic and prognostic significance and often requires ancillary studies. To the authors' knowledge, the reliability of immunostaining using a pan-melanoma cocktail, Sry-related HMG-BOX gene 10 (SOX10), and microphthalmia transc...

journal_title：Cancer cytopathology

authors： Clevenger J,Joseph C,Dawlett M,Guo M,Gong Y

更新日期：2014-10-01 00:00:00

abstract：:The recent emergence of immune checkpoint inhibitors for cancer therapy has created much excitement among cancer patients, drug and diagnostic developers, and health care professionals. This is due largely to the dramatic and sustained responses among some advanced cancers that were previously refractory to therapy. U...

journal_title：Cancer cytopathology

authors： Clark DP

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Morphologic and genetic analysis of thyroid nodules may be performed from a single vial. Preanalytic variables that affect nucleic acid extracted from a single vial are evaluated. METHODS:Thyroid fine-needle aspiration (FNA) specimens collected in CytoLyt were evaluated. A ThinPrep slide was prepared. Extra...

journal_title：Cancer cytopathology

authors： Heymann JJ,Yoxtheimer LM,Park HJ,Fernandez EM,Facey KE,Alperstein SA,Tran HV,Baek I,Scognamiglio T,Rennert H,Siddiqui MT,Song W

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:The use of topically applied hemostatic substances during surgery has become a common practice. In some cases, the material is not absorbed or induces a granulomatous reaction resulting in a pseudotumoral lesion. With imaging studies, it is not possible to differentiate this from a tumor recurrence or absces...

journal_title：Cancer cytopathology

authors： Hernández-Bonilla S,Rodríguez-García AM,Jiménez-Heffernan JA,Muñoz-Hernández P,Palacios-Lázaro E,López-Ferrer P,González-Peramato P,Vicandi B

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Human papillomavirus (HPV) tests and genotyping have been used in clinical risk assessment. The purpose of this study was to analyze the performance of 2 common HPV testing platforms in detecting high-grade cervical lesions (high-grade squamous intraepithelial lesion [HSIL] or worse [≥HSIL]). METHODS:Betwee...

journal_title：Cancer cytopathology

authors： Ge Y,Christensen P,Luna E,Armylagos D,Schwartz MR,Mody DR

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:SMARCB1 (INI-1)-deficient sinonasal carcinoma (IDSNC) is a newly described, poorly differentiated carcinoma. Herein, the authors describe the cytopathologic features of IDSNC in fine-needle aspiration (FNA) samples. METHODS:The pathology archives of 2 academic institutions were searched for cases of IDSNC w...

journal_title：Cancer cytopathology

authors： Allard FD,Bell D,Stelow EB

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:The Paris System (TPS) for Reporting Urinary Cytology aims to standardize urine cytology reporting. Per TPS, the diagnosis of "suspicious for high-grade urothelial carcinoma (SHGUC)" is applied in cases that have few urothelial cells with severe atypia but are quantitatively insufficient for a diagnosis of "...

journal_title：Cancer cytopathology

authors： Nguyen L,Nilforoushan N,Krane JF,Bose S,Bakkar R

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Much of the reluctance about using cytology specimens rather than histology specimens to assess programmed death ligand 1 (PD-L1) expression for guiding the use of immune modulating drugs in the management of non-small cell lung cancer (NSCLC) is based on the belief that the alcohol-based fixatives favored b...

journal_title：Cancer cytopathology

authors： Gosney JR,Haragan A,Chadwick C,Giles TE,Grundy S,Tippett V,Gumparthy KP,Wight A,Tan HG

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Ewing sarcoma (ES) is a round cell sarcoma that can be challenging to diagnose on cytologic material given its significant overlap with numerous mesenchymal, epithelial, and lymphoid cytomorphologic mimics. The objective of this study was to assess the utility of a novel marker, NKX2.2, in the diagnosis of E...

journal_title：Cancer cytopathology

authors： Russell-Goldman E,Hornick JL,Qian X,Jo VY

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:In the United States, the rate of cervical cancer is disproportionally higher in Hispanic and Black women compared with White women. In the current study, the authors compared human papillomavirus (HPV) testing and cytology results among Black and White women over a 24-month period. They then assessed the ra...

journal_title：Cancer cytopathology

authors： Miller D,Morris CP,Maleki Z,White M,Rodriguez EF

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Fine-needle aspiration (FNA) is widely accepted in the preoperative management of salivary gland lesions. The proposed Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) aims to standardize reporting terminology. Studies regarding the risk of malignancy (ROM) for the proposed categories continu...

journal_title：Cancer cytopathology

authors： Viswanathan K,Sung S,Scognamiglio T,Yang GCH,Siddiqui MT,Rao RA

更新日期：2018-08-01 00:00:00

abstract：:Follicular cell-derived carcinomas of the thyroid gland comprise a heterogeneous group of malignant neoplasms of the thyroid gland with varied histologic appearance and molecular profiles. In most patients, these tumors represent relatively indolent neoplasms; however, certain subtypes/variants behave in an aggressive...

journal_title：Cancer cytopathology

authors： Lastra RR,LiVolsi VA,Baloch ZW

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:High-risk human papillomavirus (hrHPV) DNA detection is generally accepted for the triage of women with a cytologic diagnosis of atypical squamous cells of undetermined significance (ASC-US). However, no consensus has been reached on the optimal management of low-grade squamous intraepithelial lesions (LSIL)...

journal_title：Cancer cytopathology

authors： Verdoodt F,Szarewski A,Halfon P,Cuschieri K,Arbyn M

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:New developments in the treatment of lung cancer have necessitated the further histologic and cytologic subtyping of nonsmall cell lung carcinomas. Thyroid transcription factor-1 (TTF-1) long has served as the predominant marker for demonstrating lung origin. However, it is also expressed in a variety of oth...

journal_title：Cancer cytopathology

authors： Stoll LM,Johnson MW,Gabrielson E,Askin F,Clark DP,Li QK

更新日期：2010-12-25 00:00:00

abstract：BACKGROUND:Homozygous deletion of 9p21 detected by fluorescence in situ hybridization (FISH) and loss of BRCA1-associated protein 1 (BAP1) expression detected by immunohistochemistry (IHC) are useful for the differentiation between malignant pleural mesothelioma (MPM) and reactive mesothelial hyperplasia. The authors p...

journal_title：Cancer cytopathology

authors： Kinoshita Y,Hida T,Hamasaki M,Matsumoto S,Sato A,Tsujimura T,Kawahara K,Hiroshima K,Oda Y,Nabeshima K

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Fine-needle aspiration biopsy of spindled mesenchymal lesions, including schwannomas, are challenging because of overlapping cytomorphological features. The objective of the current study was to identify key diagnostic cytological criteria for the diagnosis of schwannoma and to distinguish it from its common...

journal_title：Cancer cytopathology

authors： Chebib I,Hornicek FJ,Nielsen GP,Deshpande V

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Epithelioid sarcoma (ES) is a rare mesenchymal tumor that is divided into 2 types: classic and proximal. To the authors' knowledge, ES has been poorly studied in cytology, with fewer than 50 cases reported to date. The objective of the current study was to analyze the cytological and immunohistochemical info...

journal_title：Cancer cytopathology

authors： Gajdzis P,Laé M,Klijanienko J

更新日期：2018-11-01 00:00:00

abstract：:The American Society for Colposcopy and Cervical Pathology (ASCCP) guidelines for the management of women with abnormal cervical screening test results is a powerful, evidence-based document representing an advance in the consistent treatment of women with cervical abnormalities. Nevertheless, the complexity of the gu...

journal_title：Cancer cytopathology

authors： Colgan TJ

更新日期：2010-10-25 00:00:00

abstract：BACKGROUND:Urine cytology has been used for screening of bladder cancer but has been limited by its low sensitivity. UroVysion is a multiprobe fluorescence in situ hybridization (FISH) assay that detects common chromosome abnormalities in bladder cancers. For this study, the authors evaluated the effectiveness of multi...

journal_title：Cancer cytopathology

authors： Dimashkieh H,Wolff DJ,Smith TM,Houser PM,Nietert PJ,Yang J

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Second-opinion diagnosis (SOD) on pathological material is an accepted practice before definitive therapy is considered for referred patients. The thyroid gland is an anatomical site prone to diagnostic disagreement between pathologists. We performed a review of the literature that addressed the role of inte...

journal_title：Cancer cytopathology

authors： Gerhard R,Boerner SL

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:The objective of the current study was to investigate the clinical performance of detecting high-grade lesions with the CINtec PLUS p16(INK4a)/Ki-67 dual stain and the APTIMA human papillomavirus (HPV) Assay in a cohort of women with low-grade squamous intraepithelial lesion (LSIL) cytology. The authors also...

journal_title：Cancer cytopathology

authors： Waldstrøm M,Christensen RK,Ørnskov D

更新日期：2013-03-01 00:00:00