FNA smears of pancreatic ductal adenocarcinoma are superior to formalin-fixed paraffin-embedded tissue as a source of DNA: Comparison of targeted KRAS amplification and genotyping in matched preresection and postresection samples.

abstract：BACKGROUND:Germline and somatic mutations of DICER1 have been identified in various types of neoplastic lesions, with germline DICER1 mutation being linked to autosomal dominant hereditary pleiotropic tumor syndrome (DICER1 syndrome). Patients with DICER1 syndrome are at increased risk of developing thyroid disease, in...

journal_title：Cancer cytopathology

authors： Darbinyan A,Morotti R,Cai G,Prasad ML,Christison-Lagay E,Dinauer C,Adeniran AJ

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Morphologic and genetic analysis of thyroid nodules may be performed from a single vial. Preanalytic variables that affect nucleic acid extracted from a single vial are evaluated. METHODS:Thyroid fine-needle aspiration (FNA) specimens collected in CytoLyt were evaluated. A ThinPrep slide was prepared. Extra...

journal_title：Cancer cytopathology

authors： Heymann JJ,Yoxtheimer LM,Park HJ,Fernandez EM,Facey KE,Alperstein SA,Tran HV,Baek I,Scognamiglio T,Rennert H,Siddiqui MT,Song W

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Human papillomavirus (HPV) tests and genotyping have been used in clinical risk assessment. The purpose of this study was to analyze the performance of 2 common HPV testing platforms in detecting high-grade cervical lesions (high-grade squamous intraepithelial lesion [HSIL] or worse [≥HSIL]). METHODS:Betwee...

journal_title：Cancer cytopathology

authors： Ge Y,Christensen P,Luna E,Armylagos D,Schwartz MR,Mody DR

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Fluorescence in situ hybridization (FISH) to identify specific DNA target sequences in the nuclei of nondividing cells of numerous solid neoplasms has contributed to the introduction of molecular cytogenetics as a useful adjunct to cytology, leading recently to the "marriage" of the 2 disciplines. Numerous c...

journal_title：Cancer cytopathology

authors： Caria P,Frau DV,Dettori T,Boi F,Lai ML,Mariotti S,Vanni R

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:The diagnosis of breast lesions is usually confirmed by fine-needle aspiration cytology (FNAC) or histological biopsy. Although there is increasing literature regarding the advantages and limitations of both modalities, there is no literature regarding the accuracy of these modalities for diagnosing breast l...

journal_title：Cancer cytopathology

authors： Georgieva RD,Obdeijn IM,Jager A,Hooning MJ,Tilanus-Linthorst MM,van Deurzen CH

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:The primary goal of this study was to compare the clinical performance of an optimized and rigorously controlled immunocytochemical (ICC) assay for p16(INK4a) to high-risk (HR) human papillomavirus (HPV) detection by polymerase chain reaction (PCR) as diagnostic adjuncts for cytology specimens from colposcop...

journal_title：Cancer cytopathology

authors： Samarawardana P,Dehn DL,Singh M,Franquemont D,Thompson C,Gaido L,Torkko KC,Homer P,Burke S,Titmus MA,Nayi V,Shroyer KR

更新日期：2010-06-25 00:00:00

abstract：BACKGROUND:The recent revision in terminology, with noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) replacing noninvasive follicular variant of papillary thyroid carcinoma, has reclassified the clinically indolent tumor as nonmalignant. The objective of this study was to evaluate th...

journal_title：Cancer cytopathology

authors： Hang JF,Westra WH,Zhou AG,Cooper DS,Ali SZ

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Homozygous deletion of 9p21 detected by fluorescence in situ hybridization (FISH) and loss of BRCA1-associated protein 1 (BAP1) expression detected by immunohistochemistry (IHC) are useful for the differentiation between malignant pleural mesothelioma (MPM) and reactive mesothelial hyperplasia. The authors p...

journal_title：Cancer cytopathology

authors： Kinoshita Y,Hida T,Hamasaki M,Matsumoto S,Sato A,Tsujimura T,Kawahara K,Hiroshima K,Oda Y,Nabeshima K

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Diagnosing giant cell-rich bone tumors can be challenging on limited biopsies. H3 histone family member 3A (H3F3A) (G34W/V/R/L) mutations are present in the majority of giant cell tumors (GCTs) of bone and H3 histone family member 3B (H3F3B) (K36M) mutations are present in nearly all chondroblastomas, but ar...

journal_title：Cancer cytopathology

authors： Schaefer IM,Fletcher JA,Nielsen GP,Shih AR,Ferrone ML,Hornick JL,Qian X

更新日期：2018-08-01 00:00:00

abstract：:Ocular cytology specimens are small, with limited options for a repeat biopsy. Appropriate handling of these specimens and triaging for ancillary testing can be taxing. In this article, the author reviews a selection of potentially challenging diagnoses and current common practices and methods used in diagnosing ocula...

journal_title：Cancer cytopathology

authors： Laver NMV

更新日期：2020-11-02 00:00:00

abstract：BACKGROUND:Allogenic hematopoietic stem cell transplantation (allo-HSCT) is a common procedure in hematological disorders and is preceded by a conditioning regimen that usually includes busulfan. The immunosuppression caused by the conditioning regimen and graft-versus-host disease prophylaxis is associated with human ...

journal_title：Cancer cytopathology

authors： Saco A,Alòs S,Esteve R,Suárez-Lledó M,Martínez C,Perez FM,Vega N,Martí C,Torne A,Ordi J,Del Pino M

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Although thyroid fine-needle aspiration (TFNA) is an excellent test in evaluating thyroid nodules, there are occasionally false negatives (FN). The clinical impact and pathologic features of FN TFNA is understudied in the peer-reviewed literature. METHODS:A cohort of patients with thyroid cancer was separat...

journal_title：Cancer cytopathology

authors： Jean-Gilles J,Fischer AH,Luu MH,Owens CL

更新日期：2012-10-25 00:00:00

abstract：:Cervical cancer and anal cancer share many similarities including causation by oncogenic human papillomaviruses; however, significant differences exist in their epidemiology, risk factors, biologic behavior, management, and treatment. Although rare, the incidence of anal cancer is alarmingly high and continues to incr...

journal_title：Cancer cytopathology

authors： Darragh TM,Winkler B

更新日期：2011-02-25 00:00:00

abstract：BACKGROUND:Recommendations regarding how many nodules to biopsy with thyroid fine-needle aspiration vary. METHODS:The authors reviewed fine-needle aspiration specimens of 12,763 nodules from 10,506 patients and correlated them with the number of nodules biopsied. RESULTS:Compared with patients in whom only a single n...

journal_title：Cancer cytopathology

authors： Renshaw AA,Gould EW

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The Paris System (TPS) for Reporting Urinary Cytology aims to standardize urine cytology reporting. Per TPS, the diagnosis of "suspicious for high-grade urothelial carcinoma (SHGUC)" is applied in cases that have few urothelial cells with severe atypia but are quantitatively insufficient for a diagnosis of "...

journal_title：Cancer cytopathology

authors： Nguyen L,Nilforoushan N,Krane JF,Bose S,Bakkar R

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Urinary tract cytology (UTC) specimens diagnosed using high-risk indeterminate categories such as "atypical urothelial cells, cannot exclude high-grade urothelial carcinoma" (AUC-H) or "suspicious for high-grade urothelial carcinoma" (SHGUC) have a high rate of detection of high-grade urothelial carcinoma on...

journal_title：Cancer cytopathology

authors： Fite JJ,Rosenthal DL,VandenBussche CJ

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:New developments in the treatment of lung cancer have necessitated the further histologic and cytologic subtyping of nonsmall cell lung carcinomas. Thyroid transcription factor-1 (TTF-1) long has served as the predominant marker for demonstrating lung origin. However, it is also expressed in a variety of oth...

journal_title：Cancer cytopathology

authors： Stoll LM,Johnson MW,Gabrielson E,Askin F,Clark DP,Li QK

更新日期：2010-12-25 00:00:00

abstract：BACKGROUND:More accurate biomarkers in cervical cytology screening could reduce the number of women unnecessarily referred for biopsy. This study investigated the ability of p16/Ki-67 dual staining to predict high-grade cervical intraepithelial neoplasia (CIN) in human papillomavirus (HPV)-positive women from the Norwe...

journal_title：Cancer cytopathology

authors： Ovestad IT,Dalen I,Hansen E,Loge JL,Dybdahl BM,Dirdal MB,Moltu P,Berland JM

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:The newly unveiled Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has proposed salivary gland neoplasm of uncertain malignant potential (SUMP) as an indeterminate category. The category is reserved for fine-needle aspiration (FNA) cases that are diagnostic of a salivary gland neoplasm but c...

journal_title：Cancer cytopathology

authors： Hang JF,Alruwaii F,Zeng BR,Lai CR,Wu HH

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:The accumulation of cyclin-dependent kinase inhibitor 2A (p16ink4a ) protein in a cell is associated with neoplastic progression in precancerous cervical lesions. Dual staining for p16ink4a and Ki-67 has been proposed as a triage test in cervical cancer screening for women who test positive for human papillo...

journal_title：Cancer cytopathology

authors： Benevolo M,Allia E,Gustinucci D,Rollo F,Bulletti S,Cesarini E,Passamonti B,Giovagnoli MR,Carico E,Carozzi FM,Mongia A,Fantacci G,Confortini M,Rubino T,Fodero C,Prandi S,Marchi N,Farruggio A,Coccia A,Macrì L,Ghirin

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Patients with low-grade urothelial carcinoma (LGUC) are at risk of recurrence and must undergo lifelong surveillance. To date, cytology and cystoscopy are the gold standard for the detection of de novo and recurrent LGUC. The objective of the current study was is to further characterize the role of cytology ...

journal_title：Cancer cytopathology

authors： Jackson J,Barkan GA,Kapur U,Wojcik EM

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:The availability of suitable biospecimens is critical to the success of advanced genomic analyses. The objective of this study was to assess the sensitivity of fine-needle aspiration (FNA) compared with gross surgical sampling (GSS) from surgical specimens for the detection of somatic mutations in breast can...

journal_title：Cancer cytopathology

authors： Lee HB,Joung JG,Kim J,Lee KM,Ryu HS,Lee HO,Moon HG,Park WY,Noh DY,Han W

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:The objective of this study was to assess how atypical diagnostic category (ADC) is followed up, its outcomes, and the predictors that are associated with subsequent diagnosis of neoplasm/malignancy. METHODS:We reviewed pancreatic endoscopic ultrasound fine-needle aspiration (EUS-FNA) with ADC and compared ...

journal_title：Cancer cytopathology

authors： Alston E,Bae S,Eltoum IA

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Current immunohistochemical and in situ hybridization (ISH) assays are generally inconclusive for clonality unless plasmacytic differentiation is present. This study examined a series of cytology specimens and explored the ability of a branched-chain RNA (bRNA) ISH assay for immunoglobulin κ constant (IGKC) ...

journal_title：Cancer cytopathology

authors： Arora K,Chebib I,Zukerberg L,Gandhi M,Rivera M,Ting D,Deshpande V

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Fluorescence in situ hybridization (FISH) is routinely used to help clarify atypical urinary cytology. However, to the authors' knowledge, little is known regarding the frequency of chromosomal aberrations in non-neoplastic conditions that could potentially lead to false-positive FISH results. The objective ...

journal_title：Cancer cytopathology

authors： Tapia C,Glatz K,Obermann EC,Grilli B,Barascud A,Herzog M,Schönegg R,Savic S,Bubendorf L

更新日期：2011-12-25 00:00:00

abstract：BACKGROUND:The usefulness of GATA3 (GATA-binding protein 3 to DNA sequence [A/T]GATA[A/G]) as a marker for metastatic breast carcinoma in serous effusion specimens was investigated. METHODS:Cell block sections from 74 serous effusion specimens (32 ascitic, 2 pericardial, and 40 pleural fluids) were stained with an ant...

journal_title：Cancer cytopathology

authors： Shield PW,Papadimos DJ,Walsh MD

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:The workup of a malignant effusion usually requires immunostaining with a panel of markers. Although nuclear Wilms tumor 1 (WT1) expression is widely used to detect tumors of ovarian and mesothelial origin, it is less well known that WT1 is also expressed in the cytoplasm of melanomas and mesenchymal tumors....

journal_title：Cancer cytopathology

authors： Conner JR,Cibas ES,Hornick JL,Qian X

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:The Bethesda System for Reporting Thyroid Cytopathology category of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) includes fine-needle aspiration (FNA) specimens that cannot straightforwardly be classified as benign or malignant. To determine whether morphologi...

journal_title：Cancer cytopathology

authors： Bellevicine C,Sgariglia R,Migliatico I,Vigliar E,D'Anna M,Nacchio MA,Serra N,Malapelle U,Bongiovanni M,Troncone G

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Much of the reluctance about using cytology specimens rather than histology specimens to assess programmed death ligand 1 (PD-L1) expression for guiding the use of immune modulating drugs in the management of non-small cell lung cancer (NSCLC) is based on the belief that the alcohol-based fixatives favored b...

journal_title：Cancer cytopathology

authors： Gosney JR,Haragan A,Chadwick C,Giles TE,Grundy S,Tippett V,Gumparthy KP,Wight A,Tan HG

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Transbronchial needle aspiration (TBNA) of peripheral lung nodules can be difficult with conventional devices due to their limited flexibility. A promising new technology for accessing these lesions is the PeriView FLEX TBNA device, which has a flexible spiral-grooved needle. The present study reports the un...

journal_title：Cancer cytopathology

authors： Naso J,Bras J,Villamil C,Ionescu DN,Wang G,Shaipanich T,Beaudoin EL,Myers R,Lam S,Zhou C

更新日期：2020-05-01 00:00:00