Abstract:
BACKGROUND:The newly unveiled Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has proposed salivary gland neoplasm of uncertain malignant potential (SUMP) as an indeterminate category. The category is reserved for fine-needle aspiration (FNA) cases that are diagnostic of a salivary gland neoplasm but cannot be further designated as a specific tumor type. The objective of the current study was to evaluate the clinical utility of subtyping SUMP cases based on different cell types. METHODS:A retrospective search of cytology databases at 2 institutions for salivary gland FNAs from 2006 through 2017 was conducted. The cytologic diagnosis of each case was reclassified according to the MSRSGC. Histologic follow-up was retrieved for correlation. Cases reclassified as SUMP that had a follow-up pathologic diagnosis were subject to cytology review and subtyping into oncocytic/squamoid, basaloid, or myoepithelial subtypes based on cytomorphology. The risk of malignancy (ROM) for each subtype was analyzed. RESULTS:There were 92 SUMP cases, which comprised 5.9% of 1560 consecutive salivary gland FNAs within the 12-year study period. Histologic follow-up was available for 59 patients. After cytology review, there were 18 cases (30.5%) of oncocytic/squamoid subtype, 25 (42.4%) of basaloid subtype, and 16 (27.1%) of myoepithelial subtype. Pathologic correlation revealed an ROM of 61.1% (11 of 18 cases) for the oncocytic/squamoid subtype, 40.0% (10 of 25 cases) for the basaloid subtype, and 18.8% (3 of 16 cases) for the myoepithelial subtype. The differences in ROM among the 3 subtypes were statistically significant (P = .0476). CONCLUSIONS:Subtyping SUMP cases into categories based on cell type demonstrated differential ROMs for better clinical stratification. Future prospective studies are mandatory to confirm this finding.
journal_name
Cancer Cytopatholjournal_title
Cancer cytopathologyauthors
Hang JF,Alruwaii F,Zeng BR,Lai CR,Wu HHdoi
10.1002/cncy.22066subject
Has Abstractpub_date
2018-11-01 00:00:00pages
924-933issue
11eissn
1934-662Xissn
1934-6638journal_volume
126pub_type
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journal_title:Cancer cytopathology
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journal_title:Cancer cytopathology
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journal_title:Cancer cytopathology
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journal_title:Cancer cytopathology
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journal_title:Cancer cytopathology
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journal_title:Cancer cytopathology
pub_type: 杂志文章,meta分析,评审
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journal_title:Cancer cytopathology
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更新日期:2017-04-01 00:00:00
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journal_title:Cancer cytopathology
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pub_type: 杂志文章
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journal_title:Cancer cytopathology
pub_type: 杂志文章,随机对照试验
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更新日期:2012-04-25 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Cancer cytopathology
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journal_title:Cancer cytopathology
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