Programmed death ligand 1 expression in EBUS aspirates of non-small cell lung cancer: Is interpretation affected by type of fixation?

abstract：:An increasing number of renal cell carcinomas (RCCs) require ancillary studies for diagnosis. The majority of renal fine needle aspirates do not require ancillary studies. Among the most common useful stains are cytokeratin 7 (separating clear cell RCC [negative] from papillary RCC, clear cell papillary RCC, and multi...

journal_title：Cancer cytopathology

authors： Renshaw AA,Gould EW

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:BRAF mutations are highly specific for papillary thyroid carcinoma (PTC) and many cytology specimens with BRAF mutations are expected to demonstrate cytologic features typical of PTC. However, indeterminate thyroid cytology cases are inevitable and understanding the significance of the BRAF mutation within t...

journal_title：Cancer cytopathology

authors： Ohori NP,Singhal R,Nikiforova MN,Yip L,Schoedel KE,Coyne C,McCoy KL,LeBeau SO,Hodak SP,Carty SE,Nikiforov YE

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Patients with low-grade urothelial carcinoma (LGUC) are at risk of recurrence and must undergo lifelong surveillance. To date, cytology and cystoscopy are the gold standard for the detection of de novo and recurrent LGUC. The objective of the current study was is to further characterize the role of cytology ...

journal_title：Cancer cytopathology

authors： Jackson J,Barkan GA,Kapur U,Wojcik EM

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:More accurate biomarkers in cervical cytology screening could reduce the number of women unnecessarily referred for biopsy. This study investigated the ability of p16/Ki-67 dual staining to predict high-grade cervical intraepithelial neoplasia (CIN) in human papillomavirus (HPV)-positive women from the Norwe...

journal_title：Cancer cytopathology

authors： Ovestad IT,Dalen I,Hansen E,Loge JL,Dybdahl BM,Dirdal MB,Moltu P,Berland JM

更新日期：2017-04-01 00:00:00

abstract：:Two-thirds of neuroendocrine neoplasms arising in the human body originate from the gastrointestinal system or pancreas. Gastroenteropancreatic neuroendocrine neoplasms are heterogeneous, comprising both well differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). The cl...

journal_title：Cancer cytopathology

authors： Sigel CS

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Recommendations regarding how many nodules to biopsy with thyroid fine-needle aspiration vary. METHODS:The authors reviewed fine-needle aspiration specimens of 12,763 nodules from 10,506 patients and correlated them with the number of nodules biopsied. RESULTS:Compared with patients in whom only a single n...

journal_title：Cancer cytopathology

authors： Renshaw AA,Gould EW

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The authors conducted an analysis of 2 telepathology systems with different resolutions to determine how resolution affects the pathologists' ability to provide preliminary diagnoses for fine-needle aspirations (FNA). METHODS:FNA cases evaluated by telepathology between February 1, 2011 and January 18, 2012...

journal_title：Cancer cytopathology

authors： McMahon RQ,McCarthy EE,Hetzel SJ,Das K,Stewart J 3rd

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Current immunohistochemical and in situ hybridization (ISH) assays are generally inconclusive for clonality unless plasmacytic differentiation is present. This study examined a series of cytology specimens and explored the ability of a branched-chain RNA (bRNA) ISH assay for immunoglobulin κ constant (IGKC) ...

journal_title：Cancer cytopathology

authors： Arora K,Chebib I,Zukerberg L,Gandhi M,Rivera M,Ting D,Deshpande V

更新日期：2016-03-01 00:00:00

abstract：:In diagnostic cytology, the known site-specific false positive rates at various anatomical sites for the risk malignancy (ROM) when a confirmed malignant diagnosis is made are comparatively well documented. ROM figures for diagnostic cytology specimens may vary according to the anatomical site of the specimen, the exa...

journal_title：Cancer cytopathology

authors： Poller DN,Schmitt F

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Mutations of AT-rich interactive domain 1 (ARID1A) have been associated with a worse outcome after intravesical treatment with bacille Calmette-Guérin in patients with non-muscle-invasive bladder cancer (NMIBC). Loss of ARID1A protein expression in urine cytology may serve as an indication of an ARID1A mutat...

journal_title：Cancer cytopathology

authors： Dugas SG,Müller DC,Le Magnen C,Federer-Gsponer J,Seifert HH,Ruiz C,Savic Prince S,Vlajnic T,Zellweger T,Mertz KD,Bacon JVW,Wyatt AW,Rentsch CA,Bubendorf L

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Angiomyolipoma (AML), typically composed of smooth muscle, vessels, and fat, is generally a benign tumor in the kidneys. However, it occasionally occurs in extrarenal sites and behaves like a malignant tumor. AML is uncommonly encountered in fine-needle aspiration (FNA) samples and can cause diagnostic diffi...

journal_title：Cancer cytopathology

authors： Zhou H,Guo M,Gong Y

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Homozygous deletion of 9p21 detected by fluorescence in situ hybridization (FISH) and loss of BRCA1-associated protein 1 (BAP1) expression detected by immunohistochemistry (IHC) are useful for the differentiation between malignant pleural mesothelioma (MPM) and reactive mesothelial hyperplasia. The authors p...

journal_title：Cancer cytopathology

authors： Kinoshita Y,Hida T,Hamasaki M,Matsumoto S,Sato A,Tsujimura T,Kawahara K,Hiroshima K,Oda Y,Nabeshima K

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Fine-needle aspiration (FNA) is widely accepted in the preoperative management of salivary gland lesions. The proposed Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) aims to standardize reporting terminology. Studies regarding the risk of malignancy (ROM) for the proposed categories continu...

journal_title：Cancer cytopathology

authors： Viswanathan K,Sung S,Scognamiglio T,Yang GCH,Siddiqui MT,Rao RA

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Second-opinion diagnosis (SOD) on pathological material is an accepted practice before definitive therapy is considered for referred patients. The thyroid gland is an anatomical site prone to diagnostic disagreement between pathologists. We performed a review of the literature that addressed the role of inte...

journal_title：Cancer cytopathology

authors： Gerhard R,Boerner SL

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Urinary tract cytology (UTC) specimens diagnosed using high-risk indeterminate categories such as "atypical urothelial cells, cannot exclude high-grade urothelial carcinoma" (AUC-H) or "suspicious for high-grade urothelial carcinoma" (SHGUC) have a high rate of detection of high-grade urothelial carcinoma on...

journal_title：Cancer cytopathology

authors： Fite JJ,Rosenthal DL,VandenBussche CJ

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:High-risk human papillomavirus (hrHPV) DNA detection is generally accepted for the triage of women with a cytologic diagnosis of atypical squamous cells of undetermined significance (ASC-US). However, no consensus has been reached on the optimal management of low-grade squamous intraepithelial lesions (LSIL)...

journal_title：Cancer cytopathology

authors： Verdoodt F,Szarewski A,Halfon P,Cuschieri K,Arbyn M

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Undifferentiated carcinoma (UC) is a rare, aggressive subtype of endometrial carcinoma. Dedifferentiated carcinomas (DCs) are UCs associated with a component of well differentiated endometrioid carcinoma. The authors sought to describe the morphologic features of UCs and DCs in cytologic specimens. METHODS:...

journal_title：Cancer cytopathology

authors： Akbari AH,Wang L,Soslow RA,Murali R

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:In the United States, the rate of cervical cancer is disproportionally higher in Hispanic and Black women compared with White women. In the current study, the authors compared human papillomavirus (HPV) testing and cytology results among Black and White women over a 24-month period. They then assessed the ra...

journal_title：Cancer cytopathology

authors： Miller D,Morris CP,Maleki Z,White M,Rodriguez EF

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:The Paris System (TPS) for Reporting Urinary Cytology aims to standardize urine cytology reporting. Per TPS, the diagnosis of "suspicious for high-grade urothelial carcinoma (SHGUC)" is applied in cases that have few urothelial cells with severe atypia but are quantitatively insufficient for a diagnosis of "...

journal_title：Cancer cytopathology

authors： Nguyen L,Nilforoushan N,Krane JF,Bose S,Bakkar R

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Tumor spread through air spaces (STAS), a significant prognostic indicator, has been described recently as a pattern of invasion in pulmonary carcinomas. However, questions remain regarding preoperative identification of STAS and whether it represents an in vivo phenomenon versus an ex vivo artifact. METHOD...

journal_title：Cancer cytopathology

authors： Medina MA,Onken AM,de Margerie-Mellon C,Heidinger BH,Chen Y,Bankier AA,VanderLaan PA

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Personalized oncology requires molecular analysis of tumor cells. Several studies have demonstrated that cytological material is suitable for DNA analysis, but to the authors' knowledge there are no systematic studies comparing how the yield and quality of extracted DNA is affected by the various techniques ...

journal_title：Cancer cytopathology

authors： Dejmek A,Zendehrokh N,Tomaszewska M,Edsjö A

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Allogenic hematopoietic stem cell transplantation (allo-HSCT) is a common procedure in hematological disorders and is preceded by a conditioning regimen that usually includes busulfan. The immunosuppression caused by the conditioning regimen and graft-versus-host disease prophylaxis is associated with human ...

journal_title：Cancer cytopathology

authors： Saco A,Alòs S,Esteve R,Suárez-Lledó M,Martínez C,Perez FM,Vega N,Martí C,Torne A,Ordi J,Del Pino M

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:The sensitivity of conventional cytology for the detection of malignant cells in pleural effusion is insufficient. GLUT1 and CAIX are the hallmarks of metabolic change in cancer cells. The aim of this study was to evaluate the usefulness of GLUT1 and CAIX expression to the detection of cancer cells in pleura...

journal_title：Cancer cytopathology

authors： Liao ND,Shieh JM,Lee WY

更新日期：2011-10-25 00:00:00

abstract：BACKGROUND:Transbronchial needle aspiration (TBNA) of peripheral lung nodules can be difficult with conventional devices due to their limited flexibility. A promising new technology for accessing these lesions is the PeriView FLEX TBNA device, which has a flexible spiral-grooved needle. The present study reports the un...

journal_title：Cancer cytopathology

authors： Naso J,Bras J,Villamil C,Ionescu DN,Wang G,Shaipanich T,Beaudoin EL,Myers R,Lam S,Zhou C

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Epithelioid sarcoma (ES) is a rare mesenchymal tumor that is divided into 2 types: classic and proximal. To the authors' knowledge, ES has been poorly studied in cytology, with fewer than 50 cases reported to date. The objective of the current study was to analyze the cytological and immunohistochemical info...

journal_title：Cancer cytopathology

authors： Gajdzis P,Laé M,Klijanienko J

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:The 2007 Bethesda classification for thyroid cytology defines follicular neoplasm as a category of cases with cellular specimens demonstrating abundant follicular cells arranged in a microfollicular pattern with little or no colloid. The current recommendation for the management of these cases is diagnostic ...

journal_title：Cancer cytopathology

authors： Ustun B,Chhieng D,Van Dyke A,Carling T,Holt E,Udelsman R,Adeniran AJ

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:The Paris System for Reporting Urinary Cytology (TPS) defines clear morphologic criteria to classify urinary specimens into 7 diagnostic categories. According to TPS, a nuclear-to-cytoplasmic ratio (N:C ratio) >0.7 and hyperchromasia must be observed to render a diagnosis of high-grade urothelial carcinoma (...

journal_title：Cancer cytopathology

authors： Richardson CJ,Pambuccian SE,Barkan GA

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Diagnosing giant cell-rich bone tumors can be challenging on limited biopsies. H3 histone family member 3A (H3F3A) (G34W/V/R/L) mutations are present in the majority of giant cell tumors (GCTs) of bone and H3 histone family member 3B (H3F3B) (K36M) mutations are present in nearly all chondroblastomas, but ar...

journal_title：Cancer cytopathology

authors： Schaefer IM,Fletcher JA,Nielsen GP,Shih AR,Ferrone ML,Hornick JL,Qian X

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Urine cytology results that are suspicious for urothelial carcinoma (UC) are challenging. The objective of this study was to elucidate the clinical significance of such results in patients who have a negative cystoscopy. METHODS:In this prospective study, 83 patients who had urine cytology that was suspicio...

journal_title：Cancer cytopathology

authors： Montalbo R,Izquierdo L,Ingelmo-Torres M,Galve P,Solé M,Franco A,Ribal MJ,Alcaraz A,Mengual L

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Limited studies have examined the impact of the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) and specifically the category of atypia or follicular lesion of undetermined significance (AUS/FLUS). We studied their effects on reporting rates, subsequent management, and surgical outcome over a 10-...

journal_title：Cancer cytopathology

authors： Sullivan PS,Hirschowitz SL,Fung PC,Apple SK

更新日期：2014-12-01 00:00:00