Cytologic features and diagnostic value of PeriView FLEX transbronchial needle aspiration targeting pulmonary nodules.

abstract：:The evaluation of mediastinal and hilar lymph nodes for tissue diagnosis and staging of lung cancer is now commonly performed by minimally invasive, nonsurgical procedures such as computed tomography-guided fine-needle aspiration and endobronchial ultrasound-guided transbronchial needle aspiration. Ensuring that a suf...

journal_title：Cancer cytopathology

authors： da Cunha Santos G,Boerner SL,Geddie WR

更新日期：2011-12-25 00:00:00

abstract：BACKGROUND:The sensitivity of conventional cytology for the detection of malignant cells in pleural effusion is insufficient. GLUT1 and CAIX are the hallmarks of metabolic change in cancer cells. The aim of this study was to evaluate the usefulness of GLUT1 and CAIX expression to the detection of cancer cells in pleura...

journal_title：Cancer cytopathology

authors： Liao ND,Shieh JM,Lee WY

更新日期：2011-10-25 00:00:00

abstract：BACKGROUND:Fluorescence in situ hybridization (FISH) to identify specific DNA target sequences in the nuclei of nondividing cells of numerous solid neoplasms has contributed to the introduction of molecular cytogenetics as a useful adjunct to cytology, leading recently to the "marriage" of the 2 disciplines. Numerous c...

journal_title：Cancer cytopathology

authors： Caria P,Frau DV,Dettori T,Boi F,Lai ML,Mariotti S,Vanni R

更新日期：2014-05-01 00:00:00

abstract：:A pediatric cytopathology symposium was held at the recent 20th International Congress of Cytology, which convened in Sydney, Australia, in May 2019. This educational event brought together cytopathologists from different countries and different institutions to discuss some of the practical considerations when applyin...

journal_title：Cancer cytopathology

authors： Monaco SE,Baloch ZW,Rossi ED,Teot LA,Wright C

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Liquid-based cytology (LBC) is a useful cytopathological method, and LBC lung adenocarcinoma specimens may be used for genetic analysis in the near future. In the current study, the authors determined whether LBC specimens can be used for epidermal growth factor receptor (EGFR) mutation analysis in human lun...

journal_title：Cancer cytopathology

authors： Matsuo Y,Yoshida T,Yamashita K,Satoh Y

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Tumor spread through air spaces (STAS), a significant prognostic indicator, has been described recently as a pattern of invasion in pulmonary carcinomas. However, questions remain regarding preoperative identification of STAS and whether it represents an in vivo phenomenon versus an ex vivo artifact. METHOD...

journal_title：Cancer cytopathology

authors： Medina MA,Onken AM,de Margerie-Mellon C,Heidinger BH,Chen Y,Bankier AA,VanderLaan PA

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Patients with low-grade urothelial carcinoma (LGUC) are at risk of recurrence and must undergo lifelong surveillance. To date, cytology and cystoscopy are the gold standard for the detection of de novo and recurrent LGUC. The objective of the current study was is to further characterize the role of cytology ...

journal_title：Cancer cytopathology

authors： Jackson J,Barkan GA,Kapur U,Wojcik EM

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Fluorescence in situ hybridization (FISH) is routinely used to help clarify atypical urinary cytology. However, to the authors' knowledge, little is known regarding the frequency of chromosomal aberrations in non-neoplastic conditions that could potentially lead to false-positive FISH results. The objective ...

journal_title：Cancer cytopathology

authors： Tapia C,Glatz K,Obermann EC,Grilli B,Barascud A,Herzog M,Schönegg R,Savic S,Bubendorf L

更新日期：2011-12-25 00:00:00

abstract：BACKGROUND:Allogenic hematopoietic stem cell transplantation (allo-HSCT) is a common procedure in hematological disorders and is preceded by a conditioning regimen that usually includes busulfan. The immunosuppression caused by the conditioning regimen and graft-versus-host disease prophylaxis is associated with human ...

journal_title：Cancer cytopathology

authors： Saco A,Alòs S,Esteve R,Suárez-Lledó M,Martínez C,Perez FM,Vega N,Martí C,Torne A,Ordi J,Del Pino M

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Angiomyolipoma (AML), typically composed of smooth muscle, vessels, and fat, is generally a benign tumor in the kidneys. However, it occasionally occurs in extrarenal sites and behaves like a malignant tumor. AML is uncommonly encountered in fine-needle aspiration (FNA) samples and can cause diagnostic diffi...

journal_title：Cancer cytopathology

authors： Zhou H,Guo M,Gong Y

更新日期：2017-04-01 00:00:00

abstract：:Cervical cancer and anal cancer share many similarities including causation by oncogenic human papillomaviruses; however, significant differences exist in their epidemiology, risk factors, biologic behavior, management, and treatment. Although rare, the incidence of anal cancer is alarmingly high and continues to incr...

journal_title：Cancer cytopathology

authors： Darragh TM,Winkler B

更新日期：2011-02-25 00:00:00

abstract：:The American Society of Cytopathology has provided guidelines for goals and objectives for cytopathology fellows. There are 90 Accreditation Council for Graduate Medical Education-accredited cytopathology fellowship training programs in the United States, each with its own unique curriculum designed to achieve these g...

journal_title：Cancer cytopathology

authors： Naritoku WY,Black-Schaffer WS

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Fine-needle aspiration (FNA) is widely accepted in the preoperative management of salivary gland lesions. The proposed Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) aims to standardize reporting terminology. Studies regarding the risk of malignancy (ROM) for the proposed categories continu...

journal_title：Cancer cytopathology

authors： Viswanathan K,Sung S,Scognamiglio T,Yang GCH,Siddiqui MT,Rao RA

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Although thyroid fine-needle aspiration (TFNA) is an excellent test in evaluating thyroid nodules, there are occasionally false negatives (FN). The clinical impact and pathologic features of FN TFNA is understudied in the peer-reviewed literature. METHODS:A cohort of patients with thyroid cancer was separat...

journal_title：Cancer cytopathology

authors： Jean-Gilles J,Fischer AH,Luu MH,Owens CL

更新日期：2012-10-25 00:00:00

abstract：BACKGROUND:Urinary tract cytology (UTC) specimens diagnosed using high-risk indeterminate categories such as "atypical urothelial cells, cannot exclude high-grade urothelial carcinoma" (AUC-H) or "suspicious for high-grade urothelial carcinoma" (SHGUC) have a high rate of detection of high-grade urothelial carcinoma on...

journal_title：Cancer cytopathology

authors： Fite JJ,Rosenthal DL,VandenBussche CJ

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Fine-needle aspiration biopsy of spindled mesenchymal lesions, including schwannomas, are challenging because of overlapping cytomorphological features. The objective of the current study was to identify key diagnostic cytological criteria for the diagnosis of schwannoma and to distinguish it from its common...

journal_title：Cancer cytopathology

authors： Chebib I,Hornicek FJ,Nielsen GP,Deshpande V

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Limited studies have examined the impact of the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) and specifically the category of atypia or follicular lesion of undetermined significance (AUS/FLUS). We studied their effects on reporting rates, subsequent management, and surgical outcome over a 10-...

journal_title：Cancer cytopathology

authors： Sullivan PS,Hirschowitz SL,Fung PC,Apple SK

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Second-opinion diagnosis (SOD) on pathological material is an accepted practice before definitive therapy is considered for referred patients. The thyroid gland is an anatomical site prone to diagnostic disagreement between pathologists. We performed a review of the literature that addressed the role of inte...

journal_title：Cancer cytopathology

authors： Gerhard R,Boerner SL

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:BRAF mutations are highly specific for papillary thyroid carcinoma (PTC) and many cytology specimens with BRAF mutations are expected to demonstrate cytologic features typical of PTC. However, indeterminate thyroid cytology cases are inevitable and understanding the significance of the BRAF mutation within t...

journal_title：Cancer cytopathology

authors： Ohori NP,Singhal R,Nikiforova MN,Yip L,Schoedel KE,Coyne C,McCoy KL,LeBeau SO,Hodak SP,Carty SE,Nikiforov YE

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Adequacy assessment is one of the most controversial and overlooked components in the daily practice of cytopathology, because it is generally determined from limited samples. Because voided urine varies widely in terms of its volume and cellularity, there is little consensus about the proper role for these ...

journal_title：Cancer cytopathology

authors： VandenBussche CJ,Rosenthal DL,Olson MT

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:The Bethesda System for Reporting Thyroid Cytopathology category of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) includes fine-needle aspiration (FNA) specimens that cannot straightforwardly be classified as benign or malignant. To determine whether morphologi...

journal_title：Cancer cytopathology

authors： Bellevicine C,Sgariglia R,Migliatico I,Vigliar E,D'Anna M,Nacchio MA,Serra N,Malapelle U,Bongiovanni M,Troncone G

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Current immunohistochemical and in situ hybridization (ISH) assays are generally inconclusive for clonality unless plasmacytic differentiation is present. This study examined a series of cytology specimens and explored the ability of a branched-chain RNA (bRNA) ISH assay for immunoglobulin κ constant (IGKC) ...

journal_title：Cancer cytopathology

authors： Arora K,Chebib I,Zukerberg L,Gandhi M,Rivera M,Ting D,Deshpande V

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:The 2007 Bethesda classification for thyroid cytology defines follicular neoplasm as a category of cases with cellular specimens demonstrating abundant follicular cells arranged in a microfollicular pattern with little or no colloid. The current recommendation for the management of these cases is diagnostic ...

journal_title：Cancer cytopathology

authors： Ustun B,Chhieng D,Van Dyke A,Carling T,Holt E,Udelsman R,Adeniran AJ

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Fluorescent in situ hybridization (FISH) analysis of urine samples has proven to be a valuable adjunctive test to urine cytology for both diagnosis and monitoring recurrence of urothelial carcinoma. Automated FISH analysis has the potential to improve laboratory efficiency and to reduce interobserver and int...

journal_title：Cancer cytopathology

authors： Marganski WA,El-Sirgany Costa V,Kilpatrick MW,Tafas T,Yim J,Matthews M

更新日期：2011-08-25 00:00:00

abstract：BACKGROUND:Antigen retrieval, a crucial technique for immunostaining, is often carried out on formalin-fixed, paraffin-embedded (FFPE) tissue sections. The role of antigen retrieval in immunostaining of ethanol-fixed smears remains unclear. The authors evaluated the effects of 2 common antigen retrieval procedures, hea...

journal_title：Cancer cytopathology

authors： Denda T,Kamoshida S,Kawamura J,Harada K,Kawai K,Kuwao S

更新日期：2012-06-25 00:00:00

abstract：BACKGROUND:Mutations of AT-rich interactive domain 1 (ARID1A) have been associated with a worse outcome after intravesical treatment with bacille Calmette-Guérin in patients with non-muscle-invasive bladder cancer (NMIBC). Loss of ARID1A protein expression in urine cytology may serve as an indication of an ARID1A mutat...

journal_title：Cancer cytopathology

authors： Dugas SG,Müller DC,Le Magnen C,Federer-Gsponer J,Seifert HH,Ruiz C,Savic Prince S,Vlajnic T,Zellweger T,Mertz KD,Bacon JVW,Wyatt AW,Rentsch CA,Bubendorf L

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:The primary goal of this study was to compare the clinical performance of an optimized and rigorously controlled immunocytochemical (ICC) assay for p16(INK4a) to high-risk (HR) human papillomavirus (HPV) detection by polymerase chain reaction (PCR) as diagnostic adjuncts for cytology specimens from colposcop...

journal_title：Cancer cytopathology

authors： Samarawardana P,Dehn DL,Singh M,Franquemont D,Thompson C,Gaido L,Torkko KC,Homer P,Burke S,Titmus MA,Nayi V,Shroyer KR

更新日期：2010-06-25 00:00:00

abstract：BACKGROUND:Mantle cell lymphoma (MCL) demonstrates cytologic features that overlap with those of other types of B-cell non-Hodgkin lymphomas (B-cell NHLs) containing small to medium-sized cells. The accurate diagnosis of MCL is important because MCL has relatively more aggressive biologic behavior and thus requires spe...

journal_title：Cancer cytopathology

authors： Zhang YH,Liu J,Dawlett M,Guo M,Sun X,Gong Y

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:The availability of suitable biospecimens is critical to the success of advanced genomic analyses. The objective of this study was to assess the sensitivity of fine-needle aspiration (FNA) compared with gross surgical sampling (GSS) from surgical specimens for the detection of somatic mutations in breast can...

journal_title：Cancer cytopathology

authors： Lee HB,Joung JG,Kim J,Lee KM,Ryu HS,Lee HO,Moon HG,Park WY,Noh DY,Han W

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Much of the reluctance about using cytology specimens rather than histology specimens to assess programmed death ligand 1 (PD-L1) expression for guiding the use of immune modulating drugs in the management of non-small cell lung cancer (NSCLC) is based on the belief that the alcohol-based fixatives favored b...

journal_title：Cancer cytopathology

authors： Gosney JR,Haragan A,Chadwick C,Giles TE,Grundy S,Tippett V,Gumparthy KP,Wight A,Tan HG

更新日期：2020-02-01 00:00:00