EGFR and KRAS mutations in lung carcinoma: molecular testing by using cytology specimens.

abstract：BACKGROUND:Although thyroid fine-needle aspiration (TFNA) is an excellent test in evaluating thyroid nodules, there are occasionally false negatives (FN). The clinical impact and pathologic features of FN TFNA is understudied in the peer-reviewed literature. METHODS:A cohort of patients with thyroid cancer was separat...

journal_title：Cancer cytopathology

authors： Jean-Gilles J,Fischer AH,Luu MH,Owens CL

更新日期：2012-10-25 00:00:00

abstract：BACKGROUND:Much of the reluctance about using cytology specimens rather than histology specimens to assess programmed death ligand 1 (PD-L1) expression for guiding the use of immune modulating drugs in the management of non-small cell lung cancer (NSCLC) is based on the belief that the alcohol-based fixatives favored b...

journal_title：Cancer cytopathology

authors： Gosney JR,Haragan A,Chadwick C,Giles TE,Grundy S,Tippett V,Gumparthy KP,Wight A,Tan HG

更新日期：2020-02-01 00:00:00

abstract：:The recent emergence of immune checkpoint inhibitors for cancer therapy has created much excitement among cancer patients, drug and diagnostic developers, and health care professionals. This is due largely to the dramatic and sustained responses among some advanced cancers that were previously refractory to therapy. U...

journal_title：Cancer cytopathology

authors： Clark DP

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:In pediatric patients, a cutaneous nodule is usually diagnosed by performing an excisional biopsy, but fine-needle cytology (FNC) is a safer and noninvasive diagnostic method widely used to obtain diagnostic specimens with little stress to the patient. The authors compared the ability of FNC and biopsy to di...

journal_title：Cancer cytopathology

authors： Fassina A,Olivotto A,Cappellesso R,Vendraminelli R,Fassan M

更新日期：2011-04-25 00:00:00

abstract：BACKGROUND:The objective of this study was to evaluate the diagnostic accuracy of the Bladder EpiCheck test in the follow-up of patients with non-muscle-invasive bladder cancer (NMIBC) and to compare it with the accuracy of urinary cytology, cystoscopy, and/or histology. METHODS:In total, 243 patients were enrolled in...

journal_title：Cancer cytopathology

authors： Trenti E,D'Elia C,Mian C,Schwienbacher C,Hanspeter E,Pycha A,Kafka M,Degener S,Danuser H,Roth S,Pycha A

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Human papillomavirus (HPV) tests and genotyping have been used in clinical risk assessment. The purpose of this study was to analyze the performance of 2 common HPV testing platforms in detecting high-grade cervical lesions (high-grade squamous intraepithelial lesion [HSIL] or worse [≥HSIL]). METHODS:Betwee...

journal_title：Cancer cytopathology

authors： Ge Y,Christensen P,Luna E,Armylagos D,Schwartz MR,Mody DR

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Accurate fine-needle aspiration (FNA) diagnosis of metastatic melanoma is of therapeutic and prognostic significance and often requires ancillary studies. To the authors' knowledge, the reliability of immunostaining using a pan-melanoma cocktail, Sry-related HMG-BOX gene 10 (SOX10), and microphthalmia transc...

journal_title：Cancer cytopathology

authors： Clevenger J,Joseph C,Dawlett M,Guo M,Gong Y

更新日期：2014-10-01 00:00:00

abstract：:In diagnostic cytology, the known site-specific false positive rates at various anatomical sites for the risk malignancy (ROM) when a confirmed malignant diagnosis is made are comparatively well documented. ROM figures for diagnostic cytology specimens may vary according to the anatomical site of the specimen, the exa...

journal_title：Cancer cytopathology

authors： Poller DN,Schmitt F

更新日期：2021-01-01 00:00:00

abstract：:The American Society for Colposcopy and Cervical Pathology (ASCCP) guidelines for the management of women with abnormal cervical screening test results is a powerful, evidence-based document representing an advance in the consistent treatment of women with cervical abnormalities. Nevertheless, the complexity of the gu...

journal_title：Cancer cytopathology

authors： Colgan TJ

更新日期：2010-10-25 00:00:00

abstract：BACKGROUND:The Paris System for Reporting Urinary Cytology (TPS) defines clear morphologic criteria to classify urinary specimens into 7 diagnostic categories. According to TPS, a nuclear-to-cytoplasmic ratio (N:C ratio) >0.7 and hyperchromasia must be observed to render a diagnosis of high-grade urothelial carcinoma (...

journal_title：Cancer cytopathology

authors： Richardson CJ,Pambuccian SE,Barkan GA

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:New developments in the treatment of lung cancer have necessitated the further histologic and cytologic subtyping of nonsmall cell lung carcinomas. Thyroid transcription factor-1 (TTF-1) long has served as the predominant marker for demonstrating lung origin. However, it is also expressed in a variety of oth...

journal_title：Cancer cytopathology

authors： Stoll LM,Johnson MW,Gabrielson E,Askin F,Clark DP,Li QK

更新日期：2010-12-25 00:00:00

abstract：BACKGROUND:The accumulation of cyclin-dependent kinase inhibitor 2A (p16ink4a ) protein in a cell is associated with neoplastic progression in precancerous cervical lesions. Dual staining for p16ink4a and Ki-67 has been proposed as a triage test in cervical cancer screening for women who test positive for human papillo...

journal_title：Cancer cytopathology

authors： Benevolo M,Allia E,Gustinucci D,Rollo F,Bulletti S,Cesarini E,Passamonti B,Giovagnoli MR,Carico E,Carozzi FM,Mongia A,Fantacci G,Confortini M,Rubino T,Fodero C,Prandi S,Marchi N,Farruggio A,Coccia A,Macrì L,Ghirin

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Recommendations regarding how many nodules to biopsy with thyroid fine-needle aspiration vary. METHODS:The authors reviewed fine-needle aspiration specimens of 12,763 nodules from 10,506 patients and correlated them with the number of nodules biopsied. RESULTS:Compared with patients in whom only a single n...

journal_title：Cancer cytopathology

authors： Renshaw AA,Gould EW

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Tumor spread through air spaces (STAS), a significant prognostic indicator, has been described recently as a pattern of invasion in pulmonary carcinomas. However, questions remain regarding preoperative identification of STAS and whether it represents an in vivo phenomenon versus an ex vivo artifact. METHOD...

journal_title：Cancer cytopathology

authors： Medina MA,Onken AM,de Margerie-Mellon C,Heidinger BH,Chen Y,Bankier AA,VanderLaan PA

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:The separation of benign from malignant mesothelial proliferations on effusion cytology can be difficult. Loss of methylthioadenosine phosphorylase (MTAP) by immunohistochemistry is an established marker of malignancy in mesothelial proliferations, but to the authors' knowledge largely has been applied only ...

journal_title：Cancer cytopathology

authors： Berg KB,Churg AM,Cheung S,Dacic S

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Subtyping non-small cell lung carcinomas (NSCLC) into adenocarcinoma (ACA) or squamous cell carcinoma (SQCC) is important for treatment and specimen triage for molecular studies. To preserve tissue for molecular studies in cytology/small biopsy specimens, a 2-antibody cocktail for NSCLC subtyping was develop...

journal_title：Cancer cytopathology

authors： Nishino M,Hoang MP,Della Pelle P,Morales-Oyarvide V,Huynh TG,Mark EJ,Mino-Kenudson M

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:The current study was conducted to compare DNA yield, including normalization to nuclear area, DNA amplification functionality, and detection of KRAS mutations between matched fine-needle aspiration (FNA) specimens and pancreatic resections diagnostic of pancreatic ductal adenocarcinoma. METHODS:A retrospec...

journal_title：Cancer cytopathology

authors： Hartley CP,Mahajan AM,Selvaggi SM,Rehrauer WM

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The primary goal of this study was to compare the clinical performance of an optimized and rigorously controlled immunocytochemical (ICC) assay for p16(INK4a) to high-risk (HR) human papillomavirus (HPV) detection by polymerase chain reaction (PCR) as diagnostic adjuncts for cytology specimens from colposcop...

journal_title：Cancer cytopathology

authors： Samarawardana P,Dehn DL,Singh M,Franquemont D,Thompson C,Gaido L,Torkko KC,Homer P,Burke S,Titmus MA,Nayi V,Shroyer KR

更新日期：2010-06-25 00:00:00

abstract：BACKGROUND:The use of topically applied hemostatic substances during surgery has become a common practice. In some cases, the material is not absorbed or induces a granulomatous reaction resulting in a pseudotumoral lesion. With imaging studies, it is not possible to differentiate this from a tumor recurrence or absces...

journal_title：Cancer cytopathology

authors： Hernández-Bonilla S,Rodríguez-García AM,Jiménez-Heffernan JA,Muñoz-Hernández P,Palacios-Lázaro E,López-Ferrer P,González-Peramato P,Vicandi B

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:BRAF mutations are highly specific for papillary thyroid carcinoma (PTC) and many cytology specimens with BRAF mutations are expected to demonstrate cytologic features typical of PTC. However, indeterminate thyroid cytology cases are inevitable and understanding the significance of the BRAF mutation within t...

journal_title：Cancer cytopathology

authors： Ohori NP,Singhal R,Nikiforova MN,Yip L,Schoedel KE,Coyne C,McCoy KL,LeBeau SO,Hodak SP,Carty SE,Nikiforov YE

更新日期：2013-04-01 00:00:00

abstract：:The evaluation of mediastinal and hilar lymph nodes for tissue diagnosis and staging of lung cancer is now commonly performed by minimally invasive, nonsurgical procedures such as computed tomography-guided fine-needle aspiration and endobronchial ultrasound-guided transbronchial needle aspiration. Ensuring that a suf...

journal_title：Cancer cytopathology

authors： da Cunha Santos G,Boerner SL,Geddie WR

更新日期：2011-12-25 00:00:00

abstract：BACKGROUND:Atypical glandular cells (AGC) is a very important diagnosis in gynecological cytology. In the current study, the authors investigated the usefulness of Cellient cell blocks (CB) for characterizing AGC on Papanicolaou (Pap) tests. METHODS:A total of 148 patients with an AGC diagnosis based on Pap tests by c...

journal_title：Cancer cytopathology

authors： Xing W,Hou AY,Fischer A,Owens CL,Jiang Z

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The 2007 Bethesda classification for thyroid cytology defines follicular neoplasm as a category of cases with cellular specimens demonstrating abundant follicular cells arranged in a microfollicular pattern with little or no colloid. The current recommendation for the management of these cases is diagnostic ...

journal_title：Cancer cytopathology

authors： Ustun B,Chhieng D,Van Dyke A,Carling T,Holt E,Udelsman R,Adeniran AJ

更新日期：2014-07-01 00:00:00

abstract：:The American Society of Cytopathology has provided guidelines for goals and objectives for cytopathology fellows. There are 90 Accreditation Council for Graduate Medical Education-accredited cytopathology fellowship training programs in the United States, each with its own unique curriculum designed to achieve these g...

journal_title：Cancer cytopathology

authors： Naritoku WY,Black-Schaffer WS

更新日期：2014-12-01 00:00:00

abstract：:The practice of cytopathology has dramatically changed due to advances in genomics and information technology. Cytology laboratories have accordingly become increasingly dependent on pathology informatics support to meet the emerging demands of precision medicine. Pathology informatics deals with information technolog...

journal_title：Cancer cytopathology

authors： Hanna MG,Pantanowitz L

更新日期：2017-06-01 00:00:00

abstract：:BACKGROUND.: Pancreatic ductal adenocarcinoma is rarely detected early enough for patients to be cured. The objective of the authors was to develop a monoclonal antibody to distinguish adenocarcinoma and precancerous intraductal papillary mucinous neoplasia (IPMN) from benign epithelium. METHODS.: Mice were immunized ...

journal_title：Cancer cytopathology

authors： Morgan TK,Hardiman K,Corless CL,White SL,Bonnah R,Van de Vrugt H,Sheppard BC,Grompe M,Cosar EF,Streeter PR

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The Paris System (TPS) for Reporting Urinary Cytology aims to standardize urine cytology reporting. Per TPS, the diagnosis of "suspicious for high-grade urothelial carcinoma (SHGUC)" is applied in cases that have few urothelial cells with severe atypia but are quantitatively insufficient for a diagnosis of "...

journal_title：Cancer cytopathology

authors： Nguyen L,Nilforoushan N,Krane JF,Bose S,Bakkar R

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Ewing sarcoma (ES) is a round cell sarcoma that can be challenging to diagnose on cytologic material given its significant overlap with numerous mesenchymal, epithelial, and lymphoid cytomorphologic mimics. The objective of this study was to assess the utility of a novel marker, NKX2.2, in the diagnosis of E...

journal_title：Cancer cytopathology

authors： Russell-Goldman E,Hornick JL,Qian X,Jo VY

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Germline and somatic mutations of DICER1 have been identified in various types of neoplastic lesions, with germline DICER1 mutation being linked to autosomal dominant hereditary pleiotropic tumor syndrome (DICER1 syndrome). Patients with DICER1 syndrome are at increased risk of developing thyroid disease, in...

journal_title：Cancer cytopathology

authors： Darbinyan A,Morotti R,Cai G,Prasad ML,Christison-Lagay E,Dinauer C,Adeniran AJ

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Fine-needle aspiration biopsy of spindled mesenchymal lesions, including schwannomas, are challenging because of overlapping cytomorphological features. The objective of the current study was to identify key diagnostic cytological criteria for the diagnosis of schwannoma and to distinguish it from its common...

journal_title：Cancer cytopathology

authors： Chebib I,Hornicek FJ,Nielsen GP,Deshpande V

更新日期：2015-03-01 00:00:00