The Cellient automated cell block system is useful in the differential diagnosis of atypical glandular cells in Papanicolaou tests.


BACKGROUND:Atypical glandular cells (AGC) is a very important diagnosis in gynecological cytology. In the current study, the authors investigated the usefulness of Cellient cell blocks (CB) for characterizing AGC on Papanicolaou (Pap) tests. METHODS:A total of 148 patients with an AGC diagnosis based on Pap tests by cytotechnologists and referred to cytopathologists were studied. Among these patients, there were 68 patients with CB preparations and 80 patients with Pap tests only (TP-AGC group). Follow-up results by Pap tests or biopsies were obtained in 117 of 148 patients. The median follow-up was 13 months (range, 1 month-36 months). RESULTS:Of the 68 patients with CBs, 31 (46%) were reclassified as negative for dysplasia or low-grade intraepithelial lesion; 30 patients (44%) retained a diagnosis of AGC (CB-AGC group); and 7 patients (10%) were given specific diagnoses of high-grade intraepithelial lesion (3 patients), endocervical adenocarcinoma in situ (1 patient), and invasive adenocarcinoma (3 patients). On follow-up, the CB-AGC group was found to have a significantly lower rate of negative/low-grade squamous intraepithelial lesion diagnoses compared with the TP-AGC group (55% vs 85%; P= .006). The CB-AGC group had a significantly higher rate of endocervical or endometrial adenocarcinoma compared with the TP-AGC group (36% vs 8%; P= .003) at the time of follow-up. The rates of high-grade squamous intraepithelial lesion were not found to be statistically different between these 2 groups (9% vs 7%; P= .66). CONCLUSIONS:The Cellient CB is a useful technique to further categorize a diagnosis of AGC on Pap tests. Using the Cellient CB system, the pathologist has the ability to improve the diagnostic accuracy of AGC so that unnecessary colposcopic evaluation or biopsies can be avoided.


Cancer Cytopathol


Cancer cytopathology


Xing W,Hou AY,Fischer A,Owens CL,Jiang Z




Has Abstract


2014-01-01 00:00:00












  • Immunohistochemistry for histone H3G34W and H3K36M is highly specific for giant cell tumor of bone and chondroblastoma, respectively, in FNA and core needle biopsy.

    abstract:BACKGROUND:Diagnosing giant cell-rich bone tumors can be challenging on limited biopsies. H3 histone family member 3A (H3F3A) (G34W/V/R/L) mutations are present in the majority of giant cell tumors (GCTs) of bone and H3 histone family member 3B (H3F3B) (K36M) mutations are present in nearly all chondroblastomas, but ar...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Schaefer IM,Fletcher JA,Nielsen GP,Shih AR,Ferrone ML,Hornick JL,Qian X

    更新日期:2018-08-01 00:00:00

  • Programmed death ligand 1 expression in EBUS aspirates of non-small cell lung cancer: Is interpretation affected by type of fixation?

    abstract:BACKGROUND:Much of the reluctance about using cytology specimens rather than histology specimens to assess programmed death ligand 1 (PD-L1) expression for guiding the use of immune modulating drugs in the management of non-small cell lung cancer (NSCLC) is based on the belief that the alcohol-based fixatives favored b...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Gosney JR,Haragan A,Chadwick C,Giles TE,Grundy S,Tippett V,Gumparthy KP,Wight A,Tan HG

    更新日期:2020-02-01 00:00:00

  • Different qualifiers of AUS/FLUS thyroid FNA have distinct BRAF, RAS, RET/PTC, and PAX8/PPARg alterations.

    abstract:BACKGROUND:The Bethesda System for Reporting Thyroid Cytopathology category of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) includes fine-needle aspiration (FNA) specimens that cannot straightforwardly be classified as benign or malignant. To determine whether morphologi...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Bellevicine C,Sgariglia R,Migliatico I,Vigliar E,D'Anna M,Nacchio MA,Serra N,Malapelle U,Bongiovanni M,Troncone G

    更新日期:2018-05-01 00:00:00

  • Evaluation of chromosomal aberrations in patients with benign conditions and reactive changes in urinary cytology.

    abstract:BACKGROUND:Fluorescence in situ hybridization (FISH) is routinely used to help clarify atypical urinary cytology. However, to the authors' knowledge, little is known regarding the frequency of chromosomal aberrations in non-neoplastic conditions that could potentially lead to false-positive FISH results. The objective ...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Tapia C,Glatz K,Obermann EC,Grilli B,Barascud A,Herzog M,Schönegg R,Savic S,Bubendorf L

    更新日期:2011-12-25 00:00:00

  • The value of second opinion in thyroid cytology: a review.

    abstract:BACKGROUND:Second-opinion diagnosis (SOD) on pathological material is an accepted practice before definitive therapy is considered for referred patients. The thyroid gland is an anatomical site prone to diagnostic disagreement between pathologists. We performed a review of the literature that addressed the role of inte...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章,评审


    authors: Gerhard R,Boerner SL

    更新日期:2014-08-01 00:00:00

  • p16(INK4a) is superior to high-risk human papillomavirus testing in cervical cytology for the prediction of underlying high-grade dysplasia.

    abstract:BACKGROUND:The primary goal of this study was to compare the clinical performance of an optimized and rigorously controlled immunocytochemical (ICC) assay for p16(INK4a) to high-risk (HR) human papillomavirus (HPV) detection by polymerase chain reaction (PCR) as diagnostic adjuncts for cytology specimens from colposcop...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Samarawardana P,Dehn DL,Singh M,Franquemont D,Thompson C,Gaido L,Torkko KC,Homer P,Burke S,Titmus MA,Nayi V,Shroyer KR

    更新日期:2010-06-25 00:00:00

  • Cytologic and cystoscopic predictors of recurrence and progression in patients with low-grade urothelial carcinoma.

    abstract:BACKGROUND:Patients with low-grade urothelial carcinoma (LGUC) are at risk of recurrence and must undergo lifelong surveillance. To date, cytology and cystoscopy are the gold standard for the detection of de novo and recurrent LGUC. The objective of the current study was is to further characterize the role of cytology ...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Jackson J,Barkan GA,Kapur U,Wojcik EM

    更新日期:2013-07-01 00:00:00

  • Evaluation of p16(INK4a)/Ki-67 dual stain in comparison with an mRNA human papillomavirus test on liquid-based cytology samples with low-grade squamous intraepithelial lesion.

    abstract:BACKGROUND:The objective of the current study was to investigate the clinical performance of detecting high-grade lesions with the CINtec PLUS p16(INK4a)/Ki-67 dual stain and the APTIMA human papillomavirus (HPV) Assay in a cohort of women with low-grade squamous intraepithelial lesion (LSIL) cytology. The authors also...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Waldstrøm M,Christensen RK,Ørnskov D

    更新日期:2013-03-01 00:00:00

  • Cytopathologic features of SMARCB1 (INI-1)-deficient sinonasal carcinoma.

    abstract:BACKGROUND:SMARCB1 (INI-1)-deficient sinonasal carcinoma (IDSNC) is a newly described, poorly differentiated carcinoma. Herein, the authors describe the cytopathologic features of IDSNC in fine-needle aspiration (FNA) samples. METHODS:The pathology archives of 2 academic institutions were searched for cases of IDSNC w...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Allard FD,Bell D,Stelow EB

    更新日期:2018-08-01 00:00:00

  • Preparation of DNA from cytological material: effects of fixation, staining, and mounting medium on DNA yield and quality.

    abstract:BACKGROUND:Personalized oncology requires molecular analysis of tumor cells. Several studies have demonstrated that cytological material is suitable for DNA analysis, but to the authors' knowledge there are no systematic studies comparing how the yield and quality of extracted DNA is affected by the various techniques ...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Dejmek A,Zendehrokh N,Tomaszewska M,Edsjö A

    更新日期:2013-07-01 00:00:00

  • Subtyping salivary gland neoplasm of uncertain malignant potential based on cell type demonstrates differential risk of malignancy.

    abstract:BACKGROUND:The newly unveiled Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has proposed salivary gland neoplasm of uncertain malignant potential (SUMP) as an indeterminate category. The category is reserved for fine-needle aspiration (FNA) cases that are diagnostic of a salivary gland neoplasm but c...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章,多中心研究


    authors: Hang JF,Alruwaii F,Zeng BR,Lai CR,Wu HH

    更新日期:2018-11-01 00:00:00

  • Challenge of FNA diagnosis of angiomyolipoma: A study of 33 cases.

    abstract:BACKGROUND:Angiomyolipoma (AML), typically composed of smooth muscle, vessels, and fat, is generally a benign tumor in the kidneys. However, it occasionally occurs in extrarenal sites and behaves like a malignant tumor. AML is uncommonly encountered in fine-needle aspiration (FNA) samples and can cause diagnostic diffi...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Zhou H,Guo M,Gong Y

    更新日期:2017-04-01 00:00:00

  • Optimal antigen retrieval for ethanol-fixed cytologic smears.

    abstract:BACKGROUND:Antigen retrieval, a crucial technique for immunostaining, is often carried out on formalin-fixed, paraffin-embedded (FFPE) tissue sections. The role of antigen retrieval in immunostaining of ethanol-fixed smears remains unclear. The authors evaluated the effects of 2 common antigen retrieval procedures, hea...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Denda T,Kamoshida S,Kawamura J,Harada K,Kawai K,Kuwao S

    更新日期:2012-06-25 00:00:00

  • Should uncertainty concerning the risk of malignancy be included in diagnostic (nongynecologic) cytopathology reports?

    abstract::In diagnostic cytology, the known site-specific false positive rates at various anatomical sites for the risk malignancy (ROM) when a confirmed malignant diagnosis is made are comparatively well documented. ROM figures for diagnostic cytology specimens may vary according to the anatomical site of the specimen, the exa...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章,评审


    authors: Poller DN,Schmitt F

    更新日期:2021-01-01 00:00:00

  • Breast fine-needle aspiration cytology performance in the high-risk screening population: a study of BRCA1/BRCA2 mutation carriers.

    abstract:BACKGROUND:The diagnosis of breast lesions is usually confirmed by fine-needle aspiration cytology (FNAC) or histological biopsy. Although there is increasing literature regarding the advantages and limitations of both modalities, there is no literature regarding the accuracy of these modalities for diagnosing breast l...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Georgieva RD,Obdeijn IM,Jager A,Hooning MJ,Tilanus-Linthorst MM,van Deurzen CH

    更新日期:2013-10-01 00:00:00

  • Cytologic features and diagnostic value of PeriView FLEX transbronchial needle aspiration targeting pulmonary nodules.

    abstract:BACKGROUND:Transbronchial needle aspiration (TBNA) of peripheral lung nodules can be difficult with conventional devices due to their limited flexibility. A promising new technology for accessing these lesions is the PeriView FLEX TBNA device, which has a flexible spiral-grooved needle. The present study reports the un...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Naso J,Bras J,Villamil C,Ionescu DN,Wang G,Shaipanich T,Beaudoin EL,Myers R,Lam S,Zhou C

    更新日期:2020-05-01 00:00:00

  • BRAF mutation detection in indeterminate thyroid cytology specimens: underlying cytologic, molecular, and pathologic characteristics of papillary thyroid carcinoma.

    abstract:BACKGROUND:BRAF mutations are highly specific for papillary thyroid carcinoma (PTC) and many cytology specimens with BRAF mutations are expected to demonstrate cytologic features typical of PTC. However, indeterminate thyroid cytology cases are inevitable and understanding the significance of the BRAF mutation within t...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Ohori NP,Singhal R,Nikiforova MN,Yip L,Schoedel KE,Coyne C,McCoy KL,LeBeau SO,Hodak SP,Carty SE,Nikiforov YE

    更新日期:2013-04-01 00:00:00

  • Ocular cytology: Diagnostic features and ongoing practices.

    abstract::Ocular cytology specimens are small, with limited options for a repeat biopsy. Appropriate handling of these specimens and triaging for ancillary testing can be taxing. In this article, the author reviews a selection of potentially challenging diagnoses and current common practices and methods used in diagnosing ocula...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章,评审


    authors: Laver NMV

    更新日期:2020-11-02 00:00:00

  • Aggressive variants of follicular cell-derived thyroid carcinomas: a cytopathologist's perspective.

    abstract::Follicular cell-derived carcinomas of the thyroid gland comprise a heterogeneous group of malignant neoplasms of the thyroid gland with varied histologic appearance and molecular profiles. In most patients, these tumors represent relatively indolent neoplasms; however, certain subtypes/variants behave in an aggressive...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章,评审


    authors: Lastra RR,LiVolsi VA,Baloch ZW

    更新日期:2014-07-01 00:00:00

  • Assessment of EGFR and KRAS mutation status from FNAs and core-needle biopsies of non-small cell lung cancer.

    abstract:BACKGROUND:Molecular testing to determine gene mutation status is now the recommended standard of care for patients with advanced or metastatic Non-small cell lung cancer (NSCLC). Because the majority of patients with NSCLC present with metastatic disease, minimally invasive procedures are necessary for diagnosis, stag...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Lozano MD,Labiano T,Echeveste J,Gurpide A,Martín-Algarra S,Zhang G,Sharma A,Palma JF

    更新日期:2015-04-01 00:00:00

  • A combination of MTAP and BAP1 immunohistochemistry in pleural effusion cytology for the diagnosis of mesothelioma.

    abstract:BACKGROUND:Homozygous deletion of 9p21 detected by fluorescence in situ hybridization (FISH) and loss of BRCA1-associated protein 1 (BAP1) expression detected by immunohistochemistry (IHC) are useful for the differentiation between malignant pleural mesothelioma (MPM) and reactive mesothelial hyperplasia. The authors p...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Kinoshita Y,Hida T,Hamasaki M,Matsumoto S,Sato A,Tsujimura T,Kawahara K,Hiroshima K,Oda Y,Nabeshima K

    更新日期:2018-01-01 00:00:00

  • Preoperative bronchial cytology for the assessment of tumor spread through air spaces in lung adenocarcinoma resection specimens.

    abstract:BACKGROUND:Tumor spread through air spaces (STAS), a significant prognostic indicator, has been described recently as a pattern of invasion in pulmonary carcinomas. However, questions remain regarding preoperative identification of STAS and whether it represents an in vivo phenomenon versus an ex vivo artifact. METHOD...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Medina MA,Onken AM,de Margerie-Mellon C,Heidinger BH,Chen Y,Bankier AA,VanderLaan PA

    更新日期:2020-04-01 00:00:00

  • Lung cancer and molecular testing in small biopsies versus cytology: The Logics of Worlds.

    abstract::The 8th Annual National Molecular Cytopathology Meeting, held in Naples, Italy, on December 2 to 3, 2019, addressed updates in diagnostic cytopathology and molecular classifications and specifically focused on lung cancer biomarker testing in cytology samples. Lung cancer continues to be the most commonly diagnosed no...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Rossi ED,Wiles A,Vecchione A

    更新日期:2020-09-01 00:00:00

  • The impact of atypia/follicular lesion of undetermined significance and repeat fine-needle aspiration: 5 years before and after implementation of the Bethesda System.

    abstract:BACKGROUND:Limited studies have examined the impact of the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) and specifically the category of atypia or follicular lesion of undetermined significance (AUS/FLUS). We studied their effects on reporting rates, subsequent management, and surgical outcome over a 10-...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Sullivan PS,Hirschowitz SL,Fung PC,Apple SK

    更新日期:2014-12-01 00:00:00

  • The use of FNA samples for whole-exome sequencing and detection of somatic mutations in breast cancer surgical specimens.

    abstract:BACKGROUND:The availability of suitable biospecimens is critical to the success of advanced genomic analyses. The objective of this study was to assess the sensitivity of fine-needle aspiration (FNA) compared with gross surgical sampling (GSS) from surgical specimens for the detection of somatic mutations in breast can...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Lee HB,Joung JG,Kim J,Lee KM,Ryu HS,Lee HO,Moon HG,Park WY,Noh DY,Han W

    更新日期:2015-11-01 00:00:00

  • When words matter: A "suspicious" urinary tract cytology diagnosis improves patient follow-up among nonurologists.

    abstract:BACKGROUND:Urinary tract cytology (UTC) specimens diagnosed using high-risk indeterminate categories such as "atypical urothelial cells, cannot exclude high-grade urothelial carcinoma" (AUC-H) or "suspicious for high-grade urothelial carcinoma" (SHGUC) have a high rate of detection of high-grade urothelial carcinoma on...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Fite JJ,Rosenthal DL,VandenBussche CJ

    更新日期:2018-04-01 00:00:00

  • p16(INK4a) overexpression is not linked to oncogenic human papillomaviruses in patients with high-grade urothelial cancer cells.

    abstract:BACKGROUND:p16(INK4a) Is overexpressed in almost all precancerous and carcinomatous lesions of the uterine cervix, secondary to interference between high-risk human papillomaviruses (hr-HPVs) and the retinoblastoma gene product. Overexpression of p16(INK4a) has also been identified in patients with high-grade urothelia...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Piaton E,Casalegno JS,Advenier AS,Decaussin-Petrucci M,Mege-Lechevallier F,Ruffion A,Mekki Y

    更新日期:2014-10-01 00:00:00

  • Adequacy in voided urine cytology specimens: The role of volume and a repeat void upon predictive values for high-grade urothelial carcinoma.

    abstract:BACKGROUND:Adequacy assessment is one of the most controversial and overlooked components in the daily practice of cytopathology, because it is generally determined from limited samples. Because voided urine varies widely in terms of its volume and cellularity, there is little consensus about the proper role for these ...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: VandenBussche CJ,Rosenthal DL,Olson MT

    更新日期:2016-03-01 00:00:00

  • Urine cytology suspicious for urothelial carcinoma: Prospective follow-up of cases using cytology and urine biomarker-based ancillary techniques.

    abstract:BACKGROUND:Urine cytology results that are suspicious for urothelial carcinoma (UC) are challenging. The objective of this study was to elucidate the clinical significance of such results in patients who have a negative cystoscopy. METHODS:In this prospective study, 83 patients who had urine cytology that was suspicio...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Montalbo R,Izquierdo L,Ingelmo-Torres M,Galve P,Solé M,Franco A,Ribal MJ,Alcaraz A,Mengual L

    更新日期:2020-07-01 00:00:00

  • Cytomorphologic features of thyroid disease in patients with DICER1 mutations: A report of cytology-histopathology correlation in 7 patients.

    abstract:BACKGROUND:Germline and somatic mutations of DICER1 have been identified in various types of neoplastic lesions, with germline DICER1 mutation being linked to autosomal dominant hereditary pleiotropic tumor syndrome (DICER1 syndrome). Patients with DICER1 syndrome are at increased risk of developing thyroid disease, in...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章


    authors: Darbinyan A,Morotti R,Cai G,Prasad ML,Christison-Lagay E,Dinauer C,Adeniran AJ

    更新日期:2020-10-01 00:00:00