Diagnostic predictive value of the Bladder EpiCheck test in the follow-up of patients with non-muscle-invasive bladder cancer.

Abstract:

BACKGROUND:The objective of this study was to evaluate the diagnostic accuracy of the Bladder EpiCheck test in the follow-up of patients with non-muscle-invasive bladder cancer (NMIBC) and to compare it with the accuracy of urinary cytology, cystoscopy, and/or histology. METHODS:In total, 243 patients were enrolled in the current study. Patients were evaluated by voided urine cytology, by the Bladder EpiCheck test, and by white-light cystoscopy. RESULTS:Overall sensitivity was 33.3% for cytology, 62.3% for Bladder EpiCheck, and 66.7% for the 2 tests combined. The sensitivity of cytology increased from 7.7% in low-grade (LG) tumors to 66.6% in high-grade (HG) tumors; whereas, for the Bladder EpiCheck test, the sensitivity was 46.1% in LG tumors and 83.3% in HG tumors. Combined cytology and Bladder EpiCheck testing yielded an overall sensitivity of 56.4% for LG tumors and 90% for HG tumors. Overall specificity was 98.6% for cytology, 86.3% for Bladder EpiCheck, and 85.6% for the 2 tests combined. The positive predictive value was 92% for cytology and 68.2% for Bladder EpiCheck. For the 2 tests combined, it was 68.6%. The negative predictive value was similar for the 2 tests: 75.8% for cytology, 82.9% for Bladder EpiCheck, and 84.5% for the 2 tests combined. CONCLUSIONS:The sensitivity of the Bladder EpiCheck test was significantly higher than that of cytology. The test performed very well in terms of specificity but could not reach the high value of cytology. The positive predictive value was higher for Bladder EpiCheck, whereas the negative predictive value was approximately the same for both tests.

journal_name

Cancer Cytopathol

journal_title

Cancer cytopathology

authors

Trenti E,D'Elia C,Mian C,Schwienbacher C,Hanspeter E,Pycha A,Kafka M,Degener S,Danuser H,Roth S,Pycha A

doi

10.1002/cncy.22152

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

465-469

issue

7

eissn

1934-662X

issn

1934-6638

journal_volume

127

pub_type

杂志文章
  • Clinical and pathologic features and clinical impact of false negative thyroid fine-needle aspirations.

    abstract:BACKGROUND:Although thyroid fine-needle aspiration (TFNA) is an excellent test in evaluating thyroid nodules, there are occasionally false negatives (FN). The clinical impact and pathologic features of FN TFNA is understudied in the peer-reviewed literature. METHODS:A cohort of patients with thyroid cancer was separat...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.21196

    authors: Jean-Gilles J,Fischer AH,Luu MH,Owens CL

    更新日期:2012-10-25 00:00:00

  • The application of current classification systems in pediatric cytopathology: Perspectives from the pediatric cytopathology symposium at the 20th International Congress of Cytology 2019.

    abstract::A pediatric cytopathology symposium was held at the recent 20th International Congress of Cytology, which convened in Sydney, Australia, in May 2019. This educational event brought together cytopathologists from different countries and different institutions to discuss some of the practical considerations when applyin...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.22166

    authors: Monaco SE,Baloch ZW,Rossi ED,Teot LA,Wright C

    更新日期:2019-10-01 00:00:00

  • A combination of MTAP and BAP1 immunohistochemistry in pleural effusion cytology for the diagnosis of mesothelioma.

    abstract:BACKGROUND:Homozygous deletion of 9p21 detected by fluorescence in situ hybridization (FISH) and loss of BRCA1-associated protein 1 (BAP1) expression detected by immunohistochemistry (IHC) are useful for the differentiation between malignant pleural mesothelioma (MPM) and reactive mesothelial hyperplasia. The authors p...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.21928

    authors: Kinoshita Y,Hida T,Hamasaki M,Matsumoto S,Sato A,Tsujimura T,Kawahara K,Hiroshima K,Oda Y,Nabeshima K

    更新日期:2018-01-01 00:00:00

  • FNA cytology of postoperative pseudotumoral lesions induced by oxidized cellulose hemostatic agents.

    abstract:BACKGROUND:The use of topically applied hemostatic substances during surgery has become a common practice. In some cases, the material is not absorbed or induces a granulomatous reaction resulting in a pseudotumoral lesion. With imaging studies, it is not possible to differentiate this from a tumor recurrence or absces...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.22194

    authors: Hernández-Bonilla S,Rodríguez-García AM,Jiménez-Heffernan JA,Muñoz-Hernández P,Palacios-Lázaro E,López-Ferrer P,González-Peramato P,Vicandi B

    更新日期:2019-12-01 00:00:00

  • Evaluation of p16(INK4a)/Ki-67 dual stain in comparison with an mRNA human papillomavirus test on liquid-based cytology samples with low-grade squamous intraepithelial lesion.

    abstract:BACKGROUND:The objective of the current study was to investigate the clinical performance of detecting high-grade lesions with the CINtec PLUS p16(INK4a)/Ki-67 dual stain and the APTIMA human papillomavirus (HPV) Assay in a cohort of women with low-grade squamous intraepithelial lesion (LSIL) cytology. The authors also...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.21233

    authors: Waldstrøm M,Christensen RK,Ørnskov D

    更新日期:2013-03-01 00:00:00

  • Biomarkers for immune checkpoint inhibitors: The importance of tumor topography and the challenges to cytopathology.

    abstract::The recent emergence of immune checkpoint inhibitors for cancer therapy has created much excitement among cancer patients, drug and diagnostic developers, and health care professionals. This is due largely to the dramatic and sustained responses among some advanced cancers that were previously refractory to therapy. U...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章,评审

    doi:10.1002/cncy.21951

    authors: Clark DP

    更新日期:2018-01-01 00:00:00

  • Urine cytology suspicious for urothelial carcinoma: Prospective follow-up of cases using cytology and urine biomarker-based ancillary techniques.

    abstract:BACKGROUND:Urine cytology results that are suspicious for urothelial carcinoma (UC) are challenging. The objective of this study was to elucidate the clinical significance of such results in patients who have a negative cystoscopy. METHODS:In this prospective study, 83 patients who had urine cytology that was suspicio...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.22252

    authors: Montalbo R,Izquierdo L,Ingelmo-Torres M,Galve P,Solé M,Franco A,Ribal MJ,Alcaraz A,Mengual L

    更新日期:2020-07-01 00:00:00

  • Split-sample comparison of urothelial cells in ThinPrep and cytospin preparations in urinary cytology: Do we need to adjust The Paris System for Reporting Urinary Cytology criteria?

    abstract:BACKGROUND:The Paris System for Reporting Urinary Cytology (TPS) defines clear morphologic criteria to classify urinary specimens into 7 diagnostic categories. According to TPS, a nuclear-to-cytoplasmic ratio (N:C ratio) >0.7 and hyperchromasia must be observed to render a diagnosis of high-grade urothelial carcinoma (...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.22218

    authors: Richardson CJ,Pambuccian SE,Barkan GA

    更新日期:2020-02-01 00:00:00

  • Ancillary studies in fine needle aspiration of the kidney.

    abstract::An increasing number of renal cell carcinomas (RCCs) require ancillary studies for diagnosis. The majority of renal fine needle aspirates do not require ancillary studies. Among the most common useful stains are cytokeratin 7 (separating clear cell RCC [negative] from papillary RCC, clear cell papillary RCC, and multi...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章,评审

    doi:10.1002/cncy.22029

    authors: Renshaw AA,Gould EW

    更新日期:2018-08-01 00:00:00

  • Focus on technology: How important is resolution in telecytopathology?

    abstract:BACKGROUND:The authors conducted an analysis of 2 telepathology systems with different resolutions to determine how resolution affects the pathologists' ability to provide preliminary diagnoses for fine-needle aspirations (FNA). METHODS:FNA cases evaluated by telepathology between February 1, 2011 and January 18, 2012...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.21404

    authors: McMahon RQ,McCarthy EE,Hetzel SJ,Das K,Stewart J 3rd

    更新日期:2014-07-01 00:00:00

  • The value of second opinion in thyroid cytology: a review.

    abstract:BACKGROUND:Second-opinion diagnosis (SOD) on pathological material is an accepted practice before definitive therapy is considered for referred patients. The thyroid gland is an anatomical site prone to diagnostic disagreement between pathologists. We performed a review of the literature that addressed the role of inte...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章,评审

    doi:10.1002/cncy.21436

    authors: Gerhard R,Boerner SL

    更新日期:2014-08-01 00:00:00

  • Digitized microscopy in the diagnosis of bladder cancer: analysis of >3000 cases during a 7-month period.

    abstract:BACKGROUND:Fluorescent in situ hybridization (FISH) analysis of urine samples has proven to be a valuable adjunctive test to urine cytology for both diagnosis and monitoring recurrence of urothelial carcinoma. Automated FISH analysis has the potential to improve laboratory efficiency and to reduce interobserver and int...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.20145

    authors: Marganski WA,El-Sirgany Costa V,Kilpatrick MW,Tafas T,Yim J,Matthews M

    更新日期:2011-08-25 00:00:00

  • The role of SOX11 immunostaining in confirming the diagnosis of mantle cell lymphoma on fine-needle aspiration samples.

    abstract:BACKGROUND:Mantle cell lymphoma (MCL) demonstrates cytologic features that overlap with those of other types of B-cell non-Hodgkin lymphomas (B-cell NHLs) containing small to medium-sized cells. The accurate diagnosis of MCL is important because MCL has relatively more aggressive biologic behavior and thus requires spe...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.21465

    authors: Zhang YH,Liu J,Dawlett M,Guo M,Sun X,Gong Y

    更新日期:2014-12-01 00:00:00

  • The utility of napsin-A in the identification of primary and metastatic lung adenocarcinoma among cytologically poorly differentiated carcinomas.

    abstract:BACKGROUND:New developments in the treatment of lung cancer have necessitated the further histologic and cytologic subtyping of nonsmall cell lung carcinomas. Thyroid transcription factor-1 (TTF-1) long has served as the predominant marker for demonstrating lung origin. However, it is also expressed in a variety of oth...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.20108

    authors: Stoll LM,Johnson MW,Gabrielson E,Askin F,Clark DP,Li QK

    更新日期:2010-12-25 00:00:00

  • Napsin A/p40 antibody cocktail for subtyping non-small cell lung carcinoma on cytology and small biopsy specimens.

    abstract:BACKGROUND:Subtyping non-small cell lung carcinomas (NSCLC) into adenocarcinoma (ACA) or squamous cell carcinoma (SQCC) is important for treatment and specimen triage for molecular studies. To preserve tissue for molecular studies in cytology/small biopsy specimens, a 2-antibody cocktail for NSCLC subtyping was develop...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.21707

    authors: Nishino M,Hoang MP,Della Pelle P,Morales-Oyarvide V,Huynh TG,Mark EJ,Mino-Kenudson M

    更新日期:2016-07-01 00:00:00

  • The impact of the new proposed Papanicolaou Society of Cytopathology terminology for pancreaticobiliary cytology in endoscopic US-FNA: A single-institutional experience.

    abstract:BACKGROUND:The Papanicolaou Society of Cytopathology has recently published a new proposal for pancreaticobiliary cytology terminology. For the current study, the authors applied this new classification for pancreaticobiliary cytology to a set of previously diagnosed endoscopic ultrasound (EUS)-guided fine-needle aspir...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.21559

    authors: Saieg MA,Munson V,Colletti S,Nassar A

    更新日期:2015-08-01 00:00:00

  • Fine-needle cytology of cutaneous juvenile xanthogranuloma and langerhans cell histiocytosis.

    abstract:BACKGROUND:In pediatric patients, a cutaneous nodule is usually diagnosed by performing an excisional biopsy, but fine-needle cytology (FNC) is a safer and noninvasive diagnostic method widely used to obtain diagnostic specimens with little stress to the patient. The authors compared the ability of FNC and biopsy to di...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.20132

    authors: Fassina A,Olivotto A,Cappellesso R,Vendraminelli R,Fassan M

    更新日期:2011-04-25 00:00:00

  • Challenge of FNA diagnosis of angiomyolipoma: A study of 33 cases.

    abstract:BACKGROUND:Angiomyolipoma (AML), typically composed of smooth muscle, vessels, and fat, is generally a benign tumor in the kidneys. However, it occasionally occurs in extrarenal sites and behaves like a malignant tumor. AML is uncommonly encountered in fine-needle aspiration (FNA) samples and can cause diagnostic diffi...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.21824

    authors: Zhou H,Guo M,Gong Y

    更新日期:2017-04-01 00:00:00

  • EGFR and KRAS mutations in lung carcinoma: molecular testing by using cytology specimens.

    abstract:BACKGROUND:The aim of this study was to validate clinical utilization of routinely prepared cytology specimens for molecular testing to detect EGFR or KRAS mutations in lung cancer. METHODS:From September 2009 to April 2010, the authors collected 209 cytology specimens from patients with lung cancer at the MD Anderson...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.20151

    authors: Billah S,Stewart J,Staerkel G,Chen S,Gong Y,Guo M

    更新日期:2011-04-25 00:00:00

  • Risk stratification in follicular neoplasm: a cytological assessment using the modified Bethesda classification.

    abstract:BACKGROUND:The 2007 Bethesda classification for thyroid cytology defines follicular neoplasm as a category of cases with cellular specimens demonstrating abundant follicular cells arranged in a microfollicular pattern with little or no colloid. The current recommendation for the management of these cases is diagnostic ...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章,评审

    doi:10.1002/cncy.21425

    authors: Ustun B,Chhieng D,Van Dyke A,Carling T,Holt E,Udelsman R,Adeniran AJ

    更新日期:2014-07-01 00:00:00

  • The role of informatics in patient-centered care and personalized medicine.

    abstract::The practice of cytopathology has dramatically changed due to advances in genomics and information technology. Cytology laboratories have accordingly become increasingly dependent on pathology informatics support to meet the emerging demands of precision medicine. Pathology informatics deals with information technolog...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.21833

    authors: Hanna MG,Pantanowitz L

    更新日期:2017-06-01 00:00:00

  • Cytomorphologic features that distinguish schwannoma from other low-grade spindle cell lesions.

    abstract:BACKGROUND:Fine-needle aspiration biopsy of spindled mesenchymal lesions, including schwannomas, are challenging because of overlapping cytomorphological features. The objective of the current study was to identify key diagnostic cytological criteria for the diagnosis of schwannoma and to distinguish it from its common...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.21506

    authors: Chebib I,Hornicek FJ,Nielsen GP,Deshpande V

    更新日期:2015-03-01 00:00:00

  • Immunohistochemistry for histone H3G34W and H3K36M is highly specific for giant cell tumor of bone and chondroblastoma, respectively, in FNA and core needle biopsy.

    abstract:BACKGROUND:Diagnosing giant cell-rich bone tumors can be challenging on limited biopsies. H3 histone family member 3A (H3F3A) (G34W/V/R/L) mutations are present in the majority of giant cell tumors (GCTs) of bone and H3 histone family member 3B (H3F3B) (K36M) mutations are present in nearly all chondroblastomas, but ar...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.22000

    authors: Schaefer IM,Fletcher JA,Nielsen GP,Shih AR,Ferrone ML,Hornick JL,Qian X

    更新日期:2018-08-01 00:00:00

  • The impact of atypia/follicular lesion of undetermined significance and repeat fine-needle aspiration: 5 years before and after implementation of the Bethesda System.

    abstract:BACKGROUND:Limited studies have examined the impact of the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) and specifically the category of atypia or follicular lesion of undetermined significance (AUS/FLUS). We studied their effects on reporting rates, subsequent management, and surgical outcome over a 10-...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.21468

    authors: Sullivan PS,Hirschowitz SL,Fung PC,Apple SK

    更新日期:2014-12-01 00:00:00

  • BRAF mutation detection in indeterminate thyroid cytology specimens: underlying cytologic, molecular, and pathologic characteristics of papillary thyroid carcinoma.

    abstract:BACKGROUND:BRAF mutations are highly specific for papillary thyroid carcinoma (PTC) and many cytology specimens with BRAF mutations are expected to demonstrate cytologic features typical of PTC. However, indeterminate thyroid cytology cases are inevitable and understanding the significance of the BRAF mutation within t...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.21229

    authors: Ohori NP,Singhal R,Nikiforova MN,Yip L,Schoedel KE,Coyne C,McCoy KL,LeBeau SO,Hodak SP,Carty SE,Nikiforov YE

    更新日期:2013-04-01 00:00:00

  • Preanalytic variables in quality and quantity of nucleic acids extracted from FNA specimens of thyroid gland nodules collected in CytoLyt: Cellularity and storage time.

    abstract:BACKGROUND:Morphologic and genetic analysis of thyroid nodules may be performed from a single vial. Preanalytic variables that affect nucleic acid extracted from a single vial are evaluated. METHODS:Thyroid fine-needle aspiration (FNA) specimens collected in CytoLyt were evaluated. A ThinPrep slide was prepared. Extra...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.22270

    authors: Heymann JJ,Yoxtheimer LM,Park HJ,Fernandez EM,Facey KE,Alperstein SA,Tran HV,Baek I,Scognamiglio T,Rennert H,Siddiqui MT,Song W

    更新日期:2020-09-01 00:00:00

  • Reducing DNA damage by formaldehyde in liquid-based cytology preservation solutions to enable the molecular testing of lung cancer specimens.

    abstract:BACKGROUND:Liquid-based cytology (LBC) is a useful cytopathological method, and LBC lung adenocarcinoma specimens may be used for genetic analysis in the near future. In the current study, the authors determined whether LBC specimens can be used for epidermal growth factor receptor (EGFR) mutation analysis in human lun...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.22069

    authors: Matsuo Y,Yoshida T,Yamashita K,Satoh Y

    更新日期:2018-12-01 00:00:00

  • Cytologic and cystoscopic predictors of recurrence and progression in patients with low-grade urothelial carcinoma.

    abstract:BACKGROUND:Patients with low-grade urothelial carcinoma (LGUC) are at risk of recurrence and must undergo lifelong surveillance. To date, cytology and cystoscopy are the gold standard for the detection of de novo and recurrent LGUC. The objective of the current study was is to further characterize the role of cytology ...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.21272

    authors: Jackson J,Barkan GA,Kapur U,Wojcik EM

    更新日期:2013-07-01 00:00:00

  • Evaluation of chromosomal aberrations in patients with benign conditions and reactive changes in urinary cytology.

    abstract:BACKGROUND:Fluorescence in situ hybridization (FISH) is routinely used to help clarify atypical urinary cytology. However, to the authors' knowledge, little is known regarding the frequency of chromosomal aberrations in non-neoplastic conditions that could potentially lead to false-positive FISH results. The objective ...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.20171

    authors: Tapia C,Glatz K,Obermann EC,Grilli B,Barascud A,Herzog M,Schönegg R,Savic S,Bubendorf L

    更新日期:2011-12-25 00:00:00

  • The impact of noninvasive follicular thyroid neoplasm with papillary-like nuclear features on the rate of malignancy for atypia of undetermined significance subcategories.

    abstract:BACKGROUND:The recent revision in terminology, with noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) replacing noninvasive follicular variant of papillary thyroid carcinoma, has reclassified the clinically indolent tumor as nonmalignant. The objective of this study was to evaluate th...

    journal_title:Cancer cytopathology

    pub_type: 杂志文章

    doi:10.1002/cncy.21981

    authors: Hang JF,Westra WH,Zhou AG,Cooper DS,Ali SZ

    更新日期:2018-05-01 00:00:00