Abstract:
BACKGROUND:The Papanicolaou Society of Cytopathology has recently published a new proposal for pancreaticobiliary cytology terminology. For the current study, the authors applied this new classification for pancreaticobiliary cytology to a set of previously diagnosed endoscopic ultrasound (EUS)-guided fine-needle aspiration (EUS-FNA) samples and correlated the results with those from the corresponding available final surgical specimens. METHODS:Pancreatic FNA specimens were retrospectively collected from a 12-month period at the Mayo Clinic in Jacksonville, Florida. Cases with cytohistologic disagreement were reviewed to assess the reasons for discrepancies. The sensitivity and specificity of EUS-FNA specimens were assessed using the Pearson chi-square test. RESULTS:One hundred fifty-five pancreatic FNA specimens were retrieved. The median patient age was 70 years (range, 25-93 years). Eleven specimens previously classified as negative and 3 previously classified as non-diagnostic were reclassified as neoplastic:other, as well as all specimens primarily classified as atypical or positive for neoplasm and half the specimens primarily classified as suspicious. All positive specimens remained within their same categories in the revised classification. Sixteen patients (10.3%) had surgical resection specimens available, and complete or partial agreement with FNA results was achieved in 13 of those surgical specimens (81.2%). Reasons for discrepancy comprised sampling errors in 5 specimens and an interpretation error in 1 specimen. Overall, sensitivity was 66.7%, specificity was 66.7%, the positive predictive value was 88.9%, and the negative predictive value was 33.3%. CONCLUSIONS:The application of the new proposed terminology for pancreaticobiliary cytology had a greater impact among specimens that were previously classified as atypical and suspicious. EUS-FNA of the pancreas is a highly accurate method, and its use, allied with the new proposed terminology, may ultimately contribute to better outcomes.
journal_name
Cancer Cytopatholjournal_title
Cancer cytopathologyauthors
Saieg MA,Munson V,Colletti S,Nassar Adoi
10.1002/cncy.21559subject
Has Abstractpub_date
2015-08-01 00:00:00pages
488-94issue
8eissn
1934-662Xissn
1934-6638journal_volume
123pub_type
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