Abstract:
:Follicular cell-derived carcinomas of the thyroid gland comprise a heterogeneous group of malignant neoplasms of the thyroid gland with varied histologic appearance and molecular profiles. In most patients, these tumors represent relatively indolent neoplasms; however, certain subtypes/variants behave in an aggressive manner, and the recognition of this subset of tumors is essential because of their variable response to therapy and significant morbidity and mortality. Fine-needle aspiration is considered an essential tool for the diagnosis of suspicious thyroid nodules. In this review, the authors discuss the clinical, histologic, and molecular findings and the prognostic implications of aggressive thyroid neoplasms with emphasis on the characteristic cytomorphologic features on fine-needle aspiration smears.
journal_name
Cancer Cytopatholjournal_title
Cancer cytopathologyauthors
Lastra RR,LiVolsi VA,Baloch ZWdoi
10.1002/cncy.21417subject
Has Abstractpub_date
2014-07-01 00:00:00pages
484-503issue
7eissn
1934-662Xissn
1934-6638journal_volume
122pub_type
杂志文章,评审abstract:BACKGROUND:The newly unveiled Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has proposed salivary gland neoplasm of uncertain malignant potential (SUMP) as an indeterminate category. The category is reserved for fine-needle aspiration (FNA) cases that are diagnostic of a salivary gland neoplasm but c...
journal_title:Cancer cytopathology
pub_type: 杂志文章,多中心研究
doi:10.1002/cncy.22066
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:The objective of the current study was to investigate the clinical performance of detecting high-grade lesions with the CINtec PLUS p16(INK4a)/Ki-67 dual stain and the APTIMA human papillomavirus (HPV) Assay in a cohort of women with low-grade squamous intraepithelial lesion (LSIL) cytology. The authors also...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21233
更新日期:2013-03-01 00:00:00
abstract::The 8th Annual National Molecular Cytopathology Meeting, held in Naples, Italy, on December 2 to 3, 2019, addressed updates in diagnostic cytopathology and molecular classifications and specifically focused on lung cancer biomarker testing in cytology samples. Lung cancer continues to be the most commonly diagnosed no...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22291
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:The Paris System for Reporting Urinary Cytology (TPS) defines clear morphologic criteria to classify urinary specimens into 7 diagnostic categories. According to TPS, a nuclear-to-cytoplasmic ratio (N:C ratio) >0.7 and hyperchromasia must be observed to render a diagnosis of high-grade urothelial carcinoma (...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22218
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Atypical glandular cells (AGC) is a very important diagnosis in gynecological cytology. In the current study, the authors investigated the usefulness of Cellient cell blocks (CB) for characterizing AGC on Papanicolaou (Pap) tests. METHODS:A total of 148 patients with an AGC diagnosis based on Pap tests by c...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21343
更新日期:2014-01-01 00:00:00
abstract::In diagnostic cytology, the known site-specific false positive rates at various anatomical sites for the risk malignancy (ROM) when a confirmed malignant diagnosis is made are comparatively well documented. ROM figures for diagnostic cytology specimens may vary according to the anatomical site of the specimen, the exa...
journal_title:Cancer cytopathology
pub_type: 杂志文章,评审
doi:10.1002/cncy.22322
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Morphologic and genetic analysis of thyroid nodules may be performed from a single vial. Preanalytic variables that affect nucleic acid extracted from a single vial are evaluated. METHODS:Thyroid fine-needle aspiration (FNA) specimens collected in CytoLyt were evaluated. A ThinPrep slide was prepared. Extra...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22270
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Homozygous deletion of 9p21 detected by fluorescence in situ hybridization (FISH) and loss of BRCA1-associated protein 1 (BAP1) expression detected by immunohistochemistry (IHC) are useful for the differentiation between malignant pleural mesothelioma (MPM) and reactive mesothelial hyperplasia. The authors p...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21928
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Patients with low-grade urothelial carcinoma (LGUC) are at risk of recurrence and must undergo lifelong surveillance. To date, cytology and cystoscopy are the gold standard for the detection of de novo and recurrent LGUC. The objective of the current study was is to further characterize the role of cytology ...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21272
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Molecular testing to determine gene mutation status is now the recommended standard of care for patients with advanced or metastatic Non-small cell lung cancer (NSCLC). Because the majority of patients with NSCLC present with metastatic disease, minimally invasive procedures are necessary for diagnosis, stag...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21513
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Liquid-based cytology (LBC) is a useful cytopathological method, and LBC lung adenocarcinoma specimens may be used for genetic analysis in the near future. In the current study, the authors determined whether LBC specimens can be used for epidermal growth factor receptor (EGFR) mutation analysis in human lun...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22069
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:The accumulation of cyclin-dependent kinase inhibitor 2A (p16ink4a ) protein in a cell is associated with neoplastic progression in precancerous cervical lesions. Dual staining for p16ink4a and Ki-67 has been proposed as a triage test in cervical cancer screening for women who test positive for human papillo...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21800
更新日期:2017-03-01 00:00:00
abstract::A pediatric cytopathology symposium was held at the recent 20th International Congress of Cytology, which convened in Sydney, Australia, in May 2019. This educational event brought together cytopathologists from different countries and different institutions to discuss some of the practical considerations when applyin...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22166
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Human papillomavirus (HPV) tests and genotyping have been used in clinical risk assessment. The purpose of this study was to analyze the performance of 2 common HPV testing platforms in detecting high-grade cervical lesions (high-grade squamous intraepithelial lesion [HSIL] or worse [≥HSIL]). METHODS:Betwee...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21875
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Undifferentiated carcinoma (UC) is a rare, aggressive subtype of endometrial carcinoma. Dedifferentiated carcinomas (DCs) are UCs associated with a component of well differentiated endometrioid carcinoma. The authors sought to describe the morphologic features of UCs and DCs in cytologic specimens. METHODS:...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22351
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:SMARCB1 (INI-1)-deficient sinonasal carcinoma (IDSNC) is a newly described, poorly differentiated carcinoma. Herein, the authors describe the cytopathologic features of IDSNC in fine-needle aspiration (FNA) samples. METHODS:The pathology archives of 2 academic institutions were searched for cases of IDSNC w...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22020
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Allogenic hematopoietic stem cell transplantation (allo-HSCT) is a common procedure in hematological disorders and is preceded by a conditioning regimen that usually includes busulfan. The immunosuppression caused by the conditioning regimen and graft-versus-host disease prophylaxis is associated with human ...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22148
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:The usefulness of GATA3 (GATA-binding protein 3 to DNA sequence [A/T]GATA[A/G]) as a marker for metastatic breast carcinoma in serous effusion specimens was investigated. METHODS:Cell block sections from 74 serous effusion specimens (32 ascitic, 2 pericardial, and 40 pleural fluids) were stained with an ant...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21393
更新日期:2014-04-01 00:00:00
abstract::The evaluation of mediastinal and hilar lymph nodes for tissue diagnosis and staging of lung cancer is now commonly performed by minimally invasive, nonsurgical procedures such as computed tomography-guided fine-needle aspiration and endobronchial ultrasound-guided transbronchial needle aspiration. Ensuring that a suf...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.20166
更新日期:2011-12-25 00:00:00
abstract:BACKGROUND:New developments in the treatment of lung cancer have necessitated the further histologic and cytologic subtyping of nonsmall cell lung carcinomas. Thyroid transcription factor-1 (TTF-1) long has served as the predominant marker for demonstrating lung origin. However, it is also expressed in a variety of oth...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.20108
更新日期:2010-12-25 00:00:00
abstract:BACKGROUND:The objective of this study was to evaluate the diagnostic accuracy of the Bladder EpiCheck test in the follow-up of patients with non-muscle-invasive bladder cancer (NMIBC) and to compare it with the accuracy of urinary cytology, cystoscopy, and/or histology. METHODS:In total, 243 patients were enrolled in...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22152
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Personalized oncology requires molecular analysis of tumor cells. Several studies have demonstrated that cytological material is suitable for DNA analysis, but to the authors' knowledge there are no systematic studies comparing how the yield and quality of extracted DNA is affected by the various techniques ...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21276
更新日期:2013-07-01 00:00:00
abstract::Two-thirds of neuroendocrine neoplasms arising in the human body originate from the gastrointestinal system or pancreas. Gastroenteropancreatic neuroendocrine neoplasms are heterogeneous, comprising both well differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). The cl...
journal_title:Cancer cytopathology
pub_type: 杂志文章,评审
doi:10.1002/cncy.22073
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:p16(INK4a) Is overexpressed in almost all precancerous and carcinomatous lesions of the uterine cervix, secondary to interference between high-risk human papillomaviruses (hr-HPVs) and the retinoblastoma gene product. Overexpression of p16(INK4a) has also been identified in patients with high-grade urothelia...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21462
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Carbonic anhydrase IX (CAIX) is a hallmark of metabolic change in cancer cells. The aim was to evaluate the utility of CAIX expression for the detection of malignant pleural effusions by enzyme-linked immunosorbent assay (ELISA) and immunocytochemistry. METHODS:A total of 97 pleural effusions including 54 b...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21191
更新日期:2012-08-25 00:00:00
abstract:BACKGROUND:The objective of this study was to assess how atypical diagnostic category (ADC) is followed up, its outcomes, and the predictors that are associated with subsequent diagnosis of neoplasm/malignancy. METHODS:We reviewed pancreatic endoscopic ultrasound fine-needle aspiration (EUS-FNA) with ADC and compared ...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21389
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:The use of topically applied hemostatic substances during surgery has become a common practice. In some cases, the material is not absorbed or induces a granulomatous reaction resulting in a pseudotumoral lesion. With imaging studies, it is not possible to differentiate this from a tumor recurrence or absces...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22194
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:In the United States, the rate of cervical cancer is disproportionally higher in Hispanic and Black women compared with White women. In the current study, the authors compared human papillomavirus (HPV) testing and cytology results among Black and White women over a 24-month period. They then assessed the ra...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22316
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:The recent revision in terminology, with noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) replacing noninvasive follicular variant of papillary thyroid carcinoma, has reclassified the clinically indolent tumor as nonmalignant. The objective of this study was to evaluate th...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21981
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:The diagnosis of breast lesions is usually confirmed by fine-needle aspiration cytology (FNAC) or histological biopsy. Although there is increasing literature regarding the advantages and limitations of both modalities, there is no literature regarding the accuracy of these modalities for diagnosing breast l...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21308
更新日期:2013-10-01 00:00:00