Abstract:
BACKGROUND:To the authors' knowledge, the diagnostic value of cell block (CB) as an adjunct to ThinPrep liquid-based cytology (LBC) of bronchial washing specimens in the detection and subclassification of pulmonary neoplasms has not been well evaluated. The objective of the current study was to evaluate the diagnostic utility of CB in this setting. METHODS:A total of 74 bronchial washing specimens and concurrently prepared CBs with a diagnosis of malignant or suspicious/atypical obtained from bronchoscopy procedures performed during 2009 were reviewed along with 28 randomly selected negative cases. LBC and CBs were reviewed independently. Deeper levels and ancillary studies were performed on CBs for specific tumor classification if needed. LBC and CB diagnoses were correlated with final histology and/or bronchial brushings. RESULTS:Use of CBs increased the number of positive diagnoses from 18 (LBC only) to 30 (combined LBC and CB) and 36 (combined LBC and CB with ancillary studies), with increased diagnostic yields of 67% and 100%, respectively. CB without ancillary techniques detected 22 malignancies whereas LBC detected 18 malignancies and CB with ancillary techniques detected 29 malignancies. A specific tumor diagnosis was possible in 22 of 29 (76%) malignancies detected by CB. Bronchial brushings and histology confirmed malignancy in 91% and 92% of cases, respectively. CONCLUSIONS:CB combined with LBC was found to improve the rate of detection of malignancy over LBC alone, especially in cases with suspicious or atypical LBC diagnoses. Increased diagnostic yield is observed when CB is used with or without ancillary studies, but the yield is higher with CB using ancillary studies. CB serves as yet another available source of diagnostic material for immunohistochemical and molecular studies.
journal_name
Cancer Cytopatholjournal_title
Cancer cytopathologyauthors
Collins GR,Thomas J,Joshi N,Zhang Sdoi
10.1002/cncy.20181subject
Has Abstractpub_date
2012-04-25 00:00:00pages
134-41issue
2eissn
1934-662Xissn
1934-6638journal_volume
120pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Accurate fine-needle aspiration (FNA) diagnosis of metastatic melanoma is of therapeutic and prognostic significance and often requires ancillary studies. To the authors' knowledge, the reliability of immunostaining using a pan-melanoma cocktail, Sry-related HMG-BOX gene 10 (SOX10), and microphthalmia transc...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21458
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Urinary tract cytology (UTC) specimens diagnosed using high-risk indeterminate categories such as "atypical urothelial cells, cannot exclude high-grade urothelial carcinoma" (AUC-H) or "suspicious for high-grade urothelial carcinoma" (SHGUC) have a high rate of detection of high-grade urothelial carcinoma on...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21971
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:The Paris System (TPS) for Reporting Urinary Cytology aims to standardize urine cytology reporting. Per TPS, the diagnosis of "suspicious for high-grade urothelial carcinoma (SHGUC)" is applied in cases that have few urothelial cells with severe atypia but are quantitatively insufficient for a diagnosis of "...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22357
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Adequacy assessment is one of the most controversial and overlooked components in the daily practice of cytopathology, because it is generally determined from limited samples. Because voided urine varies widely in terms of its volume and cellularity, there is little consensus about the proper role for these ...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21634
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Although thyroid fine-needle aspiration (TFNA) is an excellent test in evaluating thyroid nodules, there are occasionally false negatives (FN). The clinical impact and pathologic features of FN TFNA is understudied in the peer-reviewed literature. METHODS:A cohort of patients with thyroid cancer was separat...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21196
更新日期:2012-10-25 00:00:00
abstract:BACKGROUND:The objective of this study was to evaluate the diagnostic accuracy of the Bladder EpiCheck test in the follow-up of patients with non-muscle-invasive bladder cancer (NMIBC) and to compare it with the accuracy of urinary cytology, cystoscopy, and/or histology. METHODS:In total, 243 patients were enrolled in...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22152
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Allogenic hematopoietic stem cell transplantation (allo-HSCT) is a common procedure in hematological disorders and is preceded by a conditioning regimen that usually includes busulfan. The immunosuppression caused by the conditioning regimen and graft-versus-host disease prophylaxis is associated with human ...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22148
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Urine cytology has been used for screening of bladder cancer but has been limited by its low sensitivity. UroVysion is a multiprobe fluorescence in situ hybridization (FISH) assay that detects common chromosome abnormalities in bladder cancers. For this study, the authors evaluated the effectiveness of multi...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21327
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Patients with low-grade urothelial carcinoma (LGUC) are at risk of recurrence and must undergo lifelong surveillance. To date, cytology and cystoscopy are the gold standard for the detection of de novo and recurrent LGUC. The objective of the current study was is to further characterize the role of cytology ...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21272
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Personalized oncology requires molecular analysis of tumor cells. Several studies have demonstrated that cytological material is suitable for DNA analysis, but to the authors' knowledge there are no systematic studies comparing how the yield and quality of extracted DNA is affected by the various techniques ...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21276
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:The Milan System for Reporting Salivary Gland Cytopathology is a tiered classification scheme that includes 6 diagnostic categories. Neoplasm, which is 1 of the 6 proposed categories, consists of benign neoplasm and neoplasm of uncertain malignant potential (NUMP). NUMP is reserved for a salivary gland neopl...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22002
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:The separation of benign from malignant mesothelial proliferations on effusion cytology can be difficult. Loss of methylthioadenosine phosphorylase (MTAP) by immunohistochemistry is an established marker of malignancy in mesothelial proliferations, but to the authors' knowledge largely has been applied only ...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22221
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:The Bethesda System for Reporting Thyroid Cytopathology category of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) includes fine-needle aspiration (FNA) specimens that cannot straightforwardly be classified as benign or malignant. To determine whether morphologi...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21984
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Subtyping non-small cell lung carcinomas (NSCLC) into adenocarcinoma (ACA) or squamous cell carcinoma (SQCC) is important for treatment and specimen triage for molecular studies. To preserve tissue for molecular studies in cytology/small biopsy specimens, a 2-antibody cocktail for NSCLC subtyping was develop...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21707
更新日期:2016-07-01 00:00:00
abstract::Follicular cell-derived carcinomas of the thyroid gland comprise a heterogeneous group of malignant neoplasms of the thyroid gland with varied histologic appearance and molecular profiles. In most patients, these tumors represent relatively indolent neoplasms; however, certain subtypes/variants behave in an aggressive...
journal_title:Cancer cytopathology
pub_type: 杂志文章,评审
doi:10.1002/cncy.21417
更新日期:2014-07-01 00:00:00
abstract::BACKGROUND.: Pancreatic ductal adenocarcinoma is rarely detected early enough for patients to be cured. The objective of the authors was to develop a monoclonal antibody to distinguish adenocarcinoma and precancerous intraductal papillary mucinous neoplasia (IPMN) from benign epithelium. METHODS.: Mice were immunized ...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21223
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Diagnosing giant cell-rich bone tumors can be challenging on limited biopsies. H3 histone family member 3A (H3F3A) (G34W/V/R/L) mutations are present in the majority of giant cell tumors (GCTs) of bone and H3 histone family member 3B (H3F3B) (K36M) mutations are present in nearly all chondroblastomas, but ar...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22000
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:The objective of the current study was to investigate the clinical performance of detecting high-grade lesions with the CINtec PLUS p16(INK4a)/Ki-67 dual stain and the APTIMA human papillomavirus (HPV) Assay in a cohort of women with low-grade squamous intraepithelial lesion (LSIL) cytology. The authors also...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21233
更新日期:2013-03-01 00:00:00
abstract::Two-thirds of neuroendocrine neoplasms arising in the human body originate from the gastrointestinal system or pancreas. Gastroenteropancreatic neuroendocrine neoplasms are heterogeneous, comprising both well differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). The cl...
journal_title:Cancer cytopathology
pub_type: 杂志文章,评审
doi:10.1002/cncy.22073
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Tumor spread through air spaces (STAS), a significant prognostic indicator, has been described recently as a pattern of invasion in pulmonary carcinomas. However, questions remain regarding preoperative identification of STAS and whether it represents an in vivo phenomenon versus an ex vivo artifact. METHOD...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22243
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Although patients found to have atypical squamous cells of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesions (LSILs) on Papanicolaou (Pap) testing are treated conservatively, 5.2% to 18.8% of them progress to high-grade squamous intraepithelial lesions (HSILs). The objective o...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21615
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Angiomyolipoma (AML), typically composed of smooth muscle, vessels, and fat, is generally a benign tumor in the kidneys. However, it occasionally occurs in extrarenal sites and behaves like a malignant tumor. AML is uncommonly encountered in fine-needle aspiration (FNA) samples and can cause diagnostic diffi...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21824
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:More accurate biomarkers in cervical cytology screening could reduce the number of women unnecessarily referred for biopsy. This study investigated the ability of p16/Ki-67 dual staining to predict high-grade cervical intraepithelial neoplasia (CIN) in human papillomavirus (HPV)-positive women from the Norwe...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21807
更新日期:2017-04-01 00:00:00
abstract::The evaluation of mediastinal and hilar lymph nodes for tissue diagnosis and staging of lung cancer is now commonly performed by minimally invasive, nonsurgical procedures such as computed tomography-guided fine-needle aspiration and endobronchial ultrasound-guided transbronchial needle aspiration. Ensuring that a suf...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.20166
更新日期:2011-12-25 00:00:00
abstract:BACKGROUND:Epithelioid sarcoma (ES) is a rare mesenchymal tumor that is divided into 2 types: classic and proximal. To the authors' knowledge, ES has been poorly studied in cytology, with fewer than 50 cases reported to date. The objective of the current study was to analyze the cytological and immunohistochemical info...
journal_title:Cancer cytopathology
pub_type: 杂志文章,评审
doi:10.1002/cncy.22052
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Recommendations regarding how many nodules to biopsy with thyroid fine-needle aspiration vary. METHODS:The authors reviewed fine-needle aspiration specimens of 12,763 nodules from 10,506 patients and correlated them with the number of nodules biopsied. RESULTS:Compared with patients in whom only a single n...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21904
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:The objective of this study was to assess how atypical diagnostic category (ADC) is followed up, its outcomes, and the predictors that are associated with subsequent diagnosis of neoplasm/malignancy. METHODS:We reviewed pancreatic endoscopic ultrasound fine-needle aspiration (EUS-FNA) with ADC and compared ...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21389
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:The availability of suitable biospecimens is critical to the success of advanced genomic analyses. The objective of this study was to assess the sensitivity of fine-needle aspiration (FNA) compared with gross surgical sampling (GSS) from surgical specimens for the detection of somatic mutations in breast can...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21599
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:The aim of this study was to validate clinical utilization of routinely prepared cytology specimens for molecular testing to detect EGFR or KRAS mutations in lung cancer. METHODS:From September 2009 to April 2010, the authors collected 209 cytology specimens from patients with lung cancer at the MD Anderson...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.20151
更新日期:2011-04-25 00:00:00
abstract:BACKGROUND:The recent revision in terminology, with noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) replacing noninvasive follicular variant of papillary thyroid carcinoma, has reclassified the clinically indolent tumor as nonmalignant. The objective of this study was to evaluate th...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21981
更新日期:2018-05-01 00:00:00