Abstract:
BACKGROUND:Although patients found to have atypical squamous cells of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesions (LSILs) on Papanicolaou (Pap) testing are treated conservatively, 5.2% to 18.8% of them progress to high-grade squamous intraepithelial lesions (HSILs). The objective of the current study was to identify predictors of progression to HSIL and determine what percentage of ASC-US/LSIL cases harbor cervical intraepithelial neoplasia of grade 2 or higher. METHODS:The current study included 381 consecutive cases with ASC-US/LSIL. After the exclusion of 87 cases because of a history of dysplasia or loss to follow-up, 165 cases with follow-up cytology were used to analyze predictive factors of progression to HSIL, and 129 cases that underwent immediate tissue biopsy were subjected to correlation analysis between cytology and histology. Disease regression was defined as a reversion to normal or benign cellular changes, disease persistence as maintenance at ASC-US/LSIL, and disease progression as progression to HSIL. Data regarding clinical parameters were obtained from medical records. Methylation-specific polymerase chain reaction was performed using cytology samples to evaluate methylation of the p16 promoter. RESULTS:Of 165 cases, 131 (79.4%) regressed, 23 (13.9%) were persistent, and 11 cases (6.7%) progressed. Human papillomavirus infection was more common in women with disease progression than in those with disease regression or persistence (P = .033). Promoter methylation of p16 in the cytology sample was more common in cases that progressed (5 of 6 cases) than in cases that regressed (0 of 8 cases). Twenty-three of 129 cases (17.8%) were found to harbor cervical intraepithelial neoplasia of grade 2 or higher on immediate tissue biopsy. CONCLUSIONS:Human papillomavirus infection and p16 promoter methylation might be valuable surrogate markers of disease progression from ASC-US/LSIL to HSIL.
journal_name
Cancer Cytopatholjournal_title
Cancer cytopathologyauthors
Lee H,Lee EJdoi
10.1002/cncy.21615subject
Has Abstractpub_date
2016-01-01 00:00:00pages
58-65issue
1eissn
1934-662Xissn
1934-6638journal_volume
124pub_type
杂志文章abstract:BACKGROUND:The use of topically applied hemostatic substances during surgery has become a common practice. In some cases, the material is not absorbed or induces a granulomatous reaction resulting in a pseudotumoral lesion. With imaging studies, it is not possible to differentiate this from a tumor recurrence or absces...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22194
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:The Paris System (TPS) for Reporting Urinary Cytology aims to standardize urine cytology reporting. Per TPS, the diagnosis of "suspicious for high-grade urothelial carcinoma (SHGUC)" is applied in cases that have few urothelial cells with severe atypia but are quantitatively insufficient for a diagnosis of "...
journal_title:Cancer cytopathology
pub_type: 杂志文章
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更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:The aim of this study was to validate clinical utilization of routinely prepared cytology specimens for molecular testing to detect EGFR or KRAS mutations in lung cancer. METHODS:From September 2009 to April 2010, the authors collected 209 cytology specimens from patients with lung cancer at the MD Anderson...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.20151
更新日期:2011-04-25 00:00:00
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journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21462
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:The usefulness of GATA3 (GATA-binding protein 3 to DNA sequence [A/T]GATA[A/G]) as a marker for metastatic breast carcinoma in serous effusion specimens was investigated. METHODS:Cell block sections from 74 serous effusion specimens (32 ascitic, 2 pericardial, and 40 pleural fluids) were stained with an ant...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21393
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Fine-needle aspiration (FNA) is widely accepted in the preoperative management of salivary gland lesions. The proposed Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) aims to standardize reporting terminology. Studies regarding the risk of malignancy (ROM) for the proposed categories continu...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22016
更新日期:2018-08-01 00:00:00
abstract::Cervical cancer and anal cancer share many similarities including causation by oncogenic human papillomaviruses; however, significant differences exist in their epidemiology, risk factors, biologic behavior, management, and treatment. Although rare, the incidence of anal cancer is alarmingly high and continues to incr...
journal_title:Cancer cytopathology
pub_type: 杂志文章,评审
doi:10.1002/cncy.20126
更新日期:2011-02-25 00:00:00
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journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21707
更新日期:2016-07-01 00:00:00
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journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.20097
更新日期:2010-10-25 00:00:00
abstract:BACKGROUND:Although thyroid fine-needle aspiration (TFNA) is an excellent test in evaluating thyroid nodules, there are occasionally false negatives (FN). The clinical impact and pathologic features of FN TFNA is understudied in the peer-reviewed literature. METHODS:A cohort of patients with thyroid cancer was separat...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21196
更新日期:2012-10-25 00:00:00
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journal_title:Cancer cytopathology
pub_type: 杂志文章,评审
doi:10.1002/cncy.22052
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:The primary goal of this study was to compare the clinical performance of an optimized and rigorously controlled immunocytochemical (ICC) assay for p16(INK4a) to high-risk (HR) human papillomavirus (HPV) detection by polymerase chain reaction (PCR) as diagnostic adjuncts for cytology specimens from colposcop...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.20078
更新日期:2010-06-25 00:00:00
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journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21229
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Morphologic and genetic analysis of thyroid nodules may be performed from a single vial. Preanalytic variables that affect nucleic acid extracted from a single vial are evaluated. METHODS:Thyroid fine-needle aspiration (FNA) specimens collected in CytoLyt were evaluated. A ThinPrep slide was prepared. Extra...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22270
更新日期:2020-09-01 00:00:00
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journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21559
更新日期:2015-08-01 00:00:00
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journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21971
更新日期:2018-04-01 00:00:00
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journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22069
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Germline and somatic mutations of DICER1 have been identified in various types of neoplastic lesions, with germline DICER1 mutation being linked to autosomal dominant hereditary pleiotropic tumor syndrome (DICER1 syndrome). Patients with DICER1 syndrome are at increased risk of developing thyroid disease, in...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22329
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Undifferentiated carcinoma (UC) is a rare, aggressive subtype of endometrial carcinoma. Dedifferentiated carcinomas (DCs) are UCs associated with a component of well differentiated endometrioid carcinoma. The authors sought to describe the morphologic features of UCs and DCs in cytologic specimens. METHODS:...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22351
更新日期:2021-02-01 00:00:00
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journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22166
更新日期:2019-10-01 00:00:00
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journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21272
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:More accurate biomarkers in cervical cytology screening could reduce the number of women unnecessarily referred for biopsy. This study investigated the ability of p16/Ki-67 dual staining to predict high-grade cervical intraepithelial neoplasia (CIN) in human papillomavirus (HPV)-positive women from the Norwe...
journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21807
更新日期:2017-04-01 00:00:00
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journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22148
更新日期:2019-06-01 00:00:00
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journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22221
更新日期:2020-02-01 00:00:00
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journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.21465
更新日期:2014-12-01 00:00:00
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journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22240
更新日期:2020-05-01 00:00:00
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journal_title:Cancer cytopathology
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncy.20181
更新日期:2012-04-25 00:00:00
abstract:BACKGROUND:Human papillomavirus (HPV) tests and genotyping have been used in clinical risk assessment. The purpose of this study was to analyze the performance of 2 common HPV testing platforms in detecting high-grade cervical lesions (high-grade squamous intraepithelial lesion [HSIL] or worse [≥HSIL]). METHODS:Betwee...
journal_title:Cancer cytopathology
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00
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journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.20145
更新日期:2011-08-25 00:00:00
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journal_title:Cancer cytopathology
pub_type: 杂志文章
doi:10.1002/cncy.22167
更新日期:2019-09-01 00:00:00