Adsorption of human salivary mucins to hydroxyapatite.

Abstract:

:The interactions between low (MG2) and high (MG1) molecular-weight human submandibular-sublingual mucin and hydroxyapatite (OHAp) were compared using a quantitative assay. Data obtained appeared to empirically fit the Langmuir adsorption isotherm. Apparent affinity constants derived from this isotherm indicated that MG1 had a greater affinity for OHAp than did MG2. Inhibition studies revealed that salivary glycolipids inhibited the interaction of MG1 and OHAp without influencing MG2 adsorption. In contrast, MG2 adsorption to OHAp was markedly inhibited by cysteine-containing salivary phosphoprotein fractions. Collectively, the data indicate MG1 and MG2 differ in their interaction with OHAp.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Tabak LA,Levine MJ,Jain NK,Bryan AR,Cohen RE,Monte LD,Zawacki S,Nancollas GH,Slomiany A,Slomiany BL

doi

10.1016/0003-9969(85)90070-6

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

423-7

issue

5

eissn

0003-9969

issn

1879-1506

journal_volume

30

pub_type

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