Abstract：
OBJECTIVE:The DNA oxidation byproduct 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a well-known biomarker used to evaluate oxidative stress. We previously reported that the generation of reactive oxygen species (ROS) is increased in cultured gingival fibroblasts (GF) from patients with Down syndrome (DS). Thus, the aim of this study was to evaluate 8-OHdG as a marker of oxidative stress in saliva of DS patients. MATERIALS AND METHODS:The study group consisted of DS patients (66 patients; age range 1-62 years) and systemically healthy control subjects (71 subjects; age range 4-58 years). Periodontal status was judged based on standard measurements of probing depth (PD) and gingival index (GI). The salivary levels of 8-OHdG were determined using an enzyme-linked immunosorbent assay. RESULTS:The mean of PD and GI values were not significantly different between young (1-12 years) patients with DS (DS-1) and controls (C-1) or between adult (30-62 years) patients with DS (DS-2) and controls (C-2). There were statistically significant positive correlations between the salivary 8-OHdG levels and GI in the DS-1, DS-2 and C-2 groups, but not in the C-1. There were also statistically significant positive correlations between salivary 8-OHdG levels and PD in the DS-2 and C-2 groups, but not in the DS-1 or C-1 groups. The salivary levels of 8-OHdG of DS-1 and DS-2 groups were significantly higher than in the C-l and C-2 groups, respectively. CONCLUSIONS:These results suggest that progressive oxidative stress occurred in DS patients. Oxidative stress may contribute to the clinical features of DS, particularly to the progressive periodontitis characteristic of early ageing.
journal_name
Arch Oral Bioljournal_title
Archives of oral biologyauthors
Komatsu T,Duckyoung Y,Ito A,Kurosawa K,Maehata Y,Kubodera T,Ikeda M,Lee MCdoi
10.1016/j.archoralbio.2013.03.017subject
Has Abstractpub_date
2013-09-01 00:00:00pages
1246-50issue
9eissn
0003-9969issn
1879-1506pii
S0003-9969(13)00112-Xjournal_volume
58pub_type
杂志文章abstract：:Inhibitory jaw reflexes are believed to be important for protecting the teeth and temporo-mandibular structures from damage during sudden or forceful biting or mastication. Accordingly, alterations in these reflexes are sometimes implicated in aetiologies proposed for oro-facial pain syndromes, although the associatio...
journal_title：Archives of oral biology
pub_type： 杂志文章
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journal_title：Archives of oral biology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.archoralbio.2012.09.017
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abstract：:The study aim was to determine whether prostaglandin E(2) (PGE(2)) in gingival crevicular fluid (GCF) could serve as a risk factor for periodontitis in human immunodeficiency virus-positive (HIV(+)) patients. Clinical measurements, including gingival index (GI), plaque index, bleeding index, probing depth (PD), attach...
journal_title：Archives of oral biology
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pub_type： 杂志文章
doi：10.1016/s0003-9969(96)00059-3
更新日期：1996-11-01 00:00:00
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journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2011.04.012
更新日期：2011-11-01 00:00:00
abstract：:Daily intravenous administration of 50 mg/kg cyclosporin A (CsA), after excision of cheek pouch tumors induced with 9,10-dimethyl-1,2-benzanthracene (DMBA), enhanced the incidence of cervical lymph node metastasis to 93%, a significant increase over the rates observed for animals receiving a dosage of 25 mg/kg (43%), ...
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pub_type： 杂志文章
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journal_title：Archives of oral biology
pub_type： 杂志文章
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journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2017.04.016
更新日期：2017-08-01 00:00:00
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journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(85)90075-5
更新日期：1985-01-01 00:00:00
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journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(85)90150-5
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journal_title：Archives of oral biology
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更新日期：2011-05-01 00:00:00
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journal_title：Archives of oral biology
pub_type： 杂志文章,评审
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更新日期：2019-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0003-9969(98)00009-0
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更新日期：2015-08-01 00:00:00
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journal_title：Archives of oral biology
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doi：10.1016/j.archoralbio.2019.05.010
更新日期：2019-07-01 00:00:00
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journal_title：Archives of oral biology
pub_type： 杂志文章,评审
doi：
更新日期：1999-05-01 00:00:00
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更新日期：2002-03-01 00:00:00
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journal_title：Archives of oral biology
pub_type： 杂志文章
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更新日期：2004-12-01 00:00:00
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journal_title：Archives of oral biology
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更新日期：1999-02-01 00:00:00
