Abstract:
OBJECTIVE:It was aimed to investigate the in vivo effects of local injection of sclerostin protein on orthodontic tooth movement. DESIGN:A total of 48 rats underwent orthodontic mesialization of the maxillary first molars on both sides. Local injection was given at the compression side in the alveolar bone on both maxillary sides, with sclerostin protein carried by hydrogel on one side, and the same volume of normal saline carried by hydrogel on the other side serving as the control. After two weeks, the tooth movement amount and effects on the periodontium were assessed through micro-computed tomography (μCT) analysis, tartrate-resistant acid phosphatase (TRAP) staining and immunohistochemistry (IHC) analysis. RESULTS:After two weeks of intervention, tooth movement was significantly greater in the 4 μg/kg and 20 μg/kg sclerostin injection groups, compared to the control. Analysis of the furcation area of the maxillary first molar showed that the 20 μg/kg group had significantly decreased BV/TV. At the compression side, the number of TRAP-positive osteoclasts was significantly increased in 20 μg/kg group compared to the control. The expression of RANKL was statistically higher in all the sclerostin groups, while the expression of OPG was statistically lower in the 4 μg/kg and 20 μg/kg groups, compared to the control. At the tension side, the expression of RUNX2 and COL-1 was statistically higher in the 20 μg/kg group compared to the control. CONCLUSIONS:Local injection of sclerostin protein in the alveolar bone at the compression side accelerates OTM in rats by promoting osteoclastogenesis.
journal_name
Arch Oral Bioljournal_title
Archives of oral biologyauthors
Lu W,Zhang X,Firth F,Mei L,Yi J,Gong C,Li H,Zheng W,Li Ydoi
10.1016/j.archoralbio.2018.12.011subject
Has Abstractpub_date
2019-03-01 00:00:00pages
43-50eissn
0003-9969issn
1879-1506pii
S0003-9969(18)30545-4journal_volume
99pub_type
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journal_title:Archives of oral biology
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journal_title:Archives of oral biology
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doi:10.1016/0003-9969(90)90110-v
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journal_title:Archives of oral biology
pub_type: 杂志文章,评审
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abstract::The study examined the glucose clearance (retention) in saliva at different surfaces of these teeth in 23 subjects. The mouth was thoroughly rinsed for 15 s with 20 ml of a 0.5 M glucose solution. The concentrations of glucose absorbed by small pieces of paper, placed on the mesial, distal, labial (buccal), lingual an...
journal_title:Archives of oral biology
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doi:10.1016/0003-9969(93)90183-m
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journal_title:Archives of oral biology
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journal_title:Archives of oral biology
pub_type: 杂志文章
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journal_title:Archives of oral biology
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更新日期:2019-07-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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doi:10.1016/j.archoralbio.2018.04.019
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pub_type: 杂志文章
doi:10.1016/s0003-9969(96)00097-0
更新日期:1996-12-01 00:00:00
abstract::Most authorities agree that the hydrodynamic theory of dentine sensitivity best explains the stimulus-response relations of most painful stimuli. However, as the usual hydrodynamic stimuli are so different, it has been impossible to compare them. The equivalency of hydrodynamic stimuli can be evaluated from measuremen...
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pub_type: 杂志文章
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更新日期:1996-11-01 00:00:00
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更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2014.06.006
更新日期:2014-10-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2008.04.004
更新日期:2008-10-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2016.06.006
更新日期:2016-10-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2015.07.005
更新日期:2015-10-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章,评审
doi:10.1016/j.archoralbio.2012.11.008
更新日期:2013-03-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(87)90074-4
更新日期:1987-01-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2005.12.006
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:The aim of the present study is to investigate the involvement of immunocompetent cells, pro-inflammatory cytokines and HSP, to evaluate a change of periodontal ligament during the initial stage of orthodontic tooth movement. DESIGN:In the present study, we investigated the distributional density of immunoco...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2010.11.010
更新日期:2011-05-01 00:00:00
abstract::To study the effects of increased occlusal vertical dimension on these kinetics, the actin-filament sliding velocity on masseter myosins in an in vitro motility assay and the ATPase activity of masseter myosins from normal (control) and bite-opened (5.6 mm increase in the vertical dimension for 1 week) guinea-pigs wer...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/s0003-9969(97)00038-1
更新日期:1997-07-01 00:00:00