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Expression of proinflammatory cytokines in osteoarthritis of the temporomandibular joint.

Abstract：

OBJECTIVE:This study reports the expression of proinflammatory cytokines in temporomandibular joint (TMJ) of patients affected with temporomandibular osteoarthritis (OA). DESIGN:In twelve OA of the TMJ (OA-TMJ) affected patients and in six healthy volunteer subjects studied as control, the expression of IL1beta (interleukin-1beta), IL2, IL4, IL5, IL6, IL10, IL12p35, IL12p40, IL17, IFNgamma (interferon-gamma), TNFalpha (tumor necrosis factor-alpha), and TNFbeta mRNAs was evaluated. Using quantitative real-time RT-PCR technique, the cytokine levels, reported as Ct (cycle threshold), DeltaCt (Ct cytokine-Ct 18S rRNA) and RQ (relative quantification), in patient and control groups were compared. RESULTS:Expression of IL1beta, IL2, IL12p35, IL12p40, IL17, TNFalpha, TNFbeta, and IFNgamma mRNAs was significantly higher in patients as compared with controls. In particular, IL12 was the predominant cytokine expressed in patients (IL12p35 RQ=30.2 and IL12p40 RQ=29.0). Conversely, IL10 mRNA levels were higher in controls (RQ=1.8). CONCLUSIONS:These data suggest that not only IL1beta, IFNgamma, and TNFalpha but also IL10, IL12, and IL17 are involved in the OA-TMJ pathogenesis. Furthermore, an inflammatory response characterised by the predominant expression of IL12 mRNA and down-regulated expression of IL10 mRNA is associated with the degenerative changes observed in OA-TMJ.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Vernal R,Velásquez E,Gamonal J,Garcia-Sanz JA,Silva A,Sanz M

doi

10.1016/j.archoralbio.2008.04.004

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

910-5

issue

10

eissn

0003-9969

issn

1879-1506

pii

S0003-9969(08)00119-2

journal_volume

53

pub_type

杂志文章

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